Publications by authors named "Alejandra Alvarez"

55Publications

Gold Nanoparticles Mediate Improved Detection of β-amyloid Aggregates by Fluorescence.

Nanomaterials (Basel) 2020 Apr 6;10(4). Epub 2020 Apr 6.

Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile.

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http://dx.doi.org/10.3390/nano10040690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221977PMC
April 2020

The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis.

Cell Rep 2020 01;30(1):215-228.e5

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1X8, ON, Canada; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.033DOI Listing
January 2020

c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers.

Front Cell Neurosci 2019 26;13:526. Epub 2019 Nov 26.

Cell Signaling Laboratory, Faculty of Biological Science, Department of Cell and Molecular Biology, Center for Aging and Regeneration (CARE), Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.3389/fncel.2019.00526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902026PMC
November 2019

Lysosome motility and distribution: Relevance in health and disease.

Biochim Biophys Acta Mol Basis Dis 2019 06 21;1865(6):1076-1087. Epub 2019 Mar 21.

Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.03.009DOI Listing
June 2019

Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease.

Nanomedicine 2017 Oct 30;13(7):2341-2350. Epub 2017 Jun 30.

Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago; Advanced Center for Chronic Diseases (ACCDiS), Sergio Livingstone 1007, Independencia, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2017.06.013DOI Listing
October 2017

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content.

Redox Biol 2017 08 2;12:274-284. Epub 2017 Mar 2.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344325PMC
August 2017

Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

J Alzheimers Dis 2016 10;54(3):1193-1205

Cell Signaling Laboratory, Cell and Molecular Biology Department, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Chile.

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http://dx.doi.org/10.3233/JAD-151087DOI Listing
October 2016

Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.

Biochim Biophys Acta 2016 Feb 19;1859(2):269-79. Epub 2015 Nov 19.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; FONDAP Center for Genome Regulation (CGR), Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2015.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014229PMC
February 2016

P73 and P63: The siblings that work together in neurodevelopment.

Cell Cycle 2015 ;14(23):3671-2

a Departamento de Biología Celular y Molecular ; Laboratorio de Señalización Celular; Facultad de Ciencias Biológicas; P. Universidad Católica de Chile ; Santiago , Chile.

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http://dx.doi.org/10.1080/15384101.2015.1112615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825780PMC
August 2016

The unique case of the Niemann-Pick type C cholesterol storage disorder.

Pediatr Endocrinol Rev 2014 Sep;12 Suppl 1:166-75

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September 2014

c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease.

Mol Cell 2014 Oct 11;56(1):163-73. Epub 2014 Sep 11.

Department of Cell & Molecular Biology, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.08.013DOI Listing
October 2014

EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.

PLoS One 2014 21;9(3):e92309. Epub 2014 Mar 21.

Departamento de Biología Celular y Molecular, Laboratorio de Señalización Celular, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago, Chile.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092309PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962387PMC
January 2015

Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease.

Oxid Med Cell Longev 2012 5;2012:205713. Epub 2012 Jun 5.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta no. 364, Casilla 114-D, 8330024 Santiago, Chile.

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http://dx.doi.org/10.1155/2012/205713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374944PMC
October 2012

Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease.

Biometals 2012 Aug 17;25(4):777-86. Epub 2012 Apr 17.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://link.springer.com/content/pdf/10.1007/s10534-012-9546
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http://link.springer.com/10.1007/s10534-012-9546-6
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http://dx.doi.org/10.1007/s10534-012-9546-6DOI Listing
August 2012

Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease.

Mol Neurodegener 2012 Mar 29;7:11. Epub 2012 Mar 29.

Physiology Department, Millennium Nucleus in Regenerative Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1186/1750-1326-7-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395862PMC
March 2012

Lysosomal vitamin E accumulation in Niemann-Pick type C disease.

Biochim Biophys Acta 2012 Feb 15;1822(2):150-60. Epub 2011 Nov 15.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbadis.2011.11.009DOI Listing
February 2012

Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia.

Int J Paediatr Dent 2012 May 15;22(3):191-6. Epub 2011 Sep 15.

Research Institute, Faculty of Dentistry, University of Zulia, Maracaibo Oncohematology Service, Children's Specialty Hospital, Maracaibo, Venezuela.

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http://dx.doi.org/10.1111/j.1365-263X.2011.01175.xDOI Listing
May 2012

Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.

Neuropeptides 2011 Aug 31;45(4):273-9. Epub 2011 May 31.

Millenium Nucleus in Stress and Addiction, Departamento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile, Santiago.

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http://dx.doi.org/10.1016/j.npep.2011.05.002DOI Listing
August 2011

Lack of activation of the unfolded protein response in mouse and cellular models of Niemann-Pick type C disease.

Neurodegener Dis 2011 13;8(3):124-8. Epub 2010 Aug 13.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1159/000316540DOI Listing
July 2011

p73 participates in male germ cells apoptosis induced by etoposide.

Mol Hum Reprod 2010 Oct 2;16(10):734-42. Epub 2010 Jun 2.

Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile.

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https://academic.oup.com/molehr/article-lookup/doi/10.1093/m
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http://dx.doi.org/10.1093/molehr/gaq045DOI Listing
October 2010

Mitochondrial DNA diversity in a population from Santa Catarina (Brazil): predominance of the European input.

Int J Legal Med 2010 Jul 18;124(4):331-6. Epub 2010 May 18.

BIOMICs Research Group, Centro de Investigación y Estudios Avanzados Lucio Lascaray, Universidad del País Vasco UPV/EHU, Miguel de Unamuno 3, 01006 Vitoria-Gasteiz, Spain.

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http://link.springer.com/content/pdf/10.1007/s00414-010-0464
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http://link.springer.com/10.1007/s00414-010-0464-2
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http://dx.doi.org/10.1007/s00414-010-0464-2DOI Listing
July 2010

Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation.

J Neurosci 2010 Mar;30(10):3728-38

Laboratorio de Señalización Celular, Departmento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile, 8331010 Santiago, Chile.

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http://dx.doi.org/10.1523/JNEUROSCI.2024-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872795PMC
March 2010

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function.

Neural Dev 2009 Nov 2;4:41. Epub 2009 Nov 2.

Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco and MIFAB, Chile.

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http://dx.doi.org/10.1186/1749-8104-4-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779803PMC
November 2009

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice.

Neurobiol Aging 2011 Jul 22;32(7):1249-61. Epub 2009 Aug 22.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Av. Alameda 340, Santiago, Chile.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.07.007DOI Listing
July 2011

c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis.

J Cell Physiol 2009 Jul;220(1):136-43

Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontifical Catholic University of Chile, Santiago, Chile.

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http://doi.wiley.com/10.1002/jcp.21743
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http://dx.doi.org/10.1002/jcp.21743DOI Listing
July 2009

Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease.

FASEB J 2008 Oct 30;22(10):3617-27. Epub 2008 Jun 30.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, casilla 114-D, Santiago, Chile.

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http://www.fasebj.org/doi/10.1096/fj.07-102715
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http://dx.doi.org/10.1096/fj.07-102715DOI Listing
October 2008

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits.

Brain 2008 Sep 17;131(Pt 9):2425-42. Epub 2008 Jun 17.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1093/brain/awn125DOI Listing
September 2008

Heparin activates Wnt signaling for neuronal morphogenesis.

J Cell Physiol 2008 Sep;216(3):805-15

Centro de Regulación Celular y Patología Joaquín V. Luco, MIFAB, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/jcp.21465DOI Listing
September 2008

Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.

FEBS J 2008 Feb 17;275(4):625-32. Epub 2008 Jan 17.

CRCP Biomedical Center, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1742-4658.2007.06238.xDOI Listing
February 2008

Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway.

Curr Alzheimer Res 2005 Jul;2(3):301-6

FONDAP-Biomedical Center, P. Catholic University of Chile, P.O. Box 114-D, Santiago, Chile.

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http://dx.doi.org/10.2174/1567205054367928DOI Listing
July 2005

[Pulmonary hemorrhage after abciximab. Risk factors and the role of protamine].

Rev Esp Cardiol 2005 Apr;58(4):453-5

Servicio de Medicina Interna, Hospital Juan Ramón Jiménez, Huelva, España.

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April 2005

Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species.

Neurobiol Dis 2004 Nov;17(2):326-36

FONDAP Center for Cell and Molecular Biology Joaquin V. Luco, P. Universidad Católica de Chile, Santiago, 114-D, Chile.

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http://dx.doi.org/10.1016/j.nbd.2004.06.007DOI Listing
November 2004

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

Exp Cell Res 2004 Jul;297(1):186-96

Centro FONDAP de Regulación Celular y Patología "Joaquín V. Luco", MIFAB, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.yexcr.2004.02.028DOI Listing
July 2004

pannier and pointedP2 act sequentially to regulate Drosophila heart development.

Development 2003 Jul;130(13):3015-26

Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.00488DOI Listing
July 2003

Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway.

FASEB J 2002 Dec 18;16(14):1982-4. Epub 2002 Oct 18.

Centro de Regulación Celular y Patología, MIFAB, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago.

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http://dx.doi.org/10.1096/fj.02-0327fjeDOI Listing
December 2002

Wnt signaling involvement in beta-amyloid-dependent neurodegeneration.

Neurochem Int 2002 Nov;41(5):341-4

Center for Cell Regulation and Pathology, P. Catholic University of Chile, P.O. Box 114-D, Alameda 340, Santiago, Chile.

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http://dx.doi.org/10.1016/s0197-0186(02)00056-6DOI Listing
November 2002