Aleixo Muise

Aleixo Muise

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Aleixo Muise

Publications by authors named "Aleixo Muise"

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Intensified Infliximab Induction is Associated with Improved Response and Decreased Colectomy in Steroid-Refractory Paediatric Ulcerative Colitis.

J Crohns Colitis 2019 Aug;13(8):982-989

Division of Gastroenterology, Hepatology & Nutrition, Department of Paediatrics, University of Toronto, Toronto, ON, Canada.

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https://academic.oup.com/ecco-jcc/advance-article/doi/10.109
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http://dx.doi.org/10.1093/ecco-jcc/jjz019DOI Listing
August 2019

Novel Exonic Deletions in TTC7A in a Newborn with Multiple Intestinal Atresia and Combined Immunodeficiency.

J Clin Immunol 2019 Aug 24;39(6):616-619. Epub 2019 Jul 24.

Department of Pathology and Laboratory Medicine, British Columbia Children's and Women's Hospital, The University of British Columbia, 4480 Oak St, Vancouver, BC, V6H3N1, Canada.

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http://dx.doi.org/10.1007/s10875-019-00669-6DOI Listing
August 2019

TTC7A: Steward of Intestinal Health.

Cell Mol Gastroenterol Hepatol 2019 13;7(3):555-570. Epub 2018 Dec 13.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Institute for Medical Science and Biochemistry, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406079PMC
June 2019

Very early onset IBD: novel genetic aetiologies.

Curr Opin Allergy Clin Immunol 2018 12;18(6):470-480

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://Insights.ovid.com/crossref?an=00130832-201812000-0000
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http://dx.doi.org/10.1097/ACI.0000000000000486DOI Listing
December 2018

Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us.

Gastroenterol Clin North Am 2018 12 4;47(4):755-772. Epub 2018 Oct 4.

Department of Biochemistry, Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Pediatrics, Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Gastroenterology, Hepatology and Nutrition, Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, SickKids, Inflammatory Bowel Disease Centre, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183006
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http://dx.doi.org/10.1016/j.gtc.2018.07.004DOI Listing
December 2018

Monogenic Intestinal Epithelium Defects and the Development of Inflammatory Bowel Disease.

Physiology (Bethesda) 2018 09;33(5):360-369

Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto , Toronto, Ontario , Canada ; and Department of Paediatrics and Biochemistry, SickKids Inflammatory Bowel Disease Center and Cell Biology Program, University of Toronto, The Hospital for Sick Children , Toronto, Ontario , Canada.

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http://dx.doi.org/10.1152/physiol.00020.2018DOI Listing
September 2018

Advances in Evaluation of Chronic Diarrhea in Infants.

Gastroenterology 2018 Jun 12;154(8):2045-2059.e6. Epub 2018 Apr 12.

Department of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children's Hospital and the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.03.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044208PMC
June 2018

Long-term outcomes for children with very early-onset colitis: Implications for surgical management.

J Pediatr Surg 2018 May 8;53(5):964-967. Epub 2018 Feb 8.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpedsurg.2018.02.023DOI Listing
May 2018

Diagnostic delay in Canadian children with inflammatory bowel disease is more common in Crohn's disease and associated with decreased height.

Arch Dis Child 2018 04 9;103(4):319-326. Epub 2017 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/archdischild-2017-313060DOI Listing
April 2018

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.

Inflamm Bowel Dis 2017 11;23(11):1950-1961

1Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; 4VEO-IBD Consortium; 5Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts; 6Harvard Medical School, Boston, Massachusetts; 7Great Ormond Street Hospital London, London, England; 8Translational Gastroenterology Unit, University of Oxford, Oxford, England; 9Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida; 10Division of Gastroenterology and Nutrition, The Children's Hospital at Montefiore, Bronx, New York; 11Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 12Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan; 13Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; 14Department of Gastroenterology, Children's National Medical Center, Washington, DC; 15Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan; 16Hospital das Clınicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 17Division of Gastroenterology, McMaster Children's Hospital, West Hamilton, Ontario, Canada; 18Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany; 19Division of Pathology, Boston Children's Hospital, Boston, Massachusetts; 20Department of Pediatrics, University of Oxford, Oxford, England; 21Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; 22Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; 23Department of Biochemistry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; and 24Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000001270DOI Listing
November 2017

Clinical Genomics in Inflammatory Bowel Disease.

Trends Genet 2017 09 26;33(9):629-641. Epub 2017 Jul 26.

Program in Cell Biology, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada; SickKids Inflammatory Bowel Disease Centre and Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.tig.2017.06.008DOI Listing
September 2017

Very Early Onset IBD: How Very Different 'on Average'?

J Crohns Colitis 2017 May;11(5):517-518

Division of Gastroenterology, Hepatology, and Nutrition, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/ecco-jcc/jjw217DOI Listing
May 2017

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

Gastroenterology 2016 10 1;151(4):710-723.e2. Epub 2016 Jul 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037012PMC
October 2016

Mucosa-Associated Ileal Microbiota in New-Onset Pediatric Crohn's Disease.

Inflamm Bowel Dis 2016 07;22(7):1533-9

*Cell Biology Program, Research Institute; †Department of Paediatrics, Hospital for Sick Children; ‡University of Toronto, Toronto; §Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa; ‖CHEO Research Institute; and ¶Department of Paediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.

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http://pdfs.journals.lww.com/ibdjournal/2016/07000/Mucosa_As
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http://dx.doi.org/10.1097/MIB.0000000000000776DOI Listing
July 2016

Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2016 07;63(1):e15-7

*Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital †Department of Pediatrics ‡Department of Medicine, Harvard Medical School, Boston, MA §Division of Pediatric Hematology and Oncology ||Division of Pathology, University of Michigan, Ann Arbor, MI ¶SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute #Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada **Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany ††Division of Gastroenterology, Brigham and Women's Hospital ‡‡interNational Early Onset Paediatric IBD Cohort Study (NEOPICS), Boston, MA.

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http://dx.doi.org/10.1097/MPG.0000000000000532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605893PMC
July 2016

Multilabel immunofluorescence and antigen reprobing on formalin-fixed paraffin-embedded sections: novel applications for precision pathology diagnosis.

Mod Pathol 2016 06 4;29(6):557-69. Epub 2016 Mar 4.

Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/modpathol.2016.52DOI Listing
June 2016

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology 2016 05 4;150(5):1196-1207. Epub 2016 Feb 4.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085160012
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http://dx.doi.org/10.1053/j.gastro.2016.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842103PMC
May 2016

Rac1 Polymorphisms and Thiopurine Efficacy in Children With Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2015 Oct;61(4):404-7

*Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition †Medical Genetics Institute ‡Clinical Gastroenterology Laboratory, Shaare Zedek Medical Center, Jerusalem, Israel §Department of Gastroenterology, Rambam Health Care Campus ||Rappaport Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology #Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1097/MPG.0000000000000820DOI Listing
October 2015

Mutations in Plasmalemma Vesicle Associated Protein Result in Sieving Protein-Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia.

Cell Mol Gastroenterol Hepatol 2015 Jul;1(4):381-394.e7

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada ; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada ; Institute of Medical Science, University of Toronto, Toronto, ON, Canada ; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X150009
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http://dx.doi.org/10.1016/j.jcmgh.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507283PMC
July 2015

Unrelated donor hematopoietic stem cell transplantation for infantile enteropathy due to IL-10/IL-10 receptor defect.

Pediatr Transplant 2015 Jun 12;19(4):E101-3. Epub 2015 Mar 12.

Division of Hematology/Oncology/BMT, Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/petr.12452DOI Listing
June 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

Very early-onset inflammatory bowel disease: gaining insight through focused discovery.

Inflamm Bowel Dis 2015 May;21(5):1166-75

*Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts; †Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; ‡Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany; §Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada; ‖SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; ¶Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts; **Division of Gastroenterology and Hepatology, Brigham & Women's Hospital, Boston, Massachusetts; and ††Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165626PMC
May 2015

The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes.

J Infect Dis 2015 Apr 3;211(7):1185-95. Epub 2014 Oct 3.

Cell Biology Program SickKids IBD Centre, Hospital for Sick Children Department of Molecular Genetics Institute of Medical Science, University of Toronto.

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https://academic.oup.com/jid/article-lookup/doi/10.1093/infd
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http://dx.doi.org/10.1093/infdis/jiu546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432431PMC
April 2015

Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease.

J Crohns Colitis 2014 Nov 10;8(11):1551-6. Epub 2014 May 10.

The Children's Hospital at Westmead, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.crohns.2014.04.004DOI Listing
November 2014

The diagnostic approach to monogenic very early onset inflammatory bowel disease.

Gastroenterology 2014 Nov 21;147(5):990-1007.e3. Epub 2014 Jul 21.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140091
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http://dx.doi.org/10.1053/j.gastro.2014.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376484PMC
November 2014

A CARD9 polymorphism is associated with decreased likelihood of persistent conjugated hyperbilirubinemia in intestinal failure.

PLoS One 2014 21;9(1):e85915. Epub 2014 Jan 21.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Toronto, Ontario, Canada ; SickKids IBD Centre, Program in Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085915PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897546PMC
October 2014

Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease.

Gastroenterology 2014 Oct 18;147(4):803-813.e7; quiz e14-5. Epub 2014 Jun 18.

Department of Paediatrics, University of Toronto, Toronto, Canada; SickKids Inflammatory Bowel Disease Center, Division of Gastroenterology Hepatology and Nutrition, Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2014.06.023DOI Listing
October 2014

Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease.

Gastroenterology 2014 Sep 12;147(3):680-689.e2. Epub 2014 Jun 12.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.06.005DOI Listing
September 2014

Infliximab maintains durable response and facilitates catch-up growth in luminal pediatric Crohn's disease.

Inflamm Bowel Dis 2014 Jul;20(7):1177-86

*Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, University of Toronto, Toronto, ON, Canada; †SickKids Inflammatory Bowel Disease Center, The Hospital for Sick Children, Toronto, ON, Canada; and ‡Cell Biology Program, Research Institute and the Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000083DOI Listing
July 2014

Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.

Adv Immunol 2014 ;122:177-210

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Gastroenterology, Brigham & Women's Hospital, Boston, Massachusetts, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97801280026740
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http://dx.doi.org/10.1016/B978-0-12-800267-4.00005-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741283PMC
May 2014

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.

Nature 2014 May 13;509(7499):230-4. Epub 2014 Apr 13.

1] Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G0A4, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S1A8, Canada [3] Institute of Medical Science, University of Toronto, Toronto, Ontario M5S1A8, Canada [4] Sickkids IBD Centre, Hospital for Sick Children, Toronto, Ontario M5G1X8, Canada.

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http://dx.doi.org/10.1038/nature13168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151619PMC
May 2014

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

Immunity 2014 May 1;40(5):706-19. Epub 2014 May 1.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS). Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513358PMC
May 2014

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

Gastroenterology 2014 Apr 11;146(4):1028-39. Epub 2014 Jan 11.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002656PMC
April 2014

A novel nonsense mutation in the EpCAM gene in a patient with congenital tufting enteropathy.

J Pediatr Gastroenterol Nutr 2014 Jan;58(1):18-21

*Division of Cell Biology, Biocenter Innsbruck, Medical University Innsbruck, Austria †Department of Paediatric Laboratory Medicine, Division of Pathology ‡Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, University of Toronto §Program in Cell Biology, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1097/MPG.0000000000000106DOI Listing
January 2014

Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.

Traffic 2014 Jan 19;15(1):22-42. Epub 2013 Nov 19.

Division of Cell Biology, Biocenter Innsbruck, Medical University Innsbruck, Innsbruck, Austria; Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1111/tra.12131DOI Listing
January 2014

Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability.

Proc Natl Acad Sci U S A 2014 Jan 2;111(2):693-8. Epub 2014 Jan 2.

Program in Cell Biology and Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada, M5G 1X8.

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http://dx.doi.org/10.1073/pnas.1315017111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896190PMC
January 2014

Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

Clin Transl Gastroenterol 2014 Jan 16;5:e46. Epub 2014 Jan 16.

1] SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [2] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada [3] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ctg.2013.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912315PMC
January 2014

Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis.

J Crohns Colitis 2013 Dec 20;7(11):916-22. Epub 2013 Jan 20.

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.crohns.2012.12.012DOI Listing
December 2013

Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection.

Autophagy 2013 Jul 12;9(7):985-95. Epub 2013 Apr 12.

Cell Biology Program; Hospital for Sick Children; Toronto, ON Canada; Institute of Medical Science; University of Toronto; Toronto, ON Canada.

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http://www.tandfonline.com/doi/abs/10.4161/auto.24406
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http://dx.doi.org/10.4161/auto.24406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722333PMC
July 2013

Association between a multi-locus genetic risk score and inflammatory bowel disease.

Bioinform Biol Insights 2013 19;7:143-52. Epub 2013 May 19.

The Centre for Applied Genomics, The Hospital for Sick Children, 101 College Street, Toronto, ON, Canada.

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http://dx.doi.org/10.4137/BBI.S11601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662393PMC
June 2013

Anti-TNF, infliximab, and adalimumab can be effective in eosinophilic bowel disease.

J Pediatr Gastroenterol Nutr 2013 May;56(5):492-7

Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1097/MPG.0b013e3182801e60DOI Listing
May 2013

The age of gene discovery in very early onset inflammatory bowel disease.

Gastroenterology 2012 Aug 21;143(2):285-8. Epub 2012 Jun 21.

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http://dx.doi.org/10.1053/j.gastro.2012.06.025DOI Listing
August 2012

C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis.

J Crohns Colitis 2011 Oct 2;5(5):423-9. Epub 2011 Jun 2.

Pediatric Gastroenterology and Nutrition Unit, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.crohns.2011.05.003DOI Listing
October 2011

Replication of genetic variation in the MYO9B gene in Crohn's disease.

Hum Immunol 2011 Jul 12;72(7):592-7. Epub 2011 Apr 12.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1016/j.humimm.2011.03.025DOI Listing
July 2011

Drug reaction with eosinophilia and systemic symptoms.

CMAJ 2010 Mar 23;182(5):481. Epub 2009 Nov 23.

Department of Gastroenterology, Hospital for Sick Children, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.090709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842858PMC
March 2010

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene.

Expert Rev Mol Diagn 2008 Jul;8(4):465-77

Department of Pediatrics, Division of Gastroenterology, Hepatology & Nutrition, Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://www.tandfonline.com/doi/full/10.1586/14737159.8.4.465
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http://dx.doi.org/10.1586/14737159.8.4.465DOI Listing
July 2008

Low levels of procalcitonin during episodes of necrotizing enterocolitis.

Dig Dis Sci 2007 Nov 28;52(11):2972-6. Epub 2007 Mar 28.

Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s10620-007-9763-yDOI Listing
November 2007

Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.

Curr Biol 2007 Jul 5;17(14):1212-8. Epub 2007 Jul 5.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cub.2007.06.013DOI Listing
July 2007

Biliary atresia with choledochal cyst: implications for classification.

Clin Gastroenterol Hepatol 2006 Nov 18;4(11):1411-4. Epub 2006 Sep 18.

Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cgh.2006.07.005DOI Listing
November 2006

MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1.

Biochemistry 2005 Jan;44(3):926-31

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada.

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http://dx.doi.org/10.1021/bi0480178DOI Listing
January 2005

Index of suspicion.

Pediatr Rev 2004 Dec;25(12):435-42

Riley Hospital, Indianapolis, Ind., USA.

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December 2004

A 17-year-old male with an unusual case of peritonitis.

CMAJ 2004 May;170(10):1541

Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ont.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400717PMC
May 2004

A 16-year-old boy with progressive central vision loss in his left eye.

CMAJ 2004 Apr;170(8):1228

Department of Pediatrics, Hospital for Sick Children, Toronto, Ont.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC385351PMC
April 2004

Eating disorders in adolescent boys: a review of the adolescent and young adult literature.

J Adolesc Health 2003 Dec;33(6):427-35

Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s1054-139x(03)00060-0DOI Listing
December 2003

Are children with Kawasaki disease and prolonged fever at risk for macrophage activation syndrome?

Pediatrics 2003 Dec;112(6 Pt 1):e495

Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1542/peds.112.6.e495DOI Listing
December 2003