Albrecht Stenzinger

Albrecht Stenzinger

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Albrecht Stenzinger

Publications by authors named "Albrecht Stenzinger"

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Label-Free Enrichment and Molecular Characterization of Viable Circulating Tumor Cells from Diagnostic Leukapheresis Products.

Clin Chem 2019 Apr 8;65(4):549-558. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, University Hospital and Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany;

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http://dx.doi.org/10.1373/clinchem.2018.296814DOI Listing
April 2019

Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.

Pathology 2019 Apr 19. Epub 2019 Apr 19.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2019.01.010DOI Listing
April 2019

Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas.

Int J Cancer 2019 03 3;144(5):1061-1072. Epub 2018 Dec 3.

Division of Cancer Genome Research, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.31939DOI Listing
March 2019

Proteogenomic systems analysis identifies targeted therapy resistance mechanisms in EGFR-mutated lung cancer.

Int J Cancer 2019 02 8;144(3):545-557. Epub 2018 Nov 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Berlin, Germany.

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http://dx.doi.org/10.1002/ijc.31845DOI Listing
February 2019

[Spindle and giant cell type undifferentiated carcinoma of the distal bile duct: a case report].

Z Gastroenterol 2019 Jan 14;57(1):52-56. Epub 2019 Jan 14.

Pathologisches Institut Heidelberg, Universitätsklinikum Heidelberg, Universität Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg.

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http://dx.doi.org/10.1055/a-0784-8763DOI Listing
January 2019

Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions.

Genes Chromosomes Cancer 2019 Jan 21. Epub 2019 Jan 21.

Institute of Pathology, Charité Berlin (on behalf of QuIP® GmbH, Berlin, Germany), Berlin, Germany.

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http://dx.doi.org/10.1002/gcc.22733DOI Listing
January 2019

Genetic profiling of melanoma in routine diagnostics: assay performance and molecular characteristics in a consecutive series of 274 cases.

Pathology 2018 Dec 20;50(7):703-710. Epub 2018 Oct 20.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Partner Site, Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.08.004DOI Listing
December 2018

Oncogene-induced senescence: a potential breakpoint mechanism against malignant transformation in plasma cell disorders.

Leuk Lymphoma 2018 11 4;59(11):2660-2669. Epub 2018 Apr 4.

a Department of Internal Medicine V , University Hospital Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.1080/10428194.2018.1443450DOI Listing
November 2018

Genetic Profiling of Cancers of the Digestive System: Biological Insights and Clinical Implications.

Pathobiology 2017 9;84(6):306-322. Epub 2017 Feb 9.

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http://dx.doi.org/10.1159/000446545DOI Listing
October 2018

Molecular dissection of large cell carcinomas of the lung with null immunophenotype.

Pathology 2018 Aug 27;50(5):530-535. Epub 2018 Jun 27.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pathol.2018.03.005DOI Listing
August 2018

Three molecular pathways model colorectal carcinogenesis in Lynch syndrome.

Int J Cancer 2018 07 23;143(1):139-150. Epub 2018 Feb 23.

Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.31300DOI Listing
July 2018

Integrated Histogenetic Analysis Reveals -Mutated Epithelioid Mesothelioma in a Patient With Cancer of Unknown Primary.

J Natl Compr Canc Netw 2018 Jun;16(6):677-682

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg; Institute of Pathology, University Hospital Heidelberg, Heidelberg; Institute of Human Genetics, University Hospital Cologne, Cologne; Laboratory for Translational Epigenetics and Tumor Genetics, Cologne; and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.6004/jnccn.2018.7012DOI Listing
June 2018

V3, treatment resistance, and survival: refining the diagnosis of ALK NSCLC.

J Thorac Dis 2018 Jun;10(Suppl 17):S1989-S1991

Department of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.21037/jtd.2018.05.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036008PMC
June 2018

Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.

Pathology 2018 Apr 18;50(3):327-332. Epub 2017 Dec 18.

Institute of Pathology, University of Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2017.10.011DOI Listing
April 2018

Ioncopy: an R Shiny app to call copy number alterations in targeted NGS data.

BMC Bioinformatics 2018 04 24;19(1):157. Epub 2018 Apr 24.

Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1186/s12859-018-2159-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921540PMC
April 2018

A field guide for cancer diagnostics using cell-free DNA: From principles to practice and clinical applications.

Genes Chromosomes Cancer 2018 03 20;57(3):123-139. Epub 2017 Dec 20.

Division of Cancer Genome Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22517DOI Listing
March 2018

Analysis of the proliferative activity in lung adenocarcinomas with specific driver mutations.

Pathol Res Pract 2018 Mar 2;214(3):408-416. Epub 2018 Jan 2.

Institute of Pathology, University Heidelberg, Heidelberg, Germany; Translational Lung Research Centre Heidelberg, Member of the German Centre for Lung Research, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2017.12.018DOI Listing
March 2018

Implementation of a novel efficacy score to compare sealing and cutting devices in a porcine model.

Surg Endosc 2018 Feb 24;32(2):1002-1011. Epub 2017 Aug 24.

Department for Gynaecology and Obstetrics, University of Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00464-017-5778-4DOI Listing
February 2018

Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types.

BMC Med Genomics 2017 Dec 6;10(1):74. Epub 2017 Dec 6.

German Cancer Consortium (DKTK), Berlin and Heidelberg partner sites, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12920-017-0308-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719741PMC
December 2017

Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomas.

Int J Cancer 2017 11 24;141(9):1841-1848. Epub 2017 Jul 24.

Member of the Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.30881DOI Listing
November 2017

Qualitative Comparison Between Carrier-based and Classical Tissue Microarrays.

Appl Immunohistochem Mol Morphol 2017 Oct;25(9):e74-e79

*Department of Hematology, Oncology and Rheumatology †Institute of Pathology, University of Heidelberg, Heidelberg ‡Proteopath Trier, Trier, Germany.

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http://dx.doi.org/10.1097/PAI.0000000000000529DOI Listing
October 2017

Mutation patterns in genes encoding interferon signaling and antigen presentation: A pan-cancer survey with implications for the use of immune checkpoint inhibitors.

Genes Chromosomes Cancer 2017 08 31;56(8):651-659. Epub 2017 May 31.

German Cancer Consortium (DKTK), Partner Sites Berlin and Heidelberg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22468DOI Listing
August 2017

Mutations in BRCA2 and taxane resistance in prostate cancer.

Sci Rep 2017 07 4;7(1):4574. Epub 2017 Jul 4.

Molecular Urooncology, Department of Urology, University of Heidelberg School of Medicine, Im Neuenheimer Feld 517, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-017-04897-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496866PMC
July 2017

MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.

Eur J Cancer 2017 05 26;77:3-12. Epub 2017 Mar 26.

Translational Radiooncology Research Laboratory, Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK) Partner Site, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.018DOI Listing
May 2017

Mutations of cancer-related genes in benign tumors: the example of hidradenoma papilliferum.

Hum Pathol 2017 04 16;62:246-247. Epub 2016 Nov 16.

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.09.034DOI Listing
April 2017

Multikinase inhibitors sorafenib and sunitinib as radiosensitizers in head and neck cancer cell lines.

Head Neck 2017 04 21;39(4):623-632. Epub 2017 Feb 21.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1002/hed.24557DOI Listing
April 2017

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with amplification.

Cold Spring Harb Mol Case Stud 2016 11;2(6):a001180

Department of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany;; Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg 69120, Germany;; German Cancer Consortium (DKTK), Heidelberg 69120, Germany.

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http://dx.doi.org/10.1101/mcs.a001180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111004PMC
November 2016

Reliable Entity Subtyping in Non-small Cell Lung Cancer by Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry on Formalin-fixed Paraffin-embedded Tissue Specimens.

Mol Cell Proteomics 2016 10 29;15(10):3081-3089. Epub 2016 Jul 29.

From the ‡Institute of Pathology, University Heidelberg, 69120 Heidelberg, Germany; ‡‡Institute of Pathology, Technical University Munich (TUM), 81675 Munich, Germany; §§German Cancer Consortium (DKTK); ‖‖National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.

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http://www.mcponline.org/content/15/10/3081.full.pdf
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http://dx.doi.org/10.1074/mcp.M115.057513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054336PMC
October 2016

Profiling of cMET and HER Family Receptor Expression in Pancreatic Ductal Adenocarcinomas and Corresponding Lymph Node Metastasis to Assess Relevant Pathways for Targeted Therapies: Looking at the Soil Before Planting the Seed.

Pancreas 2016 09;45(8):1167-74

From the *Institute of Pathology, University Hospital Heidelberg, Ruprecht-Karls Universität, Heidelberg; †Roche Pharma Research and Early Development, Roche Innovation Center, Penzberg, Germany; ‡AstraZeneca, Personalized Healthcare and Biomarkers, Innovative Medicines and Early Development, Cambridge, United Kingdom; §Department of Surgery, University Hospital Grosshadern, Ludwig-Maximilians-Universität, München, Germany; ∥National Center for Tumor Diseases, Heidelberg; and ¶German Cancer Consortium (DKTK), Dresden, Germany.

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http://dx.doi.org/10.1097/MPA.0000000000000604DOI Listing
September 2016

Molecular driver alterations and their clinical relevance in cancer of unknown primary site.

Oncotarget 2016 Jul;7(28):44322-44329

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Medicine V, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.10035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190099PMC
July 2016

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.

Genes Chromosomes Cancer 2016 Mar 9;55(3):268-77. Epub 2015 Dec 9.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22330DOI Listing
March 2016

Re: "Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course".

J Natl Compr Canc Netw 2016 Mar;14(3):lxvi-lxviii

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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March 2016

High-throughput diagnostic profiling of clinically actionable gene fusions in lung cancer.

Genes Chromosomes Cancer 2016 Jan 23;55(1):30-44. Epub 2015 Sep 23.

Institute of Pathology, University Hospital Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22297DOI Listing
January 2016

Individualized medicine and demographic change as determining workload factors in pathology: quo vadis?

Virchows Arch 2016 Jan 24;468(1):101-8. Epub 2015 Oct 24.

Institute of Pathology, University Hospital Heidelberg, INF 224, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00428-015-1869-6
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http://dx.doi.org/10.1007/s00428-015-1869-6DOI Listing
January 2016

Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma.

Medicine (Baltimore) 2016 Jan;95(2):e2491

From the Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia (JA, LS, AC, MT, NW, MF, CWT, AJG); Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany (BG, MR, AS, WW, PS); Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards (LS, AC, MF, AJG); Histopath Pathology, North Ryde (CWT); Sydney Medical School, University of Sydney, Sydney (JA,CWT, RCS, AM, JSS, TJH, AJG); Upper Gastrointestinal Surgical Unit, Royal North Shore Hospital, North Shore Private Hospital, St Leonards; Discipline of Surgery, University of Sydney (AM, JSS, TJH); Macquarie University Hospital, Macquarie University, Sydney (JSS); Department of Anatomical Pathology, SYDPATH, St Vincents Hospitals, Darlinghurst, NSW, Australia (AC); Department of Pathology and Diagnostics, ARC-NET Research Center (RTL, NS, AS); Department of Surgery, University and Hospital Trust of Verona, Verona, Italy (AR); and Sydney Vital Translational Research Centre, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, Australia (AJG).

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http://dx.doi.org/10.1097/MD.0000000000002491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718285PMC
January 2016

ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making.

Lung Cancer 2015 Dec 23;90(3):465-71. Epub 2015 Oct 23.

Institute of Pathology, Charité Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.09.022DOI Listing
December 2015

Histological tumor typing in the age of molecular profiling.

Pathol Res Pract 2015 Dec 5;211(12):897-900. Epub 2015 Sep 5.

Institute of Pathology, University Hospital Heidelberg and National Center of Tumor Diseases, Im Neuenheimer Feld 224/460, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.prp.2015.08.001DOI Listing
December 2015

Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma.

Mol Oncol 2015 Oct 20;9(8):1704-19. Epub 2015 May 20.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, D-69120, Germany; Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, D-69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528792PMC
October 2015

Classical pathology and mutational load of breast cancer - integration of two worlds.

J Pathol Clin Res 2015 Oct 20;1(4):225-38. Epub 2015 Jul 20.

Institute of Pathology, University Hospital HeidelbergHeidelbergGermany; Fellow of the NCT Heidelberg School of Oncology (NCT-HSO)HeidelbergGermany.

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http://dx.doi.org/10.1002/cjp2.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939893PMC
October 2015

Basket Trials: Just the End of the First Quarter.

J Clin Oncol 2015 Sep 13;33(25):2823-4. Epub 2015 Jul 13.

Charité University Hospital; Einstein Foundation, Berlin, Germany.

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http://dx.doi.org/10.1200/JCO.2015.62.1516DOI Listing
September 2015

Next-generation sequencing: hype and hope for development of personalized radiation therapy?

Radiat Oncol 2015 Aug 28;10:183. Epub 2015 Aug 28.

Department of Radiooncology and Radiotherapy, Charité University Hospital Berlin, Translational Radiation Oncology Research Laboratory, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1186/s13014-015-0481-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554356PMC
August 2015