Publications by authors named "Alberto Sobrero"


Adjuvant Chemotherapy for Stage II Colon Cancer.

Cancers (Basel) 2020 Sep 10;12(9). Epub 2020 Sep 10.

Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino of Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy.

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September 2020

The Amount of Evidence Needed to Support ERBB2 as a Biomarker for Resistance to EGFR Inhibitors in Metastatic Colorectal Cancer-In Reply.

JAMA Oncol 2019 Aug 15. Epub 2019 Aug 15.

Ospedale Policlinico San Martino Istituto di Ricovero e Cura a Carattere Scientifico, Genoa, Italy.

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August 2019

Maximising clinical benefit with adequate patient management beyond the second line in mCRC.

ESMO Open 2019 13;4(2):e000495. Epub 2019 May 13.

Digestive Oncology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.

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May 2019

HER2 Amplification and Anti-EGFR Sensitivity in Advanced Colorectal Cancer.

JAMA Oncol 2019 May;5(5):605-606

Ospedale Policlinico San Martino IRCCS, Genoa, Italy.

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May 2019

The Optimal Duration of Adjuvant Therapy for Stage III Colon Cancer: the European Perspective.

Curr Treat Options Oncol 2019 01 26;20(1). Epub 2019 Jan 26.

Policlinico San Martino IRCCS, Largo R. Benzi 10, 16132, Genoa, Italy.

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January 2019

FOLFOX or CAPOX in Stage II to III Colon Cancer: Efficacy Results of the Italian Three or Six Colon Adjuvant Trial.

J Clin Oncol 2018 05 5;36(15):1478-1485. Epub 2018 Apr 5.

Alberto Sobrero, IRCCS San Martino-IST, Genova; Sara Lonardi and Vittorina Zagonel, Istituto Oncologico Veneto-IRCCS, Padova; Gerardo Rosati, Ospedale San Carlo, Potenza; Maria Di Bartolomeo, Fondazione Istituto Nazionale Tumori-IRCCS; Monica Ronzoni, Ospedale San Raffaele-IRCCS; Maria Giulia Zampino, Istituto Europeo di Oncologia-IRCCS; Daris Ferrari, Azienda Ospedaliera San Paolo; and Eliana Rulli, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano; Nicoletta Pella, Azienda Ospedaliero Universitaria Santa Maria della Misericordia, Udine; Mario Scartozzi, University Hospital and University of Cagliari, Cagliari; Maria Banzi, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia; Felice Pasini, Ospedale Santa Maria della Misericordia, Rovigo; Paolo Marchetti, Sant'Andrea Hospital, Sapienza University of Roma and IDI-IRCCS, Roma; Maurizio Cantore, Civico Hospital Carrara, Carrara; Alberto Zaniboni, Fondazione Poliambulanza, Brescia; Lorenza Rimassa, Humanitas Cancer Center, Humanitas Clinical and Research Center, Rozzano; Libero Ciuffreda, Azienda Ospedaliero Universitaria San Giovanni Battista, Molinette, Torino; Evaristo Maiello, Hospital Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo; Sandro Barni, Treviglio-Caravaggio Hospital, Treviglio; and Roberto Labianca, Cancer Center ASST Papa Giovanni XXIII, Bergamo, Italy.

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May 2018

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer.

N Engl J Med 2018 Mar;378(13):1177-1188

From the Divisions of Medical Oncology (A.G.) and Biomedical Statistics and Informatics (Q.S., J.P.M., L.A.R., D.J.S.), Mayo Clinic, Rochester, MN; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Martino-IST, Genoa (A.F. Sobrero), Ospedale Papa Giovanni XXIII, Bergamo (R.L.), and IRCCS Mario Negri Institute for Pharmacological Research, Milan (V.T.) - all in Italy; Karmanos Cancer Institute, Wayne State University, Detroit (A.F. Shields); National Cancer Center Hospital East, Chiba (T. Yoshino), Yokohama City University School of Medicine, Yokohama (T. Yamanaka), and the University of Tokyo, Tokyo (T.W.) - all in Japan; the Institute of Cancer Sciences, University of Glasgow, Glasgow (J.P.), the University of Oxford, Oxford (R.K.), Christie Hospital, Manchester (M.S.), and University Hospital Southampton, Southampton (T.I.) - all in the United Kingdom; Hôpital Européen Georges-Pompidou, Sorbonne Paris Cite/Paris Descartes University (J.T.), and Saint-Antoine Hospital and Sorbonne Universités, Pierre and Marie Curie University-Paris 6 (T.A.), Paris, and Methodology and Quality of Life Unit, INSERM Unité 1098, Besançon (D.V.) - all in France; the Department of Medical Oncology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion (J.S.), and Bioclinic Thessaloniki, Thessaloniki (I.B.) - both in Greece; Dana-Farber Cancer Institute, Boston (J.A.M.); and Duke Cancer Institute, Durham, NC (D.N.).

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March 2018

The hard road to ranking the clinical benefit of antineoplastic agents: ESMO Award 2016 presentation.

Alberto Sobrero

ESMO Open 2017 9;2(1):e000157. Epub 2017 Mar 9.

Medical Oncology, IRCCS San Martino IST Genova, Largo Rosanna Benzi, Genova, Italy.

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March 2017

The urgent need to improve the tools to assess clinical benefit and value of cancer treatment.

Eur J Cancer 2017 09 24;83:324-328. Epub 2017 Jul 24.

Ospedale Policlinico San Martino IRCCS, Largo R. Benzi 10, Genova 16132, Italy.

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September 2017

Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

J Clin Oncol 2017 Jun 17;35(17):1929-1937. Epub 2017 Apr 17.

Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.

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June 2017

Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2-Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC--A Randomized Phase III Trial.

J Clin Oncol 2016 Feb 30;34(5):443-51. Epub 2015 Nov 30.

J. Randolph Hecht, Zev A. Wainberg, and Dennis Slamon, David Geffen School of Medicine, University of California Los Angeles, Santa Monica; Michael F. Press, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Yung-Jue Bang, Seoul National University College of Medicine; Hyun C. Chung, Yonsei Cancer Center, Yonsei Cancer Research Institute, Yonsei University College of Medicine; Joon O. Park, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Shukui K. Qin, People's Liberation Army Cancer Center, Nanjing Bayi Hospital, Jiangsu; Jianming M. Xu, Affiliated Hospital of the Military Medical Science Academy, Beijing; Jin Li, Cancer Hospital of Shanghai Fudan University, Shanghai, People's Republic of China; Krzysztof Jeziorski, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Yaroslav Shparyk, Lviv State Regional Oncology Medical and Diagnostic Center, Lviv, Ukraine; Paulo M. Hoff, Sociedade Beneficente de Senhoras-Hospital Sirio Libanĕs, Sao Paolo, Brazil; Alberto Sobrero, Istituto di Ricovero e Cura a Carattere Scientifico San Martino Istituto Scientifico Tumori, Genova, Italy; Pamela Salman, Fundación Arturo López Pérez, Santiago, Chile; Svetlana A. Protsenko, Petrov Research Institute of Oncology, St Petersburg, Russia; Marc Buyse, International Drug Development Institute, Leuven, Belgium; Karen Afenjar, Vincent Houé, and Agathe Garcia, Translational Research in Oncology, Paris, France; Tomomi Kaneko and Saba Khan-Wasti, GlaxoSmithKline, Brentford, United Kingdom; and Yingjie Huang and Sergio Santillana, GlaxoSmithKline, Philadelphia, PA.

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February 2016

Randomized trial of TAS-102 for refractory metastatic colorectal cancer.

N Engl J Med 2015 May;372(20):1909-19

From the Dana-Farber Cancer Institute, Boston (R.J.M, J.M.C.); University Hospitals, Leuven and KU Leuven, Leuven (E.V.C., H.P.), and Universitaire Ziekenhuizen Antwerp, Edegem (M.P.) - all in Belgium; University of Pisa, Pisa (A.F.), IRCCS Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca Sul Cancro, Genoa (A.S.), and the Fondazione Poliambulanza Istituto Ospedaliero, Brescia (A.Z.) - all in Italy; National Cancer Center Hospital East, Chiba (T.Y., A.O.), Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (N.M.), Shizuoka Cancer Center, Shizuoka (K.Y.), National Cancer Center Hospital, Tokyo (Y.S.), Hokkaido University Hospital, Hokkaido (Y.K.), and Taiho Pharmaceutical, Tokyo (M.I.) - all in Japan; Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Seville (R.G.-C.), and Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona (J.T.) - all in Spain; Centre Eugène Marquis, Rennes, France (E.B.); Royal Melbourne Hospital, Melbourne, VIC, Australia (B.T.); University of Southern California Norris Comprehensive Cancer Center, Los Angeles (H.-J.L.); Yale Cancer Center, New Haven, CT (H.H.); Taiho Oncology, Princeton, NJ (F.B., H.M.); and Stathmi, New Hope, PA (L.M.).

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May 2015

Prognostic value of KRAS mutations in stage III colon cancer: post hoc analysis of the PETACC8 phase III trial dataset.

Josef Thaler Richard Greil Johannes Gaenzer Wolfgang Eisterer Joerg Tschmelitsch Hellmut Samonigg August Zabernigg Franz Schmid Günther Steger Robert Steinacher Johannes Andel Alois Lang Reinhold Függer Friedrich Hofbauer Ewald Woell Dietmar Geissler Alfred Lenauer Manfred Prager Jean-Luc Van Laethem Eric Van Cutsem Geert D'Haens Gauthier Demolin Joseph Kerger Guido Deboever Gilbert Ghillebert Marc Polus Eric Van Cutsem Hassan RezaieKalantari Thierry Delaunoit Jean Charles Goeminne Marc Peeters Philippe Vergauwe Ghislain Houbiers Yves Humblet Jos Janssens Dirk Schrijvers Erik Vanderstraeten Jean-Luc Van Laethem Jan Vermorken Daniel Van Daele Michel Ferrante Frederic Forget Alain Hendlisz Mette Yilmaz Svend Erik Nielsen Lene Vestermark Jim Larsen Marc Ychou Ayman Zawadi Mohamed-Ayman Zawadi Olivier Bouche Laurent Mineur Jaafar Bennouna-Louridi Louis Marie Dourthe Marc Ychou Eveline Boucher Julien Taieb Denis Pezet Francoise Desseigne Michel Ducreux Patrick Texereau Laurent Miglianico Philippe Rougier Serge Fratte Charles-Briac Levache Yacine Merrouche Stephen Ellis Christophe Locher Jean-Francois Ramee Claire Garnier Frederic Viret Bruno Chauffert Isabelle Cojean-Zelek Pierre Michel Cedric Lecaille Christian Borel Jean-Francois Seitz Denis Smith Catherine Lombard-Bohas Thierry Andre Jean-Marc Gornet Francine Fein Marie-Aude Coulon-Sfairi Marie-Christine Kaminsky Jean-Paul Lagasse Dominique Luet Pierre-Luc Etienne Mohamed Gasmi Andre Vanoli Suzanne Nguyen Thomas Aparicio Hervé Perrier Noel Stremsdoerfer Philippe Laplaige Dominique Arsene Dominique Auby Laurent Bedenne Romain Coriat Bernard Denis Patrick Geoffroy Gilles Piot Yves Becouarn Gilbert Bordes Gael Deplanque Olivier Dupuis Frederic Fruge Rosine Guimbaud Thierry Lecomte Gérard Lledo Iradej Sobhani Amani Asnacios Ahmed Azzedine Christophe Desauw Marie-Pierre Galais Dany Gargot You-Heng Lam Abakar Abakar-Mahamat Jean-Francois Berdah Sylviane Catteau Marie-Christine Clavero-Fabri Jean-Francois Codoul Jean-Louis Legoux Denis Goldfain Pierre Guichard Denis Pere Verge Jocelyne Provencal Bruno Vedrenne Catherine Brezault-Bonnet Denis Cleau Jean-Paul Desir David Fallik Bruno Garcia Marie-Hélène Gaspard Dominique Genet Johannes Hartwig Yves Krummel Tamara MatysiakBudnik Vanessa Palascak-Juif Harizo Randrianarivelo Yves Rinaldi Albert Aleba Ariane Darut-Jouve Aimery de Gramont Herve Hamon Frederic Wendehenne Axel Matzdorff Michael Konrad Stahl Wolfgang Schepp Martin Burk Lothar Mueller Gunnar Folprecht Michael Geissler Luisa Mantovani-Loeffler Thomas Hoehler Walter Asperger Hendrik Kroening Ludwig Fischer von Weikersthal Stefan Fuxius Matthias Groschek Johannes Meiler Tanja Trarbach Jacqueline Rauh Nicolas Ziegenhagen Albrecht Kretzschmar Ullrich Graeven Arnd Nusch Goetz von Wichert Ralf-Dieter Hofheinz Gerhard Kleber Karl-Heinz Schmidt Ursula Vehling-Kaiser Claudia Baum Jochen Schuette Georg Martin Haag Wilhelm Holtkamp Jochen Potenberg Tobias Reiber Georg Schliesser Hans-Joachim Schmoll Wolfgang Schneider-Kappus Wolfgang Abenhardt Claudio Denzlinger Jan Henning Bartscht Marxsen Hans GuenterDerigs Helmut Lambertz Ingulf Becker-Boost Karel Caca Christian Constantin Thomas Decker Henning Eschenburg Sigrun Gabius Holger Hebart Albrecht Hoffmeister Heinz-August Horst Stephan Kremers Malte Leithaeuser Sebastian Mueller Siegfried Wagner Severin Daum Frank Schlegel Martina Stauch Volker Heinemann Roberto Labianca Giuseppe Colucci Dino Amadori Enrico Mini Alfredo Falcone Corrado Boni Evaristo Maiello Luciano Latini Alberto Zaniboni Dino Amadori Giuseppe Aprile Sandro Barni Rodolfo Mattioli Andrea Martoni Rodolfo Passalacqua Mario Nicolini Enzo Pasquini Carla Rabbi Enrico Aitini Alberto Ravaioli Carlo Barone Guido Biasco Stefano Tamberi Angelo Gambi Claudio Verusio Marina Marzola Giorgio Lelli Corrado Boni Stefano Cascinu Paolo Bidoli Massimo Vaghi Giorgio Cruciani Francesco Di Costanzo Alberto Sobrero Enrico Mini Roberto Petrioli Massimo Aglietta Oscar Alabiso Federico Capuzzo Alfredo Falcone Domenico Cristi Corsi Roberto Labianca Stefania Salvagni Silvana Chiara Francesco Ferraù Francesco Giuliani Sara Lonardi Nicola Gebbia Giovanni Mantovani Evaristo Sanches Evaristo Sanches Juan Carlos Mellidez Pedro Santos Joao Freire Cristina Sarmento Luis Costa Antonio Moreira Pinto Sergio Barroso Jorge Espirito Santo Fátima Guedes Amélia Monteiro Anabela Sa Irene Furtado Josep Tabernero Ramon Salazar Enrique Aranda Aguilar Fernando Rivera Herrero Josep Tabernero Javier Sastre Valera Manuel ValladaresAyerbes Jaime FeliuBatlle Silvia Gil Carlos Garcia-Giron Guillermo Lopez Vivanco Antonia Salud Salvia Vicente Alonso Orduña Ruth Vera Garcia Javier Gallego Bartomeu Massuti Sureda Jordi Remon Maria Jose Safont Aguilera Luis CireraNogueras BernadoQueralt Merino Cristina Gravalos Castro Purificacion Martinez de Prado Carlos PijaumePericay Manuel ConstenlaFigueiras InmaculadaGuasch Jordan Maria Jose GomeReina Amelia Lopez-Ladron Garcia Antonio Arrivi Garcia-Ramos Andres Cervantes Carlos Fernandez Martos Eugenio MarcuelloGaspar Ines Cabezas Montero Pilar Escudero Emperador Ana Leon Carbonero Manuel Gallen Castillo Teresa Garcia Garcia Jose Garcia Lopez Encarnacion Gonzalez Flores Monica GuillotMorales Marta LlanosMuñoz Ana López Martín Joan Maurel Juan Carlos Camara Rosario Dueñas Garcia Mercedes Salgado Isabel HernandezBusquier Teresa Checa Ruiz Adelaida LacastaMuñoa MiquelNogue Aliguer Amalia Velasco Ortiz de Taranco Miguel Mendez Ureña Ferran Losa Gaspa Jose Juan Ponce Carlos Bosch Roig Pedro Valero Jimenez Antonio GalanBrotons Santiago AlbiolRodriguez Jose Ales Martinez Liliana Canosa Ruiz Margarita CentellesRuiz John Bridgewater Rob Glynne-Jones Saad Tahir Tamas Hickish Jim Cassidy Leslie Samuel

Ann Oncol 2015 Apr;26(4):822-825

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April 2015

State of the art: colorectal liver metastases.

Future Oncol 2014 Nov;10(15 Suppl):29-32

IRCCS Ospedale San Martino IST, Genova, Italy.

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November 2014

Raising the bar for antineoplastic agents: how to choose threshold values for superiority trials in advanced solid tumors.

Clin Cancer Res 2015 Mar 17;21(5):1036-43. Epub 2014 Sep 17.

Medical Oncology and Epidemiology, IRCCS AOU San Martino IST, Genova, Italy.

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March 2015

Optimizing treatment outcomes with regorafenib: personalized dosing and other strategies to support patient care.

Oncologist 2014 Jun 12;19(6):669-80. Epub 2014 May 12.

Mayo Clinic, Rochester, Minnesota, USA; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA; University Hospital Gasthuisberg/Leuven, Leuven, Belgium; Léon Bérard Centre and Claude Bernard University, Lyon, France; IRCCS San Martino, Genoa, Italy.

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June 2014

Current opinion on optimal treatment for colorectal cancer.

Expert Rev Anticancer Ther 2013 May;13(5):597-611

The Queen Elizabeth Hospital, Adelaide Colorectal Tumour Group and University of Adelaide, Adelaide, South Australia, Australia.

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May 2013

TAS-102 in refractory colorectal cancer: caution is needed.

Alberto Sobrero

Lancet Oncol 2012 Oct 28;13(10):959-61. Epub 2012 Aug 28.

IRCCS Ospedale San Martino IST, Genoa, Italy.

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October 2012

Phase II study of sunitinib as second-line treatment for advanced gastric cancer.

Invest New Drugs 2011 Dec 12;29(6):1449-58. Epub 2010 May 12.

Department of Internal Medicine, Seoul National University College of Medicine, Yongon-Dong 28, Chongno-Gu, Seoul, 110-799, Republic of Korea.

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December 2011

Incremental advance or seismic shift? The need to raise the bar of efficacy for drug approval.

J Clin Oncol 2009 Dec 13;27(35):5868-73. Epub 2009 Oct 13.

Ospedale San Martino, Genova, Italy.

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December 2009

Medical Oncology: IROX as second-line therapy for metastatic colorectal cancer.

Alberto Sobrero

Nat Rev Clin Oncol 2009 May;6(5):248-50

Ospedale San Martino/Cliniche Universitarie Convenzionate, Medical Oncology, Genoa, Italy.

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May 2009

Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials.

J Natl Cancer Inst 2007 Jul 27;99(13):998-1003. Epub 2007 Jun 27.

Department of Medical Oncology, Radboud University Nijmegen Medical Center, PO Box 9101 6500 HB Nijmegen, The Netherlands.

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July 2007

Second-line therapy for advanced colorectal cancer.

Gastrointest Cancer Res 2007 Mar;1(2):57-63

Department of Medical Oncology, Ospedale San Martino, Genova, Italy.

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March 2007

Optimal treatment of metastatic colorectal cancer.

Expert Rev Anticancer Ther 2006 May;6(5):801-12

Medical Oncology Division, University Hospital San Martino, Genoa, Italy.

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May 2006

Should adjuvant chemotherapy become standard treatment for patients with stage II colon cancer? For the proposal.

Alberto Sobrero

Lancet Oncol 2006 Jun;7(6):515-6

Department of Medical Oncology, Ospedale San Martino, Genoa, Italy.

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June 2006

Current issues in adjuvant treatment of stage II colon cancer.

Ann Surg Oncol 2006 Jun 14;13(6):887-98. Epub 2006 Apr 14.

Service d'Oncologie Médicale, Hôpital Tenon, 4 Rue de la Chine, 75970, Paris Cedex 20, France, and Vall d'Hebron University Hospital, Barcelona, Spain.

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June 2006

Pemetrexed in gastric cancer.

Oncology (Williston Park) 2004 Nov;18(13 Suppl 8):51-5

Divisione di Oncologia Medica Ospedale San Martino, Genova, Italy.

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November 2004

Information given to cancer patients on diagnosis, prognosis and treatment: the clinical oncologist's perspective.

Eur J Cancer 2004 Aug;40(12):1850-4

Department of Medical Oncology, University of Udine, P.le S.M. Misericordia, 33100 Udine, Italy.

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August 2004