Alberto Sobrero

Alberto Sobrero, IRCCS San Martino-IST, Genova; Sara Lonardi and Vittorina Zagonel, Istituto Oncologico Veneto-IRCCS, Padova; Gerardo Rosati, Ospedale San Carlo, Potenza; Maria Di Bartolomeo, Fondazione Istituto Nazionale Tumori-IRCCS; Monica Ronzoni, Ospedale San Raffaele-IRCCS; Maria Giulia Zampino, Istituto Europeo di Oncologia-IRCCS; Daris Ferrari, Azienda Ospedaliera San Paolo; and Eliana Rulli, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano; Nicoletta Pella, Azienda Ospedaliero Universitaria Santa Maria della Misericordia, Udine; Mario Scartozzi, University Hospital and University of Cagliari, Cagliari; Maria Banzi, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia; Felice Pasini, Ospedale Santa Maria della Misericordia, Rovigo; Paolo Marchetti, Sant'Andrea Hospital, Sapienza University of Roma and IDI-IRCCS, Roma; Maurizio Cantore, Civico Hospital Carrara, Carrara; Alberto Zaniboni, Fondazione Poliambulanza, Brescia; Lorenza Rimassa, Humanitas Cancer Center, Humanitas Clinical and Research Center, Rozzano; Libero Ciuffreda, Azienda Ospedaliero Universitaria San Giovanni Battista, Molinette, Torino; Evaristo Maiello, Hospital Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo; Sandro Barni, Treviglio-Caravaggio Hospital, Treviglio; and Roberto Labianca, Cancer Center ASST Papa Giovanni XXIII, Bergamo, Italy.

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May 2018

Aflibercept Plus FOLFIRI in the Real-life Setting: Safety and Quality of Life Data From the Italian Patient Cohort of the Aflibercept Safety and Quality-of-Life Program Study.

Authors:

Alessandro Pastorino Maria Di Bartolomeo Evaristo Maiello Vincenzo Iaffaioli Libero Ciuffreda Gianpiero Fasola Francesco Di Costanzo Giovanni Luca Frassineti Paolo Marchetti Carlotta Antoniotti Francesco Leone Alberto Zaniboni Giuseppe Aprile Chiara Zilocchi Alberto Sobrero Roberto Bordonaro

Clin Colorectal Cancer 2018 09 8;17(3):e457-e470. Epub 2018 Mar 8.

Medical Oncology Unit, ARNAS Garibaldi, Catania, Italy.

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September 2018

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer.

N Engl J Med 2018 Mar;378(13):1177-1188

From the Divisions of Medical Oncology (A.G.) and Biomedical Statistics and Informatics (Q.S., J.P.M., L.A.R., D.J.S.), Mayo Clinic, Rochester, MN; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Martino-IST, Genoa (A.F. Sobrero), Ospedale Papa Giovanni XXIII, Bergamo (R.L.), and IRCCS Mario Negri Institute for Pharmacological Research, Milan (V.T.) - all in Italy; Karmanos Cancer Institute, Wayne State University, Detroit (A.F. Shields); National Cancer Center Hospital East, Chiba (T. Yoshino), Yokohama City University School of Medicine, Yokohama (T. Yamanaka), and the University of Tokyo, Tokyo (T.W.) - all in Japan; the Institute of Cancer Sciences, University of Glasgow, Glasgow (J.P.), the University of Oxford, Oxford (R.K.), Christie Hospital, Manchester (M.S.), and University Hospital Southampton, Southampton (T.I.) - all in the United Kingdom; Hôpital Européen Georges-Pompidou, Sorbonne Paris Cite/Paris Descartes University (J.T.), and Saint-Antoine Hospital and Sorbonne Universités, Pierre and Marie Curie University-Paris 6 (T.A.), Paris, and Methodology and Quality of Life Unit, INSERM Unité 1098, Besançon (D.V.) - all in France; the Department of Medical Oncology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion (J.S.), and Bioclinic Thessaloniki, Thessaloniki (I.B.) - both in Greece; Dana-Farber Cancer Institute, Boston (J.A.M.); and Duke Cancer Institute, Durham, NC (D.N.).

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March 2018

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study).

ESMO Open 2016 13;1(6):e000111. Epub 2017 Feb 13.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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February 2017

The hard road to ranking the clinical benefit of antineoplastic agents: ESMO Award 2016 presentation.

Authors:

Alberto Sobrero

ESMO Open 2017 9;2(1):e000157. Epub 2017 Mar 9.

Medical Oncology, IRCCS San Martino IST Genova, Largo Rosanna Benzi, Genova, Italy.

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March 2017

The urgent need to improve the tools to assess clinical benefit and value of cancer treatment.

Authors:

Alberto Sobrero Alberto Puccini Giacomo Bregni Paolo Bruzzi

Eur J Cancer 2017 09 24;83:324-328. Epub 2017 Jul 24.

Ospedale Policlinico San Martino IRCCS, Largo R. Benzi 10, Genova 16132, Italy.

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September 2017

Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

J Clin Oncol 2017 Jun 17;35(17):1929-1937. Epub 2017 Apr 17.

Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.

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June 2017

Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer: Secondary Analysis of the TRIO-013/LOGiC Randomized Clinical Trial.

JAMA Oncol 2017 Jun;3(6):767-773

Cross Cancer Institute, Department of Oncology, Edmonton, Alberta, Canada.

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June 2017

Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2-Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC--A Randomized Phase III Trial.

J Clin Oncol 2016 Feb 30;34(5):443-51. Epub 2015 Nov 30.

J. Randolph Hecht, Zev A. Wainberg, and Dennis Slamon, David Geffen School of Medicine, University of California Los Angeles, Santa Monica; Michael F. Press, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Yung-Jue Bang, Seoul National University College of Medicine; Hyun C. Chung, Yonsei Cancer Center, Yonsei Cancer Research Institute, Yonsei University College of Medicine; Joon O. Park, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Shukui K. Qin, People's Liberation Army Cancer Center, Nanjing Bayi Hospital, Jiangsu; Jianming M. Xu, Affiliated Hospital of the Military Medical Science Academy, Beijing; Jin Li, Cancer Hospital of Shanghai Fudan University, Shanghai, People's Republic of China; Krzysztof Jeziorski, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Yaroslav Shparyk, Lviv State Regional Oncology Medical and Diagnostic Center, Lviv, Ukraine; Paulo M. Hoff, Sociedade Beneficente de Senhoras-Hospital Sirio Libanĕs, Sao Paolo, Brazil; Alberto Sobrero, Istituto di Ricovero e Cura a Carattere Scientifico San Martino Istituto Scientifico Tumori, Genova, Italy; Pamela Salman, Fundación Arturo López Pérez, Santiago, Chile; Svetlana A. Protsenko, Petrov Research Institute of Oncology, St Petersburg, Russia; Marc Buyse, International Drug Development Institute, Leuven, Belgium; Karen Afenjar, Vincent Houé, and Agathe Garcia, Translational Research in Oncology, Paris, France; Tomomi Kaneko and Saba Khan-Wasti, GlaxoSmithKline, Brentford, United Kingdom; and Yingjie Huang and Sergio Santillana, GlaxoSmithKline, Philadelphia, PA.

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February 2016

Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus.

Authors:

René Adam Aimery de Gramont Joan Figueras Norihiro Kokudo Francis Kunstlinger Evelyne Loyer Graeme Poston Philippe Rougier Laura Rubbia-Brandt Alberto Sobrero Catherine Teh Sabine Tejpar Eric Van Cutsem Jean-Nicolas Vauthey Lars Påhlman

Cancer Treat Rev 2015 Nov 30;41(9):729-41. Epub 2015 Jun 30.

Department of Surgical Science, Uppsala University Hospital, Uppsala, Sweden. Electronic address:

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November 2015

The value of lactate dehydrogenase serum levels as a prognostic and predictive factor for advanced pancreatic cancer patients receiving sorafenib.

Oncotarget 2015 Oct;6(33):35087-94

Medical Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Ancona, Italy.

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October 2015

Analysis of KRAS/NRAS Mutations in a Phase III Study of Panitumumab with FOLFIRI Compared with FOLFIRI Alone as Second-line Treatment for Metastatic Colorectal Cancer.

Clin Cancer Res 2015 12 4;21(24):5469-79. Epub 2015 Sep 4.

Amgen Inc., Thousand Oaks, California, USA.

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December 2015

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.

Lancet Oncol 2015 Aug 13;16(8):937-48. Epub 2015 Jul 13.

University Hospital Gasthuisberg/Leuven and KU Leuven, Leuven, Belgium.

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August 2015

Time required to start multicentre clinical trials within the Italian Medicine Agency programme of support for independent research.

Authors:

Gianfranco De Feo Luciano Frontini Silvia Rota Antonio Pepe Simona Signoriello Roberto Labianca Alberto Sobrero Sabino De Placido Francesco Perrone

J Med Ethics 2015 Oct 11;41(10):799-803. Epub 2015 Jun 11.

Clinical Trials Unit, National Cancer Institute, Naples, Italy.

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October 2015

Randomized trial of TAS-102 for refractory metastatic colorectal cancer.

N Engl J Med 2015 May;372(20):1909-19

From the Dana-Farber Cancer Institute, Boston (R.J.M, J.M.C.); University Hospitals, Leuven and KU Leuven, Leuven (E.V.C., H.P.), and Universitaire Ziekenhuizen Antwerp, Edegem (M.P.) - all in Belgium; University of Pisa, Pisa (A.F.), IRCCS Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca Sul Cancro, Genoa (A.S.), and the Fondazione Poliambulanza Istituto Ospedaliero, Brescia (A.Z.) - all in Italy; National Cancer Center Hospital East, Chiba (T.Y., A.O.), Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (N.M.), Shizuoka Cancer Center, Shizuoka (K.Y.), National Cancer Center Hospital, Tokyo (Y.S.), Hokkaido University Hospital, Hokkaido (Y.K.), and Taiho Pharmaceutical, Tokyo (M.I.) - all in Japan; Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Seville (R.G.-C.), and Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona (J.T.) - all in Spain; Centre Eugène Marquis, Rennes, France (E.B.); Royal Melbourne Hospital, Melbourne, VIC, Australia (B.T.); University of Southern California Norris Comprehensive Cancer Center, Los Angeles (H.-J.L.); Yale Cancer Center, New Haven, CT (H.H.); Taiho Oncology, Princeton, NJ (F.B., H.M.); and Stathmi, New Hope, PA (L.M.).

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May 2015

Regorafenib plus modified FOLFOX6 as first-line treatment of metastatic colorectal cancer: A phase II trial.

Authors:

Guillem Argilés Mark P Saunders Fernando Rivera Alberto Sobrero Al Benson Carmen Guillén Ponce Stefano Cascinu Eric Van Cutsem Iain R Macpherson Dirk Strumberg Claus-Henning Köhne John Zalcberg Andrea Wagner Vittorio Luigi Garosi Julia Grunert Josep Tabernero Fortunato Ciardiello

Eur J Cancer 2015 May 25;51(8):942-9. Epub 2015 Mar 25.

Second University Hospital, Via S Pansini 5, 80131 Naples, Italy. Electronic address:

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May 2015

Prognostic value of KRAS mutations in stage III colon cancer: post hoc analysis of the PETACC8 phase III trial dataset.

Authors:

Josef Thaler Richard Greil Johannes Gaenzer Wolfgang Eisterer Joerg Tschmelitsch Hellmut Samonigg August Zabernigg Franz Schmid Günther Steger Robert Steinacher Johannes Andel Alois Lang Reinhold Függer Friedrich Hofbauer Ewald Woell Dietmar Geissler Alfred Lenauer Manfred Prager Jean-Luc Van Laethem Eric Van Cutsem Geert D'Haens Gauthier Demolin Joseph Kerger Guido Deboever Gilbert Ghillebert Marc Polus Eric Van Cutsem Hassan RezaieKalantari Thierry Delaunoit Jean Charles Goeminne Marc Peeters Philippe Vergauwe Ghislain Houbiers Yves Humblet Jos Janssens Dirk Schrijvers Erik Vanderstraeten Jean-Luc Van Laethem Jan Vermorken Daniel Van Daele Michel Ferrante Frederic Forget Alain Hendlisz Mette Yilmaz Svend Erik Nielsen Lene Vestermark Jim Larsen Marc Ychou Ayman Zawadi Mohamed-Ayman Zawadi Olivier Bouche Laurent Mineur Jaafar Bennouna-Louridi Louis Marie Dourthe Marc Ychou Eveline Boucher Julien Taieb Denis Pezet Francoise Desseigne Michel Ducreux Patrick Texereau Laurent Miglianico Philippe Rougier Serge Fratte Charles-Briac Levache Yacine Merrouche Stephen Ellis Christophe Locher Jean-Francois Ramee Claire Garnier Frederic Viret Bruno Chauffert Isabelle Cojean-Zelek Pierre Michel Cedric Lecaille Christian Borel Jean-Francois Seitz Denis Smith Catherine Lombard-Bohas Thierry Andre Jean-Marc Gornet Francine Fein Marie-Aude Coulon-Sfairi Marie-Christine Kaminsky Jean-Paul Lagasse Dominique Luet Pierre-Luc Etienne Mohamed Gasmi Andre Vanoli Suzanne Nguyen Thomas Aparicio Hervé Perrier Noel Stremsdoerfer Philippe Laplaige Dominique Arsene Dominique Auby Laurent Bedenne Romain Coriat Bernard Denis Patrick Geoffroy Gilles Piot Yves Becouarn Gilbert Bordes Gael Deplanque Olivier Dupuis Frederic Fruge Rosine Guimbaud Thierry Lecomte Gérard Lledo Iradej Sobhani Amani Asnacios Ahmed Azzedine Christophe Desauw Marie-Pierre Galais Dany Gargot You-Heng Lam Abakar Abakar-Mahamat Jean-Francois Berdah Sylviane Catteau Marie-Christine Clavero-Fabri Jean-Francois Codoul Jean-Louis Legoux Denis Goldfain Pierre Guichard Denis Pere Verge Jocelyne Provencal Bruno Vedrenne Catherine Brezault-Bonnet Denis Cleau Jean-Paul Desir David Fallik Bruno Garcia Marie-Hélène Gaspard Dominique Genet Johannes Hartwig Yves Krummel Tamara MatysiakBudnik Vanessa Palascak-Juif Harizo Randrianarivelo Yves Rinaldi Albert Aleba Ariane Darut-Jouve Aimery de Gramont Herve Hamon Frederic Wendehenne Axel Matzdorff Michael Konrad Stahl Wolfgang Schepp Martin Burk Lothar Mueller Gunnar Folprecht Michael Geissler Luisa Mantovani-Loeffler Thomas Hoehler Walter Asperger Hendrik Kroening Ludwig Fischer von Weikersthal Stefan Fuxius Matthias Groschek Johannes Meiler Tanja Trarbach Jacqueline Rauh Nicolas Ziegenhagen Albrecht Kretzschmar Ullrich Graeven Arnd Nusch Goetz von Wichert Ralf-Dieter Hofheinz Gerhard Kleber Karl-Heinz Schmidt Ursula Vehling-Kaiser Claudia Baum Jochen Schuette Georg Martin Haag Wilhelm Holtkamp Jochen Potenberg Tobias Reiber Georg Schliesser Hans-Joachim Schmoll Wolfgang Schneider-Kappus Wolfgang Abenhardt Claudio Denzlinger Jan Henning Bartscht Marxsen Hans GuenterDerigs Helmut Lambertz Ingulf Becker-Boost Karel Caca Christian Constantin Thomas Decker Henning Eschenburg Sigrun Gabius Holger Hebart Albrecht Hoffmeister Heinz-August Horst Stephan Kremers Malte Leithaeuser Sebastian Mueller Siegfried Wagner Severin Daum Frank Schlegel Martina Stauch Volker Heinemann Roberto Labianca Giuseppe Colucci Dino Amadori Enrico Mini Alfredo Falcone Corrado Boni Evaristo Maiello Luciano Latini Alberto Zaniboni Dino Amadori Giuseppe Aprile Sandro Barni Rodolfo Mattioli Andrea Martoni Rodolfo Passalacqua Mario Nicolini Enzo Pasquini Carla Rabbi Enrico Aitini Alberto Ravaioli Carlo Barone Guido Biasco Stefano Tamberi Angelo Gambi Claudio Verusio Marina Marzola Giorgio Lelli Corrado Boni Stefano Cascinu Paolo Bidoli Massimo Vaghi Giorgio Cruciani Francesco Di Costanzo Alberto Sobrero Enrico Mini Roberto Petrioli Massimo Aglietta Oscar Alabiso Federico Capuzzo Alfredo Falcone Domenico Cristi Corsi Roberto Labianca Stefania Salvagni Silvana Chiara Francesco Ferraù Francesco Giuliani Sara Lonardi Nicola Gebbia Giovanni Mantovani Evaristo Sanches Evaristo Sanches Juan Carlos Mellidez Pedro Santos Joao Freire Cristina Sarmento Luis Costa Antonio Moreira Pinto Sergio Barroso Jorge Espirito Santo Fátima Guedes Amélia Monteiro Anabela Sa Irene Furtado Josep Tabernero Ramon Salazar Enrique Aranda Aguilar Fernando Rivera Herrero Josep Tabernero Javier Sastre Valera Manuel ValladaresAyerbes Jaime FeliuBatlle Silvia Gil Carlos Garcia-Giron Guillermo Lopez Vivanco Antonia Salud Salvia Vicente Alonso Orduña Ruth Vera Garcia Javier Gallego Bartomeu Massuti Sureda Jordi Remon Maria Jose Safont Aguilera Luis CireraNogueras BernadoQueralt Merino Cristina Gravalos Castro Purificacion Martinez de Prado Carlos PijaumePericay Manuel ConstenlaFigueiras InmaculadaGuasch Jordan Maria Jose GomeReina Amelia Lopez-Ladron Garcia Antonio Arrivi Garcia-Ramos Andres Cervantes Carlos Fernandez Martos Eugenio MarcuelloGaspar Ines Cabezas Montero Pilar Escudero Emperador Ana Leon Carbonero Manuel Gallen Castillo Teresa Garcia Garcia Jose Garcia Lopez Encarnacion Gonzalez Flores Monica GuillotMorales Marta LlanosMuñoz Ana López Martín Joan Maurel Juan Carlos Camara Rosario Dueñas Garcia Mercedes Salgado Isabel HernandezBusquier Teresa Checa Ruiz Adelaida LacastaMuñoa MiquelNogue Aliguer Amalia Velasco Ortiz de Taranco Miguel Mendez Ureña Ferran Losa Gaspa Jose Juan Ponce Carlos Bosch Roig Pedro Valero Jimenez Antonio GalanBrotons Santiago AlbiolRodriguez Jose Ales Martinez Liliana Canosa Ruiz Margarita CentellesRuiz John Bridgewater Rob Glynne-Jones Saad Tahir Tamas Hickish Jim Cassidy Leslie Samuel

Ann Oncol 2015 Apr;26(4):822-825

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April 2015

State of the art: colorectal liver metastases.

Authors:

Alberto Sobrero Alessandro Pastorino

Future Oncol 2014 Nov;10(15 Suppl):29-32

IRCCS Ospedale San Martino IST, Genova, Italy.

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November 2014

Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients.

Sci Rep 2014 Nov 5;4:6828. Epub 2014 Nov 5.

Department of Biomolecular Sciences, Università degli Studi di Urbino "Carlo Bo"

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November 2014

Raising the bar for antineoplastic agents: how to choose threshold values for superiority trials in advanced solid tumors.

Authors:

Alberto F Sobrero Alessandro Pastorino Daniel J Sargent Paolo Bruzzi

Clin Cancer Res 2015 Mar 17;21(5):1036-43. Epub 2014 Sep 17.

Medical Oncology and Epidemiology, IRCCS AOU San Martino IST, Genova, Italy.

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March 2015

Optimizing treatment outcomes with regorafenib: personalized dosing and other strategies to support patient care.

Authors:

Axel Grothey Suzanne George Eric van Cutsem Jean-Yves Blay Alberto Sobrero George D Demetri

Oncologist 2014 Jun 12;19(6):669-80. Epub 2014 May 12.

Mayo Clinic, Rochester, Minnesota, USA; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA; University Hospital Gasthuisberg/Leuven, Leuven, Belgium; Léon Bérard Centre and Claude Bernard University, Lyon, France; IRCCS San Martino, Genoa, Italy.

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June 2014

Sorafenib does not improve efficacy of chemotherapy in advanced pancreatic cancer: A GISCAD randomized phase II study.

Dig Liver Dis 2014 Feb 2;46(2):182-6. Epub 2013 Nov 2.

New Drug Development Strategies Laboratory, Mario Negri Institute, Milano, Italy.

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February 2014

Axitinib or bevacizumab plus FOLFIRI or modified FOLFOX-6 after failure of first-line therapy for metastatic colorectal cancer: a randomized phase II study.

Authors:

Johanna C Bendell Christophe Tournigand Anna Swieboda-Sadlej Carlo Barone Zev A Wainberg Jong Gwang Kim Carles Pericay Davide Pastorelli Jamal Tarazi Brad Rosbrook Joanna Bloom Alejandro D Ricart Sinil Kim Alberto F Sobrero

Clin Colorectal Cancer 2013 Dec;12(4):239-47

Sarah Cannon Research Institute, Nashville, TN. Electronic address:

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December 2013

The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 months) Regimen for Patients with Stage III Colon Cancer: Trial Design and Current Status.

Authors:

Thierry André Timothy Iveson Roberto Labianca Jeffrey A Meyerhardt Ioannis Souglakos Takayuki Yoshino James Paul Alberto Sobrero Julien Taieb Anthony F Shields Atsushi Ohtsu Axel Grothey Daniel J Sargent

Curr Colorectal Cancer Rep 2013 ;9:261-269

Department of Medical Oncology, Saint-Antoine Hospital, and Université Pierre et Marie Curie (UPMC), Paris, France.

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January 2013

From trial highlights to clinical context: putting American Society of Clinical Oncology gastrointestinal news into practice.

Authors:

Giuseppe Aprile Stefania Eufemia Lutrino Alberto Sobrero

Future Oncol 2013 May;9(5):645-8

Department of Oncology, University & General Hospital, Udine, Italy.

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May 2013

Current opinion on optimal treatment for colorectal cancer.

Authors:

Timothy J Price Eva Segelov Matthew Burge Daniel G Haller Stephen P Ackland Niall C Tebbutt Christos S Karapetis Nick Pavlakis Alberto F Sobrero David Cunningham Jeremy D Shapiro

Expert Rev Anticancer Ther 2013 May;13(5):597-611

The Queen Elizabeth Hospital, Adelaide Colorectal Tumour Group and University of Adelaide, Adelaide, South Australia, Australia.

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May 2013

A multi-peptide, dual-adjuvant telomerase vaccine (GX301) is highly immunogenic in patients with prostate and renal cancer.

Authors:

Daniela Fenoglio Paolo Traverso Alessia Parodi Laura Tomasello Simone Negrini Francesca Kalli Florinda Battaglia Francesca Ferrera Stefania Sciallero Giuseppe Murdaca Maurizio Setti Alberto Sobrero Francesco Boccardo Giuseppe Cittadini Francesco Puppo Domenico Criscuolo Giorgio Carmignani Francesco Indiveri Gilberto Filaci

Cancer Immunol Immunother 2013 Jun 17;62(6):1041-52. Epub 2013 Apr 17.

Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV n. 7, 16132 Genoa, Italy.

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June 2013

Sorafenib in combination with oxaliplatin, leucovorin, and fluorouracil (modified FOLFOX6) as first-line treatment of metastatic colorectal cancer: the RESPECT trial.

Clin Cancer Res 2013 May 26;19(9):2541-50. Epub 2013 Mar 26.

Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.

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May 2013

Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial.

Lancet 2013 Jan 22;381(9863):303-12. Epub 2012 Nov 22.

Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.

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January 2013

Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III).

Authors:

Hans-Joachim Schmoll David Cunningham Alberto Sobrero Christos S Karapetis Philippe Rougier Sheryl L Koski Ilona Kocakova Igor Bondarenko György Bodoky Paul Mainwaring Ramon Salazar Peter Barker Bijoyesh Mookerjee Jane Robertson Eric Van Cutsem

J Clin Oncol 2012 Oct 10;30(29):3588-95. Epub 2012 Sep 10.

Department of Internal Medicine IV, Hematology & Oncology, University Clinic Halle (Saale), Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle, Germany.

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October 2012

The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus.

Authors:

René Adam Aimery De Gramont Joan Figueras Ashley Guthrie Norihiro Kokudo Francis Kunstlinger Evelyne Loyer Graeme Poston Philippe Rougier Laura Rubbia-Brandt Alberto Sobrero Josep Tabernero Catherine Teh Eric Van Cutsem

Oncologist 2012 7;17(10):1225-39. Epub 2012 Sep 7.

AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Université Paris Sud, UMR-S 776, Villejuf, France.

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June 2013

TAS-102 in refractory colorectal cancer: caution is needed.

Authors:

Alberto Sobrero

Lancet Oncol 2012 Oct 28;13(10):959-61. Epub 2012 Aug 28.

IRCCS Ospedale San Martino IST, Genoa, Italy.

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October 2012

Vatalanib in advanced colorectal cancer: two studies with identical results.

Authors:

Alberto F Sobrero Paolo Bruzzi

J Clin Oncol 2011 May 4;29(15):1938-40. Epub 2011 Apr 4.

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May 2011

Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.

J Clin Oncol 2010 Nov 4;28(31):4706-13. Epub 2010 Oct 4.

University Hospital Ghent, Ghent, Belgium.

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November 2010

Phase II study of NGR-hTNF, a selective vascular targeting agent, in patients with metastatic colorectal cancer after failure of standard therapy.

Authors:

Armando Santoro Lorenza Rimassa Alberto F Sobrero Giovanni Citterio Francesco Sclafani Carlo Carnaghi Anna Pessino Francesco Caprioni Valeria Andretta Maria Chiara Tronconi Giovanna Finocchiaro Gloria Rossoni Angela Zanoni Chiara Miggiano Gian-Paolo Rizzardi Catia Traversari Federico Caligaris-Cappio Antonio Lambiase Claudio Bordignon

Eur J Cancer 2010 Oct 12;46(15):2746-52. Epub 2010 Aug 12.

Department of Oncology, Istituto Clinico Humanitas, Rozzano, Italy.

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October 2010

Informed decisions regarding microsatellite instability testing: need for an intention-to-screen analysis.

Authors:

Stefania Sciallero Alberto Sobrero

J Clin Oncol 2010 Oct 2;28(28):e537; author reply e538. Epub 2010 Aug 2.

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October 2010

Phase II study of sunitinib as second-line treatment for advanced gastric cancer.

Authors:

Yung-Jue Bang Yoon-Koo Kang Won K Kang Narikazu Boku Hyun C Chung Jen-Shi Chen Toshihiko Doi Yan Sun Lin Shen Shukui Qin Wai-Tong Ng Jennifer M Tursi Maria J Lechuga Dongrui Ray Lu Ana Ruiz-Garcia Alberto Sobrero

Invest New Drugs 2011 Dec 12;29(6):1449-58. Epub 2010 May 12.

Department of Internal Medicine, Seoul National University College of Medicine, Yongon-Dong 28, Chongno-Gu, Seoul, 110-799, Republic of Korea.

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December 2011

Current Opinion on Optimal Treatment Choices in First-line Therapy for Advanced or Metastatic Colorectal Cancer: Report From the Adelaide Colorectal Tumour Group Meeting; Stockholm, Sweden; September 2008.

Authors:

Timothy J Price Niall C Tebbutt Christos S Karapetis Eva Segelov Nick Pavlakis David Cunningham Alberto F Sobrero Daniel G Haller Jeremy D Shapiro

Clin Colorectal Cancer 2010 Jan;9(1):8-14

The Queen Elizabeth Hospital and University of Adelaide, Australia.

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January 2010

Incremental advance or seismic shift? The need to raise the bar of efficacy for drug approval.

Authors:

Alberto Sobrero Paolo Bruzzi

J Clin Oncol 2009 Dec 13;27(35):5868-73. Epub 2009 Oct 13.

Ospedale San Martino, Genova, Italy.

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December 2009

Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer.

Authors:

Alberto Sobrero Stephen Ackland Stephen Clarke Ramón Perez-Carrión Silvana Chiara Silvia Chiara John Gapski Paul Mainwaring Bernd Langer Scott Young

Oncology 2009 23;77(2):113-9. Epub 2009 Jul 23.

Cliniche Universitarie Convenzionate UO, Genoa, Italy.

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September 2009

Molecular markers of chemotherapy in advanced colorectal cancer: back to square one.

Authors:

Alberto Sobrero

Eur J Cancer 2009 Jul 6;45(11):1902-3. Epub 2009 Jun 6.

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July 2009

Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3.

J Clin Oncol 2009 Jul 18;27(19):3117-25. Epub 2009 May 18.

Digestive Oncology Unit, University Hospital Gasthuisberg/Leuven, Herestraat 49, 3000 Leuven, Belgium.

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July 2009

Medical Oncology: IROX as second-line therapy for metastatic colorectal cancer.

Authors:

Alberto Sobrero

Nat Rev Clin Oncol 2009 May;6(5):248-50

Ospedale San Martino/Cliniche Universitarie Convenzionate, Medical Oncology, Genoa, Italy.

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May 2009

Resectability of initially unresectable liver metastases from colorectal cancer should not be the primary end point of clinical trials.

Authors:

Alberto Sobrero Giuseppe Aprile

Gastrointest Cancer Res 2009 Jan;3(1):41-2

Department of Oncology, San Martino Hospital, Genova.

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January 2009

Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy.

Authors:

Marc Peeters Salvatore Siena Eric Van Cutsem Alberto Sobrero Alain Hendlisz Stefano Cascinu Haralabos Kalofonos Giovanna Devercelli Michael Wolf Rafael G Amado

Cancer 2009 Apr;115(7):1544-54

Department of HepatoGastroenterology, Digestive Oncology Unit, Ghent University Hospital, Ghent, Belgium.

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April 2009

Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials.

Authors:

Daniel Sargent Alberto Sobrero Axel Grothey Michael J O'Connell Marc Buyse Thierry Andre Yan Zheng Erin Green Roberto Labianca Chris O'Callaghan Jean Francois Seitz Guido Francini Daniel Haller Greg Yothers Richard Goldberg Aimery de Gramont

J Clin Oncol 2009 Feb 5;27(6):872-7. Epub 2009 Jan 5.

Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.

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February 2009

Capecitabine versus bolus fluorouracil plus leucovorin (folinic acid) as adjuvant chemotherapy for patients with Dukes' C colon cancer : economic evaluation in an Italian NHS setting.

Authors:

Francesco Di Costanzo Roberto Ravasio Alberto Sobrero Oscar Bertetto Orazio Vinante Gabriele Luppi Roberto Labianca Dino Amadori Carlo Barone Marco Carlo Merlano Flavia Longo Giovanni Mansueto Lorenzo Antonuzzo Silvia Gasperoni

Clin Drug Investig 2008 ;28(10):645-55

Unità Complessa di Oncologia Medica, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

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February 2009

Urgent need for a new staging system in advanced colorectal cancer.

Authors:

Graeme J Poston Joan Figueras Felice Giuliante Gennaro Nuzzo Alberto F Sobrero Jean-Francois Gigot Bernard Nordlinger Rene Adam Thomas Gruenberger Michael A Choti Anton J Bilchik Eric J D Van Cutsem Jy-Ming Chiang Michael I D'Angelica

J Clin Oncol 2008 Oct 18;26(29):4828-33. Epub 2008 Aug 18.

Department of Surgery, University Hospital Aintree, Liverpool, L9 7AL, United Kingdom.

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October 2008

Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).

Authors:

Ivan Popov Alfredo Carrato Alberto Sobrero Mark Vincent David Kerr Roberto Labianca Angelo Raffaele Bianco Mostafa El-Serafi Laurent Bedenne Bernard Paillot Enrico Mini Evaristo Sanches John Welch Laurence Collette Michel Praet Jacques Wils

Eur J Cancer 2008 Oct 15;44(15):2204-11. Epub 2008 Aug 15.

Institute of Oncology and Radiology, Clinic for Medical Oncology, Pasterova 14, 11000 Belgrade, Serbia.

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October 2008

Small molecule inhibitors of tyrosine kinase: waiting for the good news in colorectal cancer as well.

Authors:

Alberto Sobrero Valeria Andretta

Onkologie 2008 May 10;31(5):224-5. Epub 2008 Apr 10.

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May 2008

EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer.

J Clin Oncol 2008 May 7;26(14):2311-9. Epub 2008 Apr 7.

Department of Medical Oncology, Ospedale San Martino, Genoa, 16132, Italy.

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May 2008

Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group.

Authors:

Bernard Nordlinger Eric Van Cutsem Philippe Rougier Claus-Henning Köhne Marc Ychou Alberto Sobrero Rene Adam Dag Arvidsson Alfredo Carrato Vassilis Georgoulias Felice Giuliante Bengt Glimelius Markus Golling Thomas Gruenberger Josep Tabernero Harpreet Wasan Graeme Poston

Eur J Cancer 2007 Sep 4;43(14):2037-45. Epub 2007 Sep 4.

Hôpital Ambroise Paré, CHU Paris Ouest, 92100 Boulogne Cedex, France.

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September 2007

Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab.

Authors:

Andrea Sartore-Bianchi Mauro Moroni Silvio Veronese Carlo Carnaghi Emilio Bajetta Gabriele Luppi Alberto Sobrero Carlo Barone Stefano Cascinu Giuseppe Colucci Enrico Cortesi Michele Nichelatti Marcello Gambacorta Salvatore Siena

J Clin Oncol 2007 Aug;25(22):3238-45

Divisione Oncologia Falck, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.

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August 2007

Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials.

Authors:

Cornelis J A Punt Marc Buyse Claus-Henning Köhne Peter Hohenberger Roberto Labianca Hans J Schmoll Lars Påhlman Alberto Sobrero Jean-Yves Douillard

J Natl Cancer Inst 2007 Jul 27;99(13):998-1003. Epub 2007 Jun 27.

Department of Medical Oncology, Radboud University Nijmegen Medical Center, PO Box 9101 6500 HB Nijmegen, The Netherlands.

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July 2007

Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial.

J Natl Cancer Inst 2007 Apr;99(8):601-7

Universita' Politecnica delle Marche, Via Conca 60020 Ancona, Italy.

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April 2007

Second-line therapy for advanced colorectal cancer.

Authors:

Alessandra P Guglielmi Alberto F Sobrero

Gastrointest Cancer Res 2007 Mar;1(2):57-63

Department of Medical Oncology, Ospedale San Martino, Genova, Italy.

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March 2007

Molecular characterization of established human colon carcinoma cell lines (HCT-8) made resistant to 5-fluorouracil by different selection schedules.

Authors:

Alessio Tempestini Barbara Caciagli Maria Morganti Ewa Witort Stefania Nobili Laura Papucci Nicola Schiavone Martino Donnini Ida Landini Andrea Lapucci Federico Perna Matteo Lulli Teresita Mazzei Alberto Sobrero Enrico Mini Sergio Capaccioli

Oncol Res 2005 ;16(3):143-56

Department of Experimental Pathology and Oncology, University of Florence, Italy.

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December 2006

Optimal treatment of metastatic colorectal cancer.

Authors:

Anna Pessino Alberto Sobrero

Expert Rev Anticancer Ther 2006 May;6(5):801-12

Medical Oncology Division, University Hospital San Martino, Genoa, Italy.

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May 2006

Should adjuvant chemotherapy become standard treatment for patients with stage II colon cancer? For the proposal.

Authors:

Alberto Sobrero

Lancet Oncol 2006 Jun;7(6):515-6

Department of Medical Oncology, Ospedale San Martino, Genoa, Italy.

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June 2006

Current issues in adjuvant treatment of stage II colon cancer.

Authors:

Thierry André Daniel Sargent Josep Tabernero Michael O'Connell Marc Buyse Alberto Sobrero Jean-Louis Misset Corrado Boni Aimery de Gramont

Ann Surg Oncol 2006 Jun 14;13(6):887-98. Epub 2006 Apr 14.

Service d'Oncologie Médicale, Hôpital Tenon, 4 Rue de la Chine, 75970, Paris Cedex 20, France, and Vall d'Hebron University Hospital, Barcelona, Spain.

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June 2006