Alberto Inga

Alberto Inga

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Alberto Inga

Publications by authors named "Alberto Inga"

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Apigenin rich- (de Girard) Kuntze promotes apoptosis in HCT116 cancer cells.

Nat Prod Res 2019 Oct 9:1-5. Epub 2019 Oct 9.

Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université Frères Mentouri Constantine 1 , Constantine , Algérie.

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http://dx.doi.org/10.1080/14786419.2019.1672070DOI Listing
October 2019

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.

Mol Cell 2019 Sep 20;75(5):982-995.e9. Epub 2019 Aug 20.

European Molecular Biology Laboratory (EMBL) Grenoble, 71 Avenue des Martyrs, Grenoble 38042, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739425PMC
September 2019

Yeast As a Chassis for Developing Functional Assays to Study Human P53.

J Vis Exp 2019 Aug 4(150). Epub 2019 Aug 4.

Department CIBIO, University of Trento;

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http://dx.doi.org/10.3791/59071DOI Listing
August 2019

Correction to: Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in 53-deficient cancer cells.

Cell Div 2019;14:10. Epub 2019 Aug 29.

2Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Biomedicum, Solnavägen 9, 171 65 Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13008-019-0052-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714447PMC
August 2019

Functional analysis of a CDKN2A 5'UTR germline variant associated with pancreatic cancer development.

PLoS One 2017 7;12(12):e0189123. Epub 2017 Dec 7.

Genetics of Rare Cancers, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189123PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720692PMC
December 2017

Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

Genome Res 2017 10 13;27(10):1645-1657. Epub 2017 Sep 13.

Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1101/gr.220533.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630028PMC
October 2017

The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein.

Biochem Biophys Res Commun 2017 01 19;483(1):516-521. Epub 2016 Dec 19.

Laboratory of Transcriptional Networks, Center for Integrative Biology, CIBIO, University of Trento, via Sommarive 9, 38123, Trento, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2016.12.113DOI Listing
January 2017

Human transcription factors in yeast: the fruitful examples of P53 and NF-кB.

FEMS Yeast Res 2016 11 27;16(7). Epub 2016 Sep 27.

Centre for Integrative Biology, CIBIO, University of Trento, via Sommarive 9, 38123, Trento, Italy.

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http://dx.doi.org/10.1093/femsyr/fow083DOI Listing
November 2016

c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.

Oncotarget 2016 Oct;7(40):65514-65539

Centre for Pharmacology and Toxicology, Hannover Medical School, 30625 Hannover, Germany.

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http://dx.doi.org/10.18632/oncotarget.11804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323172PMC
October 2016

Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay.

PLoS One 2015 6;10(7):e0130170. Epub 2015 Jul 6.

Laboratory of Transcriptional Networks, Centre for Integrative Biology (CIBIO), University of Trento, Trento, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130170PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493129PMC
March 2016

Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay.

PLoS One 2015 10;10(2):e0116177. Epub 2015 Feb 10.

Laboratory of Transcriptional Networks, Centre for Integrative Biology (CIBIO), University of Trento, Mattarello, Trento, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116177PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323202PMC
January 2016

Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements.

RNA Biol 2015 ;12(3):290-304

a Laboratory for Hereditary Cancer ; Division of Molecular Medicine ; Ruđer Bošković Institute ; Zagreb , Croatia.

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http://dx.doi.org/10.1080/15476286.2015.1008929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615190PMC
December 2015

Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.

Life Sci 2015 Dec 21;142:60-5. Epub 2015 Oct 21.

UCIBIO/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Laboratório de Farmacologia, Departamento de Ciências do Medicamento, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 164, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2015.10.015DOI Listing
December 2015

Whole-genome cartography of p53 response elements ranked on transactivation potential.

BMC Genomics 2015 Jun 17;16:464. Epub 2015 Jun 17.

Centre for Integrative Biology (CIBIO), University of Trento, via delle Regole 101, 38123, Mattarello, TN, Italy.

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http://dx.doi.org/10.1186/s12864-015-1643-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470028PMC
June 2015

In-silico identification and functional validation of allele-dependent AR enhancers.

Oncotarget 2015 Mar;6(7):4816-28

Laboratory of Computational Oncology, CIBIO, Centre for Integrative Biology, University of Trento, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467117PMC
http://dx.doi.org/10.18632/oncotarget.3019DOI Listing
March 2015

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.

Eur J Pharm Sci 2015 Jan 13;66:138-47. Epub 2014 Oct 13.

REQUIMTE, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.° 164, 4050-313 Porto, Portugal; Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.° 164, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2014.10.006DOI Listing
January 2015

Structural studies on mechanisms to activate mutant p53.

Subcell Biochem 2014 ;85:119-32

Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City, D.F., Mexico,

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http://dx.doi.org/10.1007/978-94-017-9211-0_7DOI Listing
December 2014

Cooperative interactions between p53 and NFκB enhance cell plasticity.

Oncotarget 2014 Dec;5(23):12111-25

Laboratory of Transcriptional Networks, Centre for Integrative Biology, CIBIO, University of Trento, Trento, 38123, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322992PMC
http://dx.doi.org/10.18632/oncotarget.2545DOI Listing
December 2014

A cross-platform comparison of affymetrix and Agilent microarrays reveals discordant miRNA expression in lung tumors of c-Raf transgenic mice.

PLoS One 2013 12;8(11):e78870. Epub 2013 Nov 12.

Centre of Integrative Biology (CIBIO), University of Trento, Trento, Italy ; Centre for Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078870PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827083PMC
July 2014

TP53 mutants in the tower of babel of cancer progression.

Hum Mutat 2014 Jun 14;35(6):689-701. Epub 2014 Mar 14.

Laboratory of Transcriptional Networks, Centre for Integrative Biology (CIBIO), University of Trento, Trento, Italy.

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http://dx.doi.org/10.1002/humu.22514DOI Listing
June 2014

Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.

Mutat Res 2014 Jan 7;759:45-51. Epub 2013 Nov 7.

Molecular Mutagenesis and DNA Repair Unit, Istituto di Ricerca e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa 16132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2013.10.004DOI Listing
January 2014

Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.

FEBS J 2013 Dec 23;280(24):6498-507. Epub 2013 Oct 23.

REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Universidade do Porto, Portugal.

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http://dx.doi.org/10.1111/febs.12552DOI Listing
December 2013

Identification of new p53 target microRNAs by bioinformatics and functional analysis.

BMC Cancer 2013 Nov 21;13:552. Epub 2013 Nov 21.

Laboratory of Transcriptional Networks, Center for Integrative Biology, CIBIO, University of Trento, Trento, Italy.

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http://dx.doi.org/10.1186/1471-2407-13-552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225545PMC
November 2013

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.

Nucleic Acids Res 2013 Oct 26;41(18):8637-53. Epub 2013 Jul 26.

Laboratory of Transcriptional Networks, Centre for Integrative Biology (CIBIO), University of Trento, TN, 38060 Italy, Molecular Mutagenesis and DNA Repair Unit, IRCSS Azienda Ospedaliera Universitaria San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa 16132, Italy, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA and Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIEHS, NIH, RTP, NC, 27709, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkt657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794606PMC
October 2013

EEC- and ADULT-associated TP63 mutations exhibit functional heterogeneity toward P63 responsive sequences.

Hum Mutat 2013 Jun 2;34(6):894-904. Epub 2013 Apr 2.

Molecular Mutagenesis and DNA Repair Unit, Istituto di Ricerca e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1002/humu.22304DOI Listing
June 2013

Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach.

Biochem Pharmacol 2013 May 18;85(9):1234-45. Epub 2013 Feb 18.

REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.° 164, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1016/j.bcp.2013.01.032DOI Listing
May 2013

Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics.

Cell Cycle 2013 Apr 21;12(8):1211-24. Epub 2013 Mar 21.

Laboratory of Transcriptional Networks, Centre for Integrative Biology (CIBIO), University of Trento, Mattarello, Trento, Italy.

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http://www.tandfonline.com/doi/abs/10.4161/cc.24309
Publisher Site
http://dx.doi.org/10.4161/cc.24309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674086PMC
April 2013

Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.

J Nat Prod 2013 Apr 29;76(4):774-8. Epub 2013 Mar 29.

REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1021/np400049jDOI Listing
April 2013

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.

Nucleic Acids Res 2013 Jan 17;41(Database issue):D962-9. Epub 2012 Nov 17.

Université Pierre et Marie Curie-Paris6, 75005 Paris, France.

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http://dx.doi.org/10.1093/nar/gks1033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531172PMC
January 2013

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6066-71. Epub 2012 Apr 2.

Laboratory of Structural Biochemistry, Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive 0378, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1115463109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341074PMC
April 2012

3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.

DNA Repair (Amst) 2011 Aug 14;10(8):861-8. Epub 2011 Jun 14.

Molecular Mutagenesis and DNA Repair Unit, Department of Epidemiology and Prevention, National Cancer Research Institute (IST), 16132 Genova, Italy.

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http://dx.doi.org/10.1016/j.dnarep.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146564PMC
August 2011

Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

Mol Cancer Res 2011 Mar 22;9(3):271-9. Epub 2011 Feb 22.

Molecular Mutagenesis and DNA Repair Unit, Department of Epidemiology and Prevention, National Cancer Research Institute (IST), Largo Rosanna Benzi, 10, Genova 16132, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077904PMC
March 2011

PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.

Biochem Biophys Res Commun 2010 Nov 12;402(2):345-50. Epub 2010 Oct 12.

Molecular Mutagenesis and DNA Repair Unit, Department of Epidemiology and Prevention, National Cancer Research Institute (IST), 16132 Genova, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2010.10.031DOI Listing
November 2010

MDM2 SNP309 genotype is associated with ferritin and LDH serum levels in children with stage 4 neuroblastoma.

Pediatr Blood Cancer 2010 Aug;55(2):267-72

Epidemiology and Biostatistics Section, Scientific Directorate, G. Gaslini Children's Hospital, Genova, Italy.

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http://dx.doi.org/10.1002/pbc.22477DOI Listing
August 2010

Potentiating the p53 network.

Discov Med 2010 Jul;10(50):94-100

Chromosome Stability Group, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA.

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July 2010

Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.

Mol Cancer Res 2010 May 20;8(5):701-16. Epub 2010 Apr 20.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-09-0442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873663PMC
May 2010

Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma.

Hum Mol Genet 2010 Apr 21;19(8):1479-91. Epub 2010 Jan 21.

Unit of Molecular Mutagenesis and DNA Repair, National Institute for Cancer Research IST, 16132 Genoa, Italy.

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http://dx.doi.org/10.1093/hmg/ddq022DOI Listing
April 2010

Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.

Mutat Res 2010 Jan;683(1-2):50-6

Department of Epidemiology and Prevention, National Cancer Research Institute (IST), Genova, Italy.

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http://dx.doi.org/10.1016/j.mrfmmm.2009.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794908PMC
January 2010

Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.

Proc Natl Acad Sci U S A 2010 Jan 4;107(4):1500-5. Epub 2010 Jan 4.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.0909129107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824383PMC
January 2010

High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.

Mutat Res 2009 Dec 1;671(1-2):58-66. Epub 2009 Sep 1.

Molecular Mutagenesis and DNA Repair Unit, Department of Epidemiology and Prevention, National Cancer Research Institute (IST), L.go R. Benzi, 10, 16132 Genova, Italy.

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http://dx.doi.org/10.1016/j.mrfmmm.2009.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783936PMC
December 2009

MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma.

Pediatr Blood Cancer 2009 Oct;53(4):576-83

Molecular Mutagenesis and DNA Repair Unit, National Cancer Research Institute, Genoa, Italy.

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http://dx.doi.org/10.1002/pbc.22132DOI Listing
October 2009

A functional genetic study identifies HAND1 mutations in septation defects of the human heart.

Hum Mol Genet 2009 Oct 7;18(19):3567-78. Epub 2009 Jul 7.

Molecular Medicine and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, D-30625, Hannover, Germany.

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http://hmg.oxfordjournals.org/content/18/19/3567.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddp305
Publisher Site
http://dx.doi.org/10.1093/hmg/ddp305DOI Listing
October 2009

The expanding universe of p53 targets.

Nat Rev Cancer 2009 Oct;9(10):724-37

Laboratory of Molecular Genetics, National Institute of Environmental Health Science, Research Triangle Park, North Carolina 27709, USA.

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http://www.nature.com/articles/nrc2730
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http://dx.doi.org/10.1038/nrc2730DOI Listing
October 2009

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53.

PLoS Genet 2008 Jun 27;4(6):e1000104. Epub 2008 Jun 27.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518093PMC
June 2008

A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts.

Hum Mol Genet 2008 May 14;17(10):1397-405. Epub 2008 Feb 14.

Molecular Medicine and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1093/hmg/ddn027DOI Listing
May 2008

Functional evolution of the p53 regulatory network through its target response elements.

Proc Natl Acad Sci U S A 2008 Jan 10;105(3):944-9. Epub 2008 Jan 10.

Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1073/pnas.0704694105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242714PMC
January 2008

Transcriptional properties of feline p53 and its tumour-associated mutants: a yeast-based approach.

Mutagenesis 2007 Nov 18;22(6):417-23. Epub 2007 Oct 18.

Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta, Genoa, Italy.

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http://dx.doi.org/10.1093/mutage/gem038DOI Listing
November 2007

Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype.

Digestion 2006 20;74(3-4):228-35. Epub 2007 Mar 20.

Unit of Molecular Mutagenesis, National Institute for Cancer Research, Genoa, Italy.

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http://dx.doi.org/10.1159/000100966DOI Listing
August 2007

Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

Clin Cancer Res 2007 Jul;13(13):3789-95

Molecular Mutagenesis Unit, Department of Translational Oncology, National Cancer Research Institute, Genoa, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128783PMC
July 2007

The kinetics of p53-binding and histone acetylation at target promoters do not strictly correlate with gene expression after UV damage.

J Cell Biochem 2007 Apr;100(5):1276-87

Molecular Mutagenesis Unit, Department of Translational Oncology, National Cancer Research Institute (IST), Largo R. Benzi, 10, 16132 Genova, Italy.

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http://dx.doi.org/10.1002/jcb.21122DOI Listing
April 2007

A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.

Mol Cell Biol 2007 Apr 22;27(7):2590-600. Epub 2007 Jan 22.

Laboratory of Molecular Genetics MD3-01, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/MCB.01742-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899907PMC
April 2007

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.

Mol Cell Biol 2006 Mar;26(6):2297-308

Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1128/MCB.26.6.2297-2308.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430278PMC
March 2006

A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1406-11. Epub 2006 Jan 23.

Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.0508103103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360546PMC
January 2006

Functional diversity in the gene network controlled by the master regulator p53 in humans.

Cell Cycle 2005 Aug 7;4(8):1026-9. Epub 2005 Aug 7.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.4161/cc.4.8.1904DOI Listing
August 2005

Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system.

Hum Mol Genet 2005 Jul 25;14(14):1965-75. Epub 2005 May 25.

Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/hmg/ddi202DOI Listing
July 2005

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

Proc Natl Acad Sci U S A 2005 May 20;102(18):6431-6. Epub 2005 Apr 20.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.0501721102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088378PMC
May 2005

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity.

Proc Natl Acad Sci U S A 2003 Aug 8;100(17):9934-9. Epub 2003 Aug 8.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.1633803100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187891PMC
August 2003

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

Mol Cell Biol 2002 Dec;22(24):8612-25

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139870PMC
http://dx.doi.org/10.1128/mcb.22.24.8612-8625.2002DOI Listing
December 2002

A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions.

Oncogene 2002 Aug;21(37):5704-15

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, PO Box 12233, Research Triangle Park, North Carolina, NC 27709, USA.

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http://dx.doi.org/10.1038/sj.onc.1205779DOI Listing
August 2002

Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

Oncogene 2002 Mar;21(11):1641-8

Mutagenesis-Laboratory, National Cancer Research Institute (IST), Largo R. Benzi, 10, 16132-Genova, Italy.

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http://dx.doi.org/10.1038/sj.onc.1205250DOI Listing
March 2002