Publications by authors named "Albert S Baldwin"

100Publications

Genome-wide DNA methylation analysis of KRAS mutant cell lines.

Sci Rep 2020 06 23;10(1):10149. Epub 2020 Jun 23.

Department of Translational Genomics, University of Southern California, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1038/s41598-020-66797-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311523PMC
June 2020

USP37 promotes deubiquitination of HIF2α in kidney cancer.

Proc Natl Acad Sci U S A 2020 06 27;117(23):13023-13032. Epub 2020 May 27.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.2002567117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293621PMC
June 2020

Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.

Mol Cell 2020 03 4;77(6):1294-1306.e5. Epub 2020 Feb 4.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093231PMC
March 2020

Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells.

Sci Rep 2019 12 10;9(1):18695. Epub 2019 Dec 10.

Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1038/s41598-019-55145-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904738PMC
December 2019

TBK1 Is a Synthetic Lethal Target in Cancer with Loss.

Cancer Discov 2020 03 6;10(3):460-475. Epub 2019 Dec 6.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058506PMC
March 2020

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877.

Sci Rep 2019 09 17;9(1):13470. Epub 2019 Sep 17.

Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1038/s41598-019-49707-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748941PMC
September 2019

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer.

Cells 2018 Sep 15;7(9). Epub 2018 Sep 15.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.3390/cells7090139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162516PMC
September 2018

Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G arrest independent of DRD2.

J Biol Chem 2018 10 21;293(41):15977-15990. Epub 2018 Aug 21.

From the Curriculum of Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 and

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http://dx.doi.org/10.1074/jbc.RA118.003719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187640PMC
October 2018

Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia.

Eur J Transl Myol 2018 Apr 6;28(2):7590. Epub 2018 Jun 6.

Human Cancer Genetics, Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Biomedical Research Tower, Arthur G. James Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.4081/ejtm.2018.7590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036305PMC
April 2018

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells.

Sci Signal 2018 07 10;11(538). Epub 2018 Jul 10.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/scisignal.aan5850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939384PMC
July 2018

Targeting the Canonical Nuclear Factor-κB Pathway with a High-Potency IKK2 Inhibitor Improves Outcomes in a Mouse Model of Idiopathic Pneumonia Syndrome.

Biol Blood Marrow Transplant 2017 Apr 1;23(4):569-580. Epub 2017 Feb 1.

Lineberger Comprehensive Cancer Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.01.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428988PMC
April 2017

Signal transducer and activator of transcription 3 () regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection.

J Leukoc Biol 2017 04 13;101(4):1053-1064. Epub 2016 Dec 13.

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA;

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http://dx.doi.org/10.1189/jlb.4A1016-199RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346178PMC
April 2017

Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer.

PLoS One 2016 20;11(10):e0165005. Epub 2016 Oct 20.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072726PMC
June 2017

The NF-κB Pathway and Cancer Stem Cells.

Cells 2016 Apr 6;5(2). Epub 2016 Apr 6.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.3390/cells5020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931665PMC
April 2016

PI3K/Akt promotes feedforward mTORC2 activation through IKKα.

Oncotarget 2016 Apr;7(16):21064-75

The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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http://www.oncotarget.com/fulltext/8383
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http://dx.doi.org/10.18632/oncotarget.8383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008269PMC
April 2016

Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.

Nat Commun 2016 Feb 2;7:10593. Epub 2016 Feb 2.

Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/ncomms10593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740908PMC
February 2016

Using RNA interference in lung cancer cells to target the IKK-NF-κB pathway.

Methods Mol Biol 2015 ;1280:447-58

Department of Biochemistry, Chemistry Institute, University of São Paulo, nº1280 - Butantã, São Paulo, SP, 05508-070, Brazil,

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http://dx.doi.org/10.1007/978-1-4939-2422-6_27DOI Listing
November 2015

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

J Biol Chem 2014 Sep 2;289(36):25227-40. Epub 2014 Jul 2.

From the Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.M114.554881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155685PMC
September 2014

IKK is a therapeutic target in KRAS-Induced lung cancer with disrupted p53 activity.

Genes Cancer 2014 Apr;5(1-2):41-55

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; ; Department of Biology, University of North Carolina, Chapel Hill, NC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063255PMC
http://dx.doi.org/10.18632/genesandcancer.5DOI Listing
April 2014

IKK/nuclear factor-kappaB and oncogenesis: roles in tumor-initiating cells and in the tumor microenvironment.

Adv Cancer Res 2014 ;121:125-145

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-800249-0.00003-2DOI Listing
April 2015

A phase I clinical trial of systemically delivered NEMO binding domain peptide in dogs with spontaneous activated B-cell like diffuse large B-cell lymphoma.

PLoS One 2014 5;9(5):e95404. Epub 2014 May 5.

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095404PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010398PMC
June 2015

MDA-9/syntenin is a key regulator of glioma pathogenesis.

Neuro Oncol 2014 Jan 4;16(1):50-61. Epub 2013 Dec 4.

Corresponding author: Paul B. Fisher, MPh, PhD, Professor and Chairman, Department of Human and Molecular Genetics, Director, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, 1101 East Marshall Street, Sanger Hall Building, Room 11-015, Richmond, VA 23298-0033.

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http://dx.doi.org/10.1093/neuonc/not157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870820PMC
January 2014

Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function.

Blood 2013 Jun 13;121(25):5015-24. Epub 2013 May 13.

Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1182/blood-2013-02-486142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689248PMC
June 2013

GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB.

Cancer Discov 2013 Jun 1;3(6):690-703. Epub 2013 Apr 1.

Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679268PMC
June 2013

Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.

J Immunol 2012 Nov 19;189(9):4417-25. Epub 2012 Sep 19.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1200919
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http://dx.doi.org/10.4049/jimmunol.1200919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478428PMC
November 2012

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

PLoS One 2012 30;7(7):e41494. Epub 2012 Jul 30.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041494PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408500PMC
April 2013

Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation.

Cancer Res 2012 Jul 2;72(13):3260-9. Epub 2012 May 2.

Lineberger Comprehensive Cancer Center, Department of Biology, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-4141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541677PMC
July 2012

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer.

Authors:
Albert S Baldwin

Immunol Rev 2012 Mar;246(1):327-45

Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01095.xDOI Listing
March 2012

p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.

Mol Cell 2012 Mar 16;45(6):719-30. Epub 2012 Feb 16.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765120005
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http://dx.doi.org/10.1016/j.molcel.2012.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319231PMC
March 2012

Observing single cell NF-κB dynamics under stimulant concentration gradient.

Anal Chem 2012 Feb 19;84(3):1224-8. Epub 2012 Jan 19.

School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, Virginia 24061, USA.

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http://pubs.acs.org/doi/10.1021/ac203209t
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http://dx.doi.org/10.1021/ac203209tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299085PMC
February 2012

Monoallelic deletion of NFKBIA in glioblastoma: when less is more.

Cancer Cell 2011 Feb;19(2):163-5

Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.01.045DOI Listing
February 2011

NF-kB and Bcl-3 activation are prognostic in metastatic colorectal cancer.

Oncology 2010 23;78(3-4):181-8. Epub 2010 Apr 23.

Department of Internal Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7305, USA.

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http://dx.doi.org/10.1159/000313697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914399PMC
July 2010

Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.

Cancer Res 2010 May 20;70(9):3537-46. Epub 2010 Apr 20.

Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862109PMC
May 2010

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.

PLoS One 2010 Feb 25;5(2):e9428. Epub 2010 Feb 25.

Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009428PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828475PMC
February 2010

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.

PLoS One 2009 Sep 10;4(9):e6992. Epub 2009 Sep 10.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006992PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734988PMC
September 2009

Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells.

Cancer Res 2009 Jan;69(1):55-64

Segal Cancer Center and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, 3755 Côte Ste-Catherine Road, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0245DOI Listing
January 2009

Inhibitory kappa B kinase-beta is a target for specific nuclear factor kappa B-mediated delayed cardioprotection.

J Thorac Cardiovasc Surg 2008 Nov 9;136(5):1274-9. Epub 2008 Sep 9.

Department of Surgery, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1016/j.jtcvs.2008.07.041DOI Listing
November 2008

Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.

Cancer Res 2008 Oct;68(19):8156-63

Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, USA. 27599-7295

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647811PMC
October 2008

NF-kappaB pathways in the immune system: control of the germinal center reaction.

Immunol Res 2008 ;41(3):233-47

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 405 West Dr., Room 213, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1007/s12026-008-8033-1DOI Listing
April 2009

Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin.

Mol Cancer Ther 2008 Jul;7(7):1827-35

Lineberger Comprehensive Cancer Center and Department of Surgery, University of North Carolina at Chapel Hill, 3010 Old Clinic Building, CB 7213, Chapel Hill, NC 27599-7213, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-08
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http://dx.doi.org/10.1158/1535-7163.MCT-08-0321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581801PMC
July 2008

Essential role for epidermal growth factor receptor in glutamate receptor signaling to NF-kappaB.

Mol Cell Biol 2008 Aug 9;28(16):5061-70. Epub 2008 Jun 9.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1128/MCB.00578-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519702PMC
August 2008

Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

Genes Dev 2008 Jun;22(11):1490-500

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1662308
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http://dx.doi.org/10.1101/gad.1662308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418585PMC
June 2008

Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.

J Immunol 2008 Jun;180(11):7582-9

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.180.11.7582DOI Listing
June 2008

Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression.

Proc Natl Acad Sci U S A 2008 Mar 22;105(9):3362-7. Epub 2008 Feb 22.

Departments of Surgery and Cell and Developmental Biology, Carolina Cardiovascular Biology Center, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1073/pnas.0705842105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265140PMC
March 2008

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.

J Immunol 2008 Feb;180(4):2588-99

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.4049/jimmunol.180.4.2588DOI Listing
February 2008

IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells.

Mol Cancer Ther 2008 Feb 1;7(2):391-7. Epub 2008 Feb 1.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0305DOI Listing
February 2008

Retinoic acid modulates chromatin to potentiate tumor necrosis factor alpha signaling on the DIF2 promoter.

Nucleic Acids Res 2008 Feb 26;36(2):435-43. Epub 2007 Nov 26.

Lady Davis Institute for Medical Research, Segal Cancer Centre of the SMBD Jewish General Hospital, McGill University, Montreal H3T1E2, Quebec, Canada.

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http://dx.doi.org/10.1093/nar/gkm1058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241879PMC
February 2008

Proteasome inhibition promotes regression of left ventricular hypertrophy.

Am J Physiol Heart Circ Physiol 2008 Feb 21;294(2):H645-50. Epub 2007 Nov 21.

Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill 27599-7065, USA.

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http://ajpheart.physiology.org/content/ajpheart/294/2/H645.f
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http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0019
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http://dx.doi.org/10.1152/ajpheart.00196.2007DOI Listing
February 2008

Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas.

Oncology 2007 15;72(1-2):97-104. Epub 2007 Nov 15.

Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1159/000111116DOI Listing
January 2008

LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.

Cancer Cell 2007 Sep;12(3):239-51

Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.07.002DOI Listing
September 2007

Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.

Cancer Res 2007 Jul;67(13):6263-9

Lineberger Comprehensive Cancer Center, Department of Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1232DOI Listing
July 2007

Dendritic cells from lupus-prone mice are defective in repressing immunoglobulin secretion.

J Immunol 2007 Apr;178(8):4803-10

Department of Microbiology/Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700365PMC
http://dx.doi.org/10.4049/jimmunol.178.8.4803DOI Listing
April 2007

Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.

Blood 2007 Jan 28;109(2):653-60. Epub 2006 Sep 28.

Department of Microbiology and Immunology, Mary Ellen Jones Bldg, Rm 804, Campus Box 7290, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7290, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-04-01
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http://dx.doi.org/10.1182/blood-2006-04-017368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785106PMC
January 2007

IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation.

J Biol Chem 2006 Sep 13;281(37):26976-84. Epub 2006 Jul 13.

Lineberger Comprehensive Cancer Center, Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M603133200DOI Listing
September 2006

The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.

J Biol Chem 2006 May 3;281(18):12521-5. Epub 2006 Mar 3.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA.

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http://dx.doi.org/10.1074/jbc.M513333200DOI Listing
May 2006

Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes.

J Cell Physiol 2006 Jun;207(3):809-15

Department of Medicine and Center for GI Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1002/jcp.20626DOI Listing
June 2006

Expression of the Bcl-3 proto-oncogene suppresses p53 activation.

Genes Dev 2006 Jan 29;20(2):225-35. Epub 2005 Dec 29.

Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gad.1352206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356113PMC
January 2006

Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription.

Mol Cell Biol 2005 Oct;25(19):8444-55

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1128/MCB.25.19.8444-8455.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265740PMC
October 2005

Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression.

EMBO J 2005 Feb 20;24(3):510-20. Epub 2005 Jan 20.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548660PMC
February 2005

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.

Genes Dev 2004 Dec 15;18(23):2905-15. Epub 2004 Nov 15.

Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1101/gad.1223004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534651PMC
December 2004

Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation.

Cancer Res 2004 Oct;64(20):7473-8

Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1772DOI Listing
October 2004

The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation.

Cancer Res 2004 Oct;64(20):7248-55

Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-3898DOI Listing
October 2004

Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

Cancer Res 2004 Sep;64(18):6511-23

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20832-0001, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0852DOI Listing
September 2004

IkappaB kinase alpha and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation.

J Biol Chem 2004 Jul 20;279(30):31183-9. Epub 2004 May 20.

Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA.

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http://dx.doi.org/10.1074/jbc.M404380200DOI Listing
July 2004

Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity.

Blood 2004 Aug 27;104(4):1100-9. Epub 2004 Apr 27.

Department of Microbiology and Immunology, Mary Ellen Jones Bldg, Rm 804, Campus Box 7290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-12-43
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http://dx.doi.org/10.1182/blood-2003-12-4302DOI Listing
August 2004

NF kappa B: biology and pathology--Keystone Symposium. 11-16 January 2004, Snowbird, UT, USA.

Authors:
Albert S Baldwin

IDrugs 2004 Mar;7(3):215-6

University of North Carolina, Department of Biology, Campus Box 3280, Coker Hall, UNC-Chapel Hill, NC 27599-3280, USA.

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March 2004

Nuclear factor-kappaB activation in endothelium by Chlamydia pneumoniae without active infection.

J Infect Dis 2003 Oct 1;188(8):1094-7. Epub 2003 Oct 1.

Department of Pathology, University of North Carolina School of Medicine, North Carolina 27516, USA.

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http://dx.doi.org/10.1086/378564DOI Listing
October 2003

NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism.

Genes Dev 2003 Oct;17(19):2368-73

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gad.1114503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC218074PMC
October 2003

Oncoprotein suppression of tumor necrosis factor-induced NF kappa B activation is independent of Raf-controlled pathways.

J Biol Chem 2003 Sep 8;278(37):34910-7. Epub 2003 Jul 8.

Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, 27599-7295, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304189200
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http://dx.doi.org/10.1074/jbc.M304189200DOI Listing
September 2003

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression.

Nature 2003 Jun;423(6940):659-63

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nature01648DOI Listing
June 2003

Regulation of NF-kappaB by oncoproteins and tumor suppressor proteins.

Methods Mol Biol 2003 ;223:523-32

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.

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http://dx.doi.org/10.1385/1-59259-329-1:523DOI Listing
January 2004

Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas.

J Neurooncol 2003 Feb;61(3):187-96

Division of Neurosurgery, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599-7060, USA.

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http://link.springer.com/content/pdf/10.1023%2FA%3A102255482
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http://dx.doi.org/10.1023/a:1022554824129DOI Listing
February 2003

NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.

J Immunol 2003 Feb;170(4):1770-80

Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.170.4.1770DOI Listing
February 2003

NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B.

J Biol Chem 2003 Jan 13;278(5):2963-8. Epub 2002 Nov 13.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1074/jbc.M209995200DOI Listing
January 2003

Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury.

Am J Physiol Heart Circ Physiol 2003 Mar 7;284(3):H919-26. Epub 2002 Nov 7.

Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27516, USA.

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http://dx.doi.org/10.1152/ajpheart.00851.2002DOI Listing
March 2003