Publications by authors named "Albert M Maguire"

80Publications

Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy.

Mol Ther 2020 Dec 3. Epub 2020 Dec 3.

Center for Advanced Retinal and Ocular Therapeutics (CAROT), Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; The Children's Hospital of Philadelphia (CHOP), Philadelphia, PA, USA. Electronic address:

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December 2020

Compensatory Cross-Modal Plasticity Persists After Sight Restoration.

Front Neurosci 2020 12;14:291. Epub 2020 May 12.

Department of Ophthalmology, Center for Advanced Retinal and Ocular Therapeutics, University of Pennsylvania, Philadelphia, PA, United States.

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May 2020

Cytomegalovirus retinitis in an immunocompetent host after complicated cataract surgery.

Am J Ophthalmol Case Rep 2020 Jun 6;18:100702. Epub 2020 Apr 6.

Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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June 2020

Scleral depression saves lives.

Am J Ophthalmol Case Rep 2020 Jun 9;18:100656. Epub 2020 Mar 9.

Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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June 2020

Safety of Same-Eye Subretinal Sequential Readministration of in Non-human Primates.

Mol Ther Methods Clin Dev 2019 Dec 3;15:133-148. Epub 2019 Sep 3.

Center for Advanced Retinal and Ocular Therapeutics (CAROT), Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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December 2019

Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials.

Ophthalmology 2019 09 22;126(9):1273-1285. Epub 2019 Jun 22.

Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Cellular and Molecular Therapeutics, Inc., Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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September 2019

Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry.

Ophthalmol Retina 2019 10 8;3(10):888-899. Epub 2019 May 8.

Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Advanced Retinal and Ocular Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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October 2019

Exuberant Anterior Chamber Fibrin Reaction.

Ophthalmol Retina 2018 05 2;2(5):440. Epub 2018 May 2.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

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May 2018

RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function.

Invest Ophthalmol Vis Sci 2018 10;59(12):5225-5236

Scheie Eye Institute at the Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania, United States.

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October 2018

Identification of a novel pathogenic missense mutation in using whole exome sequencing: a case report.

Br J Ophthalmol 2019 06 20;103(6):761-767. Epub 2018 Jul 20.

Center for Advanced Retinal and Ocular Therapeutics (CAROT) and F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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June 2019

Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia.

Invest Ophthalmol Vis Sci 2018 07;59(8):3249-3258

Center for Advanced Retinal and Ocular Therapeutics (CAROT), University of Pennsylvania, Philadelphia, Pennsylvania, United States.

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July 2018

Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness.

Mol Ther 2018 06 21;26(6):1581-1593. Epub 2018 Mar 21.

Center for Advanced Retinal and Ocular Therapeutics (CAROT) and F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Penn Vision Research Center, University of Pennsylvania Perelman, Philadelphia, PA, USA. Electronic address:

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June 2018

Prescreening whole exome sequencing results from patients with retinal degeneration for variants in genes associated with retinal degeneration.

Clin Ophthalmol 2018 29;12:49-63. Epub 2017 Dec 29.

Center for Advanced Retinal and Ocular Therapeutics (CAROT), FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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December 2017

On variants and disease-causing mutations: Case studies of a SEMA4A variant identified in inherited blindness.

Ophthalmic Genet 2018 Jan-Feb;39(1):144-146. Epub 2017 Aug 14.

a Center for Advanced Retinal and Ocular Therapeutics (CAROT) and F.M. Kirby Center for Molecular Ophthalmology , Scheie Eye Institute, University of Pennsylvania , Philadelphia , Pennsylvania , USA.

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March 2018

Reply.

Am J Ophthalmol 2017 05 18;177:229. Epub 2017 Mar 18.

Philadelphia, Pennsylvania.

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May 2017

The Role of the Human Visual Cortex in Assessment of the Long-Term Durability of Retinal Gene Therapy in Follow-on RPE65 Clinical Trial Patients.

Ophthalmology 2017 06 23;124(6):873-883. Epub 2017 Feb 23.

Center for Advanced Retinal and Ocular Therapeutics, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania; F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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June 2017

Intravitreal Bevacizumab for the Treatment of Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy.

Am J Ophthalmol 2017 Apr 24;176:194-202. Epub 2017 Jan 24.

Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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April 2017

Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study.

Ophthalmology 2017 03 13;124(3):359-373. Epub 2016 Dec 13.

Scheie Eye Institute, Perelman School of Medicine, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.

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March 2017

Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization.

Ophthalmic Genet 2016 12 30;37(4):445-452. Epub 2016 Mar 30.

a Scheie Eye Institute and Perelman Center for Advanced Medicine, University of Pennsylvania , Philadelphia , Pennsylvania , USA.

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December 2016

Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina.

Hum Gene Ther 2017 02 17;28(2):154-167. Epub 2016 Oct 17.

Center for Advanced Retinal and Ocular Therapeutics (CAROT) and F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania.

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February 2017

Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial.

Lancet 2016 Aug 30;388(10045):661-72. Epub 2016 Jun 30.

Center for Advanced Retinal and Ocular Therapeutics, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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August 2016

Atypical Retinitis in the Setting of Prior Cytomegalovirus Retinitis.

JAMA Ophthalmol 2016 06;134(6):709-10

Myrin Circle, Scheie Eye Institute, Philadelphia, Pennsylvania.

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June 2016

Isolated maculopathy associated with biallelic CRB1 mutations.

Ophthalmic Genet 2017 Mar-Apr;38(2):190-193. Epub 2016 Apr 20.

a Division of Ophthalmology , Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , USA.

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November 2017

Cobalamin C Deficiency Shows a Rapidly Progressing Maculopathy With Severe Photoreceptor and Ganglion Cell Loss.

Invest Ophthalmol Vis Sci 2015 Dec;56(13):7875-87

Scheie Eye Institute and the Perelman Center for Advanced Medicine, Department of Ophthamology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States 3Division of Ophthalmology, The Children's Hospital of.

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December 2015

Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes.

Adv Exp Med Biol 2016 ;854:533-9

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Naples, Italy.

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April 2016

Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis.

Sci Transl Med 2015 Jul;7(296):296ra110

Center for Advanced Retinal and Ocular Therapeutics, University of Pennsylvania Perelman School of Medicine, 309 Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA 19104, USA. F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19014, USA. Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA.

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July 2015

High-resolution adaptive optics retinal imaging of cellular structure in choroideremia.

Invest Ophthalmol Vis Sci 2014 Sep 4;55(10):6381-97. Epub 2014 Sep 4.

Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

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September 2014

Late recurrence of retinopathy of prematurity after treatment with both intravitreal bevacizumab and laser.

J AAPOS 2014 Aug 1;18(4):402-4. Epub 2014 Aug 1.

Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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August 2014

Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models.

J Gene Med 2014 May-Jun;16(5-6):122-30

F.M. Kirby Center for Molecular Ophthalmology and Center for Advanced Retinal and Ophthalmic Therapeutics, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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March 2015

Retinal Structure in Cobalamin C Disease: Mechanistic and Therapeutic Implications.

Ophthalmic Genet 2015 10;36(4):339-48. Epub 2014 Feb 10.

b Children's Hospital of Philadelphia, Department of Ophthalmology, University of Pennsylvania , and.

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July 2016

AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models.

PLoS One 2013 7;8(5):e61396. Epub 2013 May 7.

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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December 2013

AAV9 targets cone photoreceptors in the nonhuman primate retina.

PLoS One 2013 30;8(1):e53463. Epub 2013 Jan 30.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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September 2013

Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.

Sci Transl Med 2011 Jun;3(88):88ra54

Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, and Center for Cellelar and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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June 2011

The human visual cortex responds to gene therapy-mediated recovery of retinal function.

J Clin Invest 2011 Jun 23;121(6):2160-8. Epub 2011 May 23.

Diffusion Tensor Image Analyses and Brain Morphometry Center, Department of Radiology, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania 19104, USA.

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June 2011

Recent advances in ocular gene therapy.

Curr Opin Ophthalmol 2009 Sep;20(5):377-81

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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September 2009

Treatment of Susac syndrome with gamma globulin and corticosteroids.

J Neurol Sci 2006 Dec 17;251(1-2):17-22. Epub 2006 Oct 17.

Mellen Center, Department of Neurology, U-10, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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December 2006

Total exudative retinal detachment in coats disease: biochemical analysis of the subretinal exudate.

Retina 2006 Sep;26(7):831-3

Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, and Department of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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September 2006

Transmission of retinal laser wavelengths through blood.

Retina 2005 Jun;25(4):498-502

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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June 2005

Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates.

Hum Gene Ther 2005 Feb;16(2):178-86

Gene Therapy Program, Department of Medicine, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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February 2005

Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse.

Mol Vis 2004 Nov 8;10:837-44. Epub 2004 Nov 8.

F. M. Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104-6069, USA.

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November 2004

Müller cell transduction by AAV2 in normal and degenerative retinas.

Adv Exp Med Biol 2003 ;533:439-45

Retina Foundation of the Southwest, 9900 N. Central Expressway, Suite 400, Dallas, TX 75231, USA.

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August 2004

In utero gene therapy rescues vision in a murine model of congenital blindness.

Mol Ther 2004 Feb;9(2):182-8

F.M. Kirby Center and Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 N. 39th Street, Philadelphia, PA 19104-2689, USA.

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February 2004

Atypical presentation of bone marrow transplant retinopathy.

J Pediatr Ophthalmol Strabismus 2003 Nov-Dec;40(6):361-3

Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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January 2004

Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction.

J Virol 2003 Jul;77(14):7957-63

F. M. Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, Scheie Eye Institute, 310 Stellar Chance Building, University of Pennsylvania, 422 Curie Boulevard, Philadelphia, PA 19104-6069, USA.

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July 2003

Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.

Mol Vis 2003 May 30;9:210-6. Epub 2003 May 30.

F. M. Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104, USA.

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May 2003

Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus.

Vision Res 2003 Apr;43(8):919-26

Department of Ophthalmology, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6069, USA.

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April 2003

Traumatic retinal break from viscoelastic cannula during cataract surgery.

Arch Ophthalmol 2003 Jan;121(1):128-9

Retina Service, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 N 39th St, Philadelphia, PA 19104, USA.

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January 2003

Multifocal choroiditis in patients with familial juvenile systemic granulomatosis.

Am J Ophthalmol 2002 Dec;134(6):897-904

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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December 2002

Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents.

Mol Ther 2002 Oct;6(4):490-4

F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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October 2002

Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs.

Proc Natl Acad Sci U S A 2002 Oct 13;99(20):13102-7. Epub 2002 Sep 13.

Departments of Internal Medicine and Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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October 2002

Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye.

Mol Ther 2002 Aug;6(2):238-42

Institute for Human Gene Therapy, The Wistar Institute, Department of Molecular and Cellular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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August 2002

Prolonged premonitory optic disc signs in anterior ischemic optic neuropathy.

J Neuroophthalmol 2002 Jun;22(2):110-2

Retina and Neuro-Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

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June 2002

Intraocular caterpillar setae without subsequent vitritis or iridocyclitis.

Am J Ophthalmol 2002 Jul;134(1):118-20

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104, USA.

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July 2002

Microsporidial endophthalmitis in a patient with acute myelogenous leukemia.

Retina 2002 Feb;22(1):123-5

Scheie Eye Institute, University of Pennsylvania Health System, Pennsylvania 19104, USA.

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February 2002

A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus.

Mol Ther 2002 Feb;5(2):125-32

Univeristy of Pennsylvania, F. M. Kirby Center for Molecular Ophthalmology, 310 Stellar Chance Labs, Scheie Eye Institute, 422 Curie Blvd, Philadelphia, Pennsylvania 19104-6069, USA.

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February 2002