Publications by authors named "Albert M Berghuis"

79Publications

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective.

Front Chem 2020 6;8:612728. Epub 2021 Jan 6.

Department of Biochemistry, McGill University, Montreal, QC, Canada.

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January 2021

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.

Cell 2020 Dec 30;183(6):1617-1633.e22. Epub 2020 Nov 30.

Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Electronic address:

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December 2020

Revisiting the Catalytic Cycle and Kinetic Mechanism of Aminoglycoside -Nucleotidyltransferase(2″): A Structural and Kinetic Study.

ACS Chem Biol 2020 03 6;15(3):686-694. Epub 2020 Mar 6.

Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montréal, Québec Canada, H3G 1Y6.

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March 2020

Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).

J Med Chem 2019 11 16;62(21):9691-9702. Epub 2019 Oct 16.

Department of Chemistry , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada.

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November 2019

The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.

Sci Rep 2019 04 30;9(1):6656. Epub 2019 Apr 30.

Département de biochimie and Center for Green Chemistry and Catalysis (CGCC), Université de Montréal, Montréal, QC, H3T 1J4, Canada.

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April 2019

Look and Outlook on Enzyme-Mediated Macrolide Resistance.

Front Microbiol 2018 20;9:1942. Epub 2018 Aug 20.

Department of Biochemistry, McGill University, Montreal, QC, Canada.

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August 2018

Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia.

Antimicrob Agents Chemother 2018 07 26;62(7). Epub 2018 Jun 26.

Department of Biochemistry, McGill University, Montreal, Canada

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July 2018

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia.

Protein Sci 2017 Sep 21;26(9):1852-1863. Epub 2017 Jul 21.

McGill University, Biochemistry, 3649 Promenade Sir William Osler Room 470, Montreal, QC H3A 0G4, Canada.

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September 2017

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

Structure 2017 05 13;25(5):750-761.e5. Epub 2017 Apr 13.

Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada; Department of Microbiology & Immunology, McGill University, Montréal, QC H3A 2B4, Canada; Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, QC H3G 0B1, Canada. Electronic address:

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May 2017

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

Nat Commun 2017 01 18;8:14132. Epub 2017 Jan 18.

Department of Biochemistry, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 0B1.

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January 2017

The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure.

Biochim Biophys Acta 2016 12 26;1864(12):1641-1648. Epub 2016 Aug 26.

Department of Biochemistry, McGill University, 3649 Promenade Sir William Osler, Bellini Pavilion, Room 466, Montreal, Quebec H3G 0B1, Canada; Department of Microbiology & Immunology, McGill University, 3649 Promenade Sir William Osler, Bellini Pavilion, Room 466, Montreal, Quebec H3G 0B1, Canada; Groupes de recherche GRASP et PROTEO, Montreal, Quebec, Canada. Electronic address:

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December 2016

Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme.

FEBS J 2016 08 7;283(16):3029-38. Epub 2016 Jul 7.

Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, QC, Canada.

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August 2016