Publications


Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.
Structure 2017 May 13;25(5):750-761.e5. Epub 2017 Apr 13.
Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada; Department of Microbiology & Immunology, McGill University, Montréal, QC H3A 2B4, Canada; Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, QC H3G 0B1, Canada. Electronic address:

The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure.
Biochim Biophys Acta 2016 Dec 26;1864(12):1641-1648. Epub 2016 Aug 26.
Department of Biochemistry, McGill University, 3649 Promenade Sir William Osler, Bellini Pavilion, Room 466, Montreal, Quebec H3G 0B1, Canada; Department of Microbiology & Immunology, McGill University, 3649 Promenade Sir William Osler, Bellini Pavilion, Room 466, Montreal, Quebec H3G 0B1, Canada; Groupes de recherche GRASP et PROTEO, Montreal, Quebec, Canada. Electronic address:


Inhibition of outer membrane proteases of the omptin family by aprotinin.
Infect Immun 2015 Jun 30;83(6):2300-11. Epub 2015 Mar 30.
Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec, Canada Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg Med Chem Lett 2015 Mar 13;25(5):1117-23. Epub 2015 Jan 13.
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada; Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada; Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montréal, QC H3G 0B1, Canada. Electronic address:

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.
J Biol Chem 2015 Jan 29;290(3):1474-84. Epub 2014 Oct 29.
From the Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada, the Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada, the Department of Medicine, Division of Experimental Medicine, McGill University, Quebec H3A 1A3, Canada

Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis.
ACS Chem Biol 2014 Dec 21;9(12):2843-51. Epub 2014 Oct 21.
Departments of †Biochemistry and ‡Microbiology & Immunology, McGill University , 3649 Promenade Sir William Osler, Bellini Pavilion, Room 466, Montreal, Quebec, Canada H3G 0B1.

Maintenance of native-like protein dynamics may not be required for engineering functional proteins.
Chem Biol 2014 Oct 4;21(10):1330-1340. Epub 2014 Sep 4.
PROTEO Network, Université Laval, Québec QC G1V 0A6, Canada; Département de Biochimie, Université de Montréal, Montréal QC H3T 1J4, Canada; Département de Chimie, Université de Montréal, Montréal QC H3T 1J4, Canada; Center for Green Chemistry and Catalysis (CCVC), Montréal QC H3A 0B8, Canada. Electronic address:




Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.
J Virol 2011 Jan 3;85(1):286-95. Epub 2010 Nov 3.
Key Laboratory of Molecular Biology of Shann'xi Agriculture, College of Animal Science and Technology, Northwest A&F University, 22 XiNong Road, YangLing, Shaan'xi, People's Republic of China.

A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni.
J Biol Chem 2005 Feb 27;280(6):4792-802. Epub 2004 Oct 27.
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada.

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia.
Structure 2016 06 5;24(6):935-45. Epub 2016 May 5.
Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, QC H3G 0B1, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address:

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