Publications by authors named "Albert J R Heck"

100Publications

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation.

Nat Commun 2020 10 21;11(1):5338. Epub 2020 Oct 21.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-020-19142-9DOI Listing
October 2020

Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection.

Nat Commun 2020 08 28;11(1):4332. Epub 2020 Aug 28.

Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-020-18168-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455705PMC
August 2020

Targeted LC-ESI-MS characterization of human milk oligosaccharide diversity at 6 to 16 weeks post-partum reveals clear staging effects and distinctive milk groups.

Anal Bioanal Chem 2020 Oct 14;412(25):6887-6907. Epub 2020 Aug 14.

Danone Nutricia Research, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00216-020-02819-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496073PMC
October 2020

Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein.

Mol Cell Proteomics 2020 Jul 31. Epub 2020 Jul 31.

Utrecht University, Netherlands.

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http://dx.doi.org/10.1074/mcp.R120.002093DOI Listing
July 2020

Benefits of Collisional Cross Section Assisted Precursor Selection (caps-PASEF) for Cross-linking Mass Spectrometry.

Mol Cell Proteomics 2020 10 21;19(10):1677-1687. Epub 2020 Jul 21.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1074/mcp.RA120.002094DOI Listing
October 2020

Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.

Nat Microbiol 2020 11 20;5(11):1361-1373. Epub 2020 Jul 20.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/s41564-020-0759-0DOI Listing
November 2020

Fishing for newly synthesized proteins with phosphonate-handles.

Nat Commun 2020 06 26;11(1):3244. Epub 2020 Jun 26.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-020-17010-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320153PMC
June 2020

A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin.

Proc Natl Acad Sci U S A 2020 07 19;117(27):15554-15564. Epub 2020 Jun 19.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, 3584 CH Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.2002483117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355005PMC
July 2020

Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3 Ubiquitin Ligase Complex.

Cell Rep 2020 May;31(7):107664

Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Department of Biotechnology, University of Verona, 37134 Verona, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107664DOI Listing
May 2020

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Cell 2020 Jun 13;181(6):1291-1306.e19. Epub 2020 May 13.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, Hubrecht Institute, 3584 CT Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.036DOI Listing
June 2020

Insights into PPARγ Phosphorylation and Its Inhibition Mechanism.

J Med Chem 2020 05 15;63(9):4811-4823. Epub 2020 Apr 15.

Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via Salaria km. 29.300, 00015 Monterotondo Stazione, Rome, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00048DOI Listing
May 2020

Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9.

FEBS J 2020 Mar 17. Epub 2020 Mar 17.

Crystal and Structural Chemistry, Department of Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands.

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http://dx.doi.org/10.1111/febs.15295DOI Listing
March 2020

Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry.

Nat Methods 2020 04 9;17(4):395-398. Epub 2020 Mar 9.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/s41592-020-0770-7DOI Listing
April 2020

Quantitative Longitudinal Inventory of the -Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes.

J Proteome Res 2020 05 27;19(5):1941-1952. Epub 2020 Mar 27.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.9b00753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252941PMC
May 2020

Missing regions within the molecular architecture of human fibrin clots structurally resolved by XL-MS and integrative structural modeling.

Proc Natl Acad Sci U S A 2020 01 10;117(4):1976-1987. Epub 2020 Jan 10.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1911785117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995014PMC
January 2020

The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils.

J Immunol 2020 02 8;204(4):954-966. Epub 2020 Jan 8.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, the Netherlands;

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http://dx.doi.org/10.4049/jimmunol.1900852DOI Listing
February 2020

Targeting proline in (phospho)proteomics.

FEBS J 2020 Jul 13;287(14):2979-2997. Epub 2020 Jan 13.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.

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http://dx.doi.org/10.1111/febs.15190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496877PMC
July 2020

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation.

J Biol Chem 2019 12 12;294(52):20233-20245. Epub 2019 Nov 12.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.RA119.011098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937560PMC
December 2019

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.

Authors:
Maria Lorna A De Leoz David L Duewer Adam Fung Lily Liu Hoi Kei Yau Oscar Potter Gregory O Staples Kenichiro Furuki Ruth Frenkel Yunli Hu Zoran Sosic Peiqing Zhang Friedrich Altmann Clemens Gru Nwald-Grube Chun Shao Joseph Zaia Waltraud Evers Stuart Pengelley Detlev Suckau Anja Wiechmann Anja Resemann Wolfgang Jabs Alain Beck John W Froehlich Chuncui Huang Yan Li Yaming Liu Shiwei Sun Yaojun Wang Youngsuk Seo Hyun Joo An Niels-Christian Reichardt Juan Echevarria Ruiz Stephanie Archer-Hartmann Parastoo Azadi Len Bell Zsuzsanna Lakos Yanming An John F Cipollo Maja Pucic-Bakovic Jerko Štambuk Gordan Lauc Xu Li Peng George Wang Andreas Bock René Hennig Erdmann Rapp Marybeth Creskey Terry D Cyr Miyako Nakano Taiki Sugiyama Pui-King Amy Leung Paweł Link-Lenczowski Jolanta Jaworek Shuang Yang Hui Zhang Tim Kelly Song Klapoetke Rui Cao Jin Young Kim Hyun Kyoung Lee Ju Yeon Lee Jong Shin Yoo Sa-Rang Kim Soo-Kyung Suh Noortje de Haan David Falck Guinevere S M Lageveen-Kammeijer Manfred Wuhrer Robert J Emery Radoslaw P Kozak Li Phing Liew Louise Royle Paulina A Urbanowicz Nicolle H Packer Xiaomin Song Arun Everest-Dass Erika Lattová Samanta Cajic Kathirvel Alagesan Daniel Kolarich Toyin Kasali Viv Lindo Yuetian Chen Kudrat Goswami Brian Gau Ravi Amunugama Richard Jones Corné J M Stroop Koichi Kato Hirokazu Yagi Sachiko Kondo C T Yuen Akira Harazono Xiaofeng Shi Paula E Magnelli Brian T Kasper Lara Mahal David J Harvey Roisin O'Flaherty Pauline M Rudd Radka Saldova Elizabeth S Hecht David C Muddiman Jichao Kang Prachi Bhoskar Daniele Menard Andrew Saati Christine Merle Steven Mast Sam Tep Jennie Truong Takashi Nishikaze Sadanori Sekiya Aaron Shafer Sohei Funaoka Masaaki Toyoda Peter de Vreugd Cassie Caron Pralima Pradhan Niclas Chiang Tan Yehia Mechref Sachin Patil Jeffrey S Rohrer Ranjan Chakrabarti Disha Dadke Mohammedazam Lahori Chunxia Zou Christopher Cairo Béla Reiz Randy M Whittal Carlito B Lebrilla Lauren Wu Andras Guttman Marton Szigeti Benjamin G Kremkow Kelvin H Lee Carina Sihlbom Barbara Adamczyk Chunsheng Jin Niclas G Karlsson Jessica Örnros Göran Larson Jonas Nilsson Bernd Meyer Alena Wiegandt Emy Komatsu Helene Perreault Edward D Bodnar Nassur Said Yannis-Nicolas Francois Emmanuelle Leize-Wagner Sandra Maier Anne Zeck Albert J R Heck Yang Yang Rob Haselberg Ying Qing Yu William Alley Joseph W Leone Hua Yuan Stephen E Stein

Mol Cell Proteomics 2020 01 7;19(1):11-30. Epub 2019 Oct 7.

Mass Spectrometry Data Center, Biomolecular Measurement Division, Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive Gaithersburg, Maryland 20899.

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http://dx.doi.org/10.1074/mcp.RA119.001677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944243PMC
January 2020

Expanding the mass range for UVPD-based native top-down mass spectrometry.

Chem Sci 2019 Aug 1;10(30):7163-7171. Epub 2019 Jul 1.

Biomolecular Mass Spectrometry and Proteomics , Bijvoet Center for Biomolecular Research , Utrecht Institute of Pharmaceutical Sciences , Utrecht University , Padualaan 8 , 3584 Utrecht , The Netherlands . Email:

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http://xlink.rsc.org/?DOI=C9SC01857C
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http://dx.doi.org/10.1039/c9sc01857cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764275PMC
August 2019

PhoX: An IMAC-Enrichable Cross-Linking Reagent.

ACS Cent Sci 2019 Sep 19;5(9):1514-1522. Epub 2019 Aug 19.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/acscentsci.9b00416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764163PMC
September 2019

High-Throughput Assessment of Kinome-wide Activation States.

Cell Syst 2019 10 11;9(4):366-374.e5. Epub 2019 Sep 11.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, the Netherlands; Mass Spectrometry and Proteomics Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838672PMC
October 2019

Activation of Human Monocytes by Colloidal Aluminum Salts.

J Pharm Sci 2020 01 23;109(1):750-760. Epub 2019 Aug 23.

Intravacc (Institute for Translational Vaccinology), Bilthoven, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.08.014DOI Listing
January 2020

Simply Extending the Mass Range in Electron Transfer Higher Energy Collisional Dissociation Increases Confidence in N-Glycopeptide Identification.

Anal Chem 2019 08 31;91(16):10401-10406. Epub 2019 Jul 31.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , University of Utrecht , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.9b02125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706795PMC
August 2019

Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein.

Mol Cell Proteomics 2019 08 16;18(8):1479-1490. Epub 2019 May 16.

‡Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

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http://dx.doi.org/10.1074/mcp.RA119.001411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683009PMC
August 2019

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Anal Chem 2019 06 22;91(11):6953-6961. Epub 2019 May 22.

Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.

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http://dx.doi.org/10.1021/acs.analchem.9b00658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625963PMC
June 2019

Gaining Confidence in the Elusive Histidine Phosphoproteome.

Anal Chem 2019 05 23;91(9):5542-5547. Epub 2019 Apr 23.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , University of Utrecht , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.9b00734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506798PMC
May 2019

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Cell Rep 2019 03;26(11):3100-3115.e7

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193020
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http://dx.doi.org/10.1016/j.celrep.2019.02.038DOI Listing
March 2019

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome.

J Proteome Res 2019 04 26;18(4):1634-1643. Epub 2019 Feb 26.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , Utrecht University , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00821
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http://dx.doi.org/10.1021/acs.jproteome.8b00821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456874PMC
April 2019

Proteomic Profiling of Mouse Helper T Cell Differentiation.

Proteomics 2019 04 18;19(7):e1800045. Epub 2019 Mar 18.

Department Viroscience, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/pmic.201800045DOI Listing
April 2019

Toward an efficient workflow for the analysis of the human milk peptidome.

Anal Bioanal Chem 2019 Mar 2;411(7):1351-1363. Epub 2019 Feb 2.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00216-018-01566-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449315PMC
March 2019

PaDuA: A Python Library for High-Throughput (Phospho)proteomics Data Analysis.

J Proteome Res 2019 02 21;18(2):576-584. Epub 2018 Dec 21.

Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Science and Bijvoet Center for Biomolecular Research , Utrecht University , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00576
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http://dx.doi.org/10.1021/acs.jproteome.8b00576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364269PMC
February 2019

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

Nat Struct Mol Biol 2018 12 3;25(12):1119-1127. Epub 2018 Dec 3.

Bristol Synthetic Biology Centre BrisSynBio, Biomedical Sciences, School of Biochemistry, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41594-018-0156-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292499PMC
December 2018

Discovery and Quantification of Nonhuman Proteins in Human Milk.

J Proteome Res 2019 01 12;18(1):225-238. Epub 2018 Dec 12.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , University of Utrecht , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.8b00550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326037PMC
January 2019

Phosphopeptide Fragmentation and Site Localization by Mass Spectrometry: An Update.

Anal Chem 2019 01 5;91(1):126-141. Epub 2018 Dec 5.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , Utrecht University , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.8b04746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322148PMC
January 2019

Efficient and robust proteome-wide approaches for cross-linking mass spectrometry.

Nat Protoc 2018 12;13(12):2964-2990

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.

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http://www.nature.com/articles/s41596-018-0074-x
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http://dx.doi.org/10.1038/s41596-018-0074-xDOI Listing
December 2018

Label-free targeted LC-ESI-MS analysis of human milk oligosaccharides (HMOS) and related human milk groups with enhanced structural selectivity.

Anal Bioanal Chem 2019 Jan 16;411(1):231-250. Epub 2018 Nov 16.

Danone Nutricia Research, Uppsalalaan 12, 3584 CT, Utrecht, the Netherlands.

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http://link.springer.com/10.1007/s00216-018-1434-7
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http://dx.doi.org/10.1007/s00216-018-1434-7DOI Listing
January 2019

Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification.

Mol Cell Proteomics 2019 01 20;18(1):16-27. Epub 2018 Sep 20.

From the ‡Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Science4Life, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.000967
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http://dx.doi.org/10.1074/mcp.RA118.000967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317476PMC
January 2019

A New Tool to Reveal Bacterial Signaling Mechanisms in Antibiotic Treatment and Resistance.

Mol Cell Proteomics 2018 12 19;17(12):2496-2507. Epub 2018 Sep 19.

From the ‡Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research,

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http://dx.doi.org/10.1074/mcp.RA118.000880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283303PMC
December 2018

Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes.

Mol Cell Proteomics 2018 12 4;17(12):2387-2401. Epub 2018 Sep 4.

From the ‡KU Leuven, Centre of Microbial and Plant Genetics, Kasteelpark Arenberg 20, Leuven, B-3001, Belgium;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.000892
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http://dx.doi.org/10.1074/mcp.RA118.000892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283292PMC
December 2018

Direct quality control of glycoengineered erythropoietin variants.

Nat Commun 2018 08 21;9(1):3342. Epub 2018 Aug 21.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Science4Life, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-05536-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104044PMC
August 2018

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Mol Cell Proteomics 2018 10 18;17(10):2018-2033. Epub 2018 Jul 18.

From the ‡Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.000924
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http://dx.doi.org/10.1074/mcp.RA118.000924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166682PMC
October 2018

A Protein-Based Encapsulation System with Calcium-Controlled Cargo Loading and Detachment.

Angew Chem Int Ed Engl 2018 08 30;57(35):11334-11338. Epub 2018 Jul 30.

Biochemistry and Structural Biology, Lund University, PO BOX 124, Lund, Sweden.

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http://doi.wiley.com/10.1002/anie.201806466
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http://dx.doi.org/10.1002/anie.201806466DOI Listing
August 2018

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Mol Cell Proteomics 2018 10 3;17(10):1892-1908. Epub 2018 Jul 3.

From the ‡Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA117.000486
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http://dx.doi.org/10.1074/mcp.RA117.000486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166676PMC
October 2018

Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin.

J Proteome Res 2018 08 13;17(8):2861-2869. Epub 2018 Jul 13.

Biomolecular Mass Spectrometry and Proteomics , Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht , Padualaan 8 , 3584 CH Utrecht , The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.8b00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079914PMC
August 2018

Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.

Nat Commun 2018 06 27;9(1):2493. Epub 2018 Jun 27.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, 3584CH, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-04853-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021402PMC
June 2018

Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1.

Cell Rep 2018 06;23(11):3381-3391.e4

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.031DOI Listing
June 2018

Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo.

FEBS J 2018 08 19;285(15):2856-2868. Epub 2018 Jun 19.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands.

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http://dx.doi.org/10.1111/febs.14525DOI Listing
August 2018

Distinct Stabilities of the Structurally Homologous Heptameric Co-Chaperonins GroES and gp31.

J Am Soc Mass Spectrom 2019 Jan 7;30(1):7-15. Epub 2018 May 7.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s13361-018-1910-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318259PMC
January 2019

Crosstalk between phosphorylation and O-GlcNAcylation: friend or foe.

FEBS J 2018 09 13;285(17):3152-3167. Epub 2018 May 13.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.

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http://dx.doi.org/10.1111/febs.14491DOI Listing
September 2018

CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation.

Mol Cell Proteomics 2018 08 18;17(8):1502-1514. Epub 2018 Apr 18.

From the ‡Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands;

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http://dx.doi.org/10.1074/mcp.RA118.000708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072540PMC
August 2018

Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches.

J Am Soc Mass Spectrom 2018 06 12;29(6):1099-1110. Epub 2018 Mar 12.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s13361-018-1901-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003997PMC
June 2018

Defeating Major Contaminants in Fe- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment.

Mol Cell Proteomics 2018 05 15;17(5):1028-1034. Epub 2018 Feb 15.

From the ‡Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1074/mcp.TIR117.000518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930410PMC
May 2018

Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation.

Mol Cell Proteomics 2018 12 8;17(12):2297-2308. Epub 2018 Feb 8.

¶Division of Cell Biology and Cancer Genomics Center, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands;

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http://dx.doi.org/10.1074/mcp.RA118.000652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283304PMC
December 2018

Widespread bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics.

Nat Methods 2018 03 29;15(3):187-190. Epub 2018 Jan 29.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nmeth.4580DOI Listing
March 2018

Parsimonious Charge Deconvolution for Native Mass Spectrometry.

J Proteome Res 2018 03 8;17(3):1216-1226. Epub 2018 Feb 8.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Science4Life, Utrecht University and Netherlands Proteomics Centre , Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00839
Publisher Site
http://dx.doi.org/10.1021/acs.jproteome.7b00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838638PMC
March 2018

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.

J Lipid Res 2018 03 17;59(3):515-530. Epub 2018 Jan 17.

Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabrück, D-49076 Osnabrück, Germany

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http://dx.doi.org/10.1194/jlr.M082354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832928PMC
March 2018

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus.

Molecules 2018 Jan 16;23(1). Epub 2018 Jan 16.

Laboratory of Biochemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.

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http://dx.doi.org/10.3390/molecules23010184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017737PMC
January 2018

Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer.

J Proteome Res 2018 02 28;17(2):926-933. Epub 2017 Dec 28.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University , Utrecht 3584 CH, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.7b00622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799867PMC
February 2018

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.

Mol Cell Proteomics 2018 02 8;17(2):216-232. Epub 2017 Dec 8.

From the ‡Biomolecular Mass Spectrometry and Proteomics. Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands;

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http://dx.doi.org/10.1074/mcp.RA117.000470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795388PMC
February 2018

Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.

Nat Commun 2017 11 22;8(1):1708. Epub 2017 Nov 22.

Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-017-01485-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700061PMC
November 2017

Connecting color with assembly in the fluorescent B-phycoerythrin protein complex.

FEBS J 2018 01 28;285(1):178-187. Epub 2017 Nov 28.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics Centre, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/febs.14331DOI Listing
January 2018

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes.

Analyst 2017 Dec;143(1):100-105

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, 3584 Utrecht, The Netherlands.

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http://dx.doi.org/10.1039/c7an01629hDOI Listing
December 2017

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry.

Nat Commun 2017 11 3;8(1):1280. Epub 2017 Nov 3.

Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Dept. of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-017-01461-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668376PMC
November 2017

Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry.

Sci Rep 2017 10 18;7(1):13453. Epub 2017 Oct 18.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-13663-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647383PMC
October 2017

Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells.

Front Immunol 2017 25;8:1163. Epub 2017 Sep 25.

Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine Solna, Karolinska University Hospital, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fimmu.2017.01163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622166PMC
September 2017

Phosphate Transfer in Activated Protein Complexes Reveals Interaction Sites.

Angew Chem Int Ed Engl 2017 10 27;56(44):13641-13644. Epub 2017 Sep 27.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics Centre, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/anie.201706749DOI Listing
October 2017

Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation.

Proc Natl Acad Sci U S A 2017 08 14;114(35):E7255-E7261. Epub 2017 Aug 14.

Biomolecular Mass Spectrometry and Proteomics, Utrecht University, 3584 CH Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1620529114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584407PMC
August 2017

Aspergillus niger Prolyl Endoprotease for Hydrogen-Deuterium Exchange Mass Spectrometry and Protein Structural Studies.

Anal Chem 2017 08 12;89(15):7966-7973. Epub 2017 Jul 12.

DSM Biotechnology Center , PO Box 1, 2600 MA Delft, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.7b01161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541327PMC
August 2017

Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry.

ACS Chem Biol 2017 08 28;12(8):2078-2084. Epub 2017 Jun 28.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics Centre, Utrecht University , Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/acschembio.7b00371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565903PMC
August 2017

Proteasome Activation by Small Molecules.

Cell Chem Biol 2017 Jun 25;24(6):725-736.e7. Epub 2017 May 25.

Division of Cell Biology II, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Department of Chemical Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.05.010DOI Listing
June 2017

Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis.

Trends Biotechnol 2017 07 17;35(7):598-609. Epub 2017 May 17.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands; Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01677799173009
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http://dx.doi.org/10.1016/j.tibtech.2017.04.010DOI Listing
July 2017

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

Nat Commun 2017 05 19;8:15473. Epub 2017 May 19.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/ncomms15473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454533PMC
May 2017

Human CD62L neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling.

Blood 2017 06 17;129(26):3476-3485. Epub 2017 May 17.

Department of Respiratory Medicine and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1182/blood-2016-07-727669DOI Listing
June 2017