Albert Giralt

Albert Giralt

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Albert Giralt

Albert Giralt

Publications by authors named "Albert Giralt"

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Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.

Exp Neurol 2020 Jan 8;323:113095. Epub 2019 Nov 8.

Stem Cell and Regenerative Medicine Laboratory, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Neurosciences Institute, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Casanova 143, Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2019.113095DOI Listing
January 2020

Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens.

Biol Psychiatry 2019 Aug 13;86(3):196-207. Epub 2019 Mar 13.

Department of Biomedical Science, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.03.001DOI Listing
August 2019

Early Downregulation of p75 by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice.

Mol Neurobiol 2019 Feb 27;56(2):935-953. Epub 2018 May 27.

Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-018-1126-5DOI Listing
February 2019

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

Exp Neurol 2018 09 24;307:62-73. Epub 2018 May 24.

Inserm UMR-S 839, Paris, France; Sorbonne Université, Science and Engineering Faculty, Paris, France; Institut du Fer a Moulin, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2018.05.020DOI Listing
September 2018

Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF.

Mol Cell Neurosci 2018 01 6;86:41-49. Epub 2017 Nov 6.

Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Catalonia; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.11.003DOI Listing
January 2018

E2F1, a Novel Regulator of Metabolism.

Front Endocrinol (Lausanne) 2017 10;8:311. Epub 2017 Nov 10.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.3389/fendo.2017.00311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686046PMC
November 2017

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Mol Cell 2017 Oct;68(2):336-349.e6

Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland; Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.09.034DOI Listing
October 2017

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.

Hum Mol Genet 2017 08;26(16):3144-3160

Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1093/hmg/ddx198DOI Listing
August 2017

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.

Development 2017 04 13;144(8):1566-1577. Epub 2017 Mar 13.

Stem Cells and Regenerative Medicine Laboratory, Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain

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http://dx.doi.org/10.1242/dev.138248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399659PMC
April 2017

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity.

Neurobiol Dis 2016 Nov 11;95:22-34. Epub 2015 Sep 11.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Casanova, 143, 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Casanova, 143, 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.09.001DOI Listing
November 2016

Acute drug-induced spine changes in the nucleus accumbens are dependent on β-adducin.

Neuropharmacology 2016 11 29;110(Pt A):333-342. Epub 2016 Jul 29.

Inserm UMR-S 839, Paris, 75005, France; Sorbonne Universités, UPMC, Université Paris 06, Paris, 75005, France; Institut du Fer à Moulin, Paris, 75005, France. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.07.035DOI Listing
November 2016

Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.

Biochim Biophys Acta 2016 07 6;1862(7):1255-66. Epub 2016 Apr 6.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; TargetsLab, Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.04.002DOI Listing
July 2016

Pyk2 is essential for astrocytes mobility following brain lesion.

Glia 2016 Apr 11;64(4):620-34. Epub 2015 Dec 11.

Inserm UMR-S839, Paris, 75005, France.

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http://dx.doi.org/10.1002/glia.22952DOI Listing
April 2016

Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms.

J Huntingtons Dis 2012 ;1(2):155-73

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://dx.doi.org/10.3233/JHD-120023DOI Listing
February 2016

A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.

Hum Mol Genet 2015 Dec 12;24(25):7265-85. Epub 2015 Oct 12.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, CIBERNED, Madrid, Spain,

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http://dx.doi.org/10.1093/hmg/ddv426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664166PMC
December 2015

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

Hum Mol Genet 2015 Sep 10;24(17):4958-70. Epub 2015 Jun 10.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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http://dx.doi.org/10.1093/hmg/ddv218DOI Listing
September 2015

Cryostat Slice Irregularities May Introduce Bias in Tissue Thickness Estimation: Relevance for Cell Counting Methods.

Microsc Microanal 2015 Aug 15;21(4):893-901. Epub 2015 Jul 15.

1Human Anatomy and Embryology Unit,Facultat de Medicina,Universitat de Barcelona,c/Casanova 143,08036 Barcelona,Spain.

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http://dx.doi.org/10.1017/S143192761501380XDOI Listing
August 2015

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.

PLoS One 2014 5;9(3):e90671. Epub 2014 Mar 5.

CIMA, Neurosciences Division, University of Navarra, Pamplona, Spain; Oncology Area, Lung Cancer Unit, Center for Biomedical Research of la Rioja (CIBIR), Logroño, Spain; Department of Neurosciences, University of Basque Country, Achucarro Basque Center for Neuroscience, Leioa, Spain; Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic; Centro de Investigaciones Biomédicas en red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Cellular Biology, Immunology and Neurosciences, Medicine School, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America; Institute for Research in Biomedicine (IRB), Barcelona, Spain; Universidad de Castilla la Mancha, Albacete, Spain; Department of Biochemistry and Molecular Biology, School of Biology, University of Barcelona, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090671PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944389PMC
November 2014

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.

PLoS One 2013 5;8(9):e73664. Epub 2013 Sep 5.

Departament de Biologia Cel·lular, Immunologia Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain ; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764028PMC
July 2014

Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.

Mol Neurobiol 2014 Apr 7;49(2):784-95. Epub 2013 Nov 7.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-013-8556-xDOI Listing
April 2014

Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety.

Exp Neurol 2013 Sep 18;247:122-9. Epub 2013 Apr 18.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Spain.

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http://dx.doi.org/10.1016/j.expneurol.2013.03.028DOI Listing
September 2013

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.

Hippocampus 2013 Aug 29;23(8):684-95. Epub 2013 Apr 29.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/hipo.22128DOI Listing
August 2013

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

Exp Neurol 2012 Oct 6;237(2):335-45. Epub 2012 Jul 6.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.expneurol.2012.06.033DOI Listing
October 2012

Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease.

J Neurochem 2012 May 28;121(4):639-48. Epub 2012 Mar 28.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07711.xDOI Listing
May 2012

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.

Biochem J 2012 May;444(1):1-10

Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, University of Barcelona, Spain.

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http://dx.doi.org/10.1042/BJ20120030DOI Listing
May 2012

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.

Hum Mol Genet 2011 Nov 11;20(21):4232-47. Epub 2011 Aug 11.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1093/hmg/ddr351DOI Listing
November 2011

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction.

Mol Neurodegener 2011 Oct 10;6(1):71. Epub 2011 Oct 10.

Departament de Biologia Cel•lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/1750-1326-6-71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205049PMC
October 2011

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

J Neurosci 2011 Jun;31(22):8150-62

Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.3446-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472648PMC
June 2011

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype.

J Biol Chem 2011 May 27;286(19):16958-66. Epub 2011 Mar 27.

Departament de Bioquímica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutrición, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M110.202390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089539PMC
May 2011

Thermogenic activation induces FGF21 expression and release in brown adipose tissue.

J Biol Chem 2011 Apr 13;286(15):12983-90. Epub 2011 Feb 13.

Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, and CIBER Fisiopatología de la Obesidad y Nutrición, 08028 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1074/jbc.M110.215889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075644PMC
April 2011

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Neurobiol Dis 2009 Dec 4;36(3):461-9. Epub 2009 Sep 4.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E-08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbd.2009.08.012DOI Listing
December 2009

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study.

J Neuroimmunol 2009 Oct 19;215(1-2):31-5. Epub 2009 Aug 19.

Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d'Investigació Biomèdica August Pi i Sunyer, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280900296
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http://dx.doi.org/10.1016/j.jneuroim.2009.07.014DOI Listing
October 2009

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling.

Neurobiol Dis 2008 Mar 23;29(3):409-21. Epub 2007 Oct 23.

Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbd.2007.10.003DOI Listing
March 2008

Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice.

J Neurosci 2007 Feb;27(9):2253-60

Genes and Disease Program, Genomic Regulation Center, Universidad Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4055-06.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.4055-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673497PMC
February 2007