Publications Authored by Albert C Ludolph

In vivo tracking of TDP43 in ALS: cognition as a new biomarker for brain pathology.

Authors:

J Neurol Neurosurg Psychiatry 2020 Feb 31;91(2):125. Epub 2019 Oct 31.

Department of Neurology, University of Ulm, Ulm, Germany

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http://dx.doi.org/10.1136/jnnp-2019-321940	DOI Listing

February 2020

Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis.

Ann Neurol 2020 Feb 6;87(2):206-216. Epub 2020 Jan 6.

National Institute of Health and Medical Research, University of Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1002/ana.25661	DOI Listing

February 2020

Neurofilament light chain in serum of adolescent and adult SMA patients under treatment with nusinersen.

Authors:

Claudia D Wurster Petra Steinacker René Günther Jan C Koch Paul Lingor Zeljko Uzelac Simon Witzel Kurt Wollinsky Benedikt Winter Alma Osmanovic Olivia Schreiber-Katz Rami Al Shweiki Albert C Ludolph Susanne Petri Andreas Hermann Markus Otto

J Neurol 2020 Jan 24;267(1):36-44. Epub 2019 Sep 24.

Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-019-09547-y	DOI Listing

January 2020

Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis.

Authors:

Patrick Oeckl Patrick Weydt Dietmar R Thal Jochen H Weishaupt Albert C Ludolph Markus Otto

Acta Neuropathol 2020 Jan 7;139(1):119-134. Epub 2019 Nov 7.

Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00401-019-02093-x	DOI Listing

January 2020

Severe white matter damage in SHANK3 deficiency: a human and translational study.

Authors:

Sarah Jesse Hans-Peter Müller Michael Schoen Harun Asoglu Juergen Bockmann Hans-Juergen Huppertz Volker Rasche Albert C Ludolph Tobias M Boeckers Jan Kassubek

Ann Clin Transl Neurol 2020 Jan 2;7(1):46-58. Epub 2019 Dec 2.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1002/acn3.50959	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952316	PMC

January 2020

CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration.

Authors:

Samir Abu-Rumeileh Steffen Halbgebauer Petra Steinacker Sarah Anderl-Straub Barbara Polischi Albert C Ludolph Sabina Capellari Piero Parchi Markus Otto

Ann Clin Transl Neurol 2020 Jan 20. Epub 2020 Jan 20.

Department of Neurology, Ulm University Hospital, 89081, Ulm, Germany.

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http://dx.doi.org/10.1002/acn3.50980	DOI Listing

January 2020

Association of Insulin-like Growth Factor 1 Concentrations with Risk for and Prognosis of Amyotrophic Lateral Sclerosis - Results from the ALS Registry Swabia.

Authors:

Gabriele Nagel Raphael S Peter Angela Rosenbohm Wolfgang Koenig Luc Dupuis Dietrich Rothenbacher Albert C Ludolph

Sci Rep 2020 Jan 20;10(1):736. Epub 2020 Jan 20.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1038/s41598-020-57744-x	DOI Listing

January 2020

Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations.

Brain 2019 Dec;142(12):e67

Neurology Department, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1093/brain/awz306	DOI Listing

December 2019

Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis.

Authors:

Marcel Naumann Kevin Peikert Rene Günther Anneke J van der Kooi Eleonora Aronica Annemarie Hübers Veronique Danel Philippe Corcia Francisco Pan-Montojo Sebahattin Cirak Göknur Haliloglu Albert C Ludolph Anand Goswami Peter M Andersen Johannes Prudlo Florian Wegner Philip Van Damme Jochen H Weishaupt Andreas Hermann

Ann Clin Transl Neurol 2019 Dec 4;6(12):2384-2394. Epub 2019 Nov 4.

Department of Neurology, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1002/acn3.50930	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917314	PMC

December 2019

Clinical and neuroimaging disparity between Chinese and German patients with cerebral small vessel disease: a comparative study.

Authors:

Junlong Shu Hermann Neugebauer Fan Li Dorothée Lulé Hans-Peter Müller Jing Zhang Albert C Ludolph Yining Huang Jan Kassubek Wei Zhang

Sci Rep 2019 Dec 27;9(1):20015. Epub 2019 Dec 27.

Department of Neurology, Peking University First Hospital, Xishiku Street 7, Beijing, 100034, China.

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http://dx.doi.org/10.1038/s41598-019-55899-w	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934729	PMC

December 2019

Genotypes of amyotrophic lateral sclerosis in Mongolia.

J Neurol Neurosurg Psychiatry 2019 Nov 29;90(11):1300-1302. Epub 2019 Jul 29.

Department of Neurology, University of Ulm, Ulm, Germany

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http://dx.doi.org/10.1136/jnnp-2019-320640	DOI Listing

November 2019

Olfactory screening of Parkinson's Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin' Sticks 12-identification test.

Authors:

Elmar H Pinkhardt Huijing Liu Di Ma Jing Chen Adrian Pachollek Martin S Kunz Jan Kassubek Albert C Ludolph Yining Huang Haibo Chen G Bernhard Landwehrmeyer Zhaoxia Wang Wen Su

PLoS One 2019 8;14(11):e0224331. Epub 2019 Nov 8.

Neurology Department, Beijing Hospital, National Center of Gerontology, China, Dong Dan, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224331	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839844	PMC

November 2019

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species.

Cell Rep 2019 Nov;29(9):2862-2874.e9

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.089	DOI Listing

November 2019

Routine Cerebrospinal Fluid (CSF) Parameters in Patients With Spinal Muscular Atrophy (SMA) Treated With Nusinersen.

Authors:

Claudia D Wurster Jan C Koch Isabell Cordts Jens Dreyhaupt Markus Otto Zeljko Uzelac Simon Witzel Benedikt Winter Tugrul Kocak Michael Schocke Patrick Weydt Kurt Wollinsky Albert C Ludolph Marcus Deschauer Paul Lingor Hayrettin Tumani Andreas Hermann René Günther

Front Neurol 2019 7;10:1179. Epub 2019 Nov 7.

Department of Neurology, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.3389/fneur.2019.01179	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854024	PMC

November 2019

Safety and efficacy of immunoadsorption versus plasma exchange in steroid-refractory relapse of multiple sclerosis and clinically isolated syndrome: A randomised, parallel-group, controlled trial.

Authors:

Johannes Dorst Tanja Fangerau Daniela Taranu Pia Eichele Jens Dreyhaupt Sebastian Michels Joachim Schuster Albert C Ludolph Makbule Senel Hayrettin Tumani

EClinicalMedicine 2019 Nov 14;16:98-106. Epub 2019 Nov 14.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.eclinm.2019.10.017	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890948	PMC

November 2019

SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden.

Authors:

Rüstem Yilmaz Kathrin Müller David Brenner Alexander E Volk Guntram Borck Andreas Hermann Thomas Meitinger Tim M Strom Karin M Danzer Albert C Ludolph Peter M Andersen Jochen H Weishaupt

Neurobiol Aging 2019 Nov 2. Epub 2019 Nov 2.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.018	DOI Listing

November 2019

Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.

Authors:

Alberto Catanese Florian Olde Heuvel Medhanie Mulaw Maria Demestre Julia Higelin Gotthold Barbi Axel Freischmidt Jochen H Weishaupt Albert C Ludolph Francesco Roselli Tobias M Boeckers

Autophagy 2019 Oct 2;15(10):1719-1737. Epub 2019 Apr 2.

Institute of Anatomy and Cell Biology, Ulm University , Ulm , DE , Germany.

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http://dx.doi.org/10.1080/15548627.2019.1589257	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735587	PMC

October 2019

Differential diagnosis of peripheral facial nerve palsy: a retrospective clinical, MRI and CSF-based study.

Authors:

Julia Zimmermann Sarah Jesse Jan Kassubek Elmar Pinkhardt Albert C Ludolph

J Neurol 2019 Oct 27;266(10):2488-2494. Epub 2019 Jun 27.

Department of Neurology, University of Ulm, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-019-09387-w	DOI Listing

October 2019

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.

Authors:

Veselin Grozdanov Luc Bousset Meike Hoffmeister Corinna Bliederhaeuser Christoph Meier Karine Madiona Laura Pieri Martin Kiechle Pamela J McLean Jan Kassubek Christian Behrends Albert C Ludolph Jochen H Weishaupt Ronald Melki Karin M Danzer

Ann Neurol 2019 Oct 15;86(4):593-606. Epub 2019 Aug 15.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1002/ana.25557	DOI Listing

October 2019

Therapeutic advances in SMA.

Authors:

Albert C Ludolph Claudia D Wurster

Curr Opin Neurol 2019 Oct;32(5):777-781

Department of Neurology, University of Ulm, DZNE, Ulm, Germany.

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http://dx.doi.org/10.1097/WCO.0000000000000738	DOI Listing

October 2019

Morphological MRI investigations of the hypothalamus in 232 individuals with Parkinson's disease.

Authors:

Martin Gorges Barbara Kuntz Kelly Del Tredici Daniel G Schmidt Hans-Peter Müller Albert C Ludolph Luc Dupuis Jan Kassubek

Mov Disord 2019 10 21;34(10):1566-1570. Epub 2019 Aug 21.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/mds.27814	DOI Listing

October 2019

An observational study on quality of life and preferences to sustain life in locked-in state.

Authors:

Magdalena Kuzma-Kozakiewicz Peter M Andersen Katarzyna Ciecwierska Cynthia Vázquez Olga Helczyk Markus Loose Ingo Uttner Albert C Ludolph Dorothée Lulé

Neurology 2019 Sep 7;93(10):e938-e945. Epub 2019 Aug 7.

From the Department of Neurology (M.K.-K., K.C.) and Neurodegenerative Diseases Research Group (M.K.-K.), Medical University of Warsaw, Poland; Institute of Pharmacology and Clinical Neuroscience (P.M.A.), Umeå University, Sweden; and Department of Neurology (C.V., O.H., M.L., I.U., A.C.L., D.L.), University of Ulm, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000008064	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745736	PMC

September 2019

Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging.

Cortex 2019 Aug 25;117:33-40. Epub 2019 Feb 25.

Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Clinic of Cognitive Neurology, University of Leipzig, Germany; FTLD Consortium Germany, Germany.

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http://dx.doi.org/10.1016/j.cortex.2019.02.015	DOI Listing

August 2019

The same cortico-efferent tract involvement in progressive bulbar palsy and in 'classical' ALS: A tract of interest-based MRI study.

Authors:

Hans-Peter Müller Martin Gorges Kelly Del Tredici Albert C Ludolph Jan Kassubek

Neuroimage Clin 2019 9;24:101979. Epub 2019 Aug 9.

Department of Neurology, University of Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101979	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706345	PMC

August 2019

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the ALS mouse model.

Authors:

Hans-Peter Müller David Brenner Francesco Roselli Diana Wiesner Alireza Abaei Martin Gorges Karin M Danzer Albert C Ludolph William Tsao Philip C Wong Volker Rasche Jochen H Weishaupt Jan Kassubek

Transl Neurodegener 2019 30;8:27. Epub 2019 Aug 30.

1Department of Neurology, University of Ulm, Oberer Eselsberg 45, RKU, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1186/s40035-019-0163-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716821	PMC

August 2019

Heparin for prophylaxis of venous thromboembolism in intracerebral haemorrhage.

Authors:

Maximilian I Sprügel Jochen A Sembill Joji B Kuramatsu Stefan T Gerner Manuel Hagen Sebastian S Roeder Matthias Endres Karl Georg Haeusler Jan Sobesky Johannes Schurig Sarah Zweynert Miriam Bauer Peter Vajkoczy Peter Arthur Ringleb Jan Christoph Purrucker Timolaos Rizos Jens Volkmann Wolfgang Muellges Peter Kraft Anna-Lena Schubert Frank Erbguth Martin Nueckel Peter D Schellinger Jörg Glahn Ulrich J Knappe Gereon Rudolf Fink Christian Dohmen Henning Stetefeld Anna Lena Fisse Jens Minnerup Georg Hagemann Florian Rakers Heinz Reichmann Hauke Schneider Sigrid Wöpking Albert C Ludolph Sebastian Stösser Hermann Neugebauer Joachim Röther Peter Michels Michael Schwarz Gernot Reimann Hansjörg Bäzner Henning Schwert Joseph Classen Dominik Michalski Armin Grau Frederick Palm Christian Urbanek Johannes C Wöhrle Fahid Alshammari Markus Horn Dirk Bahner Otto W Witte Albrecht Guenther Gerhard F Hamann Hannes Lücking Arnd Dörfler Stefan Schwab Hagen B Huttner

J Neurol Neurosurg Psychiatry 2019 Jul 16;90(7):783-791. Epub 2019 Apr 16.

Neurology, University of Erlangen-Nürnberg, Erlangen, Germany

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-319786	Publisher Site
http://dx.doi.org/10.1136/jnnp-2018-319786	DOI Listing

July 2019

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.

Authors:

Laura Rué Patrick Oeckl Mieke Timmers Annette Lenaerts Jasmijn van der Vos Silke Smolders Lindsay Poppe Antina de Boer Ludo Van Den Bosch Philip Van Damme Jochen H Weishaupt Albert C Ludolph Markus Otto Wim Robberecht Robin Lemmens

Acta Neuropathol Commun 2019 Jul 12;7(1):114. Epub 2019 Jul 12.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s40478-019-0759-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626434	PMC

July 2019

Parvalbumin Interneurons Shape Neuronal Vulnerability in Blunt TBI.

Authors:

Akila Chandrasekar Florian Olde Heuvel Lilla Tar Anna M Hagenston Annette Palmer Birgit Linkus Albert C Ludolph Markus Huber-Lang Tobias Boeckers Hilmar Bading Francesco Roselli

Cereb Cortex 2019 Jun;29(6):2701-2715

Department of Neurology, Ulm University, Ulm-DE, Germany.

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http://dx.doi.org/10.1093/cercor/bhy139	DOI Listing

June 2019

Combined cerebral atrophy score in Huntington's disease based on atlas-based MRI volumetry: Sample size calculations for clinical trials.

Authors:

Hans-Peter Müller Hans-Jürgen Huppertz Jens Dreyhaupt Albert C Ludolph Sarah J Tabrizi Raymund A C Roos Alexandra Durr G Bernhard Landwehrmeyer Jan Kassubek

Parkinsonism Relat Disord 2019 06 5;63:179-184. Epub 2019 Feb 5.

Department of Neurology, University of Ulm, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.004	DOI Listing

June 2019

Prognostic factors in ALS: a comparison between Germany and China.

J Neurol 2019 Jun 28;266(6):1516-1525. Epub 2019 Mar 28.

Department of Neurology, Universitätsklinik Ulm, RKU, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-019-09290-4	DOI Listing

June 2019

Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia.

Authors:

Mhd Rami Al Shweiki Petra Steinacker Patrick Oeckl Bastian Hengerer Adrian Danek Klaus Fassbender Janine Diehl-Schmid Holger Jahn Sarah Anderl-Straub Albert C Ludolph Carlos Schönfeldt-Lecuona Markus Otto

J Psychiatr Res 2019 06 24;113:137-140. Epub 2019 Mar 24.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2019.03.019	DOI Listing

June 2019

Non-invasive ventilation in amyotrophic lateral sclerosis.

Authors:

Johannes Dorst Albert C Ludolph

Ther Adv Neurol Disord 2019 21;12:1756286419857040. Epub 2019 Jun 21.

Universitätsklinik Ulm, Abteilung für Neurologie, Oberer Eselsberg 45, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1177/1756286419857040	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589990	PMC

June 2019

Story of the ALS-FTD continuum retold: rather two distinct entities.

Authors:

Dorothée E Lulé Helena E A Aho-Özhan Cynthia Vázquez Ulrike Weiland Jochen H Weishaupt Markus Otto Sarah Anderl-Straub Elisa Semler Ingo Uttner Albert C Ludolph

J Neurol Neurosurg Psychiatry 2019 May 26;90(5):586-589. Epub 2018 Sep 26.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2018-318800	DOI Listing

May 2019

Juxtacortical lesions are associated with seizures in cerebral small vessel disease.

Authors:

Sebastian Stösser Stefanie Böckler Albert C Ludolph Jan Kassubek Hermann Neugebauer

J Neurol 2019 May 26;266(5):1230-1235. Epub 2019 Feb 26.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-019-09253-9	DOI Listing

May 2019

Neurochemical markers in CSF of adolescent and adult SMA patients undergoing nusinersen treatment.

Authors:

Claudia D Wurster René Günther Petra Steinacker Jens Dreyhaupt Kurt Wollinsky Zeljko Uzelac Simon Witzel Tugrul Kocak Benedikt Winter Jan C Koch Paul Lingor Susanne Petri Albert C Ludolph Andreas Hermann Markus Otto

Ther Adv Neurol Disord 2019 10;12:1756286419846058. Epub 2019 May 10.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1177/1756286419846058	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535708	PMC

May 2019

[Treatment evaluation in patients with 5q-associated spinal muscular atrophy : Real-world experience].

Authors:

Maggie C Walter Bianca Dräger Rene Günther Andreas Hermann Tim Hagenacker Christoph Kleinschnitz Wolfgang Löscher Thomas Meyer Berthold Schrank Inge Schwersenz Claudia D Wurster Albert C Ludolph Janbernd Kirschner

Nervenarzt 2019 Apr;90(4):343-351

Klinik für Neuropädiatrie und Muskelerkrankungen, Medizinische Fakultät, Universitätsklinikum Freiburg, Freiburg, Deutschland.

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http://link.springer.com/10.1007/s00115-018-0653-7	Publisher Site
http://dx.doi.org/10.1007/s00115-018-0653-7	DOI Listing

April 2019

Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis.

Sci Rep 2019 Apr 11;9(1):5931. Epub 2019 Apr 11.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://www.nature.com/articles/s41598-019-42091-3	Publisher Site
http://dx.doi.org/10.1038/s41598-019-42091-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459905	PMC

April 2019

Can we turn mice into men?: An Editorial for 'Effects of cannabinoids in Amyotrophic Lateral Sclerosis (ALS) murine models: a systematic review and meta-analysis' page 284.

Authors:

Albert C Ludolph

J Neurochem 2019 Apr;149(2):168-169

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1111/jnc.14651	DOI Listing

April 2019

Ethical Principles in Patient-Centered Medical Care to Support Quality of Life in Amyotrophic Lateral Sclerosis.

Authors:

Dorothée Lulé Andrea Kübler Albert C Ludolph

Front Neurol 2019 22;10:259. Epub 2019 Mar 22.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3389/fneur.2019.00259	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439311	PMC

March 2019

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort.

Authors:

Makbule Senel Fatemeh Mojib-Yezdani Ulrike Braisch Franziska Bachhuber Jan Lewerenz Albert C Ludolph Markus Otto Hayrettin Tumani

Front Immunol 2019 29;10:641. Epub 2019 Mar 29.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00641	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449445	PMC

March 2019

Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis.

Authors:

Federico Verde Petra Steinacker Jochen H Weishaupt Jan Kassubek Patrick Oeckl Steffen Halbgebauer Hayrettin Tumani Christine A F von Arnim Johannes Dorst Emily Feneberg Benjamin Mayer Hans-Peter Müller Martin Gorges Angela Rosenbohm Alexander E Volk Vincenzo Silani Albert C Ludolph Markus Otto

J Neurol Neurosurg Psychiatry 2019 02 11;90(2):157-164. Epub 2018 Oct 11.

Department of Neurology, University of Ulm, Ulm, Germany

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-318704	Publisher Site
http://dx.doi.org/10.1136/jnnp-2018-318704	DOI Listing

February 2019

Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort.

Neurobiol Aging 2019 02 22;74:234.e9-234.e15. Epub 2018 Sep 22.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183033	Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.012	DOI Listing

February 2019

Analysis of CACNA1A CAG repeat lengths in patients with familial ALS.

Authors:

David Brenner Kathrin Müller Regina Gastl Martin Gorges Markus Otto Elmar H Pinkhardt Jan Kassubek Jochen H Weishaupt Albert C Ludolph

Neurobiol Aging 2019 02 22;74:235.e5-235.e8. Epub 2018 Sep 22.

Department of Neurology, University of Ulm, Ulm, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183034	Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.019	DOI Listing

February 2019

Cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A two-centre tract of interest-based DTI analysis.

Authors:

Hans-Peter Müller Federica Agosta Martin Gorges Rebecca Kassubek Edoardo Gioele Spinelli Nilo Riva Albert C Ludolph Massimo Filippi Jan Kassubek

Neuroimage Clin 2018 9;20:1062-1069. Epub 2018 Oct 9.

Department of Neurology, University of Ulm, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183031	Publisher Site
http://dx.doi.org/10.1016/j.nicl.2018.10.005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198122	PMC

February 2019

Non-invasive ventilation and hypercapnia-associated symptoms in amyotrophic lateral sclerosis.

Authors:

Johannes Dorst Georg Behrendt Albert C Ludolph

Acta Neurol Scand 2019 Feb 19;139(2):128-134. Epub 2018 Nov 19.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1111/ane.13043	DOI Listing

February 2019

Cognitive and behavioral impairments in German and Chinese ALS populations - a post-hoc comparison of national study data.

Authors:

Shan Ye Angela Rosenbohm Sarah Böhm Ingo Uttner Ying Ji Albert C Ludolph Dorothée Lulé Dongsheng Fan

Amyotroph Lateral Scler Frontotemporal Degener 2019 02 26;20(1-2):28-36. Epub 2018 Nov 26.

a Department of Neurology , Peking University Third Hospital , Beijing , China.

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http://dx.doi.org/10.1080/21678421.2018.1542535	DOI Listing

February 2019

Moral judgment in patients with behavioral variant of frontotemporal dementia and amyotrophic lateral sclerosis: no impairment of the moral position, but rather its execution.

Authors:

Elisa Semler Lukas Petersdorff Sarah Anderl-Straub Sarah Böhm Dorothée Lulé Heiner Fangerau Albert C Ludolph Markus Otto Ingo Uttner

Amyotroph Lateral Scler Frontotemporal Degener 2019 02 4;20(1-2):12-18. Epub 2018 Dec 4.

a Department of Neurology , University of Ulm , Ulm , Germany and.

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https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1	Publisher Site
http://dx.doi.org/10.1080/21678421.2018.1534972	DOI Listing

February 2019

Heterozygous loss has opposing effects in early and late stages of ALS in mice.

J Exp Med 2019 02 11;216(2):267-278. Epub 2019 Jan 11.

Department of Neurology, University of Ulm, Ulm, Germany

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http://dx.doi.org/10.1084/jem.20180729	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363427	PMC

February 2019

A biallelic mutation links MYORG to autosomal-recessive primary familial brain calcification.

Authors:

Yalda Forouhideh Kathrin Müller Wolfgang Ruf Muhannad Assi Tuncay Seker Ceren Tunca Antje Knehr Tim M Strom Martin Gorges Falk Schradt Thomas Meitinger Albert C Ludolph Elmar H Pinkhardt A Nazli Basak Jan Kassubek Ingo Uttner Jochen H Weishaupt

Brain 2019 02;142(2):e4

Neurology Department, Ulm University, Ulm, Germany.

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https://academic.oup.com/brain/article/142/2/e4/5288799	Publisher Site
http://dx.doi.org/10.1093/brain/awy343	DOI Listing

February 2019

Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A tract of interest-based MRI study.

Authors:

Hans-Peter Müller Martin Gorges Rebecca Kassubek Johannes Dorst Albert C Ludolph Jan Kassubek

Neuroimage Clin 2018 15;18:762-769. Epub 2018 Mar 15.

Department of Neurology, University of Ulm, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183008	Publisher Site
http://dx.doi.org/10.1016/j.nicl.2018.03.018	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959739	PMC

January 2019

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase.

J Neurol Neurosurg Psychiatry 2019 01 17;90(1):4-10. Epub 2018 Sep 17.

Department of Neurology, Ulm University Hospital, Ulm, Germany

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-318868	Publisher Site
http://dx.doi.org/10.1136/jnnp-2018-318868	DOI Listing

January 2019

Intrathecal administration of nusinersen in adolescent and adult SMA type 2 and 3 patients.

Authors:

Claudia D Wurster Benedikt Winter Kurt Wollinsky Albert C Ludolph Zeljko Uzelac Simon Witzel Michael Schocke Ralf Schneider Tugrul Kocak

J Neurol 2019 Jan 20;266(1):183-194. Epub 2018 Nov 20.

Department of Orthopedic Surgery, RKU-University and Rehabilitation Clinics, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-018-9124-0	DOI Listing

January 2019

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment.

Authors:

Patrick Oeckl Steffen Halbgebauer Sarah Anderl-Straub Petra Steinacker André M Huss Hermann Neugebauer Christine A F von Arnim Janine Diehl-Schmid Timo Grimmer Johannes Kornhuber Piotr Lewczuk Adrian Danek Albert C Ludolph Markus Otto

J Alzheimers Dis 2019 ;67(2):481-488

Department of Neurology, Ulm University Hospital, Ulm, Germany.

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http://dx.doi.org/10.3233/JAD-180325	DOI Listing

January 2019

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS.

Authors:

Anika M Helferich Sarah J Brockmann Jörg Reinders Dhruva Deshpande Karlheinz Holzmann David Brenner Peter M Andersen Susanne Petri Dietmar R Thal Jens Michaelis Markus Otto Steffen Just Albert C Ludolph Karin M Danzer Axel Freischmidt Jochen H Weishaupt

Cell Mol Life Sci 2018 Dec 20;75(23):4301-4319. Epub 2018 Jul 20.

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://link.springer.com/10.1007/s00018-018-2873-1	Publisher Site
http://dx.doi.org/10.1007/s00018-018-2873-1	DOI Listing

December 2018

Short-term and long-term effects of immunoadsorption in refractory chronic inflammatory demyelinating polyneuropathy: a prospective study in 17 patients.

Authors:

Johannes Dorst Albert C Ludolph Makbule Senel Hayrettin Tumani

J Neurol 2018 Dec 6;265(12):2906-2915. Epub 2018 Oct 6.

Universitätsklinik Ulm, RKU, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://link.springer.com/10.1007/s00415-018-9082-6	Publisher Site
http://dx.doi.org/10.1007/s00415-018-9082-6	DOI Listing

December 2018

Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis.

Authors:

Lara Maria Krämer Johannes Brettschneider Jochen K Lennerz Daniel Walcher Lubin Fang Angela Rosenbohm Karthikeyan Balakrishnan Julian Benckendorff Peter Möller Steffen Just Michael Willem Albert C Ludolph Dietmar Rudolf Thal

Sci Rep 2018 11 9;8(1):16594. Epub 2018 Nov 9.

Institute of Pathology, Ulm University, Ulm, Germany.

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http://www.nature.com/articles/s41598-018-34808-7	Publisher Site
http://dx.doi.org/10.1038/s41598-018-34808-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226444	PMC

November 2018

Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions.

Authors:

Karin M E Forsberg Yingshuang Zhang Johanna Reiners Martina Ander Alexandra Niedermayer Lubin Fang Hermann Neugebauer Jan Kassubek Istvan Katona Joachim Weis Albert C Ludolph Kelly Del Tredici Heiko Braak Deniz Yilmazer-Hanke

Acta Neuropathol Commun 2018 11 23;6(1):128. Epub 2018 Nov 23.

Clinical Neuroanatomy Section, Neurology, School of Medicine, Ulm University, Helmholtzstr. 8/1, 89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s40478-018-0632-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260986	PMC

November 2018

Serum neurofilament light chain in behavioral variant frontotemporal dementia.

Neurology 2018 10 12;91(15):e1390-e1401. Epub 2018 Sep 12.

From the Department of Neurology (P.S., S.A.-S., E.S., I.U., C.A.F.v.A., J. Kassubek, B.L., P.O., A.C.L., M.O.) and Institute of Epidemiology and Medical Biometry (B.M.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., T.G.), Klinikum Rechts der Isar, Technical University of Munich; Department of Nuclear Medicine (H.B.), Leipzig University Hospital; Department of Neurology (A.D.), Ludwig-Maximilians-University, Munich; Department of Neurology (K.F.), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K.F.), University of Bonn, Germany; Swiss Epilepsy Center (H.-J.H.), Zurich, Switzerland; Department of Psychiatry and Psychotherapy (H.J.), University Medical Center Hamburg-Eppendorf, Hamburg; AMEOS Klinikum (H.J.), Heiligenhafen; Department of Psychiatry and Psychotherapy (J. Kornhuber, J.M.M.), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; Department of Neurology (J.P.), University of Rostock; DZNE (J.P.), Rostock; Department of Neurodegenerative Diseases and Geriatric Psychiatry (A.S.), University Hospital Bonn; DZNE (A.S.), Bonn; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (J.W.), University Medical Center Göttingen; DZNE (J.W.), Göttingen, Germany; iBiMED (J.W.), Medical Sciences Department, University of Aveiro, Portugal; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig; and Max Planck Institute for Human Cognitive and Brain Sciences (M.L.S.), Leipzig, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006318	DOI Listing

October 2018

Corticoefferent pathology distribution in amyotrophic lateral sclerosis: in vivo evidence from a meta-analysis of diffusion tensor imaging data.

Authors:

Martin Gorges Kelly Del Tredici Jens Dreyhaupt Heiko Braak Albert C Ludolph Hans-Peter Müller Jan Kassubek

Sci Rep 2018 10 18;8(1):15389. Epub 2018 Oct 18.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://www.nature.com/articles/s41598-018-33830-z	Publisher Site
http://dx.doi.org/10.1038/s41598-018-33830-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194130	PMC

October 2018

Retinoids and Amyotrophic Lateral Sclerosis-Reply.

Authors:

Gabriele Nagel Dietrich Rothenbacher Albert C Ludolph

JAMA Neurol 2018 09;75(9):1153-1154

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1001/jamaneurol.2018.2257	DOI Listing

September 2018

Provision of assistive technology devices among people with ALS in Germany: a platform-case management approach.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 30;19(5-6):342-350. Epub 2018 Jan 30.

a Outpatient Center for ALS and other Motor Neuron Disorders , Charité - Universitätsmedizin Berlin , Berlin , Germany.

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https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1	Publisher Site
http://dx.doi.org/10.1080/21678421.2018.1431786	DOI Listing

August 2018

Comprehensive analysis of the mutation spectrum in 301 German ALS families.

J Neurol Neurosurg Psychiatry 2018 08 12;89(8):817-827. Epub 2018 Apr 12.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2017-317611	DOI Listing

August 2018

Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

Lancet Neurol 2018 08 19;17(8):681-688. Epub 2018 Jun 19.

Department of Neurology, University Hospital of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1016/S1474-4422(18)30176-5	DOI Listing

August 2018

Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9.

Authors:

Barbara Commisso Lingjun Ding Karl Varadi Martin Gorges David Bayer Tobias M Boeckers Albert C Ludolph Jan Kassubek Oliver J Müller Francesco Roselli

Elife 2018 08 23;7. Epub 2018 Aug 23.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.7554/eLife.36892	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125125	PMC

August 2018

Screening for Cognitive Function in Complete Immobility Using Brain-Machine Interfaces: A Proof of Principle Study.

Authors:

Dorothée Lulé Katharina Hörner Cynthia Vazquez Helena Aho-Özhan Jürgen Keller Martin Gorges Ingo Uttner Albert C Ludolph

Front Neurosci 2018 15;12:517. Epub 2018 Aug 15.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3389/fnins.2018.00517	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104564	PMC

August 2018

Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Authors:

Federico Verde Petra Steinacker Patrick Oeckl Jochen H Weishaupt Angela Rosenbohm Vincenzo Silani Albert C Ludolph Markus Otto

Neurobiol Aging 2018 07 27;67:21-22. Epub 2018 Feb 27.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.017	DOI Listing

July 2018

Therapeutic decisions in ALS patients: cross-cultural differences and clinical implications.

J Neurol 2018 Jul 4;265(7):1600-1606. Epub 2018 May 4.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://link.springer.com/10.1007/s00415-018-8861-4	Publisher Site
http://dx.doi.org/10.1007/s00415-018-8861-4	DOI Listing

July 2018

NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons.

Authors:

Julia Higelin Alberto Catanese Lena Luisa Semelink-Sedlacek Sertap Oeztuerk Anne-Kathrin Lutz Julia Bausinger Gotthold Barbi Günter Speit Peter M Andersen Albert C Ludolph Maria Demestre Tobias M Boeckers

Stem Cell Res 2018 07 12;30:150-162. Epub 2018 Jun 12.

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.06.005	DOI Listing

July 2018

Acute DWI Reductions In Patients After Single Epileptic Seizures - More Common Than Assumed.

Authors:

Annemarie Hübers Katharina Thoma Michael Schocke Susanne Fauser Albert C Ludolph Jan Kassubek Elmar H Pinkhardt

Front Neurol 2018 25;9:550. Epub 2018 Jul 25.

Department of Neurology, University of Ulm, Ulm, Germany.

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https://www.frontiersin.org/article/10.3389/fneur.2018.00550	Publisher Site
http://dx.doi.org/10.3389/fneur.2018.00550	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094998	PMC

July 2018

Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis.

Authors:

Alexander E Volk Jochen H Weishaupt Peter M Andersen Albert C Ludolph Christian Kubisch

Med Genet 2018 13;30(2):252-258. Epub 2018 Jul 13.

1Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1007/s11825-018-0185-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132774	PMC

July 2018

Fast progressive lower motor neuron disease is an ALS variant: A two-centre tract of interest-based MRI data analysis.

Authors:

Hans-Peter Müller Federica Agosta Nilo Riva Edoardo G Spinelli Giancarlo Comi Albert C Ludolph Massimo Filippi Jan Kassubek

Neuroimage Clin 2018 14;17:145-152. Epub 2017 Oct 14.

Department of Neurology, University of Ulm, Germany.

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http://dx.doi.org/10.1016/j.nicl.2017.10.008	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651542	PMC

June 2018

Alpha-synuclein is present in dental calculus but not altered in Parkinson's disease patients in comparison to controls.

Authors:

Sabrina Schmid Eva Goldberg-Bockhorn Silke Schwarz Nicole Rotter Jan Kassubek Kelly Del Tredici Elmar Pinkhardt Markus Otto Albert C Ludolph Patrick Oeckl

J Neurol 2018 Jun 29;265(6):1334-1337. Epub 2018 Mar 29.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-018-8847-2	DOI Listing

June 2018

The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy.

J Neurol 2018 May 20;265(5):1026-1036. Epub 2018 Feb 20.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-018-8790-2	DOI Listing

May 2018

Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis.

Authors:

Angela Rosenbohm Gabriele Nagel Raphael S Peter Torben Brehme Wolfgang Koenig Luc Dupuis Dietrich Rothenbacher Albert C Ludolph

JAMA Neurol 2018 05;75(5):600-607

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1001/jamaneurol.2017.5129	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885207	PMC

May 2018

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model.

Lancet Neurol 2018 05 26;17(5):423-433. Epub 2018 Mar 26.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183008	Publisher Site
http://dx.doi.org/10.1016/S1474-4422(18)30089-9	DOI Listing

May 2018

Antisense oligonucleotides in neurological disorders.

Authors:

Claudia D Wurster Albert C Ludolph

Ther Adv Neurol Disord 2018 23;11:1756286418776932. Epub 2018 May 23.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1177/1756286418776932	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971383	PMC

May 2018

Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker.

Authors:

Jan Kassubek Hans-Peter Müller Kelly Del Tredici Dorothée Lulé Martin Gorges Heiko Braak Albert C Ludolph

J Neurol Neurosurg Psychiatry 2018 04 3;89(4):374-381. Epub 2017 Nov 3.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2017-316365	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869447	PMC

April 2018

Hyperconnective and hypoconnective cortical and subcortical functional networks in multiple system atrophy.

Authors:

Johannes Rosskopf Martin Gorges Hans-Peter Müller Elmar H Pinkhardt Albert C Ludolph Jan Kassubek

Parkinsonism Relat Disord 2018 04 12;49:75-80. Epub 2018 Jan 12.

Department of Neurology, University of Ulm, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.01.012	DOI Listing

April 2018

Phenotypic differences of amyotrophic lateral sclerosis (ALS) in China and Germany.

Authors:

Angela Rosenbohm Mingsheng Liu Gabriele Nagel Raphael S Peter Bo Cui Xiaoguang Li Jan Kassubek Dietrich Rothenbacher Dorothée Lulé Liying Cui Albert C Ludolph

J Neurol 2018 Apr 1;265(4):774-782. Epub 2018 Feb 1.

Department of Neurology, Ulm University Clinic, Oberer Eselsberg 45, Ulm, 89081, Germany.

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http://dx.doi.org/10.1007/s00415-018-8735-9	DOI Listing

April 2018

Cognitive phenotypes of sequential staging in amyotrophic lateral sclerosis.

Authors:

Dorothée Lulé Sarah Böhm Hans-Peter Müller Helena Aho-Özhan Jürgen Keller Martin Gorges Markus Loose Jochen H Weishaupt Ingo Uttner Elmar Pinkhardt Jan Kassubek Kelly Del Tredici Heiko Braak Sharon Abrahams Albert C Ludolph

Cortex 2018 04 31;101:163-171. Epub 2018 Jan 31.

University of Ulm, Department of Neurology, Germany.

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http://dx.doi.org/10.1016/j.cortex.2018.01.004	DOI Listing

April 2018

A language-based sum score for the course and therapeutic intervention in primary progressive aphasia.

Alzheimers Res Ther 2018 04 25;10(1):41. Epub 2018 Apr 25.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s13195-018-0345-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922300	PMC

April 2018

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.

J Neurol Neurosurg Psychiatry 2018 03 15;89(3):239-247. Epub 2017 Nov 15.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2017-317138	DOI Listing

March 2018

Hot-spot KIF5A mutations cause familial ALS.

Brain 2018 03;141(3):688-697

Neurology Department, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1093/brain/awx370	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837483	PMC

March 2018

Longitudinal Diffusion Tensor Imaging Resembles Patterns of Pathology Progression in Behavioral Variant Frontotemporal Dementia (bvFTD).

Authors:

Jan Kassubek Hans-Peter Müller Kelly Del Tredici Michael Hornberger Matthias L Schroeter Karsten Müller Sarah Anderl-Straub Ingo Uttner Murray Grossman Heiko Braak John R Hodges Olivier Piguet Markus Otto Albert C Ludolph

Front Aging Neurosci 2018 6;10:47. Epub 2018 Mar 6.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3389/fnagi.2018.00047	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845670	PMC

March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:

Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896	PMC

March 2018

Nusinersen for spinal muscular atrophy.

Authors:

Claudia D Wurster Albert C Ludolph

Ther Adv Neurol Disord 2018 13;11:1756285618754459. Epub 2018 Mar 13.

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http://dx.doi.org/10.1177/1756285618754459	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858681	PMC

March 2018

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.

Acta Neuropathol 2018 02 22;135(2):213-226. Epub 2017 Dec 22.

Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1007/s00401-017-1797-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773656	PMC

February 2018

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency.

Hum Mol Genet 2018 02;27(4):706-715

Department of Neurology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1093/hmg/ddx436	DOI Listing

February 2018

The fecal microbiome of ALS patients.

Authors:

David Brenner Andreas Hiergeist Carolin Adis Benjamin Mayer André Gessner Albert C Ludolph Jochen H Weishaupt

Neurobiol Aging 2018 01 3;61:132-137. Epub 2017 Oct 3.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.023	DOI Listing

January 2018

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Neurology 2018 01 6;90(1):e22-e30. Epub 2017 Dec 6.

From the Nuffield Department of Clinical Neurosciences (E.F., E.G., M.R.T.), University of Oxford, UK; Department of Neurology (P.O., P.S., F.V., J.H.W., P.W., A.C.L., M.O.), Ulm University Hospital, Germany; Department of Pathophysiology and Transplantation (F.V., V.S.), Università degli Studi di Milano; Department of Neurology-Stroke Unit and Laboratory of Neuroscience (F.V., C.M., V.S.), IRCCS Istituto Auxologico Italiano, Milan, Italy; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine (C.B., J.K.), University Hospital and University of Basel, Switzerland; Department of Neurology (P.V.D.) and Laboratory of Molecular Neurobiomarker Research and Laboratory Medicine (K.P.), University Hospitals Leuven; KU Leuven-University of Leuven (P.V.D.); Department of Neurosciences (P.V.D.), VIB-Center for Brain & Disease Research, Leuven, Belgium; Department of Neurology (J.G., P.M., B.S.), Jena University Hospital, Germany; Department of Metabolic Biochemistry (C.J., F.L.) and Neurological Diseases Department (M.d.M.A., F.S.), Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology (S.K., S.P.), Hannover Medical School; Institute for Epidemiology and Medical Biometry (B.M.) Ulm University, Germany; Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (J.R., M.M.V.), and Radboud Alzheimer Center, Department of Laboratory Medicine (M.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; and Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology (P.W.), Bonn University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004761	DOI Listing

January 2018

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Nat Commun 2018 01 23;9(1):335. Epub 2018 Jan 23.

Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.

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http://dx.doi.org/10.1038/s41467-017-02299-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780468	PMC

January 2018

Bevacizumab in temozolomide refractory high-grade gliomas: single-centre experience and review of the literature.

Authors:

Jennifer Jeck Rebecca Kassubek Jan Coburger Simone Edenhofer Stefan S Schönsteiner Albert C Ludolph Bernd Schmitz Jens Engelke Regine Mayer-Steinacker Jan Lewerenz Lars Bullinger

Ther Adv Neurol Disord 2018 21;11:1756285617753597. Epub 2018 Jan 21.

Department of Internal Medicine III, Ulm University Medical Centre, Ulm, Germany; Medical Department, Division of Hematology, Oncology and Tumour Immunology, Charité Universitätsmedizin Berlin, Germany.

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