Mr. Albert Breier, PhD., DSc. - Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology

Mr. Albert Breier

PhD., DSc.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology

Bratislava | Slovakia (Slovak Republic)

Main Specialties: Hematology & Oncology

ORCID logohttps://orcid.org/0000-0003-2174-786X

Mr. Albert Breier, PhD., DSc. - Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology

Mr. Albert Breier

PhD., DSc.

Introduction

Qualification:
1981 Ing., fermentation chemistry and biotechnology, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
1987 PhD., biochemistry, Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Slovak Republic, (supervisor: Ing. Attila Ziegelhöffer, DrSc.)
2002 Doctor of Science, biochemistry, Slovak Academy of Sciences, Bratislava, Slovak Republic
2008 Associated professor, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
2018 Professor, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic

Primary Affiliation: Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology - Bratislava , Slovakia (Slovak Republic)

Specialties:

Research Interests:

Education

Apr 2018
Slovak University of Technology in Bratislava
professor
Jan 2008 - Jan 2008
Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology
Associated professor
Jan 2002 - Jan 2002
Institute of Moloecular Physiology and Genetics, Slovak Academy of sciences
DrSc. - Doctor of Sciences
Oct 1983 - Dec 1987
Centre of Physiological Sciences, Slovak Academy od Sciences, Bratislava; Defended at: Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology
PhD.
Faculty of Chemical and Food Technology
Jun 1976 - Jan 1981
Slovak University of Technology in Bratislava
Master degree
Faculty of Chemical and Food Technology

Experience

Jun 2013 - Jun 2013
Slovenská technická univerzita v Bratislave Fakulta chemickej a potravinárskej technológie
Head of Institute
Institute of Biochemistry and Microbiology
Jul 2009
Slovak Academy of Sciences
Vice President
period July 2009-June 2013
Jul 1998
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Director
period July 1998-June 2009
Aug 1981 - Apr 1990
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Principal investigator
Department of Transport Proteins

Publications

138Publications

988Reads

149Profile Views

248PubMed Central Citations

Screening of Phenanthroquinolizidine Alkaloid Derivatives for Inducing Cell Death of L1210 Leukemia Cells with Negative and Positive P-glycoprotein Expression.

Molecules 2019 Jun 5;24(11). Epub 2019 Jun 5.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovakia.

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http://dx.doi.org/10.3390/molecules24112127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600356PMC
June 2019
2 Reads
2.416 Impact Factor

Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter.

Int J Mol Sci 2018 07 7;19(7). Epub 2018 Jul 7.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava 1, Slovakia.

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http://dx.doi.org/10.3390/ijms19071985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073605PMC
July 2018
8 Reads
2.862 Impact Factor

Triorganotin Derivatives Induce Cell Death Effects on L1210 Leukemia Cells at Submicromolar Concentrations Independently of P-glycoprotein Expression.

Molecules 2018 05 1;23(5). Epub 2018 May 1.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinskeho 9, 81237 Bratislava, Slovakia.

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http://dx.doi.org/10.3390/molecules23051053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100532PMC
May 2018
31 Reads
2.420 Impact Factor

Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.

Gen Physiol Biophys 2018 May;37(3):353-357

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinskeho 9, 812 37 Bratislava, Slovakia.

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http://dx.doi.org/10.4149/gpb_2018008DOI Listing
May 2018
43 Reads
1.173 Impact Factor

Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors.

Molecules 2018 Feb 6;23(2). Epub 2018 Feb 6.

Institute of Molecular Physiology and Genetics, Centre of Bioscience, Slovak Academy of Sciences, Dúbravska cesta 9, 84505 Bratislava, Slovakia.

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http://dx.doi.org/10.3390/molecules23020337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017601PMC
February 2018
16 Reads
2 Citations
2.420 Impact Factor

A decrease in cellular microRNA-27a content is involved in azacytidine-induced P-glycoprotein expression in SKM-1 cells.

Toxicol In Vitro 2016 Oct 7;36:81-88. Epub 2016 Jul 7.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinskeho 9, 812 37 Bratislava, Slovakia; Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Dubravska cesta 9, 840 05 Bratislava, Slovakia. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2016.07.002DOI Listing
October 2016
33 Reads
1 Citation
2.903 Impact Factor

The expression of P-gp in leukemia cells is associated with cross-resistance to protein N-glycosylation inhibitor tunicamycin.

Gen Physiol Biophys 2016 Oct;35(4):497-510

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Dubravska cesta 9, 840 05 Bratislava, Slovak Republic.

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http://dx.doi.org/10.4149/gpb_2016039DOI Listing
October 2016
23 Reads
1 Citation
1.173 Impact Factor

The expression of P-glycoprotein in leukemia cells is associated with the upregulated expression of nestin, a class 6 filament protein.

Leuk Res 2016 09 21;48:32-9. Epub 2016 Jul 21.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinskeho 9, 812 37 Bratislava, Slovak Republic; Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Dúbravska cesta 9, 840 05 Bratislava, Slovak Republic. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2016.05.021DOI Listing
September 2016
24 Reads
2 Citations
2.351 Impact Factor

Acute myeloid leukemia cells MOLM-13 and SKM-1 established for resistance by azacytidine are crossresistant to P-glycoprotein substrates.

Toxicol In Vitro 2015 Oct 22;29(7):1405-15. Epub 2015 May 22.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 83334 Bratislava, Slovakia.

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http://dx.doi.org/10.1016/j.tiv.2015.05.011DOI Listing
October 2015
77 Reads
2.903 Impact Factor

Molecular changes induced by repeated restraint stress in the heart: the effect of oxytocin receptor antagonist atosiban.

Can J Physiol Pharmacol 2015 Sep 24;93(9):827-34. Epub 2015 Jun 24.

b Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1139/cjpp-2015-0096DOI Listing
September 2015
25 Reads
1.550 Impact Factor

Selection of resistant acute myeloid leukemia SKM-1 and MOLM-13 cells by vincristine-, mitoxantrone- and lenalidomide-induced upregulation of P-glycoprotein activity and downregulation of CD33 cell surface exposure.

Eur J Pharm Sci 2015 Sep 19;77:29-39. Epub 2015 May 19.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava, Slovak Republic. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09280987150027
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http://dx.doi.org/10.1016/j.ejps.2015.05.022DOI Listing
September 2015
16 Reads
3.350 Impact Factor

Reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity.

Anticancer Res 2015 May;35(5):2627-34

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic

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May 2015
23 Reads
2 Citations
1.872 Impact Factor

Potentiation of anticancer drugs: effects of pentoxifylline on neoplastic cells.

Int J Mol Sci 2012 28;13(1):369-82. Epub 2011 Dec 28.

Institute for Heart Research, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava 840 05, Slovakia.

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http://dx.doi.org/10.3390/ijms13010369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269692PMC
February 2015
8 Reads
2 Citations
2.862 Impact Factor

Tunicamycin depresses P-glycoprotein glycosylation without an effect on its membrane localization and drug efflux activity in L1210 cells.

Int J Mol Sci 2011 10;12(11):7772-84. Epub 2011 Nov 10.

Institute of Molecular Physiology and Genetics, Centre of Excellence of the Slovak Research and Development Agency "BIOMEMBRANES2008", Slovak Academy of Sciences, Vlárska 5, Bratislava 83334, Slovakia; E-Mails: (M.Š.); (T.B.).

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http://dx.doi.org/10.3390/ijms12117772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233437PMC
December 2014
14 Reads
8 Citations
2.862 Impact Factor

Vincristine-induced expression of P-glycoprotein in MOLM-13 and SKM-1 acute myeloid leukemia cell lines is associated with coexpression of nestin transcript.

Gen Physiol Biophys 2014 26;33(4):425-31. Epub 2014 Jun 26.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 83334, Bratislava Slovak Republic.

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http://dx.doi.org/10.4149/gpb_2014015DOI Listing
December 2014
18 Reads
1 Citation
1.173 Impact Factor

New insight into p-glycoprotein as a drug target.

Anticancer Agents Med Chem 2013 Jan;13(1):159-70

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 83334 Bratislava, Slovak Republic.

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January 2013
7 Reads
22 Citations
2.470 Impact Factor

Detection of glycomic alterations induced by overexpression of p-glycoprotein on the surfaces of L1210 cells using sialic acid binding lectins.

Int J Mol Sci 2012 Nov 16;13(11):15177-92. Epub 2012 Nov 16.

Institute of Molecular Physiology and Genetics, Center of Excellence of the Slovak Research and Development Agency "BIOMEMBRANES2008", Slovak Academy of Sciences, Vlarska 5, Bratislava 83334, Slovakia.

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http://dx.doi.org/10.3390/ijms131115177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509634PMC
November 2012
15 Reads
1 Citation
2.862 Impact Factor

P-glycoprotein depresses cisplatin sensitivity in L1210 cells by inhibiting cisplatin-induced caspase-3 activation.

Toxicol In Vitro 2012 Apr 17;26(3):435-44. Epub 2012 Jan 17.

Institute of Molecular Physiology and Genetics, Centre of Excellence of the Slovak Research and Development Agency BIOMEMBRANES2008, Slovak Academy of Sciences, 83334 Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/j.tiv.2012.01.014DOI Listing
April 2012
15 Reads
11 Citations
2.903 Impact Factor

α2 integrin as regulator of metastatic potential.

Acta Pharmacol Sin 2011 Mar;32(3):279

Institute for Heart Research SAS, Bratislava, Slovakia.

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http://dx.doi.org/10.1038/aps.2011.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002781PMC
March 2011
6 Reads
2.500 Impact Factor

Effect of thapsigargin on P-glycoprotein-negative and P-glycoprotein-positive L1210 mouse leukaemia cells.

Gen Physiol Biophys 2010 Dec;29(4):396-401

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833 34 Bratislava, Slovakia.

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http://dx.doi.org/10.4149/gpb_2010_04_396DOI Listing
December 2010
5 Reads
4 Citations
1.173 Impact Factor

Effect of quercetin on kinetic properties of renal Na,K-ATPase in normotensive and hypertensive rats.

J Physiol Pharmacol 2010 Oct;61(5):593-8

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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October 2010
4 Reads
3 Citations
2.720 Impact Factor

Why the xanthine derivatives are used to study of P-glycoprotein-mediated multidrug resistance in L1210/VCR line cells.

Gen Physiol Biophys 2010 Sep;29(3):215-21

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833 34 Bratislava.

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http://dx.doi.org/10.4149/gpb_2010_03_215DOI Listing
September 2010
2 Reads
1.173 Impact Factor

The presence of P-glycoprotein in L1210 cells directly induces down-regulation of cell surface saccharide targets of concanavalin A.

Anticancer Res 2010 Sep;30(9):3661-8

Institute of Molecular Physiology and Genetics, Centre of Excellence of the Slovak Research and Development Agency Biomembranes2008, Slovak Academy of Sciences, 83334 Bratislava, Slovak Republic.

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September 2010
18 Reads
3 Citations
1.872 Impact Factor

Does any relationship exist between P-glycoprotein-mediated multidrug resistance and intracellular calcium homeostasis.

Gen Physiol Biophys 2009 ;28 Spec No Focus:F89-95

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Centre of Excellence of the Slovak Research and Development Agency BIOMEMBRANES2008, 833 34 Bratislava, Slovakia.

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August 2010
52 Reads
16 Citations
1.173 Impact Factor

Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia.

Can J Physiol Pharmacol 2010 Apr;88(4):465-71

Institute for Heart Research, Slovak Academy of Sciences, Centre of Excellence for Cardiovascular Research SAS, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1139/y10-025DOI Listing
April 2010
6 Reads
5 Citations
1.550 Impact Factor

Multidrug resistant P-glycoprotein positive L1210/VCR cells are also cross-resistant to cisplatin via a mechanism distinct from P-glycoprotein-mediated drug efflux activity.

Gen Physiol Biophys 2009 Dec;28(4):391-403

Institute of Molecular Physiology and Genetics, Centre of Excellence of the Slovak Research and Development Agency BIOMEMBRANES 2008, Vlárska 5, 833 34 Bratislava, Slovakia.

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http://dx.doi.org/10.4149/pb_2009_04_391DOI Listing
December 2009
10 Reads
2 Citations
1.173 Impact Factor

Membrane transport and apoptosis-related proteins in radiation-associated acute myeloid leukemia following the Chornobyl accident.

Gen Physiol Biophys 2009 Mar;28(1):63-9

Research Centre for Radiation Medicine, 53 Melnikova, 04050 Kyiv, Ukraine.

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http://dx.doi.org/10.4149/gpb_2009_01_63DOI Listing
March 2009
2 Reads
1.173 Impact Factor

Vincristine-induced overexpression of P-glycoprotein in L1210 cells is associated with remodeling of cell surface saccharides.

J Proteome Res 2009 Feb;8(2):513-20

Institute of Molecular Physiology and Genetics, Centre of Excellence of the Slovak Research and Development Agency, BIOMEMBRANES2008, Slovak Academy of Sciences, Bratislava, Slovakia.

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http://dx.doi.org/10.1021/pr8007094DOI Listing
February 2009
15 Reads
3 Citations
4.250 Impact Factor

H(2)S and HS(-) donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells.

Pflugers Arch 2008 Nov 6;457(2):271-9. Epub 2008 May 6.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34, Bratislava, Slovak Republic.

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http://link.springer.com/10.1007/s00424-008-0519-0
Publisher Site
http://dx.doi.org/10.1007/s00424-008-0519-0DOI Listing
November 2008
11 Reads
21 Citations
4.101 Impact Factor

Overexpression of P-glycoprotein in L1210/VCR cells is associated with changes in several endoplasmic reticulum proteins that may be partially responsible for the lack of thapsigargin sensitivity.

Gen Physiol Biophys 2008 Sep;27(3):211-21

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, Bratislava, Slovakia.

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September 2008
2 Reads
1 Citation
1.173 Impact Factor

Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all-trans retinoic acid induces down-regulation of P-glycoprotein expression and transport activity.

Toxicol In Vitro 2008 Feb 31;22(1):96-105. Epub 2007 Aug 31.

Institute of Molecular Physiology and Genetics, Centre of Excelence for Cardiovascular Research, Slovak Academy of Sciences, Vlárska 5, 83334 Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/j.tiv.2007.08.011DOI Listing
February 2008
24 Reads
3 Citations
2.903 Impact Factor

Inhibitory effect of DIDS, NPPB, and phloretin on intracellular chloride channels.

Pflugers Arch 2007 Nov 5;455(2):349-57. Epub 2007 Jul 5.

Institute of Molecular Physiology and Genetics, Centre of Excellence for Cardiovascular Research, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava, Slovak Republic.

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http://dx.doi.org/10.1007/s00424-007-0300-9DOI Listing
November 2007
7 Reads
9 Citations
4.101 Impact Factor

Modulation of expression of Na+/Ca2+ exchanger in heart of rat and mouse under stress.

Acta Physiol (Oxf) 2007 Jun 30;190(2):127-36. Epub 2007 Mar 30.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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http://dx.doi.org/10.1111/j.1748-1716.2007.01673.xDOI Listing
June 2007
14 Reads
4.382 Impact Factor

Structural differences between sensitive and resistant L1210 cells.

Gen Physiol Biophys 2006 Dec;25(4):427-38

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833 34 Bratislava 37, Slovakia.

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December 2006
3 Reads
1 Citation
1.173 Impact Factor

Inhibition of (Na(+)/K(+))-ATPase by Cibacron Blue 3G-A and its analogues.

Gen Physiol Biophys 2006 Dec;25(4):439-53

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 83334 Bratislava 37, Slovakia.

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December 2006
1.173 Impact Factor

L1210 cells cultivated under the selection pressure of doxorubicin or vincristine express common mechanisms of multidrug resistance based on the overexpression of P-glycoprotein.

Toxicol In Vitro 2006 Dec 2;20(8):1560-8. Epub 2006 Aug 2.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 83334 Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/j.tiv.2006.07.011DOI Listing
December 2006
11 Reads
2 Citations
2.903 Impact Factor

LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance.

Eur J Pharm Sci 2006 Dec 22;29(5):426-34. Epub 2006 Aug 22.

Institute for Heart Research, Slovak Academy of Sciences, Dúbravská cesta 9, PO Box 104, 840 05, Bratislava 45, Slovak Republic.

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http://dx.doi.org/10.1016/j.ejps.2006.08.006DOI Listing
December 2006
20 Reads
21 Citations
3.350 Impact Factor

Prolongation of pentoxifylline aliphatic side chain positively affects the reversal of P-glycoprotein-mediated multidrug resistance in L1210/VCR line cells.

Gen Physiol Biophys 2005 Dec;24(4):461-6

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833 34 Bratislava 37, Slovakia.

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December 2005
7 Reads
1.173 Impact Factor

P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.

Curr Cancer Drug Targets 2005 Sep;5(6):457-68

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833-34 Bratislava, Slovak Republic.

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http://dx.doi.org/10.2174/1568009054863636DOI Listing
September 2005
17 Reads
13 Citations
3.522 Impact Factor

Expression of P-glycoprotein in L1210 cells is linked with rise in sensitivity to Ca2+.

Biochem Biophys Res Commun 2005 Sep;335(3):777-84

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833 34 Bratislava, Slovakia.

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http://dx.doi.org/10.1016/j.bbrc.2005.07.144DOI Listing
September 2005
13 Reads
2 Citations
2.300 Impact Factor

Proteins released from liver after ischaemia induced an elevation of heart resistance against ischaemia-reperfusion injury: 2. Beneficial effect of liver ischaemia in situ.

Gen Physiol Biophys 2004 Dec;23(4):489-97

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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December 2004
3 Reads
1.173 Impact Factor

Functional fluo-3/AM assay on P-glycoprotein transport activity in L1210/VCR cells by confocal microscopy.

Gen Physiol Biophys 2004 Sep;23(3):357-66

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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September 2004
5 Reads
2 Citations
1.173 Impact Factor

Reversal of P-glycoprotein mediated vincristine resistance of L1210/VCR cells by analogues of pentoxifylline. A QSAR study.

Eur J Pharm Sci 2004 Feb;21(2-3):283-93

Institute for Heart Research, Slovak Academy of Sciences, Dúbravská cesta 9, 84233, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/j.ejps.2003.10.019DOI Listing
February 2004
5 Reads
1 Citation
3.350 Impact Factor

Proteins released from liver after ischaemia induced an elevation of heart resistance against ischaemia-reperfusion injury: 1. Beneficial effect of protein fraction isolated from perfusate after ischaemia and reperfusion of liver.

Gen Physiol Biophys 2003 Dec;22(4):567-77

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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December 2003
1 Read
1.173 Impact Factor

P-glycoprotein-mediated multidrug resistance phenotype of L1210/VCR cells is associated with decreases of oligo- and/or polysaccharide contents.

Biochim Biophys Acta 2003 Nov;1639(3):213-24

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 83334 Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/j.bbadis.2003.09.009DOI Listing
November 2003
1 Read
3 Citations

Hypoxia increases cell death in multidrug-resistant leukemia cells. Differences in viability and ultrastructure between sensitive and multidrug-resistant L1210 mouse leukemic cells under hypoxia.

Gen Physiol Biophys 2003 Jun;22(2):265-73

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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June 2003
3 Reads
1 Citation
1.173 Impact Factor

Carbonyl group of aliphatic side chain of pentoxifylline does not play role for P-glycoprotein antagonizing effect of pentoxifylline.

Gen Physiol Biophys 2002 Dec;21(4):471-8

Institute for Heart Research, Slovak Academy of Sciences, Dúbravská cesta 9, 842 33 Bratislava 4, Slovakia.

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December 2002
3 Reads
1.173 Impact Factor

Pentoxifylline influences drug transport activity of P-glycoprotein and decreases mdrl gene expression in multidrug resistant mouse leukemic L1210/VCR cells.

Gen Physiol Biophys 2002 Mar;21(1):103-9

Institute for Heart Research, Bratislava, Slovakia.

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March 2002
4 Reads
2 Citations
1.173 Impact Factor

Reversal effect of specific inhibitors of extracellular-signal regulated protein kinase pathway on P-glycoprotein mediated vincristine resistance of L1210 cells.

Gen Physiol Biophys 2001 Dec;20(4):439-44

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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December 2001
3 Reads
8 Citations
1.173 Impact Factor

Drug transporters and their role in multidrug resistance of neoplastic cells.

Gen Physiol Biophys 2001 Sep;20(3):215-37

Institute for Heart Research, Slovak Academy of Sciences, Bratislava.

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September 2001
4 Reads
2 Citations
1.173 Impact Factor

SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance.

Eur J Pharm Sci 2001 Aug;14(1):29-36

Institute for Heart Research, Slovak Academy of Sciences, Dúbravská cesta 9, 842 33, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/s0928-0987(01)00139-7DOI Listing
August 2001
1 Read
31 Citations
3.350 Impact Factor

Glutathione S-transferase does not play a role in multidrug resistance of L1210/VCR cell line.

Physiol Res 2000 ;49(4):447-53

Institute of Molecular Physiology and Genetic, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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February 2001
5 Reads
1 Citation
1.490 Impact Factor

Cytotoxic activity of several unrelated drugs on L1210 mouse leukemic cell sublines with P-glycoprotein (PGP) mediated multidrug resistance (MDR) phenotype. A QSAR study.

Neoplasma 2000 ;47(2):100-6

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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September 2000
4 Reads
3 Citations
1.642 Impact Factor

"Lysine is the Lord", thought some scientists in regard to the group interacting with fluorescein isothiocyanate in ATP-binding sites of P-type ATPases but, is it not cysteine?

Gen Physiol Biophys 2000 Sep;19(3):253-63

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava.

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September 2000
6 Reads
3 Citations
1.173 Impact Factor

Na,K-ATPase in the myocardium: molecular principles, functional and clinical aspects.

Gen Physiol Biophys 2000 Mar;19(1):9-47

Institute for Heart Research, Slovak Academy of Sciences, Bratislava.

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March 2000
5 Reads
1 Citation
1.173 Impact Factor

Microvascular endothelial cells remodel cultured adult cardiomyocytes and increase their survival.

Am J Physiol 1999 06;276(6):H2179-87

Department of Experimental Cardiology, Max Planck Institute, D-61231 Bad Nauheim, Germany.

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http://dx.doi.org/10.1152/ajpheart.1999.276.6.H2179DOI Listing
June 1999
20 Reads
1 Citation

Differential expression of regulatory proteins in L1210/VCR cells with multidrug resistance mediated by P-glycoprotein.

Gen Physiol Biophys 1999 Mar;18(1):45-56

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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March 1999
5 Reads
1.173 Impact Factor

Direct interaction between verapamil and doxorubicin causes the lack of reversal effect of verapamil on P-glycoprotein mediated resistance to doxorubicin in vitro using L1210/VCR cells.

Neoplasma 1998 ;45(4):248-53

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska, Bratislava.

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January 1999
5 Reads
1.642 Impact Factor

Ca(2+)-induced inhibition of sodium pump: effects on energetic metabolism of mouse diaphragm tissue.

Gen Physiol Biophys 1998 Sep;17(3):271-83

Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia.

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September 1998
11 Reads
1 Citation
1.173 Impact Factor

Interaction of lactate dehydrogenase with anthraquinone dyes: characterization of ligands for dye-ligand chromatography.

J Chromatogr B Biomed Sci Appl 1998 Sep;715(1):273-81

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/s0378-4347(98)00088-7DOI Listing
September 1998
3 Reads
1 Citation

Ca(2+)-induced inhibition of sodium pump: noncompetitive inhibition in respect of magnesium and sodium cations.

Gen Physiol Biophys 1998 Jun;17(2):179-88

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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June 1998
2 Reads
1 Citation
1.173 Impact Factor

Mechanisms that may be involved in calcium tolerance of the diabetic heart.

Mol Cell Biochem 1997 Nov;176(1-2):191-8

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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November 1997
4 Reads
2 Citations
2.393 Impact Factor

Prevention by 7-oxo-prostacyclin of the calcium paradox in rat heart: role of the sarcolemmal (Na,K)-ATPase.

Mol Cell Biochem 1996 Jul-Aug;160-161:257-63

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1007/BF00240057DOI Listing
February 1997
3 Reads
1 Citation
2.393 Impact Factor

Is cysteine residue important in FITC-sensitive ATP-binding site of P-type ATPases? A commentary to the state of the art.

Mol Cell Biochem 1996 Jul-Aug;160-161:89-93

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1007/BF00240036DOI Listing
February 1997
4 Reads
2.393 Impact Factor

Overcoming of P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cells could be induced by pentoxifyline but not by theophylline and caffeine.

Neoplasma 1996 ;43(1):11-5

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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November 1996
4 Reads
2 Citations
1.642 Impact Factor

Competitive inhibition of (Na/K)-ATPase by furylethylenes with respect to potassium ions.

Gen Physiol Biophys 1996 Aug;15(4):291-307

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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August 1996
3 Reads
1.173 Impact Factor

Diabetic cardiomyopathy in rats: biochemical mechanisms of increased tolerance to calcium overload.

Diabetes Res Clin Pract 1996 Jul;31 Suppl:S93-103

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1016/0168-8227(96)01236-3DOI Listing
July 1996
17 Reads
2.540 Impact Factor

The membrane effect of benfluron: modulation of the heart sarcolemmal (Na+, K+)-ATPase and Mg(2+)-ATPase activities.

Gen Physiol Biophys 1996 Feb;15(1):71-5

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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February 1996
4 Reads
1.173 Impact Factor

Adaptation of the heart to ischemia by preconditioning: effects on energy equilibrium, properties of sarcolemmal ATPases and release of cardioprotective proteins.

Mol Cell Biochem 1995 Jun 7-21;147(1-2):129-37

Institute for Heart Research, Slovak Academy of Sciences, Bratislava.

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http://dx.doi.org/10.1007/BF00944793DOI Listing
January 1996
6 Reads
2.393 Impact Factor

Distribution of proteins in aqueous two-phase systems formed by dextran and polyethylene glycol. Influence of protein hydrophobicity.

Gen Physiol Biophys 1995 Aug;14(4):277-91

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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August 1995
9 Reads
1.173 Impact Factor

Effect of phorbol myristate acetate (PMA) on P-glycoprotein mediated vincristine resistance of L1210 cells.

Gen Physiol Biophys 1995 Apr;14(2):171-5

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia.

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April 1995
3 Reads
1.173 Impact Factor

Effect of pentoxifylline on P-glycoprotein mediated vincristine resistance of L1210 mouse leukemic cell line.

Neoplasma 1994 ;41(5):297-303

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava.

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March 1995
4 Reads
2 Citations
1.642 Impact Factor

The effects of calcium and calcium channel blockers on sodium pump.

Pflugers Arch 1995 Mar;429(5):716-21

Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1007/BF00373994DOI Listing
March 1995
6 Reads
3 Citations
4.101 Impact Factor

Reversal effects of several Ca(2+)-entry blockers, neuroleptics and local anaesthetics on P-glycoprotein-mediated vincristine resistance of L1210/VCR mouse leukaemic cell line.

Drugs Exp Clin Res 1994 ;20(1):13-8

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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October 1994
5 Reads
1 Citation

Inhibition of (Na/K)-ATPase by NFE induces an increase in mechanical activity of perfused guinea-pig heart.

Gen Physiol Biophys 1994 Oct;13(5):433-41

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava.

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October 1994
7 Reads
1.173 Impact Factor

Time dependence of [3H]-vincristine accumulation by L1210 mouse leukemic cells. Effect of P-glycoprotein overexpression.

Gen Physiol Biophys 1994 Aug;13(4):287-98

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava.

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August 1994
4 Reads
1 Citation
1.173 Impact Factor

Characterization of morphological and histochemical changes induced by overexpression of P-glycoprotein in mouse leukemic cell line L1210.

Neoplasma 1994 ;41(2):83-8

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava.

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July 1994
19 Reads
1.642 Impact Factor

2,4,6-Trinitrobenzenesulfonic acid modification of the carboxyl-terminal region (C-domain) of calreticulin.

Molecular and cellular biochemistry

The role of the primary amino groups of lysine sidechains in Ca2+ binding to calreticulin was evaluated by chemical modification of the amino group with 2,4,6-trinitrobenzenesulfonic acid (TNBS). TNBS binding to calreticulin could be described by two steps: (i) a fast reaction, with low affinity, and (ii) a slow reaction with a relatively high affinity. Inclusion of Ca2+ and/or Mg2+ decreased both the amount of TNBS bound to calreticulin and the apparent affinity constant of the slower reaction. In contrast, the properties of the faster reaction for TNBS binding were not sensitive to Ca2+ and/or Mg2+. Analysis of TNBS binding to the carboxyl-terminal (C-domain) and aminoterminal (N-domain) of calreticulin revealed that the C-domain and N-domain are responsible for the slow and fast component of the TNBS binding, respectively. In keeping with this, in the presence of Ca2+, TNBS binding to the C-domain was significantly reduced, whereas modification of the N-domain was unaffected. TNBS modification of calreticulin significantly decreased Ca2+ binding to the low affinity/high capacity Ca2+ binding site(s) which are localized to the C-domain but had no effect on the high affinity/low capacity Ca2+ binding localized to the N domain. In the C-domain of calreticulin, which contains the low affinity/high capacity Ca2+ binding sites, acidic residues are interspersed at regular intervals with one or more positively charged lysine and arginine residues. Our results indicate that the aminogroups of the lysine sidechains in the C-domain of calreticulin have a role in the low affinity/high capacity Ca2+ binding that is characteristic of this region of the protein and which is proposed to contribute significantly to the capacity of the endoplasmic reticulum Ca2+ store.

https://doi.org/10.1007/bf01084264

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January 1994
2 Reads

Overcoming of vincristine resistance in L1210/VCR cells by several corticosteroids. Collateral sensitivity of resistant cells.

Neoplasma 1993 ;40(1):21-5

Institute of Heart Research, Slovak Academy of Sciences, Bratislava.

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September 1993
4 Reads
1 Citation
1.642 Impact Factor

Adaptation of mouse leukemia cells L1210 to vincristine. Evidence for expression of P-glycoprotein.

Neoplasma 1992 ;39(2):73-7

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava.

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October 1992
2 Reads
5 Citations
1.642 Impact Factor

Comparison of ATP binding in the active sites of (Na+ + K(+)-ATPase, Mg(2+)-ATPase and Ca(2+)-ATPase with low affinity to calcium from cardiac sarcolemma.

Bratisl Lek Listy 1991 Mar-Apr;92(3-4):142-5

Institute for Heart Research, Slovak Academy of Sciences, Bratislava.

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June 1991
2 Reads
0.450 Impact Factor

Increased activity of sarcolemmal (Na+K+)-ATPase is involved in the late cardioprotective action of 7-oxo-prostacyclin.

Cardioscience 1991 Jun;2(2):105-8

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

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June 1991
2 Reads
1 Citation

Influence of calcium antagonists on heart sarcolemmal (Na+ + K(+)-ATPase.

Bratisl Lek Listy 1991 Mar-Apr;92(3-4):155-8

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, CSFR.

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June 1991
5 Reads
0.450 Impact Factor

Application of adsorption kinetics for estimation of dissociation constants.

J Biochem Biophys Methods 1991 Apr;22(3):185-93

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

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http://dx.doi.org/10.1016/0165-022x(91)90067-7DOI Listing
April 1991
3 Reads

Interaction of Cibacron Blue 3GA and Remazol Brilliant Blue R with the nucleotide binding site of lactate dehydrogenase and (Na+ + K+)-ATPase.

Gen Physiol Biophys 1990 Oct;9(5):519-28

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

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October 1990
3 Reads
1 Citation
1.173 Impact Factor

[(Na(+)+K+)-ATPase--the molecular basis].

Cesk Fysiol 1990 ;39(3):195-206

Ustav molekulárnej fyziológie a genetiky SAV, Bratislava.

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October 1990
6 Reads

Hypothetical structure of the ATP-binding site of (Na+ + K+)-ATPase.

Gen Physiol Biophys 1989 Jun;8(3):283-6

Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava.

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June 1989
12 Reads
1.173 Impact Factor

Principles of selectivity of sodium and potassium binding sites of the Na+/K+-ATPase. A corollary hypothesis.

Biochim Biophys Acta 1988 Dec;946(1):129-34

Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

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http://dx.doi.org/10.1016/0005-2736(88)90465-8DOI Listing
December 1988
2 Reads

Some properties of the active site and cation binding site of the heart sarcolemmal (Na+ + K+)-ATPase.

Biomed Biochim Acta 1987 ;46(8-9):S553-6

Department of Biochemistry, Slovak Acad. Sci., Bratislava, Czechoslovakia.

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March 1988
3 Reads

Interaction of ATP with the active sites of ATPases in heart sarcolemma. Role of the hydroxylic group in position two on the ribose moiety.

Gen Physiol Biophys 1987 Apr;6(2):193-6

Centre of Physiological Sciences, Department of Biochemistry, Bratislava, Czechoslovakia.

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April 1987
2 Reads
1.173 Impact Factor

Heart sarcolemmal (Na+ + K+)-ATPase has an essential amino group in the potassium binding site on the enzyme molecule.

Gen Physiol Biophys 1986 Oct;5(5):537-44

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October 1986
2 Reads
1.173 Impact Factor

Effect of calcium on the structure-function relationship of (Na+ + K+)-ATPase in cardiac sarcolemma.

Gen Physiol Biophys 1986 Oct;5(5):545-9

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October 1986
1.173 Impact Factor

How do the ATPases in cardiac cell membranes work?

Biomed Biochim Acta 1986 ;45(1-2):S211-4

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May 1986

Aldehydic derivatives of bead cellulose--relationships between matrix structure and function in immobilization of enzymes catalyzing hydrolysis of high molecular substrates.

Authors:
P Gemeiner A Breier

Biotechnol Bioeng 1982 Nov;24(11):2573-82

Institute of Chemistry, Slovak Academy of Sciences, 842 38 Bratislava, Czechoslovakia.

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http://dx.doi.org/10.1002/bit.260241119DOI Listing
November 1982
6 Reads
4.130 Impact Factor

Top co-authors

Zdena Sulova
Zdena Sulova

Institute of Molecular Physiology and Genetics

12
Zdena Sulova
Zdena Sulova

Institute of Molecular Physiology and Genetics

9
Lenka Gibalova
Lenka Gibalova

Institute of Molecular Physiology and Genetics

7
Denisa Imrichova
Denisa Imrichova

Institute of Molecular Physiology and Genetics

6
Zdenka Sulova
Zdenka Sulova

Institute of Molecular Physiology and Genetics

6
Jan Sedlak
Jan Sedlak

Cancer Research Institute

6