Albert Becker

Albert Becker

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[Epileptogenesis and consequences for treatment].

Nervenarzt 2019 Aug;90(8):773-780

Abteilung Neurologie mit Schwerpunkt Epileptologie, Hertie-Institut für klinische Hirnforschung, Universität Tübingen, Hoppe Seyler Straße 3, 72076, Tübingen, Deutschland.

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http://dx.doi.org/10.1007/s00115-019-0749-8DOI Listing
August 2019

Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.

J Neurosci 2019 Apr 21;39(17):3175-3187. Epub 2019 Feb 21.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1731-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788814PMC
April 2019

Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.

Mol Neurobiol 2019 Mar 22;56(3):1825-1840. Epub 2018 Jun 22.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://link.springer.com/10.1007/s12035-018-1181-y
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http://dx.doi.org/10.1007/s12035-018-1181-yDOI Listing
March 2019

Retinoencephalopathy with occipital lobe epilepsy in an OPA-1 mutation carrier.

Seizure 2019 Mar 30;66:1-3. Epub 2019 Jan 30.

Department of Epileptology, University of Bonn Hospital, Bonn, Germany; Institute of Experimental Epileptology and Cognition Research, University Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2019.01.029DOI Listing
March 2019

Cancer frequency detected by positron emission tomography-computed tomography in limbic encephalitis.

Epilepsy Behav 2018 Dec 6;89:105-111. Epub 2018 Nov 6.

Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183072
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http://dx.doi.org/10.1016/j.yebeh.2018.09.043DOI Listing
December 2018

A web-based diagnostic reference centre for the European Reference Network "EpiCare": recommendations of the eNeuropathology working group.

Epileptic Disord 2018 Oct;20(5):339-345

Neuropathologisches Institut, Universitätsklinikum Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1684/epd.2018.1002DOI Listing
October 2018

Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis.

Mol Neurobiol 2018 May 1;55(5):4463-4472. Epub 2017 Jul 1.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s12035-017-0660-xDOI Listing
May 2018

Age at epilepsy onset in patients with focal cortical dysplasias, gangliogliomas and dysembryoplastic neuroepithelial tumours.

Seizure 2018 May 4;58:82-89. Epub 2018 Apr 4.

Department of Epileptology, University of Bonn Medical Centre, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.seizure.2018.04.002DOI Listing
May 2018

New developments in understanding focal cortical malformations.

Curr Opin Neurol 2018 04;31(2):151-155

Institute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1097/WCO.0000000000000531DOI Listing
April 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Hippocampal "gliosis only" on MR imaging represents a distinct entity in epilepsy patients.

Neuroradiology 2018 Feb 30;60(2):161-168. Epub 2017 Oct 30.

Institute of Neuropathology, University Clinics Bonn, Bonn, Germany.

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http://link.springer.com/10.1007/s00234-017-1939-3
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http://dx.doi.org/10.1007/s00234-017-1939-3DOI Listing
February 2018

Large-scale analysis of herpesviridae in epilepsy-patients with signs of autoimmune encephalitis.

Seizure 2017 Dec 16;53:100-102. Epub 2017 Nov 16.

Dept. of Neuropathology, University of Bonn Medical Center, Germany; Dept. of Neuro-/Pathology, Oslo University Hospital, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2017.11.012DOI Listing
December 2017

Neuropathic pain in experimental autoimmune neuritis is associated with altered electrophysiological properties of nociceptive DRG neurons.

Exp Neurol 2017 11 19;297:25-35. Epub 2017 Jul 19.

Department of Neurology, University of Bonn Medical Center, Sigmund Freud Straße 25, 53105 Bonn, Germany; Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Straße 25, 53105 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2017.07.011DOI Listing
November 2017

Personalized translational epilepsy research - Novel approaches and future perspectives: Part II: Experimental and translational approaches.

Epilepsy Behav 2017 11 14;76:7-12. Epub 2017 Sep 14.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1). Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2017.06.040DOI Listing
November 2017

Personalized translational epilepsy research - Novel approaches and future perspectives: Part I: Clinical and network analysis approaches.

Epilepsy Behav 2017 11 13;76:13-18. Epub 2017 Sep 13.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1).

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http://dx.doi.org/10.1016/j.yebeh.2017.06.041DOI Listing
November 2017

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.

N Engl J Med 2017 10;377(17):1648-1656

From the Departments of Neuropathology (I.B., G.H., R.C., K.K.) and Neurosurgery (K.R.) and the Epilepsy Center (H. Hamer, H.S.), University Hospital Erlangen, Erlangen, the Epilepsy Center Bethel, Krankenhaus Mara, Bielefeld (C.G.B., M.P.), the Departments of Epileptology (C.E., G.W.) and Neuropathology (A.B.), University of Bonn Medical Center, and Medical Faculty, University of Bonn (J.S.), Bonn, the Neuropediatric Clinic, Epilepsy Center for Children and Adolescents, Schön Klinik Vogtareuth, Vogtareuth (T.P., H. Holthausen, M.K., P.A.W.), the Epilepsy Center Berlin-Brandenburg, Berlin (H.J.M.), the Epilepsy Center (G.H., A.S.-B.) and Department of Neurosurgery (J.Z., D.H.H.), University Hospital, and the Department of Neuroradiology, Medical Center-University of Freiburg, and Faculty of Medicine, University of Freiburg (H.U.) Freiburg, Kork Epilepsy Center, Kehl-Kork (B.J.S., T.B.), the Departments of Neuropathology (S.V.) and Neurology (U.R.), University Hospital Greifswald, Greifswald, the Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen (H.L., Y.W.), the Department of Neurology, University of Ulm, Ulm (H.L., Y.W.), the Epilepsy Center, Department of Neurology, Ludwig-Maximilians-University Hospital, Munich (S.N., E.H., P.A.W.), Sächsisches Epilepsiezentrum Radeberg, Radeberg (T.M., M.L.), Epilepsy Center Frankfurt Rhine-Main and the Department of Neurology, Goethe University, Frankfurt am Main (F.R., A.H.), the Epilepsy Center Hessen-Marburg, Philipps-University Marburg, Marburg (F.R., A.H.), and the Department of Social Medicine, Occupational and Environmental Dermatology, Heidelberg University, Heidelberg (T.L.D.) - all in Germany; the Clinical Epileptology and Experimental Neurophysiology Unit (R.S.) and the Department of Neurophysiology, Epilepsy Center (G.A.), IRCCS Foundation, Neurological Institute C. Besta, and the Claudio Munari Epilepsy Surgery Center, Niguarda Hospital (L.T., G.L.R.), Milan, and the Pediatric Neurology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence (R.G., C.B.) - all in Italy; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery (K.P.B., F.L.), and the Department of (Neuro)Pathology (E.A.), University Medical Center Utrecht, Utrecht, the Department of Neurosurgery, VU University Medical Center (J.C.B.), and the Department of (Neuro)Pathology, Academic Medisch Centrum, University of Amsterdam (E.A., A.M.), and the Department of (Neuro)Pathology, VU University Medical Center (E.A., A.M.), Amsterdam, Stichting Epilepsie Instellingen Nederland, Heemstede (E.A.), and the Department of Neurosurgery, Academic Center for Epileptology, Maastricht University Medical Center, Maastricht (O.S.) - all in the Netherlands; the Department of Neurosurgery, Sainte-Anne Hospital, and Paris Descartes University, Paris (F.C.), the Department of Neurology, Michallon Hospital, GIN INSERM Unité 836, Grenoble Alpes University, Grenoble (P. Kahane), and the Department of Clinical Epileptology, Sleep Disorders and Functional Neurology in Children, University Hospitals of Lyon, and the Brain Dynamics and Cognition team, Lyon Neurosciences Research Center, Lyon (A.A., A.U.-C.) - all in France; the Departments of Neuropathology (M.T.) and Clinical and Experimental Epilepsy (M.C.W., S.M.S., J.S.D., A.W.M.), UCL Institute of Neurology, and the Developmental Biology and Cancer Programme (T.S.J.) and Developmental Neurosciences Program (J.H.C.), UCL-Great Ormond Street Institute of Child Health, and the Department of Histopathology, Great Ormond Street Hospital for Children (T.S.J.), London, and Young Epilepsy, Lingfield (J.H.C.) - all in the United Kingdom; the Departments of Neurology (C.Ö.) and Pathology (B.O.), Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey; the Department of Pediatric Neurology, Motol Epilepsy Center, Charles University in Prague, and the 2nd Faculty of Medicine, Motol University Hospital, Prague, Czech Republic (P. Krsek); the Department of Anatomical Pathology, Hospital Pedro Hispano, Matosinhos (M.H.), and the Laboratory of Neuropathology, Department of Neurosciences, Hospital de Santa Maria-Centro Hospitalar de Lisboa Norte, Lisbon (J.P.) - both in Portugal; the Epilepsy Unit, Child Neurology Department, Hospital San Juan de Dios, Barcelona (A.A., A.U.-C.); the Department of Pediatrics, Medical University Vienna, Vienna (M.F., A.M.), the Departments of Neurology (E.T.) and Neurosurgery (P.A.W.), Christian Doppler Medical Center, Paracelsus Medical University, Center for Cognitive Neuroscience, Salzburg, and the Department of Neurology I, Neuromed Campus, Kepler Universitätsklinikum, Linz (T.J.O.) - all in Austria; the Swiss Epilepsy Center and Department of Neurology, University Hospital, Zurich, Switzerland (T.G.); the Department of Neurology, Hospital Ruber Internacional, Madrid (A.G.-N., R.T.D.); and the Neurosurgical Department (B.Z.) and Epilepsy Monitoring Unit (K.G.), St. Luke's Hospital, Thessaloniki, Greece.

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http://www.nejm.org/doi/10.1056/NEJMoa1703784
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http://dx.doi.org/10.1056/NEJMoa1703784DOI Listing
October 2017

Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.

Epilepsia 2017 07 24;58(7):1159-1171. Epub 2017 May 24.

Unit of Epileptology and Experimental Neurophysiology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1111/epi.13795DOI Listing
July 2017

Innate and adaptive immunity in human epilepsies.

Epilepsia 2017 07;58 Suppl 3:57-68

IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy.

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http://dx.doi.org/10.1111/epi.13784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535008PMC
July 2017

Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration.

J Virol 2017 06 12;91(11). Epub 2017 May 12.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, and Center for Molecular Medicine, Stockholm, Sweden

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http://dx.doi.org/10.1128/JVI.02105-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432873PMC
June 2017

WONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients?

Epilepsia 2017 06 7;58(6):951-961. Epub 2017 Apr 7.

Department of Neurology and Rehabilitation, The University of Illinois at Chicago, Chicago, Illinois, U.S.A.

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http://dx.doi.org/10.1111/epi.13728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806696PMC
June 2017

Synthesis and Evaluation of Amyloid β Derived and Amyloid β Independent Enhancers of the Peroxidase-like Activity of Heme.

J Med Chem 2017 01 15;60(1):373-385. Epub 2016 Dec 15.

Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn , Brühler Strasse 7, 53119 Bonn, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01432DOI Listing
January 2017

Molecular rescue of Tsc1-ablated cortical tuber mice.

Oncotarget 2017 Jan;8(4):5678-5679

Department of Neuropathology, Section for Translational Epilepsy Research, Bonn, Germany.

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http://dx.doi.org/10.18632/oncotarget.14239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351577PMC
January 2017

Common data elements and data management: Remedy to cure underpowered preclinical studies.

Epilepsy Res 2017 01 22;129:87-90. Epub 2016 Nov 22.

Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2016.11.010DOI Listing
January 2017

Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification.

Nat Rev Neurol 2016 12 18;12(12):732-740. Epub 2016 Nov 18.

Department of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1038/nrneurol.2016.173DOI Listing
December 2016

Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice.

Neurobiol Dis 2016 Nov 15;95:134-44. Epub 2016 Jul 15.

Section for Translational Epilepsy Research, Dept. of Neuropathology, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.07.006DOI Listing
November 2016

Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy.

Acta Neuropathol 2016 08 18;132(2):277-288. Epub 2016 Mar 18.

Division of Neurochemistry, Department of Epileptology, University Bonn Medical Center, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00401-016-1561-1DOI Listing
August 2016

Non-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence?

Neuropathology 2016 Aug 15;36(4):376-80. Epub 2016 Jan 15.

Department of Neurology / Pathology, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1111/neup.12283DOI Listing
August 2016

Advances in the development of biomarkers for epilepsy.

Lancet Neurol 2016 07;15(8):843-856

Laboratory for Experimental Epileptology and Cognition Research, Department of Epileptology, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Electronic address:

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http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(
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http://dx.doi.org/10.1016/S1474-4422(16)00112-5DOI Listing
July 2016

Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas.

Life Sci 2016 Jun 30;155:70-5. Epub 2016 Apr 30.

Dept. of Neurosurgery, University of Bonn Medical Center, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2016.01.049DOI Listing
June 2016

Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis.

Neurol Neuroimmunol Neuroinflamm 2016 Jun 29;3(3):e232. Epub 2016 Apr 29.

Departments of Neurology (K.S.G., K.B., C.M., M.H., H.W., S.G.M., H.L., C.C.G., N.M.) and Clinical Radiology (W.S.), and Institute of Physiology I-Neuropathophysiology (S.G.M.), University of Münster; Departments of Epileptology (G.W., C.E.E.) and Neuropathology (K.M.v.L., A.J.B.), University of Bonn; Epilepsy Center Hamburg (M.L.), Evangelisches Krankenhaus Alsterdorf, Hamburg; and Department of Neuropathology (M.G.), University of Hamburg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853055PMC
June 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus.

Neuron 2016 05 5;90(4):853-65. Epub 2016 May 5.

Laboratory for Experimental Epileptology and Cognition Research, Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.003DOI Listing
May 2016

Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration.

J Neurosci 2016 Mar;36(9):2561-70

Section of Translational Epilepsy Research at the Department of Neuropathology, and Department of Epileptology, University of Bonn Medical Center, D-53105 Bonn, Germany

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http://dx.doi.org/10.1523/JNEUROSCI.2027-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604865PMC
March 2016

Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery.

Curr Protoc Pharmacol 2016 Mar 18;72:14.37.1-14.37.12. Epub 2016 Mar 18.

Department of Physiology and Neurobiology, University of Connecticut, Storrs, Conn.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043528PMC
http://dx.doi.org/10.1002/0471141755.ph1437s72DOI Listing
March 2016

Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance.

Neurobiol Dis 2016 Feb 26;86:121-30. Epub 2015 Nov 26.

Dept. of Neuropathology, University of Bonn Medical Center, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.11.011DOI Listing
February 2016

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization.

Neurobiol Dis 2016 Feb 2;86:170-6. Epub 2015 Dec 2.

Dept. of Neuropathology/Section for Translational Epilepsy Research, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1016/j.nbd.2015.11.021DOI Listing
February 2016

Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.

J Neurosci 2015 Nov;35(46):15240-53

Laboratory for Experimental Epileptology and Cognition Research, Department of Epileptology, and Deutsches Zentrum für Neurodegenerative Erkrankungen e.V., 53175 Bonn, Germany

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http://dx.doi.org/10.1523/JNEUROSCI.0493-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605494PMC
November 2015

Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy.

J Neurol 2015 Oct 3;262(10):2214-24. Epub 2015 Jul 3.

Department of Epileptology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00415-015-7831-3DOI Listing
October 2015

Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling.

Development 2015 Oct 23;142(20):3601-11. Epub 2015 Sep 23.

Department of Physiology and Neurobiology, Institute for Systems Genomics, Institute for Brain and Cognitive Science, University of Connecticut, Storrs, CT 06268, USA

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http://dx.doi.org/10.1242/dev.118836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631763PMC
October 2015

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.

Nat Commun 2015 Oct 26;6:8688. Epub 2015 Oct 26.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany.

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http://dx.doi.org/10.1038/ncomms9688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846312PMC
October 2015

Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.

Brain Struct Funct 2015 Sep 3;220(5):3067-73. Epub 2014 Jun 3.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00429-014-0801-1DOI Listing
September 2015

Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.

Epilepsia 2015 Sep 15;56(9):e129-33. Epub 2015 Jul 15.

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1111/epi.13076DOI Listing
September 2015

Investigation of GRIN2A in common epilepsy phenotypes.

Epilepsy Res 2015 Sep 2;115:95-9. Epub 2015 Jun 2.

Division of Human Genetics, University Children's Hospital Inselspital, Bern, Switzerland; Institute of Human Genetics, University Medical Center Leipzig, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2015.05.010DOI Listing
September 2015

Calcium-binding proteins in focal cortical dysplasia.

Epilepsia 2015 Aug 17;56(8):1207-16. Epub 2015 Jun 17.

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/epi.13053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006823PMC
August 2015

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction.

Neurobiol Dis 2015 Jun 30;78:115-25. Epub 2015 Mar 30.

Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720-3140, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720-3140, USA; Canadian Institute for Advanced Research (CIFAR) Program in Child and Brain Development Toronto, ON M5G 1Z8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426044PMC
June 2015

Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.

Authors:
Stéphanie Debette Carla A Ibrahim Verbaas Jan Bressler Maaike Schuur Albert Smith Joshua C Bis Gail Davies Christiane Wolf Vilmundur Gudnason Lori B Chibnik Qiong Yang Anita L deStefano Dominique J F de Quervain Velandai Srikanth Jari Lahti Hans J Grabe Jennifer A Smith Lutz Priebe Lei Yu Nazanin Karbalai Caroline Hayward James F Wilson Harry Campbell Katja Petrovic Myriam Fornage Ganesh Chauhan Robin Yeo Ruth Boxall James Becker Oliver Stegle Karen A Mather Vincent Chouraki Qi Sun Lynda M Rose Susan Resnick Christopher Oldmeadow Mirna Kirin Alan F Wright Maria K Jonsdottir Rhoda Au Albert Becker Najaf Amin Mike A Nalls Stephen T Turner Sharon L R Kardia Ben Oostra Gwen Windham Laura H Coker Wei Zhao David S Knopman Gerardo Heiss Michael E Griswold Rebecca F Gottesman Veronique Vitart Nicholas D Hastie Lina Zgaga Igor Rudan Ozren Polasek Elizabeth G Holliday Peter Schofield Seung Hoan Choi Toshiko Tanaka Yang An Rodney T Perry Richard E Kennedy Michèle M Sale Jing Wang Virginia G Wadley David C Liewald Paul M Ridker Alan J Gow Alison Pattie John M Starr David Porteous Xuan Liu Russell Thomson Nicola J Armstrong Gudny Eiriksdottir Arezoo A Assareh Nicole A Kochan Elisabeth Widen Aarno Palotie Yi-Chen Hsieh Johan G Eriksson Christian Vogler John C van Swieten Joshua M Shulman Alexa Beiser Jerome Rotter Carsten O Schmidt Wolfgang Hoffmann Markus M Nöthen Luigi Ferrucci John Attia Andre G Uitterlinden Philippe Amouyel Jean-François Dartigues Hélène Amieva Katri Räikkönen Melissa Garcia Philip A Wolf Albert Hofman W T Longstreth Bruce M Psaty Eric Boerwinkle Philip L DeJager Perminder S Sachdev Reinhold Schmidt Monique M B Breteler Alexander Teumer Oscar L Lopez Sven Cichon Daniel I Chasman Francine Grodstein Bertram Müller-Myhsok Christophe Tzourio Andreas Papassotiropoulos David A Bennett M Arfan Ikram Ian J Deary Cornelia M van Duijn Lenore Launer Annette L Fitzpatrick Sudha Seshadri Thomas H Mosley

Biol Psychiatry 2015 Apr 25;77(8):749-63. Epub 2014 Nov 25.

Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1016/j.biopsych.2014.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513651PMC
April 2015

Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies.

Epilepsia 2015 Feb 20;56(2):234-43. Epub 2014 Dec 20.

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/epi.12890DOI Listing
February 2015

Sources of CNS tumor heterogeneity.

Oncoscience 2014 2;1(7):482-3. Epub 2014 Jul 2.

Department of Physiology and Neurobiology, University of Connecticut, Storrs, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278322PMC
http://dx.doi.org/10.18632/oncoscience.60DOI Listing
January 2015

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.

Neuron 2014 Dec 13;84(5):1023-33. Epub 2014 Nov 13.

Neuronal Networks Group, Deutsches Zentrum für Neurodegenerative Erkrankungen, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany; Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53125 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.10.024DOI Listing
December 2014

WONOEP appraisal: new genetic approaches to study epilepsy.

Epilepsia 2014 Aug 25;55(8):1170-86. Epub 2014 Jun 25.

Pediatric & Neuroscience Department & Brain Disease Research Group, CHU Ste-Justine, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/epi.12692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126888PMC
August 2014

Epilepsies associated with hippocampal sclerosis.

Acta Neuropathol 2014 Jul 14;128(1):21-37. Epub 2014 May 14.

Department of Neurology, FCM, University of Campinas-UNICAMP, Campinas, SP, 13083-880, Brazil,

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http://link.springer.com/content/pdf/10.1007/s00401-014-1292
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http://dx.doi.org/10.1007/s00401-014-1292-0DOI Listing
July 2014

Contribution of tumor heterogeneity in a new animal model of CNS tumors.

Mol Cancer Res 2014 May 5;12(5):742-53. Epub 2014 Feb 5.

Authors' Affiliations: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut; and 2Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024448PMC
May 2014

Commentary: Morris-Coole/Epilepsia prize.

Epilepsia 2014 May 16;55(5):640-1. Epub 2014 May 16.

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http://dx.doi.org/10.1111/epi.12618DOI Listing
May 2014

BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression.

Brain Pathol 2014 Apr 29;24(3):221-9. Epub 2014 Jan 29.

Department of Neuropathology, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/bpa.12111DOI Listing
April 2014

Molecular biomarkers of epileptogenesis.

Neurotherapeutics 2014 Apr;11(2):319-23

The Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02 093, Warsaw, Poland,

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http://dx.doi.org/10.1007/s13311-014-0261-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996120PMC
April 2014

Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer.

Diagn Pathol 2014 Mar 4;9:48. Epub 2014 Mar 4.

Department of Cardiology, Angiology and Pneumology, University of Bonn Medical School, Sigmund-Freud-Strasse 25, Bonn 53127, Germany.

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http://dx.doi.org/10.1186/1746-1596-9-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975884PMC
March 2014

Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi.

Neurobiol Dis 2013 Dec 7;60:115-25. Epub 2013 Sep 7.

Dept. of Neuropathology, University of Bonn Medical Center, Germany.

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http://dx.doi.org/10.1016/j.nbd.2013.08.015DOI Listing
December 2013

Recent aspects of classification and epidemiology of epilepsy-associated tumors.

Epilepsia 2013 Dec;54 Suppl 9:5-11

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/epi.12436DOI Listing
December 2013

Focal cortical dysplasia type IIIc associates with multiple cerebral cavernomas.

Epilepsy Res 2013 Nov 5;107(1-2):190-4. Epub 2013 Aug 5.

Dept. of Neuropathology, University of Bonn Medical Center, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2013.07.006DOI Listing
November 2013

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue.

Seizure 2013 Oct 22;22(8):675-8. Epub 2013 May 22.

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1016/j.seizure.2013.04.023DOI Listing
October 2013

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.

Brain 2013 Oct 6;136(Pt 10):3140-50. Epub 2013 Sep 6.

1 NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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https://academic.oup.com/brain/article/136/10/3140/330027
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http://dx.doi.org/10.1093/brain/awt233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784283PMC
October 2013

Differences between RNA and DNA due to RNA editing in temporal lobe epilepsy.

Neurobiol Dis 2013 Aug 20;56:66-73. Epub 2013 Apr 20.

Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstr. 29, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.nbd.2013.04.006DOI Listing
August 2013

Outcome after epilepsy surgery in patients with MRI features of bilateral ammon's horn sclerosis.

Epilepsy Res 2013 Jul 13;105(1-2):150-7. Epub 2013 Mar 13.

Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.eplepsyres.2013.02.003DOI Listing
July 2013

RIM3γ and RIM4γ are key regulators of neuronal arborization.

J Neurosci 2013 Jan;33(2):824-39

Department of Neuropathology, Department of Epileptology, Laboratory for Experimental Epileptology and Cognition Research, University of Bonn, 53105 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.2229-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704911PMC
January 2013