Publications by authors named "Alastair R O Miller"

6 Publications

  • Page 1 of 1

HIV dementia: a diagnosis to keep in mind.

Br J Hosp Med (Lond) 2012 Jul;73(7):410-1

University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.12968/hmed.2012.73.7.410DOI Listing
July 2012

General physicians do not take adequate travel histories.

J Travel Med 2011 Jul-Aug;18(4):271-4. Epub 2011 Jun 15.

Acute Medical Unit, Royal Liverpool University Hospital, Liverpool, UK.

Background: Our aim was to document how often travel histories were taken and the quality of their content.

Methods: Patients admitted over 2 months to acute medical units of two hospitals in the Northwest of England with a history of fever, rash, diarrhea, vomiting, jaundice, or presenting as "unwell post-travel" were identified. The initial medical clerking was assessed.

Results: A total of 132 relevant admissions were identified. A travel history was documented in only 26 patients (19.7%). Of the 16 patients who had traveled, there was no documentation of pretravel advice or of sexual/other activities abroad in 15 (93.8%) and 12 (75.0%) patients, respectively.

Conclusions: There needs to be better awareness and education about travel-related illness and the importance of taking an adequate travel history.
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http://dx.doi.org/10.1111/j.1708-8305.2011.00521.xDOI Listing
October 2011

Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report.

J Med Case Rep 2008 Dec 4;2:370. Epub 2008 Dec 4.

Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK.

Introduction: Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneuropathy has occasionally been reported in acute Immunodeficiency Virus infection but little data exists on frequency, management and outcome.

Case Presentation: We describe an episode of Guillain-Barré syndrome presenting as acute inflammatory demyelinating polyneuropathy in a 30-year-old man testing positive for Immunodeficiency Virus, probably during acute seroconversion. Clinical suspicion was confirmed by cerebrospinal fluid analysis and nerve conduction studies. Rapid clinical deterioration prompted intravenous immunoglobulin therapy and early commencement of highly active anti-retroviral therapy. All symptoms resolved within nine weeks.

Conclusion: Unusual neurological presentations in previously fit patients are an appropriate indication for Immunodeficiency-Virus testing. Highly active anti-retroviral therapy with adequate penetration of the central nervous system should be considered as an early intervention, alongside conventional therapies such as intravenous immunoglobulin.
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http://dx.doi.org/10.1186/1752-1947-2-370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629480PMC
December 2008

Serum creatine phosphokinase monitoring in patients infected with HIV.

Int J STD AIDS 2006 Jan;17(1):61-2

Worcestershire HIV Clinic, Worcestershire Acute Hospitals NHS Trust, Worcestershire Royal Hospital, Charles Hastings Way, Worcester WR5 1DD, UK.

Creatine phosphokinase (CPK) estimations are done routinely in some HIV clinics, irrespective of patient symptoms. We studied patients attending the Worcestershire HIV clinic between 1987 and 2001 to identify whether routine elevations in serum levels of CPK in patients with HIV were associated with clinical features of muscle disease (CFMD), and whether such elevations influenced patient management. There was no association between CFMD and a rise in CPK. Major rises of CPK >400 IU/L were significantly associated with CFMD. No individual had a persistent CPK rise >200 IU/L without CFMD. In the great majority of cases, there was no change in management consequent to enzyme rises. In patients with HIV infection and no CFMD, the chance of finding a major and persistent CPK rise is low. This study does not support the practice of routine monitoring of CPK in asymptomatic patients attending HIV clinics.
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http://dx.doi.org/10.1258/095646206775220487DOI Listing
January 2006

Biological warfare and bioterrorism.

BMJ 2002 Feb;324(7333):336-9

Division of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5QA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1122269PMC
http://dx.doi.org/10.1136/bmj.324.7333.336DOI Listing
February 2002