Alan W Thomas

Alan W Thomas

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Alan W Thomas

Alan W Thomas

Publications by authors named "Alan W Thomas"

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Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques.

Malar J 2011 Jul 4;10:182. Epub 2011 Jul 4.

Department of Parasitology, Biomedical Primate Research Centre, Postbox 3306, 2280 GH, Rijswijk, The Netherlands.

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http://dx.doi.org/10.1186/1475-2875-10-182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142537PMC
July 2011

Plasmodium CDP-DAG synthase: an atypical gene with an essential N-terminal extension.

Int J Parasitol 2010 Sep 10;40(11):1257-68. Epub 2010 Apr 10.

CNRS UMR5235, University of Montpellier 2, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1016/j.ijpara.2010.03.006DOI Listing
September 2010

Red blood cell (RBC) membrane proteomics--Part I: Proteomics and RBC physiology.

J Proteomics 2010 Jan 21;73(3):403-20. Epub 2009 Jun 21.

Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.jprot.2009.06.005DOI Listing
January 2010

Red blood cell (RBC) membrane proteomics--Part II: Comparative proteomics and RBC patho-physiology.

J Proteomics 2010 Jan 19;73(3):421-35. Epub 2009 Jul 19.

Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.jprot.2009.07.004DOI Listing
January 2010

A novel method to clean protein G agarose for affinity column matrix with renewed binding capacity and high IgG selectivity.

J Immunol Methods 2010 Jan 3;352(1-2):192-4. Epub 2009 Nov 3.

Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.jim.2009.10.008DOI Listing
January 2010

Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.

PLoS One 2009 Dec 1;4(12):e8110. Epub 2009 Dec 1.

Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008110PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779588PMC
December 2009

Prospective identification of malaria parasite genes under balancing selection.

PLoS One 2009 15;4(5):e5568. Epub 2009 May 15.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679211PMC
August 2009

Transgenic Plasmodium knowlesi: relieving a bottleneck in malaria research?

Trends Parasitol 2009 Aug 25;25(8):370-4. Epub 2009 Jul 25.

Department of Parasitology, Biomedical Primate Research Centre, GH Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.pt.2009.05.009DOI Listing
August 2009

Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum.

Clin Vaccine Immunol 2008 Sep 11;15(9):1345-55. Epub 2008 Jun 11.

Centre for Medical Parasitology, Institute for International Health, Immunology and Microbiology, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1128/CVI.00172-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546674PMC
September 2008

Deep coverage mouse red blood cell proteome: a first comparison with the human red blood cell.

Mol Cell Proteomics 2008 Jul 14;7(7):1317-30. Epub 2008 Mar 14.

Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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http://dx.doi.org/10.1074/mcp.M700458-MCP200DOI Listing
July 2008

A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits.

Infect Immun 2008 Jun 31;76(6):2660-70. Epub 2008 Mar 31.

Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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http://dx.doi.org/10.1128/IAI.00170-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423090PMC
June 2008

Detection of new Babesia microti-like parasites in a rhesus monkey (Macaca mulatta) with a suppressed Plasmodium cynomolgi infection.

Am J Trop Med Hyg 2008 Apr;78(4):643-5

Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands.

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April 2008

Apical membrane antigen 1: a malaria vaccine candidate in review.

Trends Parasitol 2008 Feb 15;24(2):74-84. Epub 2008 Jan 15.

Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.pt.2007.12.002DOI Listing
February 2008

Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.

J Biol Chem 2007 Mar 27;282(10):7431-41. Epub 2006 Dec 27.

Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M610562200
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http://dx.doi.org/10.1074/jbc.M610562200DOI Listing
March 2007

Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation.

J Mol Biol 2007 Mar 16;366(5):1523-37. Epub 2006 Dec 16.

Unité d'Immunologie Structurale, CNRS URA 2185, Département de Biologie Structurale et Chimie, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris cedex 15, France.

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http://dx.doi.org/10.1016/j.jmb.2006.12.028DOI Listing
March 2007

Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens.

Int J Parasitol 2007 Jan 25;37(1):77-85. Epub 2006 Sep 25.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1016/j.ijpara.2006.09.001DOI Listing
January 2007

In-depth analysis of the membrane and cytosolic proteome of red blood cells.

Blood 2006 Aug;108(3):791-801

Department of Proteomics and Signal Transduction, Am Klopferspitz 18, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1182/blood-2005-11-007799DOI Listing
August 2006

Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.

Exp Parasitol 2006 Jul 3;113(3):197-200. Epub 2006 Feb 3.

Biomedical Primate Research Centre, Department of Parasitology, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S001448940500345
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http://dx.doi.org/10.1016/j.exppara.2005.12.016DOI Listing
July 2006

Orthologous gene sequences of merozoite surface protein 1 (MSP1) from Plasmodium reichenowi and P. gallinaceum confirm an ancient divergence of P. falciparum alleles.

Mol Biochem Parasitol 2005 Jul 20;142(1):25-31. Epub 2005 Apr 20.

London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2005.02.012DOI Listing
July 2005

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

Science 2005 Apr 24;308(5720):408-11. Epub 2005 Feb 24.

Unité d'Immunologie Structurale, Centre National de la Recherche Scientifique, URA 2185, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France.

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http://dx.doi.org/10.1126/science.1107449DOI Listing
April 2005

Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum.

Infect Immun 2005 Apr;73(4):2116-22

Department of Immunology, Walter Reed Army Institute of Research, Rm. 3W53, 503 Robert Grant Ave., Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.1128/IAI.73.4.2116-2122.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087451PMC
April 2005

Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion.

Mol Microbiol 2005 Mar;55(6):1925-34

Malaria Research Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04523.xDOI Listing
March 2005

Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1.

Int J Parasitol 2005 Feb 19;35(2):185-92. Epub 2004 Dec 19.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Prof Lineu Prestes, 580, Cidade Universitária, São Paulo SP 05508-900, Brazil.

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http://dx.doi.org/10.1016/j.ijpara.2004.11.003DOI Listing
February 2005

Merozoite surface proteins 4 and 5 of Plasmodium knowlesi have differing cellular localisation and association with lipid rafts.

Mol Biochem Parasitol 2004 Nov;138(1):153-8

Department of Microbiology and the Victorian Bioinformatics Consortium, Monash University, Clayton, Vic. 3800, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2004.07.006DOI Listing
November 2004

Expression, crystallization and preliminary structural analysis of the ectoplasmic region of apical membrane antigen 1 from Plasmodium vivax, a malaria-vaccine candidate.

Acta Crystallogr D Biol Crystallogr 2004 Nov 20;60(Pt 11):2040-3. Epub 2004 Oct 20.

Unité d'Immunologie Structurale, CNRS URA 2185, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris, France.

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http://dx.doi.org/10.1107/S090744490402116XDOI Listing
November 2004

TB diagnosis in non-human primates: comparison of two interferon-gamma assays and the skin test for identification of Mycobacterium tuberculosis infection.

Vet Immunol Immunopathol 2004 Jul;100(1-2):61-71

Department of Parasitology, Biomedical Primate Research Centre, P.O. Box 3306, 2280GH Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.vetimm.2004.03.003DOI Listing
July 2004

A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.

J Biol Chem 2004 Mar 15;279(10):9490-6. Epub 2003 Dec 15.

INSERM U511, Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Université Pierre et Marie Curie, 75013 Paris, France.

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http://www.jbc.org/content/279/10/9490.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M311331200
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http://dx.doi.org/10.1074/jbc.M311331200DOI Listing
March 2004

Plasmodium falciparum-activated chloride channels are defective in erythrocytes from cystic fibrosis patients.

J Biol Chem 2004 Mar 16;279(11):10316-22. Epub 2003 Dec 16.

Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M311540200DOI Listing
March 2004

New selectable markers and single crossover integration for the highly versatile Plasmodium knowlesi transfection system.

Mol Biochem Parasitol 2004 Mar;134(1):97-104

Department of Parasitology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/j.molbiopara.2003.10.019DOI Listing
March 2004

Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes.

Infect Immun 2004 Feb;72(2):1126-34

Cooperative Research Center for Diagnostics, Department of Biochemistry, La Trobe University, Victoria 3086, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321628PMC
http://dx.doi.org/10.1128/iai.72.2.1126-1134.2004DOI Listing
February 2004

Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development.

J Cell Sci 2003 Sep 5;116(Pt 18):3825-34. Epub 2003 Aug 5.

Department of Anatomy, Cell and Human Biology, Guy's, King's and St Thomas' School of Biomedical Science, Guy's Hospital, London SE1 1UL, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.00665
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http://dx.doi.org/10.1242/jcs.00665DOI Listing
September 2003

Experimental infection of the olive baboon (Paplio anubis) with Plasmodium knowlesi: severe disease accompanied by cerebral involvement.

Am J Trop Med Hyg 2003 Aug;69(2):188-94

Institute of Primate Research, National Museums of Kenya, Karen, Nairobi, Kenya.

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August 2003

Heterologous promoter activity in stable and transient Plasmodium knowlesi transgenes.

Mol Biochem Parasitol 2003 Aug;130(1):61-4

Department of Parasitology, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands.

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http://dx.doi.org/10.1016/s0166-6851(03)00141-5DOI Listing
August 2003

Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax.

Genetics 2003 Apr;163(4):1327-36

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462517PMC
April 2003

A novel and sensitive method to monitor helminth infections by faecal sampling.

Acta Trop 2002 Aug;83(2):183-7

Department of Biology, University of York, P.O. Box 373, York YO10 5YW, UK.

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http://dx.doi.org/10.1016/s0001-706x(02)00089-xDOI Listing
August 2002

A class of potent antimalarials and their specific accumulation in infected erythrocytes.

Science 2002 Feb;295(5558):1311-4

CNRS UMR 5539, CP 107, CNRS UMR 5810, CP 22, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5, France.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1067236
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http://dx.doi.org/10.1126/science.1067236DOI Listing
February 2002