Alan V Smrcka

Alan V Smrcka

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Alan V Smrcka

Publications by authors named "Alan V Smrcka"

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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP)-Dependent Rac Exchanger 1 (P-Rex1) PIP-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.

Mol Pharmacol 2020 Mar 3;97(3):226-236. Epub 2020 Jan 3.

Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana

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http://dx.doi.org/10.1124/mol.119.117556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994817PMC
March 2020

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling.

Cell Mol Life Sci 2019 Nov 21;76(22):4447-4459. Epub 2019 Aug 21.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48104, USA.

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http://dx.doi.org/10.1007/s00018-019-03275-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842434PMC
November 2019

Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.

Immunity 2019 08 6;51(2):298-309.e6. Epub 2019 Aug 6.

David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904228PMC
August 2019

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy.

Elife 2019 08 21;8. Epub 2019 Aug 21.

Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, United States.

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http://dx.doi.org/10.7554/eLife.48167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726460PMC
August 2019

Targeting G protein-coupled receptor signalling by blocking G proteins.

Nat Rev Drug Discov 2018 11 28;17(11):789-803. Epub 2018 Sep 28.

Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/nrd.2018.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409483PMC
November 2018

Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.

Sci Signal 2018 09 11;11(547). Epub 2018 Sep 11.

Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1126/scisignal.aan1210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413320PMC
September 2018

Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.

J Mol Cell Cardiol 2018 08 7;121:51-59. Epub 2018 Jun 7.

Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373484PMC
August 2018

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5.

Mol Pharmacol 2018 05 23;93(5):477-488. Epub 2018 Feb 23.

Departments of Pharmacology (H.M.S., A.V.S., G.G.T.) and Medicinal Chemistry (S.D.L.), University of Michigan, Ann Arbor, Michigan

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.111476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878671PMC
May 2018

G protein βγ subunits directly interact with and activate phospholipase Cϵ.

J Biol Chem 2018 04 13;293(17):6387-6397. Epub 2018 Mar 13.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109

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http://dx.doi.org/10.1074/jbc.RA118.002354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925795PMC
April 2018

Activated heterotrimeric G protein α subunits inhibit Rap-dependent cell adhesion and promote cell migration.

J Biol Chem 2018 02 19;293(5):1570-1578. Epub 2017 Dec 19.

From the Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, 14623 and

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http://dx.doi.org/10.1074/jbc.RA117.000964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798289PMC
February 2018

Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.

PLoS One 2016 9;11(9):e0162338. Epub 2016 Sep 9.

Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, 14642, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017709PMC
August 2017

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.

Nat Commun 2017 05 15;8:15365. Epub 2017 May 15.

Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/ncomms15365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440668PMC
May 2017

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.

J Neurosci 2017 03 16;37(11):3030-3044. Epub 2017 Feb 16.

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226,

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http://dx.doi.org/10.1523/JNEUROSCI.2810-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354337PMC
March 2017

PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation.

Proc Natl Acad Sci U S A 2017 03 17;114(10):2693-2698. Epub 2017 Feb 17.

Department of Medicine, New York University School of Medicine, New York, NY 10016;

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http://dx.doi.org/10.1073/pnas.1612900114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347583PMC
March 2017

Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.

Arthritis Rheumatol 2016 09;68(9):2244-56

University of Rochester School of Medicine, Rochester, New York.

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http://dx.doi.org/10.1002/art.39673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001921PMC
September 2016

Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.

Mol Pharmacol 2016 09 23;90(3):214-24. Epub 2016 Jun 23.

Department of Pharmacology and Physiology (H.M.S., L.L.B., M.W.A., A.P.W., A.V.S.), and Department of Anesthesiology (L.L.B., A.P.W.), University of Rochester Medical Center, Rochester, New York; and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (G.G.T.)

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http://dx.doi.org/10.1124/mol.116.104828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998661PMC
September 2016

Phospholipase C-ε signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury.

Am J Physiol Lung Cell Mol Physiol 2016 08 1;311(2):L517-24. Epub 2016 Jul 1.

Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York;

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http://ajplung.physiology.org/lookup/doi/10.1152/ajplung.000
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http://dx.doi.org/10.1152/ajplung.00069.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243226PMC
August 2016

Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ.

Sci Signal 2016 Feb 23;9(416):ra22. Epub 2016 Feb 23.

Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA. Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1126/scisignal.aad8163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364554PMC
February 2016

Fingerprinting G protein-coupled receptor signaling.

Authors:
Alan V Smrcka

Sci Signal 2015 Dec 1;8(405):fs20. Epub 2015 Dec 1.

Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aad8
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http://dx.doi.org/10.1126/scisignal.aad8140DOI Listing
December 2015

Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.

Mol Pharmacol 2015 Oct 23;88(4):758-67. Epub 2015 Jul 23.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas (C.S.B., C.W.D.); Department of Natural Sciences, University of Houston-Downtown, Houston, Texas (R.S.); and Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York (S.M., A.V.S.)

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http://dx.doi.org/10.1124/mol.115.099556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576683PMC
October 2015

Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes.

Authors:
Alan V Smrcka

J Cardiovasc Pharmacol 2015 Mar;65(3):203-10

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY.

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http://dx.doi.org/10.1097/FJC.0000000000000195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355108PMC
March 2015

Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression.

J Am Coll Cardiol 2014 Jun 2;63(23):2549-2557. Epub 2014 Apr 2.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2014.02.587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083020PMC
June 2014

A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.

J Biol Chem 2014 Jun 7;289(25):17791-801. Epub 2014 May 7.

From the Departments of Biochemistry and Biophysics and Pharmacology and Physiology, University of Rochester, Rochester, New York 14642

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http://dx.doi.org/10.1074/jbc.M114.576827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067212PMC
June 2014

WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.

J Biol Chem 2013 Jun 26;288(23):16715-25. Epub 2013 Apr 26.

Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M113.462564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675605PMC
June 2013

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.

Authors:
Alan V Smrcka

Trends Pharmacol Sci 2013 May 1;34(5):290-8. Epub 2013 Apr 1.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

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http://dx.doi.org/10.1016/j.tips.2013.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924570PMC
May 2013

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Cell 2013 Mar;153(1):216-27

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.cell.2013.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615249PMC
March 2013

Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.

Proc Natl Acad Sci U S A 2013 Feb 11;110(9):3609-14. Epub 2013 Feb 11.

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1217355110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587233PMC
February 2013

Role of phospholipase Cε in physiological phosphoinositide signaling networks.

Cell Signal 2012 Jun 20;24(6):1333-43. Epub 2012 Jan 20.

Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.cellsig.2012.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325758PMC
June 2012

Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits.

J Mol Cell Cardiol 2011 Oct 21;51(4):462-7. Epub 2011 Jan 21.

Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137754PMC
October 2011

Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting.

Mol Pharmacol 2011 Oct 7;80(4):551-7. Epub 2011 Jul 7.

Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1124/mol.111.073072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187535PMC
October 2011

Direct-reversible binding of small molecules to G protein βγ subunits.

Biochim Biophys Acta 2011 Sep 18;1814(9):1210-8. Epub 2011 May 18.

Department of Pharmacology and Physiology, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.bbapap.2011.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140432PMC
September 2011

Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes.

J Biol Chem 2011 Jul 5;286(26):23012-21. Epub 2011 May 5.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M111.231993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123069PMC
July 2011

Conformational flexibility and binding interactions of the G protein βγ heterodimer.

Proteins 2011 Feb;79(2):518-27

Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1002/prot.22899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974715PMC
February 2011

Rational design of a selective covalent modifier of G protein βγ subunits.

Mol Pharmacol 2011 Jan 29;79(1):24-33. Epub 2010 Sep 29.

Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA.

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http://dx.doi.org/10.1124/mol.110.068155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014279PMC
January 2011

Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf).

J Biol Chem 2011 Jan 29;286(4):2625-35. Epub 2010 Nov 29.

Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M110.178897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024758PMC
January 2011

Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes.

J Biol Chem 2010 Dec 26;285(53):41356-65. Epub 2010 Oct 26.

Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.159111
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http://dx.doi.org/10.1074/jbc.M110.159111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009861PMC
December 2010

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.

Circ Res 2010 Aug 24;107(4):532-9. Epub 2010 Jun 24.

Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.217075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924955PMC
August 2010

Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1.

J Biol Chem 2010 Jan 28;285(1):620-30. Epub 2009 Oct 28.

Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M109.027508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804210PMC
January 2010

Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.

J Biol Chem 2009 Oct 27;284(42):28599-606. Epub 2009 Aug 27.

Program for Vascular Biology and Therapeutics and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520,, USA.

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http://dx.doi.org/10.1074/jbc.M109.047282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781403PMC
October 2009

Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits.

J Chem Inf Model 2009 Feb;49(2):437-43

Departments of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14627, USA.

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http://pubs.acs.org/doi/abs/10.1021/ci800384q
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846521PMC
http://dx.doi.org/10.1021/ci800384qDOI Listing
February 2009

Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

J Biol Chem 2009 Jan 27;284(3):1514-22. Epub 2008 Oct 27.

Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M806994200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615515PMC
January 2009

A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence.

J Neurosci 2008 Nov;28(47):12183-9

Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642-8711, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2326-08.2
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http://dx.doi.org/10.1523/JNEUROSCI.2326-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646892PMC
November 2008

G protein betagamma subunits as targets for small molecule therapeutic development.

Comb Chem High Throughput Screen 2008 Jun;11(5):382-95

Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688719PMC
http://dx.doi.org/10.2174/138620708784534761DOI Listing
June 2008

Analysis and pharmacological targeting of phospholipase C beta interactions with G proteins.

Methods Enzymol 2007 ;434:29-48

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)34003-2DOI Listing
December 2007

Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation.

Proc Natl Acad Sci U S A 2007 Sep 18;104(39):15543-8. Epub 2007 Sep 18.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0702943104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000505PMC
September 2007

Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8.

J Biol Chem 2007 Jul 19;282(27):19938-47. Epub 2007 Apr 19.

Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M700396200DOI Listing
July 2007

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins.

J Neurosci 2007 May;27(20):5484-94

Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1421-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655354PMC
May 2007

Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.

Pharmacol Ther 2007 Mar 28;113(3):488-506. Epub 2006 Nov 28.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, United States.

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http://dx.doi.org/10.1016/j.pharmthera.2006.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978177PMC
March 2007

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.

J Biol Chem 2007 Feb 17;282(8):5488-95. Epub 2006 Dec 17.

Department of Pharmacology, University of Rochester School of Medicine, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M608495200DOI Listing
February 2007

Differential targeting of Gbetagamma-subunit signaling with small molecules.

Science 2006 Apr;312(5772):443-6

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1126/science.1120378DOI Listing
April 2006

G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner.

J Biol Chem 2006 Feb 28;281(5):2639-48. Epub 2005 Nov 28.

Department of Medicine and Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.

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http://dx.doi.org/10.1074/jbc.M507681200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483126PMC
February 2006

A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.

Mol Endocrinol 2006 Jan 11;20(1):136-46. Epub 2005 Aug 11.

Endocrine Unit, Massachusetts General Hospital, Boston, Massachuesetts 02114, USA.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2005-0169DOI Listing
January 2006

Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma.

Proc Natl Acad Sci U S A 2006 Jan 9;103(3):797-802. Epub 2006 Jan 9.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1073/pnas.0507467103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334649PMC
January 2006

Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.

Circ Res 2005 Dec 17;97(12):1305-13. Epub 2005 Nov 17.

Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1161/01.RES.0000196578.15385.bbDOI Listing
December 2005

Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits.

Biochemistry 2005 Aug;44(31):10593-604

Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 9050, Dallas, Texas 75390-9050, USA.

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http://dx.doi.org/10.1021/bi050655iDOI Listing
August 2005

Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells.

Mol Pharmacol 2005 Jul 31;68(1):129-36. Epub 2005 Mar 31.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Box 711, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1124/mol.104.010116DOI Listing
July 2005

Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.

J Biol Chem 2005 Mar 16;280(11):10174-81. Epub 2004 Dec 16.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester, New York 14642, USA,

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http://dx.doi.org/10.1074/jbc.M412514200DOI Listing
March 2005

Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.

J Biol Chem 2004 Nov 2;279(46):48055-62. Epub 2004 Sep 2.

Pharmacology and Anesthesiology, University of Illinois, College of Medicine, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1074/jbc.M405837200DOI Listing
November 2004

Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells.

Methods Mol Biol 2004 ;237:55-64

Department of Pharmacology and Physiology, University of Rochester School of Medicine, NY, USA.

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http://dx.doi.org/10.1385/1-59259-430-1:55DOI Listing
February 2004

Assay for G protein-dependent activation of phospholipase C beta using purified protein components.

Methods Mol Biol 2004 ;237:67-75

Department of Pharmacology and Physiology, University of Rochester School of Medicine, NY, USA.

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http://dx.doi.org/10.1385/1-59259-430-1:67DOI Listing
February 2004

Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.

Biochem J 2004 Feb;378(Pt 1):129-39

Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.

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http://dx.doi.org/10.1042/BJ20031370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223921PMC
February 2004

Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation.

J Biol Chem 2003 Sep 24;278(37):34747-50. Epub 2003 Jul 24.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.C300271200DOI Listing
September 2003

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

Cell 2003 Jul;114(2):215-27

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00559-2DOI Listing
July 2003

Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.

J Biol Chem 2003 May 20;278(22):19634-41. Epub 2003 Mar 20.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M300052200DOI Listing
May 2003

Discovery of ligands for beta gamma subunits from phage-displayed peptide libraries.

Methods Enzymol 2002 ;344:557-76

Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987783PMC
http://dx.doi.org/10.1016/s0076-6879(02)44740-4DOI Listing
June 2002