Publications by authors named "Alan V Boddy"

75Publications

Is there scope for better individualisation of anthracycline cancer chemotherapy?

Br J Clin Pharmacol 2020 Oct 28. Epub 2020 Oct 28.

School of Pharmacy and Medical Sciences and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA, Australia.

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http://dx.doi.org/10.1111/bcp.14628DOI Listing
October 2020

Physiologically-Based Pharmacokinetic Predictions of the Effect of Curcumin on Metabolism of Imatinib and Bosutinib: In Vitro and In Vivo Disconnect.

Pharm Res 2020 Jun 11;37(7):128. Epub 2020 Jun 11.

Sydney Pharmacy School, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s11095-020-02834-8DOI Listing
June 2020

Clinical Pharmacokinetic and Pharmacodynamic Considerations in the (Modern) Treatment of Melanoma.

Clin Pharmacokinet 2019 08;58(8):1029-1043

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia.

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http://link.springer.com/10.1007/s40262-019-00753-5
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http://dx.doi.org/10.1007/s40262-019-00753-5DOI Listing
August 2019

Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort.

Clin Pharmacokinet 2019 07;58(7):911-926

The University of Sydney, Sydney Pharmacy School, Pharmacy and Bank Building (A15), Camperdown, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s40262-019-00736-6DOI Listing
July 2019

Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia.

Cancer Chemother Pharmacol 2019 04 19;83(4):693-704. Epub 2019 Jan 19.

Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/s00280-019-03780-yDOI Listing
April 2019

A Strategy to Refine the Phenotyping Approach and Its Implementation to Predict Drug Clearance: A Physiologically Based Pharmacokinetic Simulation Study.

CPT Pharmacometrics Syst Pharmacol 2018 12 24;7(12):798-808. Epub 2018 Oct 24.

Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales, Australia.

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http://doi.wiley.com/10.1002/psp4.12355
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http://dx.doi.org/10.1002/psp4.12355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310868PMC
December 2018

The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients.

Eur J Clin Pharmacol 2018 Dec 30;74(12):1575-1584. Epub 2018 Aug 30.

School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

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http://link.springer.com/10.1007/s00228-018-2544-z
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http://dx.doi.org/10.1007/s00228-018-2544-zDOI Listing
December 2018

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions.

Expert Opin Drug Metab Toxicol 2017 Sep 10;13(9):953-972. Epub 2017 Aug 10.

a Faculty of Pharmacy , The University of Sydney , Sydney , Australia.

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http://dx.doi.org/10.1080/17425255.2017.1360279DOI Listing
September 2017

Pharmacogenetic association of MBL2 and CD95 polymorphisms with grade 3 infection following adjuvant therapy for breast cancer with doxorubicin and cyclophosphamide.

Eur J Cancer 2017 01 8;71:15-24. Epub 2016 Dec 8.

Faculty of Pharmacy, Pharmacy and Bank Building (A15), University of Sydney, Science Road, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.10.035DOI Listing
January 2017

Pharmacokinetics of dabrafenib in a patient with metastatic melanoma undergoing haemodialysis.

Pigment Cell Melanoma Res 2017 01;30(1):68-71

Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia.

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http://dx.doi.org/10.1111/pcmr.12557DOI Listing
January 2017

The path to implementation of personalized medicine of aromatase inhibitors in patients with breast cancer.

Pharmacogenomics 2016 Nov 28;17(17):1861-1864. Epub 2016 Oct 28.

Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.2217/pgs-2016-0141DOI Listing
November 2016

Pharmacokinetic and pharmacodynamic study of doxorubicin in children with cancer: results of a "European Pediatric Oncology Off-patents Medicines Consortium" trial.

Cancer Chemother Pharmacol 2016 Dec 21;78(6):1175-1184. Epub 2016 Oct 21.

Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00280-016-3174-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114325PMC
December 2016

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours.

Eur J Cancer 2016 11 28;68:1-10. Epub 2016 Sep 28.

Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK; Northern Centre for Cancer Care, Newcastle Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.08.026DOI Listing
November 2016

Towards a Model-Based Dose Recommendation for Doxorubicin in Children.

Clin Pharmacokinet 2017 03;56(3):215-223

Paediatric Haematology and Oncology, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s40262-016-0451-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315724PMC
March 2017

Monte Carlo simulations of the clinical benefits from therapeutic drug monitoring of sunitinib in patients with gastrointestinal stromal tumours.

Cancer Chemother Pharmacol 2016 07 13;78(1):209-16. Epub 2016 Jun 13.

Discipline of Clinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.

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http://dx.doi.org/10.1007/s00280-016-3071-1DOI Listing
July 2016

The implications of genetic variation for the pharmacokinetics and pharmacodynamics of aromatase inhibitors.

Expert Opin Drug Metab Toxicol 2016 Aug 16;12(8):851-63. Epub 2016 Jun 16.

a Faculty of Pharmacy , University of Sydney , Sydney , Australia.

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http://dx.doi.org/10.1080/17425255.2016.1196189DOI Listing
August 2016

Imagestream detection and characterisation of circulating tumour cells - A liquid biopsy for hepatocellular carcinoma?

J Hepatol 2016 08 27;65(2):305-13. Epub 2016 Apr 27.

Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK; The Liver Group, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals, NHS Foundation Trust, UK.

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http://dx.doi.org/10.1016/j.jhep.2016.04.014DOI Listing
August 2016

Cyclophosphamide pharmacokinetics and pharmacogenetics in children with B-cell non-Hodgkin's lymphoma.

Eur J Cancer 2016 Mar 12;55:56-64. Epub 2016 Jan 12.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom; Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1016/j.ejca.2015.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778608PMC
March 2016

Genetic variants in the HER2 gene: Influence on HER2 overexpression and loss of heterozygosity in breast cancer.

Eur J Cancer 2016 Mar 8;55:27-37. Epub 2016 Jan 8.

Northern Institute for Cancer Research, Newcastle University, Paul O'Gorman Building, Medical School, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.10.066DOI Listing
March 2016

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

Br J Clin Pharmacol 2016 May 25;81(5):989-98. Epub 2016 Feb 25.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/bcp.12878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834588PMC
May 2016

Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer.

Sci Rep 2015 Aug 3;5:11878. Epub 2015 Aug 3.

1] Faculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia [2] Department of Nanobiomedical Science &BK21 Plus NBM Global Research Center of Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea.

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http://dx.doi.org/10.1038/srep11878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522685PMC
August 2015

Age-Dependent Pharmacokinetics of Doxorubicin in Children with Cancer.

Clin Pharmacokinet 2015 Nov;54(11):1139-49

Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Corrensstraße 48, 48149, Muenster, Germany.

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http://dx.doi.org/10.1007/s40262-015-0272-4DOI Listing
November 2015

Pharmacogenetics of adjuvant breast cancer treatment with cyclophosphamide, epirubicin and 5-fluorouracil.

Cancer Chemother Pharmacol 2014 Oct 24;74(4):667-74. Epub 2014 Jul 24.

Northern Institute for Cancer Research Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00280-014-2541-6DOI Listing
October 2014

Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer.

Clin Pharmacokinet 2014 Aug;53(8):741-51

Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s40262-014-0153-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111883PMC
August 2014

Sources of preanalytical error in pharmacokinetic analyses - focus on intravenous drug administration and collection of blood samples.

Expert Opin Drug Metab Toxicol 2014 Jun 16;10(6):825-38. Epub 2014 Apr 16.

University Hospital Muenster, Centre for Clinical Trials (ZKS) , Von-Esmarch-Straße 62, 48149 Muenster , Germany +49 251 83 57104 ; +49 251 57026 ;

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http://www.tandfonline.com/doi/full/10.1517/17425255.2014.90
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http://dx.doi.org/10.1517/17425255.2014.907273DOI Listing
June 2014

Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years.

Cancer Chemother Pharmacol 2013 Mar 13;71(3):749-63. Epub 2013 Jan 13.

Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Hittorfstraße 58-62, 48149 Muenster, Germany.

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http://dx.doi.org/10.1007/s00280-013-2069-1DOI Listing
March 2013

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.

Biochem Pharmacol 2013 Jan 11;85(1):29-37. Epub 2012 Oct 11.

Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.bcp.2012.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545186PMC
January 2013

Chemotherapy in newborns and preterm babies.

Semin Fetal Neonatal Med 2012 Aug 28;17(4):243-248. Epub 2012 Mar 28.

Newcastle Cancer Centre at the Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4H, UK.

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http://dx.doi.org/10.1016/j.siny.2012.03.002DOI Listing
August 2012

Minimization of the preanalytical error in plasma samples for pharmacokinetic analyses and therapeutic drug monitoring--using doxorubicin as an example.

Ther Drug Monit 2011 Dec;33(6):766-71

Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Muenster, Germany.

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http://dx.doi.org/10.1097/FTD.0b013e31823aa8abDOI Listing
December 2011

Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy.

Pharmacogenet Genomics 2011 Dec;21(12):808-19

Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1097/FPC.0b013e32834b6918DOI Listing
December 2011

Pharmacogenetics of genes across the doxorubicin pathway.

Expert Opin Drug Metab Toxicol 2011 Oct;7(10):1201-10

Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1517/17425255.2011.610180DOI Listing
October 2011

Pharmacokinetics of cyclophosphamide and its metabolites in paediatric patients receiving high-dose myeloablative therapy.

Eur J Cancer 2011 Jul 7;47(10):1556-63. Epub 2011 Apr 7.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.ejca.2011.03.008DOI Listing
July 2011

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

Drug Metab Dispos 2010 Aug 26;38(8):1261-6. Epub 2010 Apr 26.

Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1124/dmd.109.030866DOI Listing
August 2010

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

Drug Metab Dispos 2010 Jul 22;38(7):1211-7. Epub 2010 Mar 22.

Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1124/dmd.109.031625DOI Listing
July 2010

Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients.

Cancer Chemother Pharmacol 2010 May 23;65(6):1057-66. Epub 2009 Aug 23.

Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00280-009-1111-9DOI Listing
May 2010

Development and validation of cell-based ELISA for the quantification of trastuzumab in human plasma.

J Immunol Methods 2009 Jun 17;345(1-2):106-11. Epub 2009 Apr 17.

Northern Institute for Cancer Research, University of Newcastle upon Tyne, Paul O'Gorman Building, Medical School, Newcastle upon Tyne, NE2 4HH, UK.

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http://www.ufjf.br/ppgpmi/files/2010/11/3-Cell-based-ELISA-f
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http://linkinghub.elsevier.com/retrieve/pii/S002217590900109
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http://dx.doi.org/10.1016/j.jim.2009.04.006DOI Listing
June 2009

Population pharmacokinetic investigation of actinomycin-D in children and young adults.

J Clin Pharmacol 2008 Jan;48(1):35-42

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1177/0091270007310383
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http://dx.doi.org/10.1177/0091270007310383DOI Listing
January 2008

Pharmacokinetic investigation of imatinib using accelerator mass spectrometry in patients with chronic myeloid leukemia.

Clin Cancer Res 2007 Jul;13(14):4164-9

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2179DOI Listing
July 2007

Recent developments in the clinical pharmacology of classical cytotoxic chemotherapy.

Authors:
Alan V Boddy

Br J Clin Pharmacol 2006 Jul;62(1):27-34

Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne, UK.

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http://doi.wiley.com/10.1111/j.1365-2125.2006.02714.x
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http://dx.doi.org/10.1111/j.1365-2125.2006.02714.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885069PMC
July 2006

An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.

Cancer Chemother Pharmacol 2007 Feb 24;59(2):197-206. Epub 2006 May 24.

Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00280-006-0258-xDOI Listing
February 2007

Biliary excretion of etoposide in children with cancer.

Cancer Chemother Pharmacol 2006 Sep 18;58(3):415-7. Epub 2006 Jan 18.

Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00280-005-0180-7DOI Listing
September 2006

Potential clinical impact of taking multiple blood samples for research studies in paediatric oncology: how much do we really know?

Pediatr Blood Cancer 2006 Jun;46(7):723-7

Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/pbc.20463DOI Listing
June 2006

Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy.

Cancer Chemother Pharmacol 2004 Oct 4;54(4):295-300. Epub 2004 May 4.

Northern Institute for Cancer Research, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00280-004-0820-3DOI Listing
October 2004

Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma.

Clin Cancer Res 2004 Jan;10(2):455-60

Department of Child Health, Yorkhill National Health Service Trust, Glasgow, United Kongdom.

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http://dx.doi.org/10.1158/1078-0432.ccr-0844-03DOI Listing
January 2004

Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2003 Oct;795(2):237-43

Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/s1570-0232(03)00573-7DOI Listing
October 2003

Chemotherapy individualization.

Invest New Drugs 2003 May;21(2):149-56

Northern Institute for Cancer Research, Cancer Research Unit, Medical School, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1023/a:1023517311879DOI Listing
May 2003

Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma.

J Clin Oncol 2002 Aug;20(16):3533-44

Department of Medical Oncology, Northern Centre for Cancer Treatment, Newcastle General Hospital, Westgate Road, Newcastle Upon Tyne NE4 6BE, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2002.10.073DOI Listing
August 2002

Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells.

Biochem Pharmacol 2002 Jan;63(2):207-15

Cancer Research Unit, Medical School, University of Newcastle-upon-Tyne, NE2 4HH, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1016/s0006-2952(01)00844-9DOI Listing
January 2002