Alan Saghatelian

Alan Saghatelian

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Alan Saghatelian

Publications by authors named "Alan Saghatelian"

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Substrate-Selective Enzyme Inhibitors.

Trends Pharmacol Sci 2019 Oct 2;40(10):716-718. Epub 2019 Aug 2.

The Salk Institute for Biological Studies, Clayton Foundation Laboratories for Peptide Biology, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.07.009DOI Listing
October 2019

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.

J Clin Invest 2019 Oct;129(10):4138-4150

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI127092DOI Listing
October 2019

Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids.

Org Lett 2019 Oct 23;21(19):8080-8084. Epub 2019 Sep 23.

Skaggs School of Pharmacy and Pharmaceutical Sciences , UC San Diego , 9500 Gilman Drive , La Jolla , California 92093-0934 , United States.

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http://dx.doi.org/10.1021/acs.orglett.9b03054DOI Listing
October 2019

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

J Clin Invest 2019 08 5;129:3717-3731. Epub 2019 Aug 5.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI122445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715391PMC
August 2019

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals.

J Biol Chem 2019 Jul 31;294(27):10698-10707. Epub 2019 May 31.

From the Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, California 92037,

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http://dx.doi.org/10.1074/jbc.RA118.006956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615670PMC
July 2019

Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA.

J Antibiot (Tokyo) 2019 06 15;72(6):498-506. Epub 2019 Apr 15.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0934, USA.

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http://www.nature.com/articles/s41429-019-0180-1
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http://dx.doi.org/10.1038/s41429-019-0180-1DOI Listing
June 2019

Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.

J Am Chem Soc 2019 Jun 13;141(22):8798-8806. Epub 2019 May 13.

Clayton Foundation Laboratories for Peptide Biology , Salk Institute for Biological Studies , 10010 North Torrey Pines Road , La Jolla , California 92037-1002 , United States.

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http://dx.doi.org/10.1021/jacs.9b00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662584PMC
June 2019

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.

Genes Dev 2019 04 28;33(7-8):418-435. Epub 2019 Feb 28.

Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.322339.118
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http://dx.doi.org/10.1101/gad.322339.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446539PMC
April 2019

A Hidden ORF Reveals an Immune Protector.

Biochemistry 2019 Feb 6;58(8):1022-1023. Epub 2019 Feb 6.

Clayton Foundation Laboratories for Peptide Biology , Salk Institute for Biological Studies , 10010 North Torrey Pines Road , La Jolla , California 92037-1002 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b01317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443401PMC
February 2019

Small, but mighty? Searching for human microproteins and their potential for understanding health and disease.

Expert Rev Proteomics 2018 12 15;15(12):963-965. Epub 2018 Nov 15.

a Clayton Foundation Laboratories for Peptide Biology , The Salk Institute for Biological Studies , La Jolla , CA , USA.

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https://www.tandfonline.com/doi/full/10.1080/14789450.2018.1
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http://dx.doi.org/10.1080/14789450.2018.1547194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497149PMC
December 2018

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Cell Metab 2018 10 20;28(4):543-546. Epub 2018 Sep 20.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542592PMC
October 2018

MIEF1 Microprotein Regulates Mitochondrial Translation.

Biochemistry 2018 09 14;57(38):5564-5575. Epub 2018 Sep 14.

Clayton Foundation Laboratories for Peptide Biology , The Salk Institute for Biological Studies , 10010 North Torrey Pines Road , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443411PMC
September 2018

The influence of transcript assembly on the proteogenomics discovery of microproteins.

PLoS One 2018 27;13(3):e0194518. Epub 2018 Mar 27.

Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194518PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870951PMC
July 2018

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.

Nat Commun 2018 07 20;9(1):2872. Epub 2018 Jul 20.

Regulatory Biology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41467-018-05336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054678PMC
July 2018

Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.

Anal Chem 2018 04 26;90(8):5358-5365. Epub 2018 Mar 26.

Clayton Foundation Laboratories for Peptide Biology , Salk Institute for Biological Studies , 10010 North Torrey Pines Road , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b00503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962352PMC
April 2018

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Cell Metab 2018 02;27(2):419-427.e4

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Center for Life Sciences, Room 747, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807007PMC
February 2018

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.

Nature 2018 01 10;553(7688):351-355. Epub 2018 Jan 10.

Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://www.nature.com/doifinder/10.1038/nature25170
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http://dx.doi.org/10.1038/nature25170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924733PMC
January 2018

Novel Biology and Druggable Targets via Chemoproteomics.

Authors:
Alan Saghatelian

Biochemistry 2017 12 7;56(50):6515-6516. Epub 2017 Dec 7.

Salk Institute for Biological Studies , 10010 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b01167DOI Listing
December 2017

Identification of Microprotein-Protein Interactions via APEX Tagging.

Biochemistry 2017 07 7;56(26):3299-3306. Epub 2017 Jun 7.

Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies , 10010 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499098PMC
July 2017

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.

J Am Chem Soc 2017 04 28;139(13):4943-4947. Epub 2017 Mar 28.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego , 9500 Gilman Drive, La Jolla, California 92093-0934, United States.

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http://pubs.acs.org/doi/10.1021/jacs.7b01269
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http://dx.doi.org/10.1021/jacs.7b01269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568760PMC
April 2017

Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis.

Endocrinology 2017 03;158(3):477-489

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1210/en.2016-1570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460780PMC
March 2017

A human microprotein that interacts with the mRNA decapping complex.

Nat Chem Biol 2017 02 5;13(2):174-180. Epub 2016 Dec 5.

Department of Chemistry and Chemical Biology, Chemical Biology Institute, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nchembio.2249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247292PMC
February 2017

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.

Cell Metab 2017 02 12;25(2):463-471. Epub 2017 Jan 12.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299044PMC
February 2017

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Nature 2017 01 26;541(7636):228-232. Epub 2016 Dec 26.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/nature21034
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http://dx.doi.org/10.1038/nature21034DOI Listing
January 2017

Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.

Proc Natl Acad Sci U S A 2017 01 3;114(3):580-585. Epub 2017 Jan 3.

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1614035114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255630PMC
January 2017

Glucagon and Thyroid Hormone: A Championship Team.

Cell 2016 Oct;167(3):604-605

Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.008DOI Listing
October 2016

Revealing disease-associated pathways by network integration of untargeted metabolomics.

Nat Methods 2016 09 1;13(9):770-6. Epub 2016 Aug 1.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209295PMC
September 2016

HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective.

J Am Chem Soc 2016 08 19;138(30):9473-8. Epub 2016 Jul 19.

Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies , 10010 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063305PMC
http://dx.doi.org/10.1021/jacs.6b03463DOI Listing
August 2016

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Biochemistry 2016 08 10;55(33):4636-41. Epub 2016 Aug 10.

Peptide Biology Laboratories, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies , La Jolla, California 92037, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056623PMC
http://dx.doi.org/10.1021/acs.biochem.6b00565DOI Listing
August 2016

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.

Diabetes 2016 07 10;65(7):1808-15. Epub 2016 Jun 10.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db16-0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915575PMC
July 2016

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

Nat Chem Biol 2016 May 28;12(5):367-372. Epub 2016 Mar 28.

The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037.

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http://dx.doi.org/10.1038/nchembio.2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837090PMC
May 2016

Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG).

Biotechnol Prog 2015 May-Jun;31(3):840-8. Epub 2015 Apr 15.

Clayton Foundations Laboratories for Peptide Biology, Salk Institute, La Jolla, CA, 92037.

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http://dx.doi.org/10.1002/btpr.2078DOI Listing
April 2016

Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.

Anal Chem 2016 Apr 24;88(7):3967-75. Epub 2016 Mar 24.

Salk Institute for Biological Studies, Clayton Foundation Laboratories for Peptide Biology , 10010 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939623PMC
April 2016

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects.

Cell Metab 2016 Mar 14;23(3):479-91. Epub 2016 Jan 14.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785078PMC
March 2016

Editorial overview: Omics: The maturation of chemical biology.

Curr Opin Chem Biol 2016 Feb 28;30:v-vi. Epub 2015 Dec 28.

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http://dx.doi.org/10.1016/j.cbpa.2015.12.005DOI Listing
February 2016

Identification and characterization of sORF-encoded polypeptides.

Crit Rev Biochem Mol Biol 2015 Mar-Apr;50(2):134-41. Epub 2015 Apr 10.

Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, Helmsley Center for Genomic Medicine , La Jolla, CA , USA and.

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http://dx.doi.org/10.3109/10409238.2015.1016215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761265PMC
January 2016

Discovery and characterization of smORF-encoded bioactive polypeptides.

Nat Chem Biol 2015 Dec;11(12):909-16

School of Life Sciences, University of Sussex, Falmer, Brighton, UK.

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http://dx.doi.org/10.1038/nchembio.1964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956473PMC
December 2015

Primate-specific ORF0 contributes to retrotransposon-mediated diversity.

Cell 2015 Oct 22;163(3):583-93. Epub 2015 Oct 22.

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Center for Academic Research and Training in Anthropogeny (CARTA), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Kavli Institute for Brain and Mind (KIBM), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01187-3.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501187
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http://dx.doi.org/10.1016/j.cell.2015.09.025DOI Listing
October 2015

Regulation of mitochondrial ceramide distribution by members of the BCL-2 family.

J Lipid Res 2015 Aug 9;56(8):1501-10. Epub 2015 Jun 9.

Clayton Foundation Laboratories for Peptide Biology, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies, San Diego, CA 92037.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M058750
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http://dx.doi.org/10.1194/jlr.M058750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513991PMC
August 2015

A nonapoptotic role for BAX and BAK in eicosanoid metabolism.

ACS Chem Biol 2015 Jun 6;10(6):1398-403. Epub 2015 Apr 6.

†Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acschembio.5b00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599777PMC
June 2015

Defining the metabolome: size, flux, and regulation.

Mol Cell 2015 May;58(4):699-706

Department of Chemistry and Department of Medicine, Washington University, St. Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831058PMC
May 2015

Maternal adiponectin controls milk composition to prevent neonatal inflammation.

Endocrinology 2015 Apr 15;156(4):1504-13. Epub 2015 Jan 15.

Department of Pharmacology (Z.J., Y.D., Y.W.), Touchstone Diabetes Center and Department of Internal Medicine (I.W.A., P.E.S.), The University of Texas Southwestern Medical Center, Dallas, Texas 75390; and Department of Chemistry and Chemical Biology (A.G.S., A.S.), Harvard University, Cambridge, Massachusetts 02138.

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http://dx.doi.org/10.1210/en.2014-1738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399311PMC
April 2015

Data-driven synthesis of proteolysis-resistant peptide hormones.

J Am Chem Soc 2014 Dec 12;136(51):17710-3. Epub 2014 Dec 12.

Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/ja5065735DOI Listing
December 2014

Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.

Mol Cell Proteomics 2014 Nov 23;13(11):3082-96. Epub 2014 Jul 23.

From the ‡Protein Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065; §Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065;

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http://dx.doi.org/10.1074/mcp.M114.038836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223493PMC
November 2014

Localization of anionic phospholipids in Escherichia coli cells.

J Bacteriol 2014 Oct 7;196(19):3386-98. Epub 2014 Jul 7.

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA

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http://dx.doi.org/10.1128/JB.01877-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187673PMC
October 2014

A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo.

J Am Chem Soc 2014 Sep 5;136(37):12848-51. Epub 2014 Sep 5.

Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/ja507168tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183665PMC
September 2014

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Nature 2014 Jul 21;511(7507):94-8. Epub 2014 May 21.

1] Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature13297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142213PMC
July 2014

A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

J Biol Chem 2014 Apr 7;289(16):10950-7. Epub 2014 Mar 7.

From the Department of Chemistry and Chemical Biology and.

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http://dx.doi.org/10.1074/jbc.C113.533968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036235PMC
April 2014

Proteolysis controls endogenous substance P levels.

PLoS One 2013 19;8(7):e68638. Epub 2013 Jul 19.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068638PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716696PMC
March 2014

Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue.

J Proteome Res 2014 Mar 14;13(3):1757-65. Epub 2014 Feb 14.

Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/pr401280wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993966PMC
March 2014

MAIT recognition of a stimulatory bacterial antigen bound to MR1.

J Immunol 2013 Nov 9;191(10):5268-77. Epub 2013 Oct 9.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637;

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http://dx.doi.org/10.4049/jimmunol.1301958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819123PMC
November 2013

Chemoproteomic discovery of cysteine-containing human short open reading frames.

J Am Chem Soc 2013 Nov 25;135(45):16750-3. Epub 2013 Oct 25.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1021/ja406606jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868496PMC
November 2013

Emerging roles of lipids in BCL-2 family-regulated apoptosis.

Biochim Biophys Acta 2013 Oct 21;1831(10):1542-54. Epub 2013 Mar 21.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13881981130005
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http://dx.doi.org/10.1016/j.bbalip.2013.03.001DOI Listing
October 2013

A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.

Nature 2013 Oct;502(7472):550-4

1] Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA [2].

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http://dx.doi.org/10.1038/nature12710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141623PMC
October 2013

Analysis of the proteolysis of bioactive peptides using a peptidomics approach.

Nat Protoc 2013 Sep 15;8(9):1730-42. Epub 2013 Aug 15.

Department of Chemical Engineering, Soongsil University, Seoul, South Korea.

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http://dx.doi.org/10.1038/nprot.2013.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170687PMC
September 2013

Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.

Arterioscler Thromb Vasc Biol 2013 Aug 30;33(8):1788-94. Epub 2013 May 30.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/ATVBAHA.113.301300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794714PMC
August 2013

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.

Proc Natl Acad Sci U S A 2013 May 23;110(19):E1771-8. Epub 2013 Apr 23.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1222678110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651419PMC
May 2013

Methods for the elucidation of protein-small molecule interactions.

Chem Biol 2013 May;20(5):667-73

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10745521130016
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http://dx.doi.org/10.1016/j.chembiol.2013.04.008DOI Listing
May 2013

Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates.

Nat Commun 2012 ;3:1008

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncomms2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520613PMC
February 2013

Peptidomics methods for the identification of peptidase-substrate interactions.

Curr Opin Chem Biol 2013 Feb 15;17(1):83-9. Epub 2013 Jan 15.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.cbpa.2012.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594040PMC
February 2013

Peptidomic discovery of short open reading frame-encoded peptides in human cells.

Nat Chem Biol 2013 Jan 18;9(1):59-64. Epub 2012 Nov 18.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625679PMC
January 2013

Discovering ligand-receptor interactions.

Nat Biotechnol 2012 Oct;30(10):959-61

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http://www.nature.com/articles/nbt.2373
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http://dx.doi.org/10.1038/nbt.2373DOI Listing
October 2012

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.

Genes Dev 2012 Jun;26(12):1306-11

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.191031.112
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387658PMC
June 2012

Functional analysis of protein targets by metabolomic approaches.

Top Curr Chem 2012 ;324:137-62

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA, USA.

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http://dx.doi.org/10.1007/128_2011_284DOI Listing
May 2012

Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.

Proc Natl Acad Sci U S A 2012 May 14;109(22):8523-7. Epub 2012 May 14.

Department of Chemical Engineering, Soongsil University, Seoul 156-743, South Korea.

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http://dx.doi.org/10.1073/pnas.1203195109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365226PMC
May 2012

Cytotoxicity of a Ti(IV) compound is independent of serum proteins.

Proc Natl Acad Sci U S A 2012 Mar 12;109(13):5016-21. Epub 2012 Mar 12.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1119303109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323991PMC
March 2012

VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses.

PLoS One 2011 5;6(7):e21209. Epub 2011 Jul 5.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021209PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130023PMC
December 2011

Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach.

J Am Chem Soc 2011 Nov 11;133(43):17168-71. Epub 2011 Oct 11.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja208199hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569094PMC
November 2011

Investigating endogenous peptides and peptidases using peptidomics.

Biochemistry 2011 Sep 15;50(35):7447-61. Epub 2011 Aug 15.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/bi200417kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418817PMC
September 2011

A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.

J Am Chem Soc 2011 Aug 12;133(30):11665-74. Epub 2011 Jul 12.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja2036095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145007PMC
August 2011

A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands.

Mol Biosyst 2011 Apr 31;7(4):1046-9. Epub 2011 Jan 31.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA, USA.

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http://dx.doi.org/10.1039/c0mb00324gDOI Listing
April 2011

Monoalkylglycerol ether lipids promote adipogenesis.

J Am Chem Soc 2011 Apr 23;133(14):5178-81. Epub 2011 Mar 23.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja111173cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761264PMC
April 2011

A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones.

Biochemistry 2011 Mar 22;50(12):2213-22. Epub 2011 Feb 22.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/bi2000033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076939PMC
March 2011

Peptidomics of the prolyl peptidases.

AAPS J 2010 Dec 16;12(4):483-91. Epub 2010 Jun 16.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1208/s12248-010-9208-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976987PMC
December 2010

Untargeted metabolomics.

Curr Protoc Mol Biol 2010 Apr;Chapter 30:Unit 30.1.1-24

Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/0471142727.mb3001s90DOI Listing
April 2010

Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform.

J Am Chem Soc 2010 Mar;132(11):3819-30

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja909524eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842575PMC
March 2010

Exploring disease through metabolomics.

ACS Chem Biol 2010 Jan;5(1):91-103

Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/cb900271rDOI Listing
January 2010

Peptidomics of prolyl endopeptidase in the central nervous system.

Biochemistry 2009 Dec;48(50):11971-81

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/bi901637cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813186PMC
December 2009