Alan S Gamis

Alan S Gamis

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Alan S Gamis

Alan S Gamis

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Treatment of children with relapsed and refractory acute lymphoblastic leukemia with mitoxantrone, vincristine, pegaspargase, dexamethasone, and bortezomib.

Pediatr Blood Cancer 2019 Nov 14:e28062. Epub 2019 Nov 14.

Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri.

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http://dx.doi.org/10.1002/pbc.28062DOI Listing
November 2019

Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431.

Arch Pathol Lab Med 2019 Aug 20. Epub 2019 Aug 20.

From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Drs Mast, Mosse, Jones, and Head); the Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit (Dr Taub); the Department of Biostatistics, University of Southern California, Monrovia (Dr Alonzo and Mr Wang); the Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospital, Kansas City, Missouri (Dr Gamis); the Pathology and Laboratory Medicine Service, VA Tennessee Valley Healthcare System, Nashville (Dr Mosse); the Department of Pediatrics, University of New Mexico, Albuquerque (Dr Mathew); the Division of Hematology-Oncology, IWK Health Centre, Halifax, Nova Scotia, Canada (Dr Berman); the Departments of Oncology (Dr Campana and Ms Coustan-Smith) and Pathology (Dr Raimondi), St. Jude Children's Research Hospital, Memphis, Tennessee; the Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, The National University Cancer Institute, NUH Medical Centre, Singapore (Dr Campana and Ms Coustan-Smith); the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis (Dr Hirsch); the Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada (Dr Hitzler); and the Division of Hematology/Oncology, The Hospital for Sick Children Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada (Dr Hitzler). Dr Mast now has a joint appointment at the Pathology and Laboratory Medicine Service, VA Tennessee Valley Healthcare System, Nashville. Dr Mathew is currently at the Department of Pediatrics, Presbyterian Health Services, Albuquerque, New Mexico. Dr Berman is currently at the Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. Dr Jones is currently at Pathgroup Labs, Nashville, Tennessee. Dr Campana is no longer at the Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee. Ms Coustan-Smith is no longer at the Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.5858/arpa.2018-0526-OADOI Listing
August 2019

Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group.

Pediatr Blood Cancer 2017 Dec 28;64(12). Epub 2017 Apr 28.

Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospitals and Clinic, Kansas City, Missouri.

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http://dx.doi.org/10.1002/pbc.26612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647219PMC
December 2017

Arsenic Trioxide Consolidation Allows Anthracycline Dose Reduction for Pediatric Patients With Acute Promyelocytic Leukemia: Report From the Children's Oncology Group Phase III Historically Controlled Trial AAML0631.

J Clin Oncol 2017 Sep 2;35(26):3021-3029. Epub 2017 Aug 2.

Matthew A. Kutny, University of Alabama at Birmingham, Birmingham, AL; Todd A. Alonzo, University of Southern California; Cecilia H. Fu, Children's Hospital Los Angeles, Los Angeles; Robert B. Gerbing and Yi-Cheng Wang, Children's Oncology Group, Monrovia; James H. Feusner, Children's Hospital and Research Center Oakland, Oakland, CA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota Medical Center-Fairview, Minneapolis, MN; Soheil Meshinchi, Fred Hutchinson Cancer Research Center, Seattle, WA; Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; and John J. Gregory Jr, Goryeb Children's Hospital, Morristown, NJ.

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http://dx.doi.org/10.1200/JCO.2016.71.6183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590801PMC
September 2017

CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531.

J Clin Oncol 2017 Aug 23;35(23):2674-2682. Epub 2017 Jun 23.

Jatinder K. Lamba, Lata Chauhan, and Miyoung Shin, University of Florida, Gainesville, FL; Michael R. Loken, Hematologics Inc; Rhonda E. Ries, Irwin D. Bernstein, and Soheil Meshinchi, Fred Hutchinson Cancer Research Center; Roland B. Walter and Soheil Meshinchi, University of Washington, Seattle, WA; Jessica A. Pollard, Maine Medical Center, Portland, ME; Jessica A. Pollard, Tufts University, Boston, MA; Yi-Cheng Wang, Children's Oncology Group, Monrovia; Todd A. Alonzo, University of Southern California, Los Angeles, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; and Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO.

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http://dx.doi.org/10.1200/JCO.2016.71.2513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549451PMC
August 2017

Association between prolonged neutropenia and reduced relapse risk in pediatric AML: A report from the children's oncology group.

Int J Cancer 2016 Nov 4;139(9):1930-5. Epub 2016 Jul 4.

Department of Hematology-Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

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http://dx.doi.org/10.1002/ijc.30236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990479PMC
November 2016

Shorter Remission Telomere Length Predicts Delayed Neutrophil Recovery After Acute Myeloid Leukemia Therapy: A Report From the Children's Oncology Group.

J Clin Oncol 2016 11;34(31):3766-3772

Robert B. Gerbing and Todd A. Alonzo, Children's Oncology Group, Monrovia; Todd A. Alonzo, University of Southern California, Los Angeles, CA; Lillian Sung, Hospital for Sick Children, Toronto, Ontario, Canada; Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Soheil Meshinchi, University of Washington School of Medicine, Seattle, WA; and Sharon E. Plon, Alison A. Bertuch, and Maria M. Gramatges, Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.66.9622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446304PMC
November 2016

Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia.

J Clin Oncol 2016 05 16;34(13):1537-43. Epub 2016 Feb 16.

Tamara P. Miller, Yimei Li, Marko Kavcic, Yuan-Shun V. Huang, Rochelle Bagatell, Alix E. Seif, Brian T. Fisher, Peter C. Adamson, and Richard Aplenc, The Children's Hospital of Philadelphia; Yimei Li, Andrea B. Troxel, Rochelle Bagatell, Alix E. Seif, Brian T. Fisher, Selina Luger, Peter C. Adamson, and Richard Aplenc, University of Pennsylvania School of Medicine, Philadelphia, PA; Lillian Sung, The Hospital for Sick Children, Toronto, Ontario, Canada; Todd A. Alonzo and Michael A. Pulsipher, University of Southern California; Michael A. Pulsipher, Children's Hospital of Los Angeles, Los Angeles; Todd A. Alonzo and Robert Gerbing, Children's Oncology Group, Monrovia, CA; Matt Hall, Children's Hospital Association, Overland Park, Kansas; Marla H. Daves, Children's Healthcare of Atlanta, Atlanta, GA; Terzah M. Horton, Texas Children's Hospital, Houston, TX; Jessica A. Pollard, Seattle Children's Hospital, Seattle, WA; and Alan S. Gamis, Children's Mercy Hospital, Kansas City, MO.

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http://dx.doi.org/10.1200/JCO.2015.65.5860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872308PMC
May 2016

CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531.

J Clin Oncol 2016 Mar 19;34(7):747-55. Epub 2016 Jan 19.

Jessica A. Pollard, Maine Medical Center, Portland, ME; and Tufts University, Boston, MA; Michael Loken, Hematologics; Irwin D. Bernstein and Soheil Meshinchi, Fred Hutchinson Cancer Research Center; Irwin D. Bernstein and Soheil Meshinchi, University of Washington, Seattle, WA; Robert B. Gerbing and Todd A. Alonzo, Children's Oncology Group, Arcadia; Todd A. Alonzo, Keck School of Medicine of University of Southern California, Los Angeles, CA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy Hirsch, University of Minnesota Cancer Center, Minneapolis, MN; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; and Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO.

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http://dx.doi.org/10.1200/JCO.2015.62.6846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872025PMC
March 2016

Earlier initiation of antibiotic therapy: Does prophylaxis offer greater benefit in AML?

Authors:
Alan S Gamis

Pediatr Blood Cancer 2015 Jul 24;62(7):1121-2. Epub 2015 Mar 24.

Division of Hematology/Oncology/BMT, Children's Mercy Hospitals and Clinics, Kansas City, Missouri.

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http://dx.doi.org/10.1002/pbc.25512DOI Listing
July 2015

Multimerin-1 (MMRN1) as Novel Adverse Marker in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.

Clin Cancer Res 2015 Jul 30;21(14):3187-95. Epub 2015 Mar 30.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington. Department of Epidemiology, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506237PMC
July 2015

Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Cancer Epidemiol Biomarkers Prev 2015 Feb 10;24(2):454-8. Epub 2014 Dec 10.

Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota. University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323733PMC
February 2015

BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Pediatr Blood Cancer 2014 Apr 11;61(4):647-52. Epub 2013 Oct 11.

Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia; Children's Health Queensland Hospital and Health Service, Brisbane, Australia.

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http://dx.doi.org/10.1002/pbc.24822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285339PMC
April 2014

Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization.

Clin Cancer Res 2014 Feb 11;20(3):754-63. Epub 2013 Nov 11.

Authors' Affiliations: University of Washington Schools of Pharmacy and Medicine; Fred Hutchinson Cancer Research Center; Seattle Children's Hospital, Seattle, Washington; Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Children's Mercy Hospitals and Clinics, Kansas City, Missouri; and Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946385PMC
February 2014

The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: report from the Children's Oncology Group.

Pediatr Blood Cancer 2014 Jan 16;61(1):81-8. Epub 2013 Aug 16.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Pediatric Hematology/Oncology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington; Children's Oncology Group, Arcadia, California.

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http://dx.doi.org/10.1002/pbc.24700DOI Listing
January 2014

Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group.

Am J Hematol 2013 Aug 20;88(8):694-702. Epub 2013 Jun 20.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/ajh.23486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757130PMC
August 2013

Children's Oncology Group's 2013 blueprint for research: acute myeloid leukemia.

Pediatr Blood Cancer 2013 Jun 19;60(6):964-71. Epub 2012 Dec 19.

Children's Mercy Hospitals & Clinics, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1002/pbc.24432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605815PMC
June 2013

Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder.

Br J Haematol 2012 Nov 12;159(3):277-87. Epub 2012 Sep 12.

Division of Hematology/Oncology, Children's Mercy Hospitals & Clinics, Kansas City, MO 64108, USA.

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https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.12041
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https://www.researchgate.net/publication/230831314_Transient
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https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.12041
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http://doi.wiley.com/10.1111/bjh.12041
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http://dx.doi.org/10.1111/bjh.12041DOI Listing
November 2012

Congenital abnormalities and acute leukemia among children with Down syndrome: a Children's Oncology Group study.

Cancer Epidemiol Biomarkers Prev 2008 Oct 30;17(10):2572-7. Epub 2008 Sep 30.

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street Southeast, MMC 422, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610427PMC
October 2008

Vitamin supplement use among children with Down's syndrome and risk of leukaemia: a Children's Oncology Group (COG) study.

Paediatr Perinat Epidemiol 2008 May;22(3):288-95

University of Minnesota Cancer Center, Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1111/j.1365-3016.2008.00928.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365502PMC
May 2008

Exposure to medical test irradiation and acute leukemia among children with Down syndrome: a report from the Children's Oncology Group.

Pediatrics 2006 Nov 9;118(5):e1499-508. Epub 2006 Oct 9.

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1542/peds.2006-0644DOI Listing
November 2006

Surveys: a tool to provoke thought and identify areas of need.

Authors:
Alan S Gamis

Pediatr Blood Cancer 2005 Mar;44(3):205-6

Division of Hematology/Oncology, Children's Mercy Hospital, 2401 Gillham Rd, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1002/pbc.20220DOI Listing
March 2005

Acute myeloid leukemia and Down syndrome evolution of modern therapy--state of the art review.

Authors:
Alan S Gamis

Pediatr Blood Cancer 2005 Jan;44(1):13-20

Children's Mercy Hospital and Clinics, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1002/pbc.20207DOI Listing
January 2005

Increased age at diagnosis has a significantly negative effect on outcome in children with Down syndrome and acute myeloid leukemia: a report from the Children's Cancer Group Study 2891.

J Clin Oncol 2003 Sep 28;21(18):3415-22. Epub 2003 Jul 28.

Section of Hematology/Oncology/Blood and Marrow Transplantation, Children's Mercy Hospital and Clinics, 2401 Gillham Rd, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1200/JCO.2003.08.060DOI Listing
September 2003

Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis.

Blood 2003 Jun 30;101(11):4298-300. Epub 2003 Jan 30.

Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-12-39
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http://dx.doi.org/10.1182/blood-2002-12-3904DOI Listing
June 2003

Transient myeloproliferative disorder, a disorder with too few data and many unanswered questions: does it contain an important piece of the puzzle to understanding hematopoiesis and acute myelogenous leukemia?

J Pediatr Hematol Oncol 2002 Jan;24(1):2-5

Children's Mercy Hospital and Clinics, The Cleveland Clinic Foundation, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1097/00043426-200201000-00002DOI Listing
January 2002