Publications by authors named "Alan Mackay"

100Publications

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
July 2020

Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.

Cell 2017 Aug 17;170(5):845-859.e19. Epub 2017 Aug 17.

Department of Neurology, Stanford University, Palo Alto, CA 94305, USA; Department of Pathology, Stanford University, Palo Alto, CA 94305, USA; Department of Neurosurgery, Stanford University, Palo Alto, CA 94305, USA; Department of Pediatrics, Stanford University, Palo Alto, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587159PMC
August 2017

Copy Number Profiling of Brazilian Astrocytomas.

G3 (Bethesda) 2016 07 7;6(7):1867-78. Epub 2016 Jul 7.

Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, 4704 553, Portugal 3B's - PT Government Associate Laboratory, Braga/Guimarães, 4704 553, Portugal

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http://dx.doi.org/10.1534/g3.116.029884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938641PMC
July 2016

Molecular Diagnostic and Prognostic Subtyping of Gliomas in Tunisian Population.

Mol Neurobiol 2017 05 9;54(4):2381-2394. Epub 2016 Mar 9.

Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Street Ibn Eljazzar, 4000, Sousse, Tunisia.

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http://dx.doi.org/10.1007/s12035-016-9805-6DOI Listing
May 2017

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Molecular Profiling of a Rare Rosette-Forming Glioneuronal Tumor Arising in the Spinal Cord.

PLoS One 2015 15;10(9):e0137690. Epub 2015 Sep 15.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; 3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137690PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570813PMC
May 2016

Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.

Clin Cancer Res 2015 Sep 26;21(18):4212-23. Epub 2015 May 26.

Renal Cancer Unit, The Royal Free Hospital, London, United Kingdom. Centre for Experimental Cancer Medicine, Bart's Cancer Institute, Queen Mary University of London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0207DOI Listing
September 2015

The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.

Acta Neuropathol Commun 2014 Feb 18;2:23. Epub 2014 Feb 18.

Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1186/2051-5960-2-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938307PMC
February 2014

Genomic profiling of histological special types of breast cancer.

Breast Cancer Res Treat 2013 Nov 27;142(2):257-69. Epub 2013 Oct 27.

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-013-2740-6DOI Listing
November 2013

The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer.

Clin Cancer Res 2013 Dec 15;19(24):6924-34. Epub 2013 Oct 15.

Authors' Affiliations: Barts Cancer Institute, Queen Mary University of London; Experimental Cancer Medicine Centre, University College; The Institute of Cancer Research; Guys and St Thomas' Hospital; The Royal Free Hospital London, London; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh; Astra Zeneca, Manchester; School of Medicine, University of St Andrews, Fife, United Kingdom; National Cancer Institute, Amsterdam, the Netherlands; and University of Ghent, Ghent, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1631DOI Listing
December 2013

GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.

Cancer Res 2013 Jun 6;73(12):3783-95. Epub 2013 May 6.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Department of Academic Biochemistry, The Royal Marsden Hospital; and London Research Institute, Cancer Research UK, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686594PMC
June 2013

Where Birt-Hogg-Dubé meets Cowden syndrome: mirrored genetic defects in two cases of syndromic oncocytic tumours.

Eur J Hum Genet 2013 Oct 6;21(10):1169-72. Epub 2013 Feb 6.

Dip. Sc. Mediche e Chirurgiche-DIMEC, U.O. Genetica Medica, Policlinico Universitario S.Orsola-Malpighi, Bologna, Italy.

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http://dx.doi.org/10.1038/ejhg.2013.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778364PMC
October 2013

Molecular characterisation of cell line models for triple-negative breast cancers.

BMC Genomics 2012 Nov 14;13:619. Epub 2012 Nov 14.

Breakthrough Breast Cancer Research Unit, Guy's Hospital, King's Health Partners AHSC, King's College London School of Medicine, London SE1 9RT, UK.

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http://dx.doi.org/10.1186/1471-2164-13-619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546428PMC
November 2012

Beyond crystals: the dialectic of materials and information.

Philos Trans A Math Phys Eng Sci 2012 Jun;370(1969):2807-22

Instituto Andaluz de Ciencias de la Tierra, CSIC-Universidad de Granada, Campus Fuentenueva, E-18071 Granada, Spain.

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http://dx.doi.org/10.1098/rsta.2012.0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367679PMC
June 2012

Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties.

Stem Cells 2012 Feb;30(2):292-303

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1002/stem.791DOI Listing
February 2012

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor.

Genes Chromosomes Cancer 2011 Dec 31;50(12):982-95. Epub 2011 Aug 31.

Molecular Haematology and Cancer Biology Unit, University College London, Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/gcc.20907DOI Listing
December 2011

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment.

Breast Cancer Res 2011 Aug 11;13(4):R79. Epub 2011 Aug 11.

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1186/bcr2928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236343PMC
August 2011

Functional characterization of EMSY gene amplification in human cancers.

J Pathol 2011 Sep 7;225(1):29-42. Epub 2011 Jul 7.

Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1002/path.2944DOI Listing
September 2011

Direct evidence for concurrent morphological and genetic heterogeneity in an invasive ductal carcinoma of triple-negative phenotype.

J Clin Pathol 2011 Sep 14;64(9):822-8. Epub 2011 Jun 14.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1136/jclinpath-2011-200135DOI Listing
September 2011

Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement.

J Natl Cancer Inst 2011 Apr 18;103(8):662-73. Epub 2011 Mar 18.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, UK.

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http://dx.doi.org/10.1093/jnci/djr071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079850PMC
April 2011

Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas.

Clin Cancer Res 2011 Mar;17(6):1521-34

Department of Gynaecologic Oncology, Royal Marsden Hospital NHS Foundation Trust, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1688DOI Listing
March 2011

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.

Mod Pathol 2011 Feb 12;24(2):209-31. Epub 2010 Nov 12.

Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/modpathol.2010.205DOI Listing
February 2011

Gene expression following ionising radiation: identification of biomarkers for dose estimation and prediction of individual response.

Int J Radiat Biol 2011 Feb 10;87(2):115-29. Epub 2010 Nov 10.

Biological Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency, Chilton, Didcot, Oxfordshire, UK.

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http://dx.doi.org/10.3109/09553002.2010.519424DOI Listing
February 2011

Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer.

BMC Syst Biol 2010 Sep 8;4:127. Epub 2010 Sep 8.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1186/1752-0509-4-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946304PMC
September 2010

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

Cell Stem Cell 2010 Sep;7(3):403-17

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.stem.2010.07.010DOI Listing
September 2010

A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.

Clin Cancer Res 2010 Jul 22;16(13):3368-77. Epub 2010 Jun 22.

Section of Paediatric Oncology, The Institute of Cancer Research, Royal Marsden Hospital, Sutton, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896553PMC
July 2010

ROCK: a breast cancer functional genomics resource.

Breast Cancer Res Treat 2010 Nov 20;124(2):567-72. Epub 2010 Jun 20.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1007/s10549-010-0945-5DOI Listing
November 2010

Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast.

Mod Pathol 2010 Jul 7;23(7):951-60. Epub 2010 May 7.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/modpathol201082
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http://dx.doi.org/10.1038/modpathol.2010.82DOI Listing
July 2010

Breast cancer molecular profiling with single sample predictors: a retrospective analysis.

Lancet Oncol 2010 Apr 22;11(4):339-49. Epub 2010 Feb 22.

Cancer Research UK, London Research Institute, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(10)70008-5DOI Listing
April 2010

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines.

Breast Cancer Res Treat 2009 Dec 24;118(3):481-98. Epub 2009 Jan 24.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1007/s10549-008-0296-7DOI Listing
December 2009

Impact of estrogen deprivation on gene expression profiles of normal postmenopausal breast tissue in vivo.

Cancer Epidemiol Biomarkers Prev 2008 Apr;17(4):855-63

Department of Medical Oncology, Guys and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-2718DOI Listing
April 2008

Molecular response to aromatase inhibitor treatment in primary breast cancer.

Breast Cancer Res 2007 ;9(3):R37

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1186/bcr1732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929101PMC
September 2007

Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.

Genes Chromosomes Cancer 2007 Jun;46(6):607-15

Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, UK.

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http://dx.doi.org/10.1002/gcc.20446DOI Listing
June 2007

Coherent coexistence of nanodiamonds and carbon onions in icosahedral core-shell particles.

Acta Crystallogr A 2007 Mar 15;63(Pt 2):172-6. Epub 2007 Feb 15.

Grebenshchikov Institute of Silicate Chemistry, Russian Academy of Sciences, nab. Makarova 2, Saint Petersburg 199034, Russia.

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http://dx.doi.org/10.1107/S0108767307002723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525862PMC
March 2007

A conditionally immortalized cell line model for the study of human prostatic epithelial cell differentiation.

Differentiation 2007 Jan;75(1):35-48

Prostate Cancer Research Centre, Institute of Urology, University College London, 67 Riding House Street, London W1W 7EJ, UK.

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http://dx.doi.org/10.1111/j.1432-0436.2006.00113.xDOI Listing
January 2007