Publications by authors named "Alan Knapton"

25Publications

Quantitative analysis of underivatized 17 β-estradiol using a high-throughput LC-MS/MS assay - Application to support a pharmacokinetic study in ovariectomized guinea pigs.

J Pharm Biomed Anal 2020 Jan 28;178:112897. Epub 2019 Sep 28.

Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.

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January 2020

Evaluation of a TGN1412 analogue using in vitro assays and two immune humanized mouse models.

Toxicol Appl Pharmacol 2019 06 23;372:57-69. Epub 2019 Mar 23.

Division of Applied Regulatory Sciences, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address:

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June 2019

MicroRNA biomarkers of pancreatic injury in a canine model.

Exp Toxicol Pathol 2017 Jan 17;69(1):33-43. Epub 2016 Nov 17.

U. S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, HFD-910, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.

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January 2017

The utility of serum biomarkers to detect myocardial alterations induced by Imatinib in rats.

Pharmacol Res Perspect 2014 Feb 3;2(1):e00015. Epub 2014 Mar 3.

Department of Pediatrics, Mailman Center for Child Development, Leonard A. Miller School of Medicine, University of Miami Miami, Florida.

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February 2014

Acute effects of nonexcitatory electrical stimulation during systole in isolated cardiac myocytes and perfused heart.

Physiol Rep 2014 Aug 5;2(8). Epub 2014 Aug 5.

Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA.

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August 2014

The role of eNOS phosphorylation in causing drug-induced vascular injury.

Toxicol Pathol 2014 Jun 3;42(4):709-24. Epub 2014 Apr 3.

Division of Applied Regulatory Science, CDER, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

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June 2014

The influence of age on serum concentrations of cardiac troponin I: results in rats, monkeys, and commercial sera.

Toxicol Pathol 2014 Jul 15;42(5):888-96. Epub 2013 Oct 15.

National Institutes of Health, National Cancer Institute, Carcinogen-DNA Interactions Section, Bethesda, Maryland, USA.

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July 2014

Autophagy in pancreatic acinar cells in caerulein-treated mice: immunolocalization of related proteins and their potential as markers of pancreatitis.

Toxicol Pathol 2014 2;42(2):435-57. Epub 2013 May 2.

1Division of Drug Safety Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

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September 2014

Sex-related differences in mast cell activity and doxorubicin toxicity: a study in spontaneously hypertensive rats.

Toxicol Pathol 2014 26;42(2):361-75. Epub 2013 Mar 26.

1Division of Drug Safety Research, Center for Drug Evaluation and Research Food and Drug Administration, Silver Spring, Maryland, USA.

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September 2014

Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat.

Int J Toxicol 2012 Jan-Feb;31(1):14-24. Epub 2012 Jan 19.

Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 64, Room 2036, Silver Spring, MD 20993, USA.

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June 2012

A multifaceted evaluation of imatinib-induced cardiotoxicity in the rat.

Toxicol Pathol 2011 Dec 21;39(7):1091-106. Epub 2011 Sep 21.

Food and Drug Administration, Division of Applied Pharmacology Research, Silver Spring, Maryland, USA.

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December 2011

The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats.

Cancer Chemother Pharmacol 2011 Nov 4;68(5):1125-34. Epub 2011 Mar 4.

Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29A, Room 2A-11, Bethesda, MD 20892, USA.

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November 2011

Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591.

Toxicol Pathol 2010 Aug 28;38(5):738-44. Epub 2010 Jun 28.

Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA.

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August 2010

Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats.

Cancer Chemother Pharmacol 2010 Jul 14;66(2):303-14. Epub 2009 Nov 14.

Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

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July 2010

Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385.

Toxicol Pathol 2008 Oct 5;36(6):827-39. Epub 2008 Sep 5.

Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA.

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October 2008

Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury.

Toxicol Pathol 2008 Feb 18;36(2):277-8. Epub 2008 Mar 18.

Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA.

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February 2008