Publications by authors named "Alan J Williams"

49Publications

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

J Cell Sci 2016 11 8;129(21):3983-3988. Epub 2016 Sep 8.

Sir Geraint Evans Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK

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http://dx.doi.org/10.1242/jcs.191643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117208PMC
November 2016

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating.

Sci Rep 2016 10 5;6:34452. Epub 2016 Oct 5.

Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050499PMC
http://dx.doi.org/10.1038/srep34452DOI Listing
October 2016

A Systemized Approach to Investigate Ca(2+) Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes.

Front Cell Dev Biol 2015 13;3:89. Epub 2016 Jan 13.

Ionic Cell Signalling, School of Medicine, Wales Heart Research Institute, Cardiff University Wales, UK.

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http://dx.doi.org/10.3389/fcell.2015.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710702PMC
January 2016

Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides.

Sci Rep 2015 Oct 1;5:14680. Epub 2015 Oct 1.

Biological Chemistry and Crop Protection Department, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.

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http://dx.doi.org/10.1038/srep14680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289073PMC
October 2015

The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.

Circ Res 2015 Apr 3;116(8):1324-35. Epub 2015 Feb 3.

From the Institute of Molecular and Experimental Medicine, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom (M.L.B., N.L.T., S.M., C.M., C.H.G., A.J.W.); and Myocardial Function Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (M.B.S., K.T.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305347DOI Listing
April 2015

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

Cardiovasc Res 2015 Jan 19;105(1):118-28. Epub 2014 Nov 19.

Wales Heart Research Institute, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff CF14 4XN, UK

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http://dx.doi.org/10.1093/cvr/cvu240DOI Listing
January 2015

Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).

Mol Pharmacol 2014 Sep 7;86(3):318-29. Epub 2014 Jul 7.

Institute of Molecular and Experimental Medicine, Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

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http://dx.doi.org/10.1124/mol.114.093757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216943PMC
September 2014

N-terminus oligomerization regulates the function of cardiac ryanodine receptors.

J Cell Sci 2013 Nov 13;126(Pt 21):5042-51. Epub 2013 Aug 13.

Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.

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http://dx.doi.org/10.1242/jcs.133538DOI Listing
November 2013

Functional characterization of the cardiac ryanodine receptor pore-forming region.

PLoS One 2013 12;8(6):e66542. Epub 2013 Jun 12.

Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066542PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680380PMC
January 2014

Investigations of the contribution of a putative glycine hinge to ryanodine receptor channel gating.

J Biol Chem 2013 Jun 30;288(23):16671-9. Epub 2013 Apr 30.

Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M113.465310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675601PMC
June 2013

Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current.

Cardiovasc Res 2013 May 19;98(2):286-96. Epub 2013 Jan 19.

Myocardial Function Section, National Heart and Lung Institute, Fourth Floor, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1093/cvr/cvt012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714924PMC
May 2013

A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.

J Gen Physiol 2012 Aug 16;140(2):139-58. Epub 2012 Jul 16.

Institute of Molecular and Experimental Medicine, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, Wales, UK.

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http://dx.doi.org/10.1085/jgp.201110706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409104PMC
August 2012

Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.

Adv Exp Med Biol 2012 ;740:183-215

Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

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http://link.springer.com/content/pdf/10.1007%2F978-94-007-28
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http://www.springerlink.com/index/10.1007/978-94-007-2888-2_
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http://dx.doi.org/10.1007/978-94-007-2888-2_8DOI Listing
September 2012

Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.

J Cell Sci 2012 Apr 10;125(Pt 7):1759-69. Epub 2012 Feb 10.

Wales Heart Research Institute, Department of Cardiology, Cardiff University School of Medicine, Cardiff, UK.

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http://dx.doi.org/10.1242/jcs.098012DOI Listing
April 2012

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.

FEBS Lett 2010 May 2;584(10):2153-60. Epub 2010 Feb 2.

Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

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http://doi.wiley.com/10.1016/j.febslet.2010.01.057
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http://dx.doi.org/10.1016/j.febslet.2010.01.057DOI Listing
May 2010

The ryanodine receptor pore: is there a consensus view?

Curr Top Membr 2010 25;66:49-67. Epub 2010 Jul 25.

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http://dx.doi.org/10.1016/S1063-5823(10)66003-6DOI Listing
October 2012

Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum.

Biochem Biophys Res Commun 2009 Sep 25;387(1):77-82. Epub 2009 Jun 25.

National Heart & Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.bbrc.2009.06.115DOI Listing
September 2009

Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.

Biophys J 2009 Feb;96(4):1374-87

Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LY, United Kingdom.

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http://dx.doi.org/10.1016/j.bpj.2008.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717239PMC
February 2009

Pharmacological regulators of intracellular calcium release channels.

Curr Pharm Des 2007 ;13(24):2428-42

Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, London, UK.

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http://dx.doi.org/10.2174/138161207781368620DOI Listing
September 2007

Quantification of the effects of a ryanodine receptor channel mutation on interaction with a ryanoid.

Mol Membr Biol 2007 May-Jun;24(3):185-93

Cardiac Medicine, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1080/09687860601076522DOI Listing
December 2007

Ryanodine receptor interaction with the SNARE-associated protein snapin.

J Cell Sci 2006 Jun;119(Pt 11):2386-97

Wales Heart Research Institute, Department of Cardiology, Cardiff University School of Medicine, Heath Park, UK.

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http://dx.doi.org/10.1242/jcs.02936DOI Listing
June 2006

The interaction of an impermeant cation with the sheep cardiac RyR channel alters ryanoid association.

Mol Pharmacol 2006 Jun 15;69(6):1990-7. Epub 2006 Mar 15.

Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1124/mol.105.021659DOI Listing
June 2006

Probing luminal negative charge in the type 3 ryanodine receptor.

Biochem Biophys Res Commun 2005 Dec 5;337(4):1072-9. Epub 2005 Oct 5.

The Laboratory of Functional Immunogenetics, The Babraham Institute, Cambridge CB2 4AT, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.09.163DOI Listing
December 2005

The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance.

Mol Pharmacol 2005 Sep 14;68(3):840-6. Epub 2005 Jun 14.

Myocardial Systems Biology Group, National Heart and Lung Institute, Guy Scadding Building, Imperial College London, London SW3 6LY, United Kingdom.

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http://dx.doi.org/10.1124/mol.105.012807DOI Listing
September 2005

The interaction of ryanoids with individual ryanodine receptor channels.

Biol Res 2004 ;37(4):527-38

Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse St., London SW3 6LY, UK.

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http://dx.doi.org/10.4067/s0716-97602004000400006DOI Listing
October 2005

Voltage-sensitive equilibrium between two states within a ryanoid-modified conductance state of the ryanodine receptor channel.

Biophys J 2005 Apr 14;88(4):2585-96. Epub 2005 Jan 14.

Cardiac Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College London, UK.

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http://dx.doi.org/10.1529/biophysj.104.048587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1305355PMC
April 2005

A model of the putative pore region of the cardiac ryanodine receptor channel.

Biophys J 2004 Oct;87(4):2335-51

Department of Biochemistry, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

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http://dx.doi.org/10.1529/biophysj.104.044180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304657PMC
October 2004

Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2).

Biophys J 2004 Dec 10;87(6):3814-25. Epub 2004 Sep 10.

Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1529/biophysj.104.049338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304893PMC
December 2004

Myocardial calcium signalling and arrhythmia pathogenesis.

Biochem Biophys Res Commun 2004 Oct;322(4):1286-309

Department of Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1016/j.bbrc.2004.08.034DOI Listing
October 2004

Activation of the sheep cardiac Ca2+ release channel by simple heteroaromatics.

Biochem Biophys Res Commun 2004 Apr;317(2):397-400

Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1016/j.bbrc.2004.03.073DOI Listing
April 2004

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

Mol Biol Cell 2004 Jun 26;15(6):2627-38. Epub 2004 Mar 26.

Wales Heart Research Institute, Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom CF14 4XN.

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http://dx.doi.org/10.1091/mbc.e03-09-0688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420088PMC
June 2004

Removal of clustered positive charge from dihydropyridine receptor II-III loop peptide augments activation of ryanodine receptors.

Biochem Biophys Res Commun 2004 Feb;314(3):667-74

Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, SW3 6LY, London, UK.

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http://dx.doi.org/10.1016/j.bbrc.2003.12.128DOI Listing
February 2004

Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction.

J Biol Chem 2003 Dec 13;278(51):51557-65. Epub 2003 Oct 13.

Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1074/jbc.M306788200DOI Listing
December 2003

Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize.

Plant Physiol 2003 Aug;132(4):2086-97

Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC181292PMC
http://dx.doi.org/10.1104/pp.103.022749DOI Listing
August 2003

An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channels.

J Gen Physiol 2003 Jun 12;121(6):551-61. Epub 2003 May 12.

Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, London SW3 6LY, UK.

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http://dx.doi.org/10.1085/jgp.200208753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217354PMC
June 2003

The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis.

Cardiovasc Res 2002 Dec;56(3):359-72

Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, UK.

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http://dx.doi.org/10.1016/s0008-6363(02)00574-6DOI Listing
December 2002

A novel and rapid approach to isolating functional ryanodine receptors.

Biochem Biophys Res Commun 2002 Jun;294(2):402-7

Department of Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1016/S0006-291X(02)00494-1DOI Listing
June 2002

Ion conduction and selectivity in the ryanodine receptor channel.

Authors:
Alan J Williams

Front Biosci 2002 May 1;7:d1223-30. Epub 2002 May 1.

Cardiac Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Dovehouse St., London SW3 6LY, United Kingdom.

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May 2002

Excess noise in modified conductance states following the interaction of ryanoids with cardiac ryanodine receptor channels.

FEBS Lett 2002 Apr;516(1-3):35-9

Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, SW3 6LY, London, UK.

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http://dx.doi.org/10.1016/s0014-5793(02)02462-6DOI Listing
April 2002

Ryanodine-induced structural alterations in the RyR channel suggested by neomycin block.

Biophys J 2002 Apr;82(4):1964-74

Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, London SW3 6LY, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301992PMC
http://dx.doi.org/10.1016/S0006-3495(02)75545-8DOI Listing
April 2002

Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials.

Biophys J 2002 Apr;82(4):1953-63

Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, London SW3 6LY, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S000634950275544
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301991PMC
http://dx.doi.org/10.1016/S0006-3495(02)75544-6DOI Listing
April 2002