Publications by authors named "Alan J Thompson"

100Publications

The 2013 clinical course descriptors for multiple sclerosis: A clarification.

Neurology 2020 06 29;94(24):1088-1092. Epub 2020 May 29.

From the Department of Neurology (F.D.L.), Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Icahn School of Medicine at Mount Sinai, New York, NY; National Multiple Sclerosis Society (T.C.), New York, NY; Department of Neurology (J.A.C.), Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, OH; Departments of Internal Medicine (Neurology) and Community Health Sciences (R.A.M.), Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; and Faculty of Brain Sciences (A.J.T.), University College, London, United Kingdom.

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http://dx.doi.org/10.1212/WNL.0000000000009636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455332PMC
June 2020

Disrupted principal network organisation in multiple sclerosis relates to disability.

Sci Rep 2020 02 27;10(1):3620. Epub 2020 Feb 27.

Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.

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http://dx.doi.org/10.1038/s41598-020-60611-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046772PMC
February 2020

MSJ 2020 - Editorial comment.

Mult Scler 2020 02;26(2):134

VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458519899322DOI Listing
February 2020

Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis.

Mult Scler 2020 Jan 21:1352458519900971. Epub 2020 Jan 21.

Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK/Biomedical Research Centre, University College London Hospitals (UCLH), National Institute for Health Research (NIHR), London, UK.

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http://dx.doi.org/10.1177/1352458519900971DOI Listing
January 2020

Reduced neurite density in the brain and cervical spinal cord in relapsing-remitting multiple sclerosis: A NODDI study.

Mult Scler 2020 Nov 4;26(13):1647-1657. Epub 2019 Nov 4.

NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK/National Institute for Health Research University College London Hospitals Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1177/1352458519885107DOI Listing
November 2020

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers.

Lancet Neurol 2019 12 9;18(12):1123-1135. Epub 2019 Aug 9.

Spinal Cord Injury Centre Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/S1474-4422(19)30138-3DOI Listing
December 2019

Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis.

Proc Natl Acad Sci U S A 2019 05 9;116(22):11020-11027. Epub 2019 May 9.

Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London WC1B 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1818978116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561162PMC
May 2019

Clinical relevance of cortical network dynamics in early primary progressive MS.

Mult Scler 2020 04 25;26(4):442-456. Epub 2019 Feb 25.

Queen Square MS Centre, UCL Institute of Neurology, University College London (UCL), London, UK/National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1177/1352458519831400DOI Listing
April 2020

MSJ 2019 - Editorial comment.

Mult Scler 2019 01;25(1):4-5

VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458518819096DOI Listing
January 2019

Structural network disruption markers explain disability in multiple sclerosis.

J Neurol Neurosurg Psychiatry 2019 02 22;90(2):219-226. Epub 2018 Nov 22.

Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.

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http://dx.doi.org/10.1136/jnnp-2018-318440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518973PMC
February 2019

Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury.

Neuroimage Clin 2018 19;20:556-563. Epub 2018 Aug 19.

Spinal Cord Injury Center Balgrist, University of Zurich, Switzerland; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2018.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115607PMC
January 2019

Applying the 2017 McDonald diagnostic criteria for multiple sclerosis - Authors' reply.

Lancet Neurol 2018 06;17(6):499-500

Neurologic Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30168-6DOI Listing
June 2018

Commentary on the ECTRIMS-EAN guideline for pharmacological treatment of multiple sclerosis.

Authors:
Alan J Thompson

Ther Adv Neurol Disord 2018 17;11:1756286418770378. Epub 2018 Apr 17.

Faculty of Brain Sciences, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1177/1756286418770378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912310PMC
April 2018

Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury.

Neurology 2018 04 28;90(17):e1510-e1522. Epub 2018 Mar 28.

From the Spinal Cord Injury Center (E.H., G.D., P.F.), Balgrist University Hospital, Zurich, Switzerland; Department of Brain Repair and Rehabilitation (A.J.T., P.F.) and Wellcome Trust Centre for Neuroimaging (N.W., S.M., P.F.), UCL Institute of Neurology, University College London, UK; Department of Neurophysics (N.W., P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; and Department of Systems Neuroscience (S.M.), University Medical Center Hamburg-Eppendorf, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000005361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921039PMC
April 2018

Multiple sclerosis.

Lancet 2018 04 23;391(10130):1622-1636. Epub 2018 Mar 23.

Queen Square MS Centre, UCL Institute of Neurology, London, UK; NIHR University College London Hospitals Biomedical Research Centre, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183048
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http://dx.doi.org/10.1016/S0140-6736(18)30481-1DOI Listing
April 2018

MSJ 2018-editorial comment.

Mult Scler 2018 02;24(2):90-91

VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458518756517DOI Listing
February 2018

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

Mult Scler 2018 02 20;24(2):96-120. Epub 2018 Jan 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458517751049DOI Listing
February 2018

Unified understanding of MS course is required for drug development.

Nat Rev Neurol 2018 04 12;14(4):191-192. Epub 2018 Jan 12.

Faculty of Brain Sciences, University College London, 149 Tottenham Court Road, London W1T 7NF, UK.

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http://dx.doi.org/10.1038/nrneurol.2017.184DOI Listing
April 2018

Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting.

Nat Rev Neurol 2018 02 12;14(2):75-93. Epub 2018 Jan 12.

Queen Square Multiple Sclerosis Centre, University College of London Institute of Neurology, London WC1B 5EH, UK.

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http://dx.doi.org/10.1038/nrneurol.2017.171DOI Listing
February 2018

Advancing trial design in progressive multiple sclerosis.

Mult Scler 2017 10;23(12):1571-1572

Faculty of Brain Sciences, University College London, London, UK.

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http://dx.doi.org/10.1177/1352458517729767DOI Listing
October 2017

Exercise in patients with multiple sclerosis.

Lancet Neurol 2017 10 12;16(10):848-856. Epub 2017 Sep 12.

Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(17)30281-8DOI Listing
October 2017

Spinal cord atrophy as a primary outcome measure in phase II trials of progressive multiple sclerosis.

Mult Scler 2018 06 18;24(7):932-941. Epub 2017 May 18.

Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London (UCL), London, UK/UCL Hospitals Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1177/1352458517709954DOI Listing
June 2018

Challenge of progressive multiple sclerosis therapy.

Authors:
Alan J Thompson

Curr Opin Neurol 2017 06;30(3):237-240

Faculty of Brain Sciences, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1097/WCO.0000000000000453DOI Listing
June 2017

Landscape of MS patient cohorts and registries: Recommendations for maximizing impact.

Mult Scler 2018 04 1;24(5):579-586. Epub 2017 Mar 1.

Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.

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http://dx.doi.org/10.1177/1352458517698250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987851PMC
April 2018

The measure tells the tale: Clinical outcome measures in multiple sclerosis.

Mult Scler 2017 04 16;23(5):626-627. Epub 2017 Feb 16.

Department of Anatomy & Neurosciences, VU University Medical Center, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458517690825DOI Listing
April 2017

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function.

Lancet 2017 04 24;389(10076):1357-1366. Epub 2016 Nov 24.

Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://dx.doi.org/10.1016/S0140-6736(16)31320-4DOI Listing
April 2017

Gray matter MRI differentiates neuromyelitis optica from multiple sclerosis using random forest.

Neurology 2016 Dec 2;87(23):2463-2470. Epub 2016 Nov 2.

From the Queen Square MS Centre, Institute of Neurology (A.E., V.W., R.C., O.C.), Centre for Medical Image Computing (CMIC), Department of Computer Science (A.E., V.W., D.C.A.), and Faculty of Brain Sciences (A.J.T.), University College London, UK; MS Research Centre (A.E., M.A.S.), Neuroscience Institute, Tehran University of Medical Sciences, Iran; Advanced Neuroimaging Lab (M.C.), Neurology Clinic B, Department of Neurological and Movement Sciences, University of Verona; Neuroimaging Unit (M.C.), Euganea Medica, Padua, Italy; and National Institute of Health Research (NIHR) (A.J.T., O.C.), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177679PMC
December 2016

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.

Mult Scler 2016 10 19;22(11):1386-1396. Epub 2016 May 19.

Multiple Sclerosis Centre of Catalonia (Cemcat), Department of Neurology-Neuroimmunology, Vall d'Hebron University Hospital, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458516643600DOI Listing
October 2016

Embodied neurology: an integrative framework for neurological disorders.

Brain 2016 06 21;139(Pt 6):1855-61. Epub 2016 Apr 21.

Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

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http://dx.doi.org/10.1093/brain/aww076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892755PMC
June 2016

Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy.

Sci Rep 2016 Apr 20;6:24636. Epub 2016 Apr 20.

Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/srep24636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837346PMC
April 2016

White matter tract abnormalities are associated with cognitive dysfunction in secondary progressive multiple sclerosis.

Mult Scler 2016 10 5;22(11):1429-1437. Epub 2016 Jan 5.

NMR Research Unit, Queen Square MS Centre, University College London Institute of Neurology, London, UK/NIHR University College London Hospitals Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1177/1352458515622694DOI Listing
October 2016

White and gray matter damage in primary progressive MS: The chicken or the egg?

Neurology 2016 Jan 16;86(2):170-6. Epub 2015 Dec 16.

From the Department of Neuroinflammation (B.B., D.C., D.R.A., D.T., D.H.M., A.J.T., C.W.-K., O.C.), Queen Square MS Centre, University College of London Institute of Neurology; Department of Neuroimaging (B.B.), Institute of Psychiatry, King's College London; London School of Hygiene and Tropical Medicine (D.R.A.), University of London; NIHR UCL/UCLH Biomedical Research Centre (D.H.M., A.J.T., O.C.), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000002237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731689PMC
January 2016

Early accurate diagnosis crucial in multiple sclerosis.

Practitioner 2015 Sep;259(1785):21-7, 2-3

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September 2015

Progressive MS: from pathophysiology to drug discovery.

Mult Scler 2015 Oct 11;21(11):1376-84. Epub 2015 Sep 11.

Mellen Center for Multiple Sclerosis, Neurological Institute, and Lerner College of Medicine, Cleveland Clinic, Cleveland, USA.

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http://dx.doi.org/10.1177/1352458515603802DOI Listing
October 2015

Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis.

Brain 2015 Sep;138(Pt 9):2584-95

1 NMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK 7 National Institute of Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK.

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http://brain.oxfordjournals.org/content/brain/138/9/2584.ful
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http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
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http://dx.doi.org/10.1093/brain/awv209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643627PMC
September 2015

Tracking sensory system atrophy and outcome prediction in spinal cord injury.

Ann Neurol 2015 Nov 18;78(5):751-61. Epub 2015 Sep 18.

Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/ana.24508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737098PMC
November 2015

DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

J Neurol Neurosurg Psychiatry 2016 May 29;87(5):461-7. Epub 2015 Apr 29.

NMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK NIHR UCL/UCLH Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1136/jnnp-2014-310142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853554PMC
May 2016

Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis.

Brain 2015 Jun 10;138(Pt 6):1568-82. Epub 2015 Apr 10.

1 NMR Research Unit, UCL Institute of Neurology, London, UK 2 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK 6 National Institute of Health Research, University College London Hospitals, Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1093/brain/awv086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614136PMC
June 2015

A predictive model for corticosteroid response in individual patients with MS relapses.

PLoS One 2015 18;10(3):e0120829. Epub 2015 Mar 18.

Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London and National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom; MS Clinic, Brain & Mind Research Institute, University of Sydney, Sydney, Australia; Neuroimmunology Clinic, Concord Repatriation General Hospital, Sydney, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120829PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364957PMC
February 2016

A much-needed focus on progression in multiple sclerosis.

Authors:
Alan J Thompson

Lancet Neurol 2015 Feb;14(2):133-5

Faculty of Brain Sciences, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70330-8DOI Listing
February 2015

Age related changes in metabolite concentrations in the normal spinal cord.

PLoS One 2014 13;9(10):e105774. Epub 2014 Oct 13.

NMR Research Unit, UCL Institute of Neurology, London, United Kingdom; Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; National Institute of Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105774PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195602PMC
June 2015

HLA-DRB1*15 influences the development of brain tissue damage in early PPMS.

Neurology 2014 Nov 8;83(19):1712-8. Epub 2014 Oct 8.

From the Departments of Brain Repair and Rehabilitation (C.T., B.B., Z.K., A.J.T., O.C.) and Neuroinflammation (D.R.A., D.H.M.), University College of London Institute of Neurology, UK; Multiple Sclerosis Centre of Catalonia (Cemcat) (C.T.), Neurology-Neuroimmunology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Blizard Institute (S.R.), Queen Mary University of London; Medical Statistics Department (D.R.A.), London School of Hygiene and Tropical Medicine, University of London; Clinical Imaging Sciences Centre (M.C.), Brighton and Sussex Medical School, Falmer, East Sussex; and National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK.

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http://www.neurology.org/content/83/19/1712.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000095
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http://dx.doi.org/10.1212/WNL.0000000000000959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239831PMC
November 2014

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity.

Neurology 2014 Sep;83(11):1022-4

From the Multiple Sclerosis International Federation (P.B., D.C., C.A.), London, UK; University of British Columbia (H.T.), Vancouver, Canada; Department of Non-Communicable Disease Epidemiology (C.B.), London School of Hygiene and Tropical Medicine, London, UK; Menzies Research Institute Tasmania (B.V.T.), University of Tasmania, Hobart, Australia; and Faculty of Brain Sciences (A.J.T.), University College London and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000000768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162299PMC
September 2014

Voxel-based cervical spinal cord mapping of diffusion abnormalities in MS-related myelitis.

Neurology 2014 Oct 3;83(15):1321-5. Epub 2014 Sep 3.

From the Departments of Brain Repair and Rehabilitation (A.T.T., N.K., A.J.T., O.C.) and Neuroinflammation (D.A., C.A.M.W.-K.), NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, University College London; Institute of Cognitive Neuroscience (N.K.) and NIHR UCL-UCLH Biomedical Research Centre (BRC) (A.J.T., O.C.), University College London, Queen Square; and Medical Statistics Department (D.A.), London School of Hygiene and Tropical Medicine, UK.

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http://dx.doi.org/10.1212/WNL.0000000000000857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189100PMC
October 2014

Defining the clinical course of multiple sclerosis: the 2013 revisions.

Neurology 2014 Jul 28;83(3):278-86. Epub 2014 May 28.

From the Corinne Goldsmith Dickenson Center for Multiple Sclerosis (F.D.L., A.E.M.), Icahn School of Medicine at Mount Sinai, New York, NY; Scientific and Clinical Review Associates, LLC (S.C.R.), Salisbury, CT; The Mellen Center for MS Treatment and Research (J.A.C., R.J.F., R.A.R.), Cleveland Clinic, OH; the Department of Biostatistics (G.R.C.), University of Alabama at Birmingham; the Danish Multiple Sclerosis Center (P.S.S.), Department of Neurology, Copenhagen University Hospital Rigshospitalet, Denmark; University College London Institute of Neurology (A.J.T.), UK; the Department of Neurology (J.S.W., J.A.L.), University of Texas Health Sciences Center, Houston; the Department of Neurology (L.J.B.), New York University Langone Medical Center, New York; the Division of Neurology (B. Banwell), The Children's Hospital of Philadelphia, PA; the Departments of Radiology and Nuclear Medicine (F.B.) and Neurology (C.H.P.), VU Medical Center, Amsterdam, the Netherlands; Research Programs Department (B. Bebo), National Multiple Sclerosis Society, New York, NY; the Department of Neurology (P.A.C.), The Johns Hopkins Hospital, Baltimore, MD; Fédération de Neurologie (M.C.), CHU Hôpital Purpan, Toulouse, France; the Department of Neurology (G.C.), Scientific Institute San Raffaele, University Vita-Salute San Raffaele, Milan, Italy; University of Ottawa and the Ottawa Hospital Research Institute (M.S.F.), Canada; the Department of Neurology (A.D.G.), University of Rochester Medical Center, NY; the Departments of Neurology, Radiology and Neuroscience (M.I.), Mount Sinai School of Medicine, New York, NY; the Department of Neurology (L.K.), University Hospital, Basel, Switzerland; the Department of Neurology (B.C.K.), Heinrich-Heine-University, Düsseldorf, Germany; the Department of Neurology (C.L.), Salpêtrière Hospital, UPMC, Paris, France; the Department of Neurology-Neuroimmunology (X.M.), Cemcat, Hospital Universitari Vall d'Hebron, Barcelona, Spain; the Division of

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http://dx.doi.org/10.1212/WNL.0000000000000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117366PMC
July 2014

Conversion efficiency of skutterudite-based thermoelectric modules.

Phys Chem Chem Phys 2014 Jun;16(24):12510-20

Chemical & Materials Systems Lab, GM Global Research & Development, MC 480-106-224, 30500 Mound Road, Warren, MI 48090, USA.

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http://xlink.rsc.org/?DOI=C4CP01582G
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http://dx.doi.org/10.1039/c4cp01582gDOI Listing
June 2014

Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions.

J Neurol Neurosurg Psychiatry 2014 Aug 15;85(8):833-9. Epub 2014 Jan 15.

Department of Brain Repair and Rehabilitation, NMR Research Unit, UCL Institute of Neurology, London, UK National Institute for Health and Research (NIHR) University College London Hospital (UCLH) Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1136/jnnp-2013-306662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112488PMC
August 2014

Multiple Sclerosis International Federation: stimulating international cooperation in research.

Neurology 2013 Nov;81(20):1793-5

From the Institute of Neurology (A.J.T.), Faculty of Brain Sciences, University College London; and the Multiple Sclerosis International Federation (D.C.), London, UK.

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http://www.msif.org/wp-content/uploads/2014/09/Atlas-of-MS.p
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http://www.msif.org/wp-content/uploads/2014/09/MS-in-focus-2
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http://www.neurology.org/cgi/doi/10.1212/01.wnl.0000435552.6
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http://dx.doi.org/10.1212/01.wnl.0000435552.67953.c8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821717PMC
November 2013

Temporal and spatial evolution of grey matter atrophy in primary progressive multiple sclerosis.

Neuroimage 2014 Feb 4;86:257-64. Epub 2013 Oct 4.

NMR research Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square MS Centre, London, UK; National Institute of Health Research (NIHR), UCLH, Biomedical Research Centre (BRC), London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2013.09.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898881PMC
February 2014

A novel approach with "skeletonised MTR" measures tract-specific microstructural changes in early primary-progressive MS.

Hum Brain Mapp 2014 Feb 24;35(2):723-33. Epub 2013 Apr 24.

Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869406PMC
February 2014

Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica.

Ann Neurol 2013 Aug 4;74(2):301-5. Epub 2013 Sep 4.

Department of Brain Repair and Rehabilitation, Nuclear Magnetic Resonance Research Unit, University College London Institute of Neurology, London; National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London.

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August 2013

Removal of access to alemtuzumab for patients with aggressive multiple sclerosis.

BMJ 2013 Jan 18;346:f275. Epub 2013 Jan 18.

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January 2013

Spatial variability and changes of metabolite concentrations in the cortico-spinal tract in multiple sclerosis using coronal CSI.

Hum Brain Mapp 2014 Mar 26;35(3):993-1003. Epub 2012 Dec 26.

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; Department of Medicine, Clinical Neuroimmunology Unit, Multiple Sclerosis Centre of Catalonia (CEM-Cat), Autonomous University of Barcelona, CARM-Vall d'Hebron University Hospital, Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238834PMC
March 2014

Degeneration of the injured cervical cord is associated with remote changes in corticospinal tract integrity and upper limb impairment.

PLoS One 2012 12;7(12):e51729. Epub 2012 Dec 12.

Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, University College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520920PMC
June 2013

Treatment of cognitive impairment in multiple sclerosis: position paper.

J Neurol 2013 Jun 23;260(6):1452-68. Epub 2012 Nov 23.

Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy.

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June 2013

What sample sizes for reliability and validity studies in neurology?

J Neurol 2012 Dec 24;259(12):2681-94. Epub 2012 Jun 24.

Clinical Neurology Research Group, Peninsula College of Medicine and Dentistry, Tamar Science Park, Room N13 ITTC Building, Davy Road, Plymouth, UK.

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December 2012

Axonal integrity predicts cortical reorganisation following cervical injury.

J Neurol Neurosurg Psychiatry 2012 Jun 6;83(6):629-37. Epub 2012 Apr 6.

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London WC1N 3BG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348614PMC
June 2012

Corpus callosum damage predicts disability progression and cognitive dysfunction in primary-progressive MS after five years.

Hum Brain Mapp 2013 May 13;34(5):1163-72. Epub 2012 Feb 13.

Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, United Kingdom.

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http://doi.wiley.com/10.1002/hbm.21499
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6870474PMC
May 2013

Corticomotor representation to a human forearm muscle changes following cervical spinal cord injury.

Eur J Neurosci 2011 Dec 14;34(11):1839-46. Epub 2011 Nov 14.

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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December 2011

Disability, atrophy and cortical reorganization following spinal cord injury.

Brain 2011 Jun 17;134(Pt 6):1610-22. Epub 2011 May 17.

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102242PMC
June 2011

Asymmetric hemispheric representation of periictal heart rate modulation is individually lateralised.

Epileptic Disord 2011 Jun;13(2):172-6

Department of Clinical and Experimental Epilespy, UCL Institute of Neurology, London, UK.

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June 2011

A longitudinal functional MRI study of non-arteritic anterior ischaemic optic neuropathy patients.

J Neurol Neurosurg Psychiatry 2011 Aug 1;82(8):905-13. Epub 2011 Feb 1.

Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1136/jnnp.2009.194563DOI Listing
August 2011

Dissecting the familial risk of multiple sclerosis.

Ann Neurol 2011 Jan;69(1):11-2

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January 2011

Pharmacological management of symptoms in multiple sclerosis: current approaches and future directions.

Lancet Neurol 2010 Dec;9(12):1182-1199

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, UK. Electronic address:

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December 2010

Assessing neuronal metabolism in vivo by modeling imaging measures.

J Neurosci 2010 Nov;30(45):15030-3

Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London WC1N 3BG, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044872PMC
November 2010

Atopic myelitis in a European woman residing in Japan.

J Neurol Neurosurg Psychiatry 2011 Sep 14;82(9):1022-4. Epub 2010 Aug 14.

National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

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September 2011

Effect sizes can be misleading: is it time to change the way we measure change?

J Neurol Neurosurg Psychiatry 2010 Sep 13;81(9):1044-8. Epub 2010 Jul 13.

Department of Clinical Neuroscience, Peninsula College of Medicine and Dentistry, Room N16 ITTC Building, Tamar Science Park, Plymouth, Devon, UK.

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September 2010

Scanning laser polarimetry quantification of retinal nerve fiber layer thinning following optic neuritis.

J Neuroophthalmol 2010 Sep;30(3):235-42

NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom.

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September 2010

Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis.

Mult Scler 2010 May 9;16(5):555-65. Epub 2010 Mar 9.

Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925387PMC
May 2010

Neuroplasticity predicts outcome of optic neuritis independent of tissue damage.

Ann Neurol 2010 Jan;67(1):99-113

Department of Brain Repair and Rehabilitation, University College London (UCL) Institute of Neurology, University College London, London, UK.

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January 2010

TI-relaxation time changes over five years in relapsing-remitting multiple sclerosis.

Mult Scler 2010 Apr 19;16(4):427-33. Epub 2010 Jan 19.

B Neurological Clinic, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.

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April 2010

Refinement and validation of the Parental Illness Impact Scale.

Parkinsonism Relat Disord 2010 Mar 25;16(3):181-5. Epub 2009 Nov 25.

School of Psychology, Thames Valley University, Paragon House, Brentford, Middlesex TW8 9GA, UK.

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March 2010

Diagnosing and managing multiple sclerosis.

Practitioner 2009 Sep;253(1721):25-30, 2-3

UCL Institute of Neurology, Queen Square, London.

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September 2009

The size of the treatment effect: do patients and proxies agree?

BMC Neurol 2009 Mar 25;9:12. Epub 2009 Mar 25.

Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667429PMC
March 2009

Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis.

J Neurol 2009 Mar 18;256(3):305-19. Epub 2009 Mar 18.

NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK.

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March 2009

Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM.

Hum Brain Mapp 2009 Sep;30(9):2852-61

Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1002/hbm.20713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871131PMC
September 2009

The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?

Health Qual Life Outcomes 2008 Aug 6;6:58. Epub 2008 Aug 6.

Neurological Outcome Measures Unit, Institute of Neurology, University College London, Queen Square, London, UK.

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http://dx.doi.org/10.1186/1477-7525-6-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538506PMC
August 2008

Gray matter atrophy is related to long-term disability in multiple sclerosis.

Ann Neurol 2008 Sep;64(3):247-54

Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK.

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http://dx.doi.org/10.1002/ana.21423DOI Listing
September 2008

MRI in multiple sclerosis: current status and future prospects.

Lancet Neurol 2008 Jul;7(7):615-25

Center for Neurological Imaging, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S1474-4422(08)70137-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586926PMC
July 2008

Rating scales as outcome measures for clinical trials in neurology: problems, solutions, and recommendations.

Lancet Neurol 2007 Dec;6(12):1094-105

Neurological Outcome Measures Unit, Peninsula College of Medicine and Dentistry, Plymouth, Devon, UK.

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http://dx.doi.org/10.1016/S1474-4422(07)70290-9DOI Listing
December 2007

Professor Ian McDonald (1933 2006).

Authors:
Alan J Thompson

Mult Scler 2007 Sep;13(8):953-4

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September 2007