Alan J Knox

Alan J Knox

UNVERIFIED PROFILE

Are you Alan J Knox?   Register this Author

Register author
Alan J Knox

Alan J Knox

Publications by authors named "Alan J Knox"

Are you Alan J Knox?   Register this Author

70Publications

949Reads

14Profile Views

Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.

Sci Rep 2019 Oct 8;9(1):14409. Epub 2019 Oct 8.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-50873-yDOI Listing
October 2019

Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma.

Chest 2019 Apr 8;155(4):816-824. Epub 2018 Nov 8.

Division of Respiratory Medicine, Nottingham University Hospitals NHS Trust (City Hospital Campus); and the Nottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00123692183271
Publisher Site
http://dx.doi.org/10.1016/j.chest.2018.10.038DOI Listing
April 2019

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

Clin Epigenetics 2018 5;10:32. Epub 2018 Mar 5.

Nottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, Division of Respiratory Medicine, University of Nottingham, Nottingham University Hospitals NHS Trust, City Hospital, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13148-018-0464-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838860PMC
February 2019

Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation.

Biochim Biophys Acta Gene Regul Mech 2018 May 17;1861(5):463-472. Epub 2018 Mar 17.

Division of Respiratory Medicine, University of Nottingham School of Medicine, City Hospital, Nottingham NG5 1PB, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagrm.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910054PMC
May 2018

PINX1 and TERT Are Required for TNF-α-Induced Airway Smooth Muscle Chemokine Gene Expression.

J Immunol 2018 02 5;200(4):1283-1294. Epub 2018 Jan 5.

Division of Respiratory Medicine, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1700414DOI Listing
February 2018

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis.

Am J Respir Cell Mol Biol 2017 06;56(6):772-783

1 Division of Immunology, School of Life Sciences, Faculty of Medicine and Health Sciences, Queen's Medical Centre, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2016-0306OCDOI Listing
June 2017

Matrix metalloproteinases -8 and -9 in the Airways, Blood and Urine During Exacerbations of COPD.

COPD 2016 29;13(1):26-34. Epub 2015 Sep 29.

a Division of Respiratory Medicine and Nottingham Respiratory Research Unit, School of Medicine , University of Nottingham , Nottingham , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/15412555.2015.1043522DOI Listing
October 2016

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells.

Biochem Biophys Res Commun 2016 08 27;476(4):431-437. Epub 2016 May 27.

Division of Respiratory Medicine, Nottingham Respiratory Research Unit, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.05.140DOI Listing
August 2016

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial.

Pediatr Pulmonol 2016 Mar 27;51(3):253-7. Epub 2015 Dec 27.

Division of Public Health and Epidemiology, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.23370DOI Listing
March 2016

Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2015 Aug 5;309(3):L237-49. Epub 2015 Jun 5.

Division of Respiratory Medicine, Centre for Respiratory Research, University of Nottingham.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00390.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525120PMC
August 2015

Prostanoids as anti-inflammatory therapy: separating the good from the bad.

Authors:
Alan J Knox

Thorax 2015 Aug 17;70(8):711-2. Epub 2015 Jun 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2015-207317DOI Listing
August 2015

Accelerated extracellular matrix turnover during exacerbations of COPD.

Respir Res 2015 Jun 11;16:69. Epub 2015 Jun 11.

Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK.

View Article

Download full-text PDF

Source
http://respiratory-research.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s12931-015-0225-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491243PMC
June 2015

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.

Am J Physiol Lung Cell Mol Physiol 2015 May 20;308(9):L962-72. Epub 2015 Feb 20.

Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00021.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421784PMC
May 2015

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.

FASEB J 2014 Jul 20;28(7):3183-96. Epub 2014 Mar 20.

Division of Respiratory Medicine and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, City Hospital, Nottingham, UK; and

View Article

Download full-text PDF

Source
http://www.fasebj.org/content/early/2014/03/20/fj.13-241760.
Web Search
http://www.fasebj.org/cgi/doi/10.1096/fj.13-241760
Publisher Site
http://dx.doi.org/10.1096/fj.13-241760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062820PMC
July 2014

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
March 2014

Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.

J Cyst Fibros 2013 May 5;12(3):284-9. Epub 2012 Sep 5.

Nottingham Biomedical Research Unit, Department of Respiratory Medicine, City Hospital, Nottingham NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2012.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655260PMC
May 2013

Future bronchodilator therapy: a bitter pill to swallow?

Am J Physiol Lung Cell Mol Physiol 2012 Dec 28;303(11):L953-5. Epub 2012 Sep 28.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00303.2012DOI Listing
December 2012

Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer.

J Biol Chem 2012 Nov 18;287(47):39967-81. Epub 2012 Sep 18.

Centre for Respiratory Research, University of Nottingham, Nottingham, NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.397042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501049PMC
November 2012

Ciclesonide inhibits TNFα- and IL-1β-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells.

Am J Physiol Lung Cell Mol Physiol 2012 Apr 13;302(8):L785-92. Epub 2012 Jan 13.

Division of Respiratory Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00257.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331580PMC
April 2012

Transcriptional regulation of inflammatory genes associated with severe asthma.

Curr Pharm Des 2011 ;17(7):653-66

Division of Respiratory Medicine and Nottingham Biomedical Research Unit, City hospital, England, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138161211795429000DOI Listing
March 2012

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.

J Immunol 2011 Dec 24;187(11):6094-107. Epub 2011 Oct 24.

Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1003507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242066PMC
December 2011

Endothelin-1 (ET-1) increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways: role of a phospholipase A(2)(cPLA(2))/cyclooxygenase-2 (COX-2)/prostacyclin receptor-dependent autocrine loop.

J Biol Chem 2010 Aug 7;285(34):25913-27. Epub 2010 May 7.

Division of Respiratory Medicine, Centre for Respiratory Research, University of Nottingham, City Hospital Site, Hucknall Road, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.139485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923981PMC
August 2010

Vitamin D - a new treatment for airway remodelling in asthma?

Br J Pharmacol 2009 Nov;158(6):1426-8

Centre for Respiratory Research, University of Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1476-5381.2009.00429.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795209PMC
November 2009

Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter.

J Immunol 2009 Oct 4;183(7):4682-92. Epub 2009 Sep 4.

Centre for Respiratory Research and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0803832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992371PMC
October 2009

Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling.

Am J Physiol Lung Cell Mol Physiol 2009 Jun 3;296(6):L1059-66. Epub 2009 Apr 3.

Divisions of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.90445.2008DOI Listing
June 2009

Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1.

Br J Pharmacol 2009 Jun 9;157(3):436-50. Epub 2009 Apr 9.

Nottingham Respiratory Biomedical Research Unit, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1476-5381.2009.00143.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707990PMC
June 2009

Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta).

J Biol Chem 2008 Dec 23;283(51):35337-53. Epub 2008 Oct 23.

Centre for Respiratory Research, Clinical Sciences Building, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M803342200
Publisher Site
http://dx.doi.org/10.1074/jbc.M803342200DOI Listing
December 2008

PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation.

J Immunol 2008 Sep;181(5):3503-14

Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.181.5.3503DOI Listing
September 2008

Beta-tryptase regulates IL-8 expression in airway smooth muscle cells by a PAR-2-independent mechanism.

Am J Respir Cell Mol Biol 2008 May 13;38(5):600-8. Epub 2007 Dec 13.

Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2007-0082OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643247PMC
May 2008

IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA.

Am J Physiol Lung Cell Mol Physiol 2008 Mar 21;294(3):L553-62. Epub 2007 Dec 21.

Division of Respiratory Medicine, University of Nottingham, Clinical Science Bldg., City Hospital, Nottingham, NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00044.2006DOI Listing
March 2008

Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration.

Am J Physiol Lung Cell Mol Physiol 2007 Apr 22;292(4):L1030-8. Epub 2006 Dec 22.

Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00317.2006DOI Listing
April 2007

Key developments in respiratory medicine.

Practitioner 2006 Apr;250(1681):185-6, 189-92

Division of Respiratory Medicine, University of Nottingham.

View Article

Download full-text PDF

Source
April 2006

Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.

J Immunol 2006 Mar;176(6):3788-95

Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.176.6.3788DOI Listing
March 2006

beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation.

J Immunol 2005 Jul;175(1):478-86

Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.175.1.478DOI Listing
July 2005

Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids.

FEBS Lett 2005 May 7;579(12):2551-6. Epub 2005 Apr 7.

Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2005.02.083DOI Listing
May 2005

Aspirin-induced asthma: clinical aspects, pathogenesis and management.

Drugs 2004 ;64(21):2417-32

Department of Respiratory Medicine, Al-Mansourah University, Al-Dakahlia, Egypt.

View Article

Download full-text PDF

Source
http://link.springer.com/10.2165/00003495-200464210-00004
Publisher Site
http://dx.doi.org/10.2165/00003495-200464210-00004DOI Listing
February 2005

Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists.

J Biol Chem 2005 Jan 5;280(4):2550-61. Epub 2004 Nov 5.

Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M410616200DOI Listing
January 2005

Matrix metalloproteinase expression and activity in human airway smooth muscle cells.

Br J Pharmacol 2004 Aug 20;142(8):1318-24. Epub 2004 Jul 20.

Division of Therapeutics and Molecular Medicine, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham NG7 2UH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.bjp.0705883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575191PMC
August 2004

Synthetic responses in airway smooth muscle.

J Allergy Clin Immunol 2004 Aug;114(2 Suppl):S32-50

Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2004.04.041DOI Listing
August 2004

Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function.

Am J Physiol Lung Cell Mol Physiol 2003 Nov;285(5):L973-83

Department of Respiratory Medicine, Al-Mansourah University, Al-Dakahlia, Egypt.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00033.2003DOI Listing
November 2003

Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB.

J Biol Chem 2003 Aug 14;278(31):29366-75. Epub 2003 May 14.

Division of Respiratory Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M301785200DOI Listing
August 2003

Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways.

Lung Cancer 2003 Apr;40(1):33-44

Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0169-5002(02)00530-5DOI Listing
April 2003

Aminoglycoside prescribing and surveillance in cystic fibrosis.

Am J Respir Crit Care Med 2003 Mar;167(6):819-23

Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.200109-012CCDOI Listing
March 2003

The scientific rationale of combining inhaled glucocorticoids and long acting beta 2 adrenoceptor agonists.

Authors:
Alan J Knox

Curr Pharm Des 2002 ;8(20):1863-9

Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612023393774DOI Listing
February 2003

Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.

J Immunol 2003 Jan;170(2):1043-51

Division of Respiratory Medicine, City Hospital, University of Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.170.2.1043DOI Listing
January 2003

Glucocorticoid and beta-adrenoceptor agonist interactions in asthma.

Lancet 2002 Oct;360(9342):1265-6

Division of Respiratory Medicine, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(02)11356-0DOI Listing
October 2002

Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.

Am J Physiol Lung Cell Mol Physiol 2002 Sep;283(3):L612-8

Division of Respiratory Medicine, City Hospital, Nottingham NG5 1PB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00483.2001DOI Listing
September 2002

Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells.

FASEB J 2002 Sep 18;16(11):1435-7. Epub 2002 Jul 18.

Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham NG5 1PB, UK.

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.02-0169fje
Publisher Site
http://dx.doi.org/10.1096/fj.02-0169fjeDOI Listing
September 2002

Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum.

FEMS Microbiol Lett 2002 Jan;207(1):1-7

School of Pharmaceutical Sciences, University of Nottingham, University Park, NG7 2RD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1574-6968.2002.tb11019.xDOI Listing
January 2002