Publications by authors named "Alan J Robinson"

46Publications

Nucleotide-binding sites can enhance N-acylation of nearby protein lysine residues.

Sci Rep 2020 11 20;10(1):20254. Epub 2020 Nov 20.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.

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November 2020

Neurodevelopmental regression, severe generalized dystonia, and metabolic acidosis caused by mutations.

Neurol Genet 2020 Dec 7;6(6):e521. Epub 2020 Oct 7.

Medical Research Council-Mitochondrial Biology Unit (A.R., M.J., A.J.R., C.B., M.Z.), University of Cambridge, United Kingdom; Department of Genetics (V.Z., R.L.R.S., C.B.), Federal University of Paraná-UFPR; and Neuropediatric Division (V.M., M.L.S.F.S., D.V., B.A.T.), Hospital Pequeno Príncipe, Curitiba, Brazil.

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December 2020

Novel compound heterozygous pathogenic variants in nucleotide-binding protein like protein (NUBPL) cause leukoencephalopathy with multi-systemic involvement.

Mol Genet Metab 2020 01 21;129(1):26-34. Epub 2019 Nov 21.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB20XY Cambridge, UK; Dipartimento di Scienze Mediche e Chirurgiche, Centro di Ricerca Biomedica Applicata, Università di Bologna, via Massarenti, 11, 40100 Bologna, Italy. Electronic address:

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January 2020

MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases.

Nucleic Acids Res 2019 01;47(D1):D1225-D1228

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.

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January 2019

The Causes and Consequences of Nonenzymatic Protein Acylation.

Trends Biochem Sci 2018 11 18;43(11):921-932. Epub 2018 Aug 18.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

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November 2018

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species.

Cell Rep 2018 08;24(6):1445-1455

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

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August 2018

Cardiolipin dynamics and binding to conserved residues in the mitochondrial ADP/ATP carrier.

Biochim Biophys Acta Biomembr 2018 May 31;1860(5):1035-1045. Epub 2018 Jan 31.

Medical Research Council, Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address:

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May 2018

MitoCore: a curated constraint-based model for simulating human central metabolism.

BMC Syst Biol 2017 Nov 25;11(1):114. Epub 2017 Nov 25.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.

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November 2017

Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling.

Mitochondrion 2016 Nov 30;31:45-55. Epub 2016 Sep 30.

MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK. Electronic address:

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November 2016

Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.

Proc Natl Acad Sci U S A 2016 08 5;113(31):8687-92. Epub 2016 Jul 5.

The Medical Research Council Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom

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August 2016

MitoMiner v3.1, an update on the mitochondrial proteomics database.

Nucleic Acids Res 2016 Jan 1;44(D1):D1258-61. Epub 2015 Oct 1.

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK

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January 2016

Alternative translation initiation augments the human mitochondrial proteome.

Nucleic Acids Res 2013 Feb 28;41(4):2354-69. Epub 2012 Dec 28.

MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge CB2 0XY, UK.

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February 2013

Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis.

Exp Cell Res 2012 Jul 3;318(11):1316-23. Epub 2012 Feb 3.

The Medical Research Council, Mitochondrial Biology Unit, Cambridge, UK.

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July 2012

Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.

J Biol Chem 2012 Mar 19;287(11):7925-34. Epub 2012 Jan 19.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.

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March 2012

MitoMiner: a data warehouse for mitochondrial proteomics data.

Nucleic Acids Res 2012 Jan 24;40(Database issue):D1160-7. Epub 2011 Nov 24.

Medical Research Council Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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January 2012

Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import.

FEBS Lett 2011 Dec 2;585(24):3935-40. Epub 2011 Nov 2.

Department of Biochemistry and Cell Biology, MFPL, University of Vienna, Vienna, Austria.

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December 2011

A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle.

BMC Syst Biol 2011 Jun 29;5:102. Epub 2011 Jun 29.

The Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.

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June 2011

Functional and structural role of amino acid residues in the matrix alpha-helices, termini and cytosolic loops of the bovine mitochondrial oxoglutarate carrier.

Biochim Biophys Acta 2011 Mar 15;1807(3):302-10. Epub 2010 Dec 15.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.

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March 2011

Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers.

Curr Opin Struct Biol 2010 Aug 1;20(4):440-7. Epub 2010 Jul 1.

The Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom.

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August 2010

Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance.

Proc Natl Acad Sci U S A 2010 Feb 19;107(5):1930-5. Epub 2010 Jan 19.

Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, Center for Advanced Electron Spin Resonance, Oxford OX1 3QR, United Kingdom.

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February 2010

MitoMiner, an integrated database for the storage and analysis of mitochondrial proteomics data.

Mol Cell Proteomics 2009 Jun 9;8(6):1324-37. Epub 2009 Feb 9.

MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB20XY, United Kingdom.

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June 2009

The mechanism of transport by mitochondrial carriers based on analysis of symmetry.

Proc Natl Acad Sci U S A 2008 Nov 10;105(46):17766-71. Epub 2008 Nov 10.

Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, United Kingdom.

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November 2008

Functional and structural role of amino acid residues in the odd-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier.

J Mol Biol 2007 Jun 24;369(2):400-12. Epub 2007 Mar 24.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.

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June 2007

The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP.

J Virol 2007 Apr 17;81(7):3181-6. Epub 2007 Jan 17.

Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom.

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April 2007

Functional and structural role of amino acid residues in the even-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier.

J Mol Biol 2006 Oct 22;363(1):51-62. Epub 2006 Aug 22.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.

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October 2006

The conserved substrate binding site of mitochondrial carriers.

Biochim Biophys Acta 2006 Sep-Oct;1757(9-10):1237-48. Epub 2006 Apr 4.

The Medical Research Council, Dunn Human Nutrition Unit, CB2 2XY, Cambridge, UK.

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December 2006

Mitochondrial carriers in the cytoplasmic state have a common substrate binding site.

Proc Natl Acad Sci U S A 2006 Feb 9;103(8):2617-22. Epub 2006 Feb 9.

Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom.

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February 2006

myGrid: personalised bioinformatics on the information grid.

Bioinformatics 2003 ;19 Suppl 1:i302-4

Department of Computer Science, University of Manchester, Oxford Road, Manchester, UK, M13 9PL.

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October 2004