Alan H Shih

Alan H Shih

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Alan H Shih

Alan H Shih

Publications by authors named "Alan H Shih"

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28Publications

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer Cell 2018 01 21;33(1):44-59.e8. Epub 2017 Dec 21.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173051
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http://dx.doi.org/10.1016/j.ccell.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760367PMC
January 2018

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.

Mol Cell 2016 08 28;63(4):711-719. Epub 2016 Jul 28.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992443PMC
August 2016

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

J Exp Med 2016 Jan 14;213(1):25-34. Epub 2015 Dec 14.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136 Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136 Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136

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http://dx.doi.org/10.1084/jem.20150524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710200PMC
January 2016

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Cancer Cell 2015 Apr;27(4):502-15

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518555PMC
April 2015

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.

J Exp Med 2013 Nov 11;210(12):2641-59. Epub 2013 Nov 11.

Human Oncology and Pathogenesis Program, 2 Leukemia Service, 3 Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, and 4 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1084/jem.20131141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832937PMC
November 2013

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia.

Haematologica 2013 Jun 24;98(6):908-12. Epub 2013 Jan 24.

Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.3324/haematol.2012.076729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669447PMC
June 2013

The role of mutations in epigenetic regulators in myeloid malignancies.

Nat Rev Cancer 2012 Sep 17;12(9):599-612. Epub 2012 Aug 17.

Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1038/nrc3343DOI Listing
September 2012

IDH1 mutations disrupt blood, brain, and barriers.

Cancer Cell 2012 Sep;22(3):285-7

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.08.022DOI Listing
September 2012

Molecular biology of myelodysplastic syndromes.

Semin Oncol 2011 Oct;38(5):613-20

Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY 10065, USA.

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http://link.springer.com/content/pdf/10.1007%2F978-3-642-294
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http://linkinghub.elsevier.com/retrieve/pii/S009377541100128
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http://dx.doi.org/10.1053/j.seminoncol.2011.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183432PMC
October 2011

Notch signaling enhances nestin expression in gliomas.

Neoplasia 2006 Dec;8(12):1072-82

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S147655860680113
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http://dx.doi.org/10.1593/neo.06526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790729PMC
December 2006

Platelet-derived growth factor (PDGF) and glial tumorigenesis.

Cancer Lett 2006 Feb 31;232(2):139-47. Epub 2005 Aug 31.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.02.002DOI Listing
February 2006

Developmental neurobiology and the origin of brain tumors.

J Neurooncol 2004 Nov;70(2):125-36

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://link.springer.com/content/pdf/10.1007/s11060-004-2746
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http://link.springer.com/10.1007/s11060-004-2746-3
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http://dx.doi.org/10.1007/s11060-004-2746-3DOI Listing
November 2004

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis.

Cancer Res 2004 Jul;64(14):4783-9

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-03-3831DOI Listing
July 2004