Alan H Lazarus

Alan H Lazarus

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Alan H Lazarus

Alan H Lazarus

Publications by authors named "Alan H Lazarus"

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Erythrocyte Saturation with IgG Is Required for Inducing Antibody-Mediated Immune Suppression and Impacts Both Erythrocyte Clearance and Antigen-Modulation Mechanisms.

J Immunol 2018 02 22;200(4):1295-1305. Epub 2018 Jan 22.

Department of Laboratory Medicine and the Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada;

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http://dx.doi.org/10.4049/jimmunol.1700874DOI Listing
February 2018

Anti-RhD reduces levels of detectable RhD antigen following anti-RhD infusion.

Transfusion 2018 02;58(2):542-544

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital/Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/trf.14452DOI Listing
February 2018

Prevention of hemolytic disease of the fetus and newborn: what have we learned from animal models?

Curr Opin Hematol 2017 Nov;24(6):536-543

aDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital bThe Canadian Blood Services Centre for Innovation cDepartment of Medicine and Laboratory Medicine and Pathobiology, University of Toronto; Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOH.0000000000000374DOI Listing
November 2017

Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice.

Blood 2016 08 21;128(8):1076-80. Epub 2016 Jun 21.

The Canadian Blood Services Centre for Innovation, Department of Laboratory Medicine and the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, and Department of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2016-01-692178DOI Listing
August 2016

Targeting FcγRs to treat antibody-dependent autoimmunity.

Autoimmun Rev 2016 Jun 12;15(6):510-2. Epub 2016 Feb 12.

Canadian Blood Services, Ottawa, Ontario, Canada K1G 4J5; Department of Laboratory Medicine, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada, M5B 1W8; Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.02.006DOI Listing
June 2016

CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor- and Complement Receptor 3-Dependent Mechanisms.

J Immunol 2016 Apr 4;196(8):3331-40. Epub 2016 Mar 4.

Canadian Blood Services Centre for Innovation, Toronto, Ontario K1G 4J5, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario M5B 1T8, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada

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http://dx.doi.org/10.4049/jimmunol.1502198DOI Listing
April 2016

Mechanistic properties of intravenous immunoglobulin in murine immune thrombocytopenia: support for FcγRIIB falls by the wayside.

Semin Hematol 2016 04 6;53 Suppl 1:S20-2. Epub 2016 Apr 6.

The Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital and the Department of Laboratory Medicine, Toronto, Ontario, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.04.007DOI Listing
April 2016

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia.

Blood 2016 Feb 10;127(6):735-8. Epub 2015 Nov 10.

The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Department of Medicine, Department of Laboratory Medicine and Pathobiology, and Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

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http://www.bloodjournal.org/content/bloodjournal/127/6/735.f
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-06-65
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http://dx.doi.org/10.1182/blood-2015-06-655126DOI Listing
February 2016

Monovalent Fc receptor blockade by an anti-Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity.

Blood 2016 Jan 23;127(1):132-8. Epub 2015 Oct 23.

Canadian Blood Services, Ottawa, ON, Canada; Department of Laboratory Medicine, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;

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http://dx.doi.org/10.1182/blood-2015-08-664656DOI Listing
January 2016

IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fcγ Receptors in a Full Mouse Model.

J Immunol 2015 Sep 17;195(5):2224-30. Epub 2015 Jul 17.

Canadian Blood Services, Ottawa, Ontario K1G 4J5, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada; and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A1, Canada

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1500790
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http://dx.doi.org/10.4049/jimmunol.1500790DOI Listing
September 2015

CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia.

Blood 2015 Jul 2;126(2):247-56. Epub 2015 Jun 2.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Medicine and Department of Physiology, University of Toronto, ON, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-03-63
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http://dx.doi.org/10.1182/blood-2015-03-635417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505012PMC
July 2015

CD44 antibody-mediated amelioration of murine immune thrombocytopenia (ITP): mouse background determines the effect of FcγRIIb genetic disruption.

Transfusion 2015 Jun 15;55(6 Pt 2):1492-500. Epub 2014 Dec 15.

Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/trf.12957DOI Listing
June 2015

RhD Specific Antibodies Are Not Detectable in HLA-DRB1(*)1501 Mice Challenged with Human RhD Positive Erythrocytes.

Adv Hematol 2014 31;2014:470242. Epub 2014 Dec 31.

The Canadian Blood Services, Canada ; Department of Laboratory Medicine and the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8 ; Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1155/2014/470242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297636PMC
January 2015

Antibody-mediated immune suppression of erythrocyte alloimmunization can occur independently from red cell clearance or epitope masking in a murine model.

J Immunol 2014 Sep 13;193(6):2902-10. Epub 2014 Aug 13.

The Canadian Blood Services, Ottawa, Ontario K1G 4J5, Canada; Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada; and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A1, Canada

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1302287
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http://dx.doi.org/10.4049/jimmunol.1302287DOI Listing
September 2014

Antibody specific for the glycophorin A complex mediates intravenous immune globulin-resistant anemia in a murine model.

Transfusion 2014 Mar 19;54(3):655-64. Epub 2013 Jun 19.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Canadian Blood Services, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/trf.12300
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http://dx.doi.org/10.1111/trf.12300DOI Listing
March 2014

CD44 antibodies and immune thrombocytopenia in the amelioration of murine inflammatory arthritis.

PLoS One 2013 13;8(6):e65805. Epub 2013 Jun 13.

Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681793PMC
January 2014

Monoclonal versus polyclonal anti-D in the treatment of ITP.

Authors:
Alan H Lazarus

Expert Opin Biol Ther 2013 Oct 7;13(10):1353-6. Epub 2013 Aug 7.

University of Toronto, Department of Laboratory Medicine and the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, The Canadian Blood Services, Departments of Medicine and Laboratory Medicine & Pathobiology , 30 Bond St, Toronto, Ontario, M5B 1W8 , Canada

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http://dx.doi.org/10.1517/14712598.2013.825243DOI Listing
October 2013

Innate and adaptive immunity in immune thrombocytopenia.

Semin Hematol 2013 Jan;50 Suppl 1:S68-70

The Canadian Blood Services, Ottawa, Canada.

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http://dx.doi.org/10.1053/j.seminhematol.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691820PMC
January 2013

The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia.

Blood 2011 Dec 14;118(24):6403-6. Epub 2011 Oct 14.

Canadian Blood Services, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael’s Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2011-08-374223DOI Listing
December 2011

Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb.

J Gene Med 2011 Sep;13(9):470-7

Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jgm.1598DOI Listing
September 2011

IVIg conducts DC-platelet nuptials.

Authors:
Alan H Lazarus

Blood 2010 Dec;116(23):4740-1

The Canadian Blood Services.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-09-30
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http://dx.doi.org/10.1182/blood-2010-09-303420DOI Listing
December 2010

Mechanisms of platelet recovery in ITP associated with therapy.

Ann Hematol 2010 Jul 24;89 Suppl 1:31-5. Epub 2010 Feb 24.

The Canadian Blood Services, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s00277-010-0916-2
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http://dx.doi.org/10.1007/s00277-010-0916-2DOI Listing
July 2010

Adoptive-transfer effects of intravenous immunoglobulin in autoimmunity.

Authors:
Alan H Lazarus

J Clin Immunol 2010 May;30 Suppl 1:S20-3

The Canadian Blood Services, Ottawa, ON, Canada.

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http://link.springer.com/10.1007/s10875-010-9410-9
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http://dx.doi.org/10.1007/s10875-010-9410-9DOI Listing
May 2010

Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.

Hematology Am Soc Hematol Educ Program 2009 :185-91

Canadian Blood Services, Department of Laboratory Medicine of St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1182/asheducation-2009.1.185DOI Listing
March 2010

Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn: what can we learn from rodent models?

Curr Opin Hematol 2009 Nov;16(6):488-96

The Canadian Blood Services, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOH.0b013e32833199edDOI Listing
November 2009

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk.

Blood 2009 Apr 18;113(14):3154-60. Epub 2008 Dec 18.

Department of Medicine, New York Presbyterian Hospital, Columbia University Medical Center, New York 10032, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-07-16
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http://dx.doi.org/10.1182/blood-2008-07-166439DOI Listing
April 2009

Transfusion of IgG-opsonized foreign red blood cells mediates reduction of antigen-specific B cell priming in a murine model.

J Immunol 2008 Jul;181(2):948-53

Department of Laboratory Medicine of St Michael's Hospital, Canadian Blood Services, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.181.2.948DOI Listing
July 2008

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?

Blood 2007 Jan 5;109(1):155-8. Epub 2006 Sep 5.

Canadian Blood Services, Department of Laboratory Medicine, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8.

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http://dx.doi.org/10.1182/blood-2006-05-023796DOI Listing
January 2007

Mechanisms of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia.

Pediatr Blood Cancer 2006 Oct;47(5 Suppl):710-3

The Canadian Blood Services, Department of Laboratory Medicine, St Michael's Hospital and University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20980DOI Listing
October 2006

Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells.

Nat Med 2006 Jun 21;12(6):688-92. Epub 2006 May 21.

Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, Ontario, K1G 4J5, Canada.

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http://dx.doi.org/10.1038/nm1416DOI Listing
June 2006

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.

Blood 2006 Apr 29;107(7):2976-83. Epub 2005 Nov 29.

Canadian Blood Services and Dept of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, 30 Bond St Rm 2-006, Bond Wing, Toronto, ON, Canada M5B 1W8.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-25
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http://dx.doi.org/10.1182/blood-2005-06-2562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895387PMC
April 2006

Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia.

Br J Haematol 2006 Apr;133(1):78-82

Division of Transfusion Medicine, Department of Laboratory Medicine, St Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1365-2141.2006.05981.xDOI Listing
April 2006

Monoclonal antibodies that mimic the action of anti-D in the amelioration of murine ITP act by a mechanism distinct from that of IVIg.

Blood 2005 Feb 12;105(4):1546-8. Epub 2004 Oct 12.

Transfusion Medicine Research, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8.

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http://dx.doi.org/10.1182/blood-2004-05-1886DOI Listing
February 2005

Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?

J Clin Invest 2005 Jan;115(1):155-60

Transfusion Medicine Research and the Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI22753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539200PMC
January 2005

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype.

Transfusion 2004 Nov;44(11):1572-8

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1537-2995.2004.04197.xDOI Listing
November 2004

Role of Fcgamma receptors in the pathogenesis and treatment of idiopathic thrombocytopenic purpura.

J Pediatr Hematol Oncol 2003 Dec;25 Suppl 1:S14-8

Department of Laboratory Medicine & Pathobiology, St. Michael's Hospital, The Canadian Blood Services, and The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/00043426-200312001-00004DOI Listing
December 2003

IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity.

Blood 2003 Jul 20;102(2):558-60. Epub 2003 Mar 20.

Transfusion Medicine Research, St Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2003-01-0023DOI Listing
July 2003

Mechanism of action of IVIG and anti-D in ITP.

Transfus Apher Sci 2003 Jun;28(3):249-55

The Canadian Blood Services, and The Toronto Platelet Immunobiology Group, Ont., Toronto, Canada M5B 1W8.

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http://dx.doi.org/10.1016/S1473-0502(03)00043-0DOI Listing
June 2003

Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG.

Blood 2003 May 27;101(9):3708-13. Epub 2002 Dec 27.

Transfusion Medicine Research and the Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2002-10-3078DOI Listing
May 2003

Understanding platelet function through signal transduction.

Transfus Med Rev 2003 Jan;17(1):45-56

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, The Canadian Blood Services, Toronto, Ontario, Canada. smh.toronto.on.ca

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http://dx.doi.org/10.1053/tmrv.2003.50002DOI Listing
January 2003

Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response.

Blood 2002 Aug;100(3):1055-9

Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1182/blood.v100.3.1055DOI Listing
August 2002

Mechanism of action of IVIG in ITP.

Authors:
Alan H Lazarus

Vox Sang 2002 Aug;83 Suppl 1:53-5

Canadian Blood Services, and The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1423-0410.2002.tb05268.xDOI Listing
August 2002