Alan H Fairlamb

Alan H Fairlamb

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Alan H Fairlamb

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The Q Site of Cytochrome is a Promiscuous Drug Target in and .

ACS Infect Dis 2020 Jan 30. Epub 2020 Jan 30.

Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences , University of Dundee , Dow Street , Dundee DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.9b00426DOI Listing
January 2020

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis.

Curr Med Chem 2019 ;26(23):4454-4475

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.2174/0929867325666180426164352DOI Listing
November 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.

ACS Infect Dis 2018 10 28;4(10):1475-1486. Epub 2018 Sep 28.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.8b00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199744PMC
October 2018

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Antimicrob Agents Chemother 2018 08 27;62(8). Epub 2018 Jul 27.

Wellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.00235-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105827PMC
August 2018

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Biochem J 2018 08 30;475(16):2593-2610. Epub 2018 Aug 30.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BCJ20180232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117947PMC
August 2018

Characterisation of a putative glutamate 5-kinase from Leishmania donovani.

FEBS J 2018 07 27;285(14):2662-2678. Epub 2018 May 27.

Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, UK.

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http://dx.doi.org/10.1111/febs.14511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099280PMC
July 2018

Melarsoprol Resistance in African Trypanosomiasis.

Trends Parasitol 2018 06 25;34(6):481-492. Epub 2018 Apr 25.

The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK; ORCID: http://orcid.org/0000-0001-5173-9284. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2018.04.002DOI Listing
June 2018

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Malar J 2017 11 7;16(1):446. Epub 2017 Nov 7.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/s12936-017-2085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678585PMC
November 2017

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

ACS Infect Dis 2017 10 2;3(10):718-727. Epub 2017 Oct 2.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395PMC
October 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.

J Biol Chem 2016 Nov 4;291(47):24768-24778. Epub 2016 Oct 4.

From the Division of Biological Chemistry and Drug Discovery, Wellcome Trust Building, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom

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http://dx.doi.org/10.1074/jbc.M116.750422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114424PMC
November 2016

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.

PLoS Pathog 2016 Nov 3;12(11):e1005971. Epub 2016 Nov 3.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Building, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1005971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094698PMC
November 2016

The N-myristoylome of Trypanosoma cruzi.

Sci Rep 2016 08 5;6:31078. Epub 2016 Aug 5.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/srep31078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974623PMC
August 2016

Drug resistance in eukaryotic microorganisms.

Nat Microbiol 2016 06 24;1(7):16092. Epub 2016 Jun 24.

Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.

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http://dx.doi.org/10.1038/nmicrobiol.2016.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215055PMC
June 2016

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase.

PLoS Negl Trop Dis 2016 05 13;10(5):e0004714. Epub 2016 May 13.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0004714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866688PMC
May 2016

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.

Elife 2016 05 24;5. Epub 2016 May 24.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.7554/eLife.09744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878867PMC
May 2016

Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases.

Nat Rev Drug Discov 2016 Apr 29;15(4):292. Epub 2016 Mar 29.

Department of Medicine, University of Cambridge, Cambridge CB2 0SP, UK.

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http://dx.doi.org/10.1038/nrd.2016.51DOI Listing
April 2016

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.

J Antimicrob Chemother 2016 Mar 17;71(3):625-34. Epub 2015 Nov 17.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Building, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK

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http://jac.oxfordjournals.org/content/early/2015/11/17/jac.d
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http://www.jac.oxfordjournals.org/lookup/doi/10.1093/jac/dkv
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http://dx.doi.org/10.1093/jac/dkv376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743696PMC
March 2016

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

PLoS Negl Trop Dis 2015 Dec 18;9(12):e0004299. Epub 2015 Dec 18.

School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0004299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689576PMC
December 2015

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.

Bioorg Med Chem 2015 Aug 24;23(16):5156-67. Epub 2015 Jan 24.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.01.031DOI Listing
August 2015

Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in Bihar, India: a retrospective cohort study.

PLoS Negl Trop Dis 2015 Mar 2;9(3):e0003518. Epub 2015 Mar 2.

ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1371/journal.pntd.0003518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346263PMC
March 2015

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.

Mol Microbiol 2015 Jan 25;95(1):143-56. Epub 2014 Nov 25.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1111/mmi.12853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460637PMC
January 2015

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.

Biochem J 2014 Apr;459(2):323-32

*Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20131033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969225PMC
April 2014

Norspermidine is not a self-produced trigger for biofilm disassembly.

Cell 2014 Feb;156(4):844-54

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969229PMC
February 2014

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis.

Proc Natl Acad Sci U S A 2013 Dec 28;110(49):19932-7. Epub 2013 Oct 28.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1311535110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856816PMC
December 2013

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.

Antimicrob Agents Chemother 2013 Oct 15;57(10):4699-706. Epub 2013 Jul 15.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00722-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811480PMC
October 2013

Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.

Mol Microbiol 2013 Oct 9;90(2):443-55. Epub 2013 Sep 9.

Divisional of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1111/mmi.12376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868941PMC
October 2013

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

Antimicrob Agents Chemother 2013 Jul 9;57(7):2913-22. Epub 2013 Apr 9.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1128/AAC.02398-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697379PMC
July 2013

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.

J Biol Chem 2013 May 21;288(21):15256-67. Epub 2013 Mar 21.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://www.jbc.org/content/288/21/15256.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.461137
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http://dx.doi.org/10.1074/jbc.M113.461137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663545PMC
May 2013

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes.

PLoS Negl Trop Dis 2012 29;6(11):e1932. Epub 2012 Nov 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510075PMC
April 2013

Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation.

Antimicrob Agents Chemother 2013 Feb 3;57(2):901-6. Epub 2012 Dec 3.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://aac.asm.org/cgi/doi/10.1128/AAC.01788-12
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http://dx.doi.org/10.1128/AAC.01788-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553740PMC
February 2013

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome.

Mol Microbiol 2012 Oct 16;86(1):51-64. Epub 2012 Aug 16.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2012.08189.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470933PMC
October 2012

Quinol derivatives as potential trypanocidal agents.

Bioorg Med Chem 2012 Feb 27;20(4):1607-15. Epub 2011 Dec 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2011.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281193PMC
February 2012

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Sci Transl Med 2012 Feb;4(119):119re1

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1126/scitranslmed.3003326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457684PMC
February 2012

Infectious disease: Genomics decodes drug action.

Authors:
Alan H Fairlamb

Nature 2012 Feb 8;482(7384):167-9. Epub 2012 Feb 8.

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http://dx.doi.org/10.1038/482167aDOI Listing
February 2012

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

ChemMedChem 2012 Jan 8;7(1):95-106. Epub 2011 Dec 8.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cmdc.201100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320663PMC
January 2012

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

ChemMedChem 2011 Oct 10;6(10):1832-40. Epub 2011 Aug 10.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229842PMC
October 2011

Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

PLoS Negl Trop Dis 2011 Sep 27;5(9):e1227. Epub 2011 Sep 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1371/journal.pntd.0001227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181240PMC
September 2011

Target validation: linking target and chemical properties to desired product profile.

Curr Top Med Chem 2011 ;11(10):1275-83

Drug Discovery Unit, College of Life Sciences, University of Dundee, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182078PMC
http://dx.doi.org/10.2174/156802611795429185DOI Listing
August 2011

Methylglyoxal metabolism in trypanosomes and leishmania.

Semin Cell Dev Biol 2011 May 15;22(3):271-7. Epub 2011 Feb 15.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Angus, Scotland, UK.

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http://dx.doi.org/10.1016/j.semcdb.2011.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107426PMC
May 2011

Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.

J Biol Chem 2011 Mar 6;286(10):8523-33. Epub 2011 Jan 6.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.214833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048735PMC
March 2011

Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major.

J Biol Chem 2011 Mar 14;286(12):10429-38. Epub 2011 Jan 14.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.209593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060496PMC
March 2011

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

ChemMedChem 2011 Feb 29;6(2):302-8. Epub 2010 Dec 29.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, Scotland, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047710PMC
February 2011

Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase.

ChemMedChem 2011 Feb 15;6(2):321-8. Epub 2010 Dec 15.

School of Chemistry and Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.

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http://dx.doi.org/10.1002/cmdc.201000442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047706PMC
February 2011

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Biochem Pharmacol 2010 Nov 7;80(10):1478-86. Epub 2010 Aug 7.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bcp.2010.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025325PMC
November 2010

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates.

Mol Biochem Parasitol 2010 Oct 27;173(2):162-4. Epub 2010 May 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH Scotland, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2010.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428625PMC
October 2010

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice.

Mol Microbiol 2010 Aug 1;77(3):658-71. Epub 2010 Jun 1.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2010.07236.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916222PMC
August 2010

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Antimicrob Agents Chemother 2010 Jul 3;54(7):2893-900. Epub 2010 May 3.

Division of Biological Chemistry & Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00332-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897277PMC
July 2010

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi.

Mol Biochem Parasitol 2010 Jan 10;169(1):12-9. Epub 2009 Sep 10.

The Wellcome Trust Biocentre, University of Dundee, Scotland, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2009.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789240PMC
January 2010

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.

Anal Biochem 2010 Jan 11;396(2):194-203. Epub 2009 Sep 11.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, UK.

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http://dx.doi.org/10.1016/j.ab.2009.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789237PMC
January 2010

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

J Biol Chem 2009 Dec 14;284(52):36137-45. Epub 2009 Oct 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.045336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794729PMC
December 2009

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

ChemMedChem 2009 Dec;4(12):2060-9

Drug Discovery Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855869PMC
December 2009

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Mol Microbiol 2009 Nov 24;74(3):529-40. Epub 2009 Jun 24.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://doi.wiley.com/10.1111/j.1365-2958.2009.06761.x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784880PMC
November 2009

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

ChemMedChem 2009 Aug;4(8):1333-40

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.200900097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929371PMC
August 2009

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

ChemMedChem 2009 Aug;4(8):1341-53

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929374PMC
August 2009

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Antimicrob Agents Chemother 2009 Jul 13;53(7):2824-33. Epub 2009 Apr 13.

The Walter and Eliza Hall Institute of Medical Research Biotechnology Centre, 1G Royal Parade, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus),2 Parkville, VIC-3052, Australia.

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http://dx.doi.org/10.1128/AAC.01568-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704697PMC
July 2009

A comparative study of methylglyoxal metabolism in trypanosomatids.

FEBS J 2009 Jan 3;276(2):376-86. Epub 2008 Dec 3.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06788.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702497PMC
January 2009

ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.

FEBS J 2008 Nov;275(21):5408-21

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, UK.

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http://doi.wiley.com/10.1111/j.1742-4658.2008.06670.x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702004PMC
November 2008

Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases.

Biochem J 2008 Sep;414(3):375-81

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20080889
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2552391PMC
September 2008

Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.

Mol Microbiol 2008 Jul;69(2):520-33

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2008.06305.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610392PMC
July 2008

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities.

J Biol Chem 2008 Jun 17;283(25):17672-80. Epub 2008 Apr 17.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M801850200
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427367PMC
June 2008

Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials.

Antimicrob Agents Chemother 2008 Apr 4;52(4):1359-65. Epub 2008 Feb 4.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/AAC.01563-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292513PMC
April 2008

Target assessment for antiparasitic drug discovery.

Trends Parasitol 2007 Dec 24;23(12):589-95. Epub 2007 Oct 24.

Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.pt.2007.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979298PMC
December 2007

A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.

FEBS J 2007 Nov 8;274(21):5643-58. Epub 2007 Oct 8.

Wellcome Trust Biocentre, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2007.06087.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430366PMC
November 2007

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.

Bioorg Med Chem Lett 2007 Mar 3;17(5):1422-7. Epub 2006 Dec 3.

The Walter and Eliza Hall Institute of Medical Research, Biotechnology Centre, 4 Research Avenue, La Trobe Research and Development Park, Bundoora, Vic. 3086, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2006.11.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428904PMC
March 2007

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.

Bioorg Med Chem Lett 2007 Mar 9;17(5):1280-3. Epub 2006 Dec 9.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428910PMC
March 2007

Trypanothione-dependent glyoxalase I in Trypanosoma cruzi.

Biochem J 2006 Dec;400(2):217-23

Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20060882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1652828PMC
December 2006

Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major.

Mol Biochem Parasitol 2006 Sep 26;149(1):117-20. Epub 2006 May 26.

School of Life Sciences, The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2006.05.001DOI Listing
September 2006

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.

Mol Microbiol 2006 Sep;61(6):1457-68

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2006.05332.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618733PMC
September 2006

Refinement of techniques for the propagation of Leishmania donovani in hamsters.

Acta Trop 2006 Mar 7;97(3):364-9. Epub 2006 Feb 7.

Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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March 2006

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.

Mol Microbiol 2006 Feb;59(4):1239-48

Division of Biological Chemistry & Molecular Microbiology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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February 2006

Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line.

Biochem Pharmacol 2006 Jan 28;71(3):257-67. Epub 2005 Nov 28.

Division of Biological Chemistry and Molecular Biology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH Scotland, UK.

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http://dx.doi.org/10.1016/j.bcp.2005.10.043DOI Listing
January 2006

Drug resistance in leishmaniasis.

Clin Microbiol Rev 2006 Jan;19(1):111-26

Drugs for Neglected Diseases Initiative, 1 Place Saint-Gervais, CH-1201 Geneva, Switzerland.

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http://dx.doi.org/10.1128/CMR.19.1.111-126.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360270PMC
January 2006

MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii.

Eukaryot Cell 2005 Dec;4(12):2057-65

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Building Room A-525, Indianapolis, IN 46202-5120, USA.

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http://ec.asm.org/lookup/doi/10.1128/EC.4.12.2057-2065.2005
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http://dx.doi.org/10.1128/EC.4.12.2057-2065.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317489PMC
December 2005

Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Aug 30;61(Pt 8):769-72. Epub 2005 Jul 30.

Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S174430910502169XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952357PMC
August 2005