Alan B Clark

Alan B Clark

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Alan B Clark

Alan B Clark

Publications by authors named "Alan B Clark"

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Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA.

DNA Repair (Amst) 2019 12 3;84:102641. Epub 2019 Jul 3.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102641DOI Listing
December 2019

Stimulation of Chromosomal Rearrangements by Ribonucleotides.

Genetics 2015 Nov 22;201(3):951-61. Epub 2015 Sep 22.

Department of Environmental and Radiological Health Sciences and Institute for Genome Architecture and Function, Colorado State University, Fort Collins, Colorado 80523 Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709

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http://dx.doi.org/10.1534/genetics.115.181149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649663PMC
November 2015

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Nat Struct Mol Biol 2015 Apr 9;22(4):291-7. Epub 2015 Mar 9.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/nsmb.2989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835660PMC
April 2015

Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.

Nucleic Acids Res 2015 Apr 30;43(8):4067-74. Epub 2015 Mar 30.

Genome Instability and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA

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http://nar.oxfordjournals.org/content/early/2015/03/30/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv271
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http://dx.doi.org/10.1093/nar/gkv271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417177PMC
April 2015

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

Genome Res 2014 Nov 12;24(11):1751-64. Epub 2014 Sep 12.

Laboratory of Molecular Genetics, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA; Laboratory of Structural Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA;

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http://dx.doi.org/10.1101/gr.178335.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216917PMC
November 2014

Ribonucleotides are signals for mismatch repair of leading-strand replication errors.

Mol Cell 2013 May 18;50(3):437-43. Epub 2013 Apr 18.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658170PMC
May 2013

Mismatch repair balances leading and lagging strand DNA replication fidelity.

PLoS Genet 2012 11;8(10):e1003016. Epub 2012 Oct 11.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469411PMC
March 2013

Malaria drug resistance is associated with defective DNA mismatch repair.

Mol Biochem Parasitol 2011 Jun 21;177(2):143-7. Epub 2011 Feb 21.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2011.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075314PMC
June 2011

Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I.

Science 2011 Jun;332(6037):1561-4

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/science.1205016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380281PMC
June 2011

Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε.

DNA Repair (Amst) 2011 May 16;10(5):476-82. Epub 2011 Mar 16.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S156878641100053
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http://dx.doi.org/10.1016/j.dnarep.2011.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652408PMC
May 2011

The importance of being DNA.

Cell Cycle 2010 Nov 15;9(22):4422-4. Epub 2010 Nov 15.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603967PMC
http://dx.doi.org/10.4161/cc.9.22.14052DOI Listing
November 2010

Genome instability due to ribonucleotide incorporation into DNA.

Nat Chem Biol 2010 Oct 22;6(10):774-81. Epub 2010 Aug 22.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://www.nature.com/doifinder/10.1038/nchembio.424
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http://dx.doi.org/10.1038/nchembio.424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942972PMC
October 2010

An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.

Gastroenterology 2010 Mar 18;138(3):993-1002.e1. Epub 2009 Nov 18.

Department of Medicine/Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1053/j.gastro.2009.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862591PMC
March 2010

Multiple functions for the N-terminal region of Msh6.

Nucleic Acids Res 2007 12;35(12):4114-23. Epub 2007 Jun 12.

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/nar/gkm409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919485PMC
August 2007

Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.

Mol Immunol 2007 Apr 22;44(10):2659-66. Epub 2007 Jan 22.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, D3-01, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.molimm.2006.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868521PMC
April 2007

Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.

Proc Natl Acad Sci U S A 2006 Nov 17;103(48):18083-8. Epub 2006 Nov 17.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202-1786, USA.

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http://dx.doi.org/10.1073/pnas.0605247103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838710PMC
November 2006

Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.

Cancer Res 2006 Jan;66(1):87-94

Harvard Medical School/Partners Healthcare Center for Genetics and Genomics, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1862DOI Listing
January 2006

Cadmium inhibits the functions of eukaryotic MutS complexes.

J Biol Chem 2004 Dec 27;279(52):53903-6. Epub 2004 Oct 27.

Laboratory of Molecular Genetics, NIEHS, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.C400495200DOI Listing
December 2004

Cadmium is a mutagen that acts by inhibiting mismatch repair.

Nat Genet 2003 Jul;34(3):326-9

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1038/ng1172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662193PMC
July 2003