Publications by authors named "Alan Ashworth"

100Publications

Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24 + CD29/CD49fhi in mice.

Breast Cancer Res Treat 2020 Oct 21;183(3):565-575. Epub 2020 Jul 21.

Breast Cancer Risk and Prevention Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s10549-020-05804-1DOI Listing
October 2020

Klotho and the Treatment of Human Malignancies.

Cancers (Basel) 2020 Jun 23;12(6). Epub 2020 Jun 23.

The Royal Marsden NHS Foundation Trust, London SW6 6JJ, UK.

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http://dx.doi.org/10.3390/cancers12061665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352559PMC
June 2020

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Authors:
David E Gordon Gwendolyn M Jang Mehdi Bouhaddou Jiewei Xu Kirsten Obernier Kris M White Matthew J O'Meara Veronica V Rezelj Jeffrey Z Guo Danielle L Swaney Tia A Tummino Ruth Hüttenhain Robyn M Kaake Alicia L Richards Beril Tutuncuoglu Helene Foussard Jyoti Batra Kelsey Haas Maya Modak Minkyu Kim Paige Haas Benjamin J Polacco Hannes Braberg Jacqueline M Fabius Manon Eckhardt Margaret Soucheray Melanie J Bennett Merve Cakir Michael J McGregor Qiongyu Li Bjoern Meyer Ferdinand Roesch Thomas Vallet Alice Mac Kain Lisa Miorin Elena Moreno Zun Zar Chi Naing Yuan Zhou Shiming Peng Ying Shi Ziyang Zhang Wenqi Shen Ilsa T Kirby James E Melnyk John S Chorba Kevin Lou Shizhong A Dai Inigo Barrio-Hernandez Danish Memon Claudia Hernandez-Armenta Jiankun Lyu Christopher J P Mathy Tina Perica Kala Bharath Pilla Sai J Ganesan Daniel J Saltzberg Ramachandran Rakesh Xi Liu Sara B Rosenthal Lorenzo Calviello Srivats Venkataramanan Jose Liboy-Lugo Yizhu Lin Xi-Ping Huang YongFeng Liu Stephanie A Wankowicz Markus Bohn Maliheh Safari Fatima S Ugur Cassandra Koh Nastaran Sadat Savar Quang Dinh Tran Djoshkun Shengjuler Sabrina J Fletcher Michael C O'Neal Yiming Cai Jason C J Chang David J Broadhurst Saker Klippsten Phillip P Sharp Nicole A Wenzell Duygu Kuzuoglu-Ozturk Hao-Yuan Wang Raphael Trenker Janet M Young Devin A Cavero Joseph Hiatt Theodore L Roth Ujjwal Rathore Advait Subramanian Julia Noack Mathieu Hubert Robert M Stroud Alan D Frankel Oren S Rosenberg Kliment A Verba David A Agard Melanie Ott Michael Emerman Natalia Jura Mark von Zastrow Eric Verdin Alan Ashworth Olivier Schwartz Christophe d'Enfert Shaeri Mukherjee Matt Jacobson Harmit S Malik Danica G Fujimori Trey Ideker Charles S Craik Stephen N Floor James S Fraser John D Gross Andrej Sali Bryan L Roth Davide Ruggero Jack Taunton Tanja Kortemme Pedro Beltrao Marco Vignuzzi Adolfo García-Sastre Kevan M Shokat Brian K Shoichet Nevan J Krogan

Nature 2020 07 30;583(7816):459-468. Epub 2020 Apr 30.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-020-2286-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431030PMC
July 2020

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking.

Nat Commun 2020 03 27;11(1):1446. Epub 2020 Mar 27.

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41467-020-15047-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101390PMC
March 2020

An integrated molecular profile of endometrioid ovarian cancer.

Gynecol Oncol 2020 04 3;157(1):55-61. Epub 2020 Mar 3.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of California San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2020.02.011DOI Listing
April 2020

Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy.

Cancer Discov 2020 Mar 18;10(3):351-370. Epub 2020 Feb 18.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0528DOI Listing
March 2020

Correction to: Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study.

Breast Cancer Res 2020 02 11;22(1):19. Epub 2020 Feb 11.

Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1186/s13058-020-1257-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014730PMC
February 2020

Venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock-A six-year service evaluation.

Artif Organs 2020 Jul 23;44(7):709-716. Epub 2020 Feb 23.

Department of Cardiothoracic Surgery and Transplantation, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1111/aor.13647DOI Listing
July 2020

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Authors:
Maria Escala-Garcia Jean Abraham Irene L Andrulis Hoda Anton-Culver Volker Arndt Alan Ashworth Paul L Auer Päivi Auvinen Matthias W Beckmann Jonathan Beesley Sabine Behrens Javier Benitez Marina Bermisheva Carl Blomqvist William Blot Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Anne-Lise Børresen-Dale Hiltrud Brauch Hermann Brenner Sara Y Brucker Barbara Burwinkel Carlos Caldas Federico Canzian Jenny Chang-Claude Stephen J Chanock Suet-Feung Chin Christine L Clarke Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Joe Dennis Peter Devilee Janet A Dunn Alison M Dunning Miriam Dwek Helena M Earl Diana M Eccles A Heather Eliassen Carolina Ellberg D Gareth Evans Peter A Fasching Jonine Figueroa Henrik Flyger Manuela Gago-Dominguez Susan M Gapstur Montserrat García-Closas José A García-Sáenz Mia M Gaudet Angela George Graham G Giles David E Goldgar Anna González-Neira Mervi Grip Pascal Guénel Qi Guo Christopher A Haiman Niclas Håkansson Ute Hamann Patricia A Harrington Louise Hiller Maartje J Hooning John L Hopper Anthony Howell Chiun-Sheng Huang Guanmengqian Huang David J Hunter Anna Jakubowska Esther M John Rudolf Kaaks Pooja Middha Kapoor Renske Keeman Cari M Kitahara Linetta B Koppert Peter Kraft Vessela N Kristensen Diether Lambrechts Loic Le Marchand Flavio Lejbkowicz Annika Lindblom Jan Lubiński Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Tabea Maurer Dimitrios Mavroudis Alfons Meindl Roger L Milne Anna Marie Mulligan Susan L Neuhausen Heli Nevanlinna William G Newman Andrew F Olshan Janet E Olson Håkan Olsson Nick Orr Paolo Peterlongo Christos Petridis Ross L Prentice Nadege Presneau Kevin Punie Dhanya Ramachandran Gad Rennert Atocha Romero Mythily Sachchithananthan Emmanouil Saloustros Elinor J Sawyer Rita K Schmutzler Lukas Schwentner Christopher Scott Jacques Simard Christof Sohn Melissa C Southey Anthony J Swerdlow Rulla M Tamimi William J Tapper Manuel R Teixeira Mary Beth Terry Heather Thorne Rob A E M Tollenaar Ian Tomlinson Melissa A Troester Thérèse Truong Clare Turnbull Celine M Vachon Lizet E van der Kolk Qin Wang Robert Winqvist Alicja Wolk Xiaohong R Yang Argyrios Ziogas Paul D P Pharoah Per Hall Lodewyk F A Wessels Georgia Chenevix-Trench Gary D Bader Thilo Dörk Douglas F Easton Sander Canisius Marjanka K Schmidt

Nat Commun 2020 01 16;11(1):312. Epub 2020 Jan 16.

Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-14100-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965101PMC
January 2020

Microbial contamination of heater cooler units used in extracorporeal membrane oxygenation is not aerosolized into the environment: A single-center experience.

Infect Control Hosp Epidemiol 2020 02;41(2):242-244

Biosafety, Air and Water Microbiology Group, National Infection Service, PHE Porton, Porton Down, Salisbury, United Kingdom.

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http://dx.doi.org/10.1017/ice.2019.230DOI Listing
February 2020

Synthetic lethality as an engine for cancer drug target discovery.

Nat Rev Drug Discov 2020 01 11;19(1):23-38. Epub 2019 Nov 11.

Tango Therapeutics, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41573-019-0046-zDOI Listing
January 2020

Klotho: A Major Shareholder in Vascular Aging Enterprises.

Int J Mol Sci 2019 Sep 19;20(18). Epub 2019 Sep 19.

The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.3390/ijms20184637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770519PMC
September 2019

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers.

Nat Commun 2019 04 11;10(1):1686. Epub 2019 Apr 11.

Department of Pathology, University of California, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.1038/s41467-019-09659-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459917PMC
April 2019

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.

Cell 2018 12 15;175(7):1958-1971.e15. Epub 2018 Nov 15.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183133
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http://dx.doi.org/10.1016/j.cell.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689405PMC
December 2018

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Cell 2018 07 19;174(3):758-769.e9. Epub 2018 Jul 19.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA; Department of Radiation Oncology, UCSF, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425931PMC
July 2018

Synthetic lethal therapies for cancer: what's next after PARP inhibitors?

Nat Rev Clin Oncol 2018 09;15(9):564-576

The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41571-018-0055-6DOI Listing
September 2018

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

Nat Commun 2018 05 22;9(1):2016. Epub 2018 May 22.

The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.

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http://www.nature.com/articles/s41467-018-04466-4
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http://dx.doi.org/10.1038/s41467-018-04466-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964205PMC
May 2018

Perioperative Extracorporeal Cardiopulmonary Resuscitation: The Defibrillator of the 21st Century?: A Case Report.

A A Pract 2018 Aug;11(4):87-89

From the Wythenshawe Hospital, Manchester University Hospitals, Manchester, United Kingdom.

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http://Insights.ovid.com/crossref?an=02054229-201808150-0000
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http://dx.doi.org/10.1213/XAA.0000000000000742DOI Listing
August 2018

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

Authors:
Maya Ghoussaini Stacey L Edwards Kyriaki Michailidou Silje Nord Richard Cowper-Sal Lari Kinjal Desai Siddhartha Kar Kristine M Hillman Susanne Kaufmann Dylan M Glubb Jonathan Beesley Joe Dennis Manjeet K Bolla Qin Wang Ed Dicks Qi Guo Marjanka K Schmidt Mitul Shah Robert Luben Judith Brown Kamila Czene Hatef Darabi Mikael Eriksson Daniel Klevebring Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Diether Lambrechts Bernard Thienpont Patrick Neven Hans Wildiers Annegien Broeks Laura J Van't Veer Emiel J Th Rutgers Fergus J Couch Janet E Olson Emily Hallberg Celine Vachon Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Julian Peto Isabel Dos-Santos-Silva Lorna Gibson Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Per Hall Jingmei Li Jianjun Liu Keith Humphreys Daehee Kang Ji-Yeob Choi Sue K Park Dong-Young Noh Keitaro Matsuo Hidemi Ito Hiroji Iwata Yasushi Yatabe Pascal Guénel Thérèse Truong Florence Menegaux Marie Sanchez Barbara Burwinkel Frederik Marme Andreas Schneeweiss Christof Sohn Anna H Wu Chiu-Chen Tseng David Van Den Berg Daniel O Stram Javier Benitez M Pilar Zamora Jose Ignacio Arias Perez Primitiva Menéndez Xiao-Ou Shu Wei Lu Yu-Tang Gao Qiuyin Cai Angela Cox Simon S Cross Malcolm W R Reed Irene L Andrulis Julia A Knight Gord Glendon Sandrine Tchatchou Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Annika Lindblom Sara Margolin Soo Hwang Teo Cheng Har Yip Daphne S C Lee Tien Y Wong Maartje J Hooning John W M Martens J Margriet Collée Carolien H M van Deurzen John L Hopper Melissa C Southey Helen Tsimiklis Miroslav K Kapuscinski Chen-Yang Shen Pei-Ei Wu Jyh-Cherng Yu Shou-Tung Chen Grethe Grenaker Alnæs Anne-Lise Borresen-Dale Graham G Giles Roger L Milne Catriona McLean Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Mikael Hartman Hui Miao Shaik Ahmad Bin Syed Buhari Yik Ying Teo Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Anthony Swerdlow Alan Ashworth Nick Orr Minouk J Schoemaker Montserrat García-Closas Jonine Figueroa Stephen J Chanock Jolanta Lissowska Jacques Simard Mark S Goldberg France Labrèche Martine Dumont Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Hiltrud Brauch Thomas Brüning Yon-Dschun Koto Paolo Radice Paolo Peterlongo Bernardo Bonanni Sara Volorio Thilo Dörk Natalia V Bogdanova Sonja Helbig Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Christi J Van Asperen Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Susan Slager Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Suleeporn Sangrajrang Valerie Gaborieau Paul Brennan James McKay Ute Hamann Diana Torres Wei Zheng Jirong Long Hoda Anton-Culver Susan L Neuhausen Craig Luccarini Caroline Baynes Shahana Ahmed Mel Maranian Catherine S Healey Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot Ines de Santiago Jason Carroll Carlos Caldas Melissa A Brown Mathieu Lupien Vessela N Kristensen Paul D P Pharoah Georgia Chenevix-Trench Juliet D French Douglas F Easton Alison M Dunning

Nat Commun 2018 04 10;9:16193. Epub 2018 Apr 10.

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http://dx.doi.org/10.1038/ncomms16193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898457PMC
April 2018

Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.

Int J Cancer 2018 08 23;143(4):782-792. Epub 2018 Mar 23.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1002/ijc.31364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055869PMC
August 2018

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry.

Cell Rep 2018 02;22(7):1875-1888

Stanford Comprehensive Cancer Institute and Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.053DOI Listing
February 2018

Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study.

Br J Cancer 2018 02 23;118(4):600-606. Epub 2018 Jan 23.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.

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http://dx.doi.org/10.1038/bjc.2017.359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830585PMC
February 2018

Tracheostomy Insertion During Venovenous Extracorporeal Membrane Oxygenation: Do the Benefits Outweigh the Risks?

J Cardiothorac Vasc Anesth 2018 06 12;32(3):e69-e70. Epub 2017 Dec 12.

Consultant in Cardiothoracic Anaesthesia, Critical Care and ECMO, Wythenshawe Hospital, Manchester, UK.

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http://dx.doi.org/10.1053/j.jvca.2017.12.021DOI Listing
June 2018

Intravascular Folding of a Peripheral Venous VA-ECMO Cannula for Extracorporeal Cardiopulmonary Resuscitation.

Artif Organs 2018 Jan;42(1):104-105

Consultant in Cardiothoracic Anaesthesia, , ECMO and Critical Care, University Hospital South Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/aor.13036DOI Listing
January 2018

The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer.

Health Aff (Millwood) 2018 01;37(1):54-61

Alan Ashworth is president of the Helen Diller Family Comprehensive Cancer Center and senior vice president for cancer services at UCSF Health.

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http://dx.doi.org/10.1377/hlthaff.2017.1260DOI Listing
January 2018

Reducing the Risk of Cardiac Perforation During Placement of Bicaval Veno-Venous Extracorporeal Membrane Oxygenation Cannulae.

J Cardiothorac Vasc Anesth 2018 02 5;32(1):e19-e20. Epub 2017 Sep 5.

Department of Cardiothoracic Anaesthesia, University Hospital South, Manchester, UK.

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http://dx.doi.org/10.1053/j.jvca.2017.09.003DOI Listing
February 2018

Smoking and risk of breast cancer in the Generations Study cohort.

Breast Cancer Res 2017 Nov 22;19(1):118. Epub 2017 Nov 22.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1186/s13058-017-0908-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698948PMC
November 2017

Authors' Response.

J Forensic Sci 2017 11;62(6):1684-1686

Brooke Army Medical Center, Department of Medicine, USARMY MEDCOM, 3551 Roger Brooke Drive, Fort Sam Houston, TX, 78234.

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http://dx.doi.org/10.1111/1556-4029.13635DOI Listing
November 2017

Modeling Therapy Resistance in -Mutant Cancers.

Mol Cancer Ther 2017 09 15;16(9):2022-2034. Epub 2017 Jun 15.

The CRUK Gene Function Laboratory and The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-17-0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157714PMC
September 2017

Family history and risk of breast cancer: an analysis accounting for family structure.

Breast Cancer Res Treat 2017 Aug 3;165(1):193-200. Epub 2017 Jun 3.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1007/s10549-017-4325-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511313PMC
August 2017

The effect of veno-venous ECMO on the pharmacokinetics of Ritonavir, Darunavir, Tenofovir and Lamivudine.

J Crit Care 2017 08 12;40:113-118. Epub 2017 Mar 12.

The North West Heart and Lung Centre, The University Hospital of South Manchester, Manchester M23 9LT, United Kingdom.

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http://dx.doi.org/10.1016/j.jcrc.2017.03.010DOI Listing
August 2017

PARP inhibitors: Synthetic lethality in the clinic.

Science 2017 03 16;355(6330):1152-1158. Epub 2017 Mar 16.

University of California, San Francisco (UCSF), Helen Diller Family Comprehensive Cancer Center, 1450 Third Street, San Francisco, CA 94158, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aam7344
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http://dx.doi.org/10.1126/science.aam7344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175050PMC
March 2017

Marked for death: targeting epigenetic changes in cancer.

Nat Rev Drug Discov 2017 Apr 10;16(4):241-263. Epub 2017 Mar 10.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nrd.2016.256DOI Listing
April 2017

Childhood body size and pubertal timing in relation to adult mammographic density phenotype.

Breast Cancer Res 2017 02 7;19(1):13. Epub 2017 Feb 7.

Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK.

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http://dx.doi.org/10.1186/s13058-017-0804-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297131PMC
February 2017

PARP inhibitor combination therapy.

Crit Rev Oncol Hematol 2016 Dec 31;108:73-85. Epub 2016 Oct 31.

UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2016.10.010DOI Listing
December 2016

Isoflurane use is not associated with prolonged intensive care unit stay following routine cardiac surgery when compared to sevoflurane.

Can J Anaesth 2017 Jan 25;64(1):100-101. Epub 2016 Oct 25.

Department of Cardiothoracic Anaesthesia, Critical Care and ECMO-University Hospital of South Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s12630-016-0754-3DOI Listing
January 2017

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

Authors:
Melissa C Southey David E Goldgar Robert Winqvist Katri Pylkäs Fergus Couch Marc Tischkowitz William D Foulkes Joe Dennis Kyriaki Michailidou Elizabeth J van Rensburg Tuomas Heikkinen Heli Nevanlinna John L Hopper Thilo Dörk Kathleen Bm Claes Jorge Reis-Filho Zhi Ling Teo Paolo Radice Irene Catucci Paolo Peterlongo Helen Tsimiklis Fabrice A Odefrey James G Dowty Marjanka K Schmidt Annegien Broeks Frans B Hogervorst Senno Verhoef Jane Carpenter Christine Clarke Rodney J Scott Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Julian Peto Isabel Dos-Santos-Silva Olivia Fletcher Nichola Johnson Manjeet K Bolla Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Federik Marme Barbara Burwinkel Rongxi Yang Pascal Guénel Thérèse Truong Florence Menegaux Marie Sanchez Stig Bojesen Sune F Nielsen Henrik Flyger Javier Benitez M Pilar Zamora Jose Ignacio Arias Perez Primitiva Menéndez Hoda Anton-Culver Susan Neuhausen Argyrios Ziogas Christina A Clarke Hermann Brenner Volker Arndt Christa Stegmaier Hiltrud Brauch Thomas Brüning Yon-Dschun Ko Taru A Muranen Kristiina Aittomäki Carl Blomqvist Natalia V Bogdanova Natalia N Antonenkova Annika Lindblom Sara Margolin Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Amanda B Spurdle kConFab Investigators Els Wauters Dominiek Smeets Benoit Beuselinck Giuseppe Floris Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Janet E Olson Celine Vachon Vernon S Pankratz Catriona McLean Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Vessela Kristensen Grethe Grenaker Alnæs Wei Zheng David J Hunter Sara Lindstrom Susan E Hankinson Peter Kraft Irene Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Arja Jukkola-Vuorinen Mervi Grip Saila Kauppila Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Antoinette Hollestelle Montserrat Garcia-Closas Jonine Figueroa Stephen J Chanock Jolanta Lissowska Kamila Czene Hatef Darabi Mikael Eriksson Diana M Eccles Sajjad Rafiq William J Tapper Sue M Gerty Maartje J Hooning John W M Martens J Margriet Collée Madeleine Tilanus-Linthorst Per Hall Jingmei Li Judith S Brand Keith Humphreys Angela Cox Malcolm W R Reed Craig Luccarini Caroline Baynes Alison M Dunning Ute Hamann Diana Torres Hans Ulrich Ulmer Thomas Rüdiger Anna Jakubowska Jan Lubinski Katarzyna Jaworska Katarzyna Durda Susan Slager Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Anthony Swerdlow Alan Ashworth Nick Orr Michael Jones Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot Jacques Simard Martine Dumont Penny Soucy Rosalind Eeles Kenneth Muir Fredrik Wiklund Henrik Gronberg Johanna Schleutker Børge G Nordestgaard Maren Weischer Ruth C Travis David Neal Jenny L Donovan Freddie C Hamdy Kay-Tee Khaw Janet L Stanford William J Blot Stephen Thibodeau Daniel J Schaid Joseph L Kelley Christiane Maier Adam S Kibel Cezary Cybulski Lisa Cannon-Albright Katja Butterbach Jong Park Radka Kaneva Jyotsna Batra Manuel R Teixeira Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Stefan P Renner Arndt Hartmann Alexander Hein Matthias Ruebner Diether Lambrechts Els Van Nieuwenhuysen Ignace Vergote Sandrina Lambretchs Jennifer A Doherty Mary Anne Rossing Stefan Nickels Ursula Eilber Shan Wang-Gohrke Kunle Odunsi Lara E Sucheston-Campbell Grace Friel Galina Lurie Jeffrey L Killeen Lynne R Wilkens Marc T Goodman Ingo Runnebaum Peter A Hillemanns Liisa M Pelttari Ralf Butzow Francesmary Modugno Robert P Edwards Roberta B Ness Kirsten B Moysich Andreas du Bois Florian Heitz Philipp Harter Stefan Kommoss Beth Y Karlan Christine Walsh Jenny Lester Allan Jensen Susanne Krüger Kjaer Estrid Høgdall Bernard Peissel Bernardo Bonanni Loris Bernard Ellen L Goode Brooke L Fridley Robert A Vierkant Julie M Cunningham Melissa C Larson Zachary C Fogarty Kimberly R Kalli Dong Liang Karen H Lu Michelle A T Hildebrandt Xifeng Wu Douglas A Levine Fanny Dao Maria Bisogna Andrew Berchuck Edwin S Iversen Jeffrey R Marks Lucy Akushevich Daniel W Cramer Joellen Schildkraut Kathryn L Terry Elizabeth M Poole Meir Stampfer Shelley S Tworoger Elisa V Bandera Irene Orlow Sara H Olson Line Bjorge Helga B Salvesen Anne M van Altena Katja K H Aben Lambertus A Kiemeney Leon F A G Massuger Tanja Pejovic Yukie Bean Angela Brooks-Wilson Linda E Kelemen Linda S Cook Nhu D Le Bohdan Górski Jacek Gronwald Janusz Menkiszak Claus K Høgdall Lene Lundvall Lotte Nedergaard Svend Aage Engelholm Ed Dicks Jonathan Tyrer Ian Campbell Iain McNeish James Paul Nadeem Siddiqui Rosalind Glasspool Alice S Whittemore Joseph H Rothstein Valerie McGuire Weiva Sieh Hui Cai Xiao-Ou Shu Rachel T Teten Rebecca Sutphen John R McLaughlin Steven A Narod Catherine M Phelan Alvaro N Monteiro David Fenstermacher Hui-Yi Lin Jennifer B Permuth Thomas A Sellers Y Ann Chen Ya-Yu Tsai Zhihua Chen Aleksandra Gentry-Maharaj Simon A Gayther Susan J Ramus Usha Menon Anna H Wu Celeste L Pearce David Van Den Berg Malcolm C Pike Agnieszka Dansonka-Mieszkowska Joanna Plisiecka-Halasa Joanna Moes-Sosnowska Jolanta Kupryjanczyk Paul Dp Pharoah Honglin Song Ingrid Winship Georgia Chenevix-Trench Graham G Giles Sean V Tavtigian Doug F Easton Roger L Milne

J Med Genet 2016 12 5;53(12):800-811. Epub 2016 Sep 5.

Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1136/jmedgenet-2016-103839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200636PMC
December 2016

Menopausal hormone therapy and breast cancer: what is the true size of the increased risk?

Br J Cancer 2016 08 28;115(5):607-15. Epub 2016 Jul 28.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.

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http://dx.doi.org/10.1038/bjc.2016.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997554PMC
August 2016

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.

Mol Cancer Ther 2016 07 30;15(7):1472-84. Epub 2016 Jun 30.

The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom. Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0554DOI Listing
July 2016

DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities.

Oncologist 2016 08 17;21(8):940-5. Epub 2016 Jun 17.

Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA

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http://dx.doi.org/10.1634/theoncologist.2016-0135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978560PMC
August 2016

Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.

J Pathol 2016 06 21;239(2):197-205. Epub 2016 Apr 21.

Sahlgrenska Cancer Centre, Department of Pathology, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1002/path.4717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869681PMC
June 2016

BRCAness revisited.

Nat Rev Cancer 2016 Feb 18;16(2):110-20. Epub 2016 Jan 18.

UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA.

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http://www.nature.com/articles/nrc.2015.21
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http://dx.doi.org/10.1038/nrc.2015.21DOI Listing
February 2016

Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.

Nat Med 2015 Dec 23;21(12):1481-90. Epub 2015 Nov 23.

Leukemia and Stem Cell Biology Group, Department of Haematological Medicine, Division of Cancer Studies, King's College London, London, UK.

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http://dx.doi.org/10.1038/nm.3993DOI Listing
December 2015

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

N Engl J Med 2015 Oct;373(18):1697-708

From the Institute of Cancer Research (J.M., S.C., S.S., S.M., H.M., R.P.-L., D.N.R., A.O., N.T., G.B., N.P., P.F., A.G., I.F., C.P., G.S., D.B., J.G., Z.Z., C.T.W., R.F., R.R., B.E., G.F., D. Roda, W.Y., R.B., H.P., R.A., A.S., R.E., G.A., C.J.L., A.A., E.H., J.S.B.), the Royal Marsden NHS Foundation Trust (J.M., S.S., R.P.-L., A.O., N.T., D.B., Z.Z., R.F., D. Roda, R.E., G.A., J.S.B.), and University College London Hospital (U.M.), London, Queen's University, Belfast (S.J.), University of Leeds, Leeds (C.R.), Churchill Hospital, Oxford (A.P.), University of Liverpool, Liverpool (S.H.), Beatson West of Scotland Cancer Centre, Glasgow (R.J.), and Christie Hospital, Manchester (T.E.) - all in the United Kingdom; the University of Michigan, Ann Arbor (D. Robinson, Y.-M.W., X.C., L.P.K., F.Y.F., A.M.C.); Weill Cornell Medical College, New York (M.A.R.); and Thomas Jefferson University, Philadelphia (K.E.K.).

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http://dx.doi.org/10.1056/NEJMoa1506859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228595PMC
October 2015

Inherited cylindromas: lessons from a rare tumour.

Lancet Oncol 2015 Sep;16(9):e460-e469

University of California San Francisco, Helen Diller Family Comprehensive Cancer Centre, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/S1470-2045(15)00245-4DOI Listing
September 2015

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.

Authors:
Ben Zhang Xiao-Ou Shu Ryan J Delahanty Chenjie Zeng Kyriaki Michailidou Manjeet K Bolla Qin Wang Joe Dennis Wanqing Wen Jirong Long Chun Li Alison M Dunning Jenny Chang-Claude Mitul Shah Barbara J Perkins Kamila Czene Hatef Darabi Mikael Eriksson Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Diether Lambrechts Patrick Neven Hans Wildiers Giuseppe Floris Marjanka K Schmidt Matti A Rookus Katja van den Hurk Wim L A M de Kort Fergus J Couch Janet E Olson Emily Hallberg Celine Vachon Anja Rudolph Petra Seibold Dieter Flesch-Janys Julian Peto Isabel Dos-Santos-Silva Olivia Fletcher Nichola Johnson Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Jingmei Li Keith Humphreys Judith Brand Pascal Guénel Thérèse Truong Emilie Cordina-Duverger Florence Menegaux Barbara Burwinkel Frederik Marme Rongxi Yang Harald Surowy Javier Benitez M Pilar Zamora Jose I A Perez Angela Cox Simon S Cross Malcolm W R Reed Irene L Andrulis Julia A Knight Gord Glendon Sandrine Tchatchou Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Georgia Chenevix-Trench Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Annika Lindblom Sara Margolin Maartje J Hooning John W M Martens Madeleine M A Tilanus-Linthorst J Margriet Collée John L Hopper Melissa C Southey Helen Tsimiklis Carmel Apicella Susan Slager Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Graham G Giles Roger L Milne Catriona McLean Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Anthony J Swerdlow Alan Ashworth Nick Orr Michael Jones Jonine Figueroa Montserrat Garcia-Closas Louise Brinton Jolanta Lissowska Martine Dumont Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Hiltrud Brauch Thomas Brüning Yon-Dschun Ko Paolo Peterlongo Siranoush Manoukian Bernardo Bonanni Paolo Radice Natalia Bogdanova Natalia Antonenkova Thilo Dörk Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Peter Devilee Caroline Seynaeve Christi J Van Asperen Anna Jakubowska Jan Lubiński Katarzyna Jaworska-Bieniek Katarzyna Durda Ute Hamann Diana Torres Rita K Schmutzler Susan L Neuhausen Hoda Anton-Culver Vessela N Kristensen Grethe I Grenaker Alnæs Brandon L Pierce Peter Kraft Ulrike Peters Sara Lindstrom Daniela Seminara Stephen Burgess Habibul Ahsan Alice S Whittemore Esther M John Marilie D Gammon Kathleen E Malone Daniel C Tessier Daniel Vincent Francois Bacot Craig Luccarini Caroline Baynes Shahana Ahmed Mel Maranian Catherine S Healey Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Paul D P Pharoah Jacques Simard Per Hall David J Hunter Douglas F Easton Wei Zheng

J Natl Cancer Inst 2015 Nov 20;107(11). Epub 2015 Aug 20.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center (BZ, XOS, RJD, CZ, WW, JL, WZ) and Department of Biostatistics (CL), Vanderbilt University School of Medicine, Nashville, TN; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care(KM, MKB, QW, JD, PDPP, DFE) and Department of Oncology (AMD, MS, BJP, CL, CB, SA, MM, CSH, PDPP, DFE), University of Cambridge, Cambridge, UK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, HD, ME); Copenhagen General Population Study (SEB, BGN, SFN), Department of Clinical Biochemistry (SEB, BGN, SFN), and Department of Breast Surgery (HF), Herlev Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (SEB, BGN); Vesalius Research Center (VRC), VIB, Leuven, Belgium (DL); Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium (DL); University Hospitals Leuven and Department of Oncology, Leuven, Belgium (PN, HW, GF); Netherlands Cancer Institute, Amsterdam, the Netherlands (MKS, MAR); Division Research, Department of Donor Studies, Sanquin Blood Supply, Amsterdam, the Netherlands (KVDH, WLAMDK); Department of Laboratory Medicine and Pathology (FJC) and Department of Health Sciences Research (JEO, EH, CV, SS), Mayo Clinic, Rochester, MN; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (JCC, AR, PS); Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (DFJ); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (JP, IDSS); Breakthrough Breast Cancer Research Centre, the Institute of Cancer Research, London, UK (OF, NJ); Department of Obstetrics and Gynecology (HN, TAM), D

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http://dx.doi.org/10.1093/jnci/djv219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643630PMC
November 2015

The cancer cell map initiative: defining the hallmark networks of cancer.

Mol Cell 2015 May;58(4):690-8

Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA; Moores Cancer Center, University of California, San Diego, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359018PMC
May 2015

Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer.

J Clin Oncol 2015 Oct 18;33(28):3080-1. Epub 2015 May 18.

University of California, San Francisco, Helen Diller Comprehensive Cancer Center, San Francisco, CA

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http://dx.doi.org/10.1200/JCO.2015.61.6961DOI Listing
October 2015

Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Breast Cancer.

Cancer Res 2015 Jul 14;75(14):2844-50. Epub 2015 May 14.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom. Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom. Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1692DOI Listing
July 2015

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Authors:
Antoinette Hollestelle Frederieke H van der Baan Andrew Berchuck Sharon E Johnatty Katja K Aben Bjarni A Agnarsson Kristiina Aittomäki Elisa Alducci Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Antonis C Antoniou Carmel Apicella Volker Arndt Norbert Arnold Banu K Arun Brita Arver Alan Ashworth Laura Baglietto Rosemary Balleine Elisa V Bandera Daniel Barrowdale Yukie T Bean Lars Beckmann Matthias W Beckmann Javier Benitez Andreas Berger Raanan Berger Benoit Beuselinck Maria Bisogna Line Bjorge Carl Blomqvist Natalia V Bogdanova Anders Bojesen Stig E Bojesen Manjeet K Bolla Bernardo Bonanni Judith S Brand Hiltrud Brauch Hermann Brenner Louise Brinton Angela Brooks-Wilson Fiona Bruinsma Joan Brunet Thomas Brüning Agnieszka Budzilowska Clareann H Bunker Barbara Burwinkel Ralf Butzow Saundra S Buys Maria A Caligo Ian Campbell Jonathan Carter Jenny Chang-Claude Stephen J Chanock Kathleen B M Claes J Margriet Collée Linda S Cook Fergus J Couch Angela Cox Daniel Cramer Simon S Cross Julie M Cunningham Cezary Cybulski Kamila Czene Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Miguel de la Hoya Anna deFazio Joseph Dennis Peter Devilee Ed M Dicks Orland Diez Jennifer A Doherty Susan M Domchek Cecilia M Dorfling Thilo Dörk Isabel Dos Santos Silva Andreas du Bois Martine Dumont Alison M Dunning Mercedes Duran Douglas F Easton Diana Eccles Robert P Edwards Hans Ehrencrona Bent Ejlertsen Arif B Ekici Steve D Ellis Christoph Engel Mikael Eriksson Peter A Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Annette Fontaine Stefano Fortuzzi Florentia Fostira Brooke L Fridley Tara Friebel Eitan Friedman Grace Friel Debra Frost Judy Garber Montserrat García-Closas Simon A Gayther Aleksandra Gentry-Maharaj Anne-Marie Gerdes Graham G Giles Rosalind Glasspool Gord Glendon Andrew K Godwin Marc T Goodman Martin Gore Mark H Greene Mervi Grip Jacek Gronwald Daphne Gschwantler Kaulich Pascal Guénel Starr R Guzman Lothar Haeberle Christopher A Haiman Per Hall Sandra L Halverson Ute Hamann Thomas V O Hansen Philipp Harter Jaana M Hartikainen Sue Healey Alexander Hein Florian Heitz Brian E Henderson Josef Herzog Michelle A T Hildebrandt Claus K Høgdall Estrid Høgdall Frans B L Hogervorst John L Hopper Keith Humphreys Tomasz Huzarski Evgeny N Imyanitov Claudine Isaacs Anna Jakubowska Ramunas Janavicius Katarzyna Jaworska Allan Jensen Uffe Birk Jensen Nichola Johnson Arja Jukkola-Vuorinen Maria Kabisch Beth Y Karlan Vesa Kataja Noah Kauff Linda E Kelemen Michael J Kerin Lambertus A Kiemeney Susanne K Kjaer Julia A Knight Jacoba P Knol-Bout Irene Konstantopoulou Veli-Matti Kosma Camilla Krakstad Vessela Kristensen Karoline B Kuchenbaecker Jolanta Kupryjanczyk Yael Laitman Diether Lambrechts Sandrina Lambrechts Melissa C Larson Adriana Lasa Pierre Laurent-Puig Conxi Lazaro Nhu D Le Loic Le Marchand Arto Leminen Jenny Lester Douglas A Levine Jingmei Li Dong Liang Annika Lindblom Noralane Lindor Jolanta Lissowska Jirong Long Karen H Lu Jan Lubinski Lene Lundvall Galina Lurie Phuong L Mai Arto Mannermaa Sara Margolin Frederique Mariette Frederik Marme John W M Martens Leon F A G Massuger Christine Maugard Sylvie Mazoyer Lesley McGuffog Valerie McGuire Catriona McLean Iain McNeish Alfons Meindl Florence Menegaux Primitiva Menéndez Janusz Menkiszak Usha Menon Arjen R Mensenkamp Nicola Miller Roger L Milne Francesmary Modugno Marco Montagna Kirsten B Moysich Heiko Müller Anna Marie Mulligan Taru A Muranen Steven A Narod Katherine L Nathanson Roberta B Ness Susan L Neuhausen Heli Nevanlinna Patrick Neven Finn C Nielsen Sune F Nielsen Børge G Nordestgaard Robert L Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I Olopade Janet E Olson Sara H Olson Jan C Oosterwijk Irene Orlow Nick Orr Sandra Orsulic Ana Osorio Laura Ottini James Paul Celeste L Pearce Inge Sokilde Pedersen Bernard Peissel Tanja Pejovic Liisa M Pelttari Jo Perkins Jenny Permuth-Wey Paolo Peterlongo Julian Peto Catherine M Phelan Kelly-Anne Phillips Marion Piedmonte Malcolm C Pike Radka Platte Joanna Plisiecka-Halasa Elizabeth M Poole Bruce Poppe Katri Pylkäs Paolo Radice Susan J Ramus Timothy R Rebbeck Malcolm W R Reed Gad Rennert Harvey A Risch Mark Robson Gustavo C Rodriguez Atocha Romero Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo Runnebaum Ritu Salani Helga B Salvesen Elinor J Sawyer Joellen M Schildkraut Marjanka K Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Michael G Schrauder Fredrick Schumacher Ira Schwaab Giulietta Scuvera Thomas A Sellers Gianluca Severi Caroline M Seynaeve Mitul Shah Martha Shrubsole Nadeem Siddiqui Weiva Sieh Jacques Simard Christian F Singer Olga M Sinilnikova Dominiek Smeets Christof Sohn Maria Soller Honglin Song Penny Soucy Melissa C Southey Christa Stegmaier Dominique Stoppa-Lyonnet Lara Sucheston Anthony Swerdlow Ingvild L Tangen Muy-Kheng Tea Manuel R Teixeira Kathryn L Terry Mary Beth Terry Mads Thomassen Pamela J Thompson Laima Tihomirova Marc Tischkowitz Amanda Ewart Toland Rob A E M Tollenaar Ian Tomlinson Diana Torres Thérèse Truong Helen Tsimiklis Nadine Tung Shelley S Tworoger Jonathan P Tyrer Celine M Vachon Laura J Van 't Veer Anne M van Altena C J Van Asperen David van den Berg Ans M W van den Ouweland Helena C van Doorn Els Van Nieuwenhuysen Elizabeth J van Rensburg Ignace Vergote Senno Verhoef Robert A Vierkant Joseph Vijai Allison F Vitonis Anna von Wachenfeldt Christine Walsh Qin Wang Shan Wang-Gohrke Barbara Wappenschmidt Maren Weischer Jeffrey N Weitzel Caroline Weltens Nicolas Wentzensen Alice S Whittemore Lynne R Wilkens Robert Winqvist Anna H Wu Xifeng Wu Hannah P Yang Daniela Zaffaroni M Pilar Zamora Wei Zheng Argyrios Ziogas Georgia Chenevix-Trench Paul D P Pharoah Matti A Rookus Maartje J Hooning Ellen L Goode

Gynecol Oncol 2016 05 2;141(2):386-401. Epub 2015 May 2.

Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.ygyno.2015.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630206PMC
May 2016

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.

Oncotarget 2015 May;6(13):10746-58

The CRUK Gene Function Laboratory and Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484416PMC
http://dx.doi.org/10.18632/oncotarget.3628DOI Listing
May 2015

Prediction of breast cancer risk based on profiling with common genetic variants.

Authors:
Nasim Mavaddat Paul D P Pharoah Kyriaki Michailidou Jonathan Tyrer Mark N Brook Manjeet K Bolla Qin Wang Joe Dennis Alison M Dunning Mitul Shah Robert Luben Judith Brown Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Kamila Czene Hatef Darabi Mikael Eriksson Julian Peto Isabel Dos-Santos-Silva Frank Dudbridge Nichola Johnson Marjanka K Schmidt Annegien Broeks Senno Verhoef Emiel J Rutgers Anthony Swerdlow Alan Ashworth Nick Orr Minouk J Schoemaker Jonine Figueroa Stephen J Chanock Louise Brinton Jolanta Lissowska Fergus J Couch Janet E Olson Celine Vachon Vernon S Pankratz Diether Lambrechts Hans Wildiers Chantal Van Ongeval Erik van Limbergen Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne-Lise Borresen-Dale Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Barbara Burwinkel Frederik Marme Andreas Schneeweiss Christof Sohn Amy Trentham-Dietz Polly Newcomb Linda Titus Kathleen M Egan David J Hunter Sara Lindstrom Rulla M Tamimi Peter Kraft Nazneen Rahman Clare Turnbull Anthony Renwick Sheila Seal Jingmei Li Jianjun Liu Keith Humphreys Javier Benitez M Pilar Zamora Jose Ignacio Arias Perez Primitiva Menéndez Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Natalia V Bogdanova Natalia N Antonenkova Thilo Dörk Hoda Anton-Culver Susan L Neuhausen Argyrios Ziogas Leslie Bernstein Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Christi J van Asperen Angela Cox Simon S Cross Malcolm W R Reed Elza Khusnutdinova Marina Bermisheva Darya Prokofyeva Zalina Takhirova Alfons Meindl Rita K Schmutzler Christian Sutter Rongxi Yang Peter Schürmann Michael Bremer Hans Christiansen Tjoung-Won Park-Simon Peter Hillemanns Pascal Guénel Thérèse Truong Florence Menegaux Marie Sanchez Paolo Radice Paolo Peterlongo Siranoush Manoukian Valeria Pensotti John L Hopper Helen Tsimiklis Carmel Apicella Melissa C Southey Hiltrud Brauch Thomas Brüning Yon-Dschun Ko Alice J Sigurdson Michele M Doody Ute Hamann Diana Torres Hans-Ulrich Ulmer Asta Försti Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Georgia Chenevix-Trench Rosemary Balleine Graham G Giles Roger L Milne Catriona McLean Annika Lindblom Sara Margolin Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Ursula Eilber Shan Wang-Gohrke Maartje J Hooning Antoinette Hollestelle Ans M W van den Ouweland Linetta B Koppert Jane Carpenter Christine Clarke Rodney Scott Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Hermann Brenner Volker Arndt Christa Stegmaier Aida Karina Dieffenbach Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Kenneth Offit Joseph Vijai Mark Robson Rohini Rau-Murthy Miriam Dwek Ruth Swann Katherine Annie Perkins Mark S Goldberg France Labrèche Martine Dumont Diana M Eccles William J Tapper Sajjad Rafiq Esther M John Alice S Whittemore Susan Slager Drakoulis Yannoukakos Amanda E Toland Song Yao Wei Zheng Sandra L Halverson Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot Craig Luccarini Caroline Baynes Shahana Ahmed Mel Maranian Catherine S Healey Jacques Simard Per Hall Douglas F Easton Montserrat Garcia-Closas

J Natl Cancer Inst 2015 May 8;107(5). Epub 2015 Apr 8.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (NM, PDPP, KM, MKB, QW, JD, RL, JBr, DFE); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (PDPP, JT, AMD, MS, CL, CB, SA, MM, CSH, DFE); Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK (MNB, ASw, MJS); Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark (SEB, BGN, SFN); Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark (SEB, BGN, SFN); Faculty of Health and Medical Sciences, Copenhagen University Hospital, Copenhagen, Herlev, Denmark (SEB, BGN); Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark (HF); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, HD, ME, KH, PHa); Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (JP, IdSS, FD); Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK (NJ, AA, NO, MGC); Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, the Netherlands (MKS, AB, SV, EJR); Division of Breast Cancer Research, Institute of Cancer Research, London, UK (ASw); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JF, SJC, LB, ASi, MD); Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland (JLis); Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN (FJC); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (JEO, CV, VSP, SS); Vesalius Research Center, VIB, Leuven, Belgium (DL); Laboratory for Translational Genetics, Department of Oncology, University of

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May 2015

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Cancer Discov 2015 May 13;5(5):488-505. Epub 2015 Mar 13.

Breakthrough Breast Cancer Research Unit, King's College London, London, United Kingdom. Department of Research Oncology, King's Health Partners AHSC, Life Sciences and Medicine, King's College London, London, United Kingdom. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490184PMC
May 2015

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

Authors:
Kyriaki Michailidou Jonathan Beesley Sara Lindstrom Sander Canisius Joe Dennis Michael J Lush Mel J Maranian Manjeet K Bolla Qin Wang Mitul Shah Barbara J Perkins Kamila Czene Mikael Eriksson Hatef Darabi Judith S Brand Stig E Bojesen Børge G Nordestgaard Henrik Flyger Sune F Nielsen Nazneen Rahman Clare Turnbull Olivia Fletcher Julian Peto Lorna Gibson Isabel dos-Santos-Silva Jenny Chang-Claude Dieter Flesch-Janys Anja Rudolph Ursula Eilber Sabine Behrens Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Sofia Khan Kirsimari Aaltonen Habibul Ahsan Muhammad G Kibriya Alice S Whittemore Esther M John Kathleen E Malone Marilie D Gammon Regina M Santella Giske Ursin Enes Makalic Daniel F Schmidt Graham Casey David J Hunter Susan M Gapstur Mia M Gaudet W Ryan Diver Christopher A Haiman Fredrick Schumacher Brian E Henderson Loic Le Marchand Christine D Berg Stephen J Chanock Jonine Figueroa Robert N Hoover Diether Lambrechts Patrick Neven Hans Wildiers Erik van Limbergen Marjanka K Schmidt Annegien Broeks Senno Verhoef Sten Cornelissen Fergus J Couch Janet E Olson Emily Hallberg Celine Vachon Quinten Waisfisz Hanne Meijers-Heijboer Muriel A Adank Rob B van der Luijt Jingmei Li Jianjun Liu Keith Humphreys Daehee Kang Ji-Yeob Choi Sue K Park Keun-Young Yoo Keitaro Matsuo Hidemi Ito Hiroji Iwata Kazuo Tajima Pascal Guénel Thérèse Truong Claire Mulot Marie Sanchez Barbara Burwinkel Frederik Marme Harald Surowy Christof Sohn Anna H Wu Chiu-chen Tseng David Van Den Berg Daniel O Stram Anna González-Neira Javier Benitez M Pilar Zamora Jose Ignacio Arias Perez Xiao-Ou Shu Wei Lu Yu-Tang Gao Hui Cai Angela Cox Simon S Cross Malcolm W R Reed Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Annika Lindblom Sara Margolin Soo Hwang Teo Cheng Har Yip Nur Aishah Mohd Taib Gie-Hooi Tan Maartje J Hooning Antoinette Hollestelle John W M Martens J Margriet Collée William Blot Lisa B Signorello Qiuyin Cai John L Hopper Melissa C Southey Helen Tsimiklis Carmel Apicella Chen-Yang Shen Chia-Ni Hsiung Pei-Ei Wu Ming-Feng Hou Vessela N Kristensen Silje Nord Grethe I Grenaker Alnaes Graham G Giles Roger L Milne Catriona McLean Federico Canzian Dimitrios Trichopoulos Petra Peeters Eiliv Lund Malin Sund Kay-Tee Khaw Marc J Gunter Domenico Palli Lotte Maxild Mortensen Laure Dossus Jose-Maria Huerta Alfons Meindl Rita K Schmutzler Christian Sutter Rongxi Yang Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Mikael Hartman Hui Miao Kee Seng Chia Ching Wan Chan Peter A Fasching Alexander Hein Matthias W Beckmann Lothar Haeberle Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Alan Ashworth Nick Orr Minouk J Schoemaker Anthony J Swerdlow Louise Brinton Montserrat Garcia-Closas Wei Zheng Sandra L Halverson Martha Shrubsole Jirong Long Mark S Goldberg France Labrèche Martine Dumont Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Hiltrud Brauch Ute Hamann Thomas Brüning Paolo Radice Paolo Peterlongo Siranoush Manoukian Loris Bernard Natalia V Bogdanova Thilo Dörk Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Christi J Van Asperen Anna Jakubowska Jan Lubinski Katarzyna Jaworska Tomasz Huzarski Suleeporn Sangrajrang Valerie Gaborieau Paul Brennan James McKay Susan Slager Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Maria Kabisch Diana Torres Susan L Neuhausen Hoda Anton-Culver Craig Luccarini Caroline Baynes Shahana Ahmed Catherine S Healey Daniel C Tessier Daniel Vincent Francois Bacot Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Jacques Simard Paul P D P Pharoah Peter Kraft Alison M Dunning Georgia Chenevix-Trench Per Hall Douglas F Easton

Nat Genet 2015 Apr 9;47(4):373-80. Epub 2015 Mar 9.

1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

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April 2015

Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.

Mol Cancer Ther 2015 Apr 11;14(4):865-76. Epub 2015 Feb 11.

CRUK Gene Function Laboratory, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom. Breast Unit, Royal Marsden Hospital, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485454PMC
April 2015

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

Authors:
Nick Orr Frank Dudbridge Nicola Dryden Sarah Maguire Daniela Novo Eleni Perrakis Nichola Johnson Maya Ghoussaini John L Hopper Melissa C Southey Carmel Apicella Jennifer Stone Marjanka K Schmidt Annegien Broeks Laura J Van't Veer Frans B Hogervorst Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Lorna Gibson Zoe Aitken Helen Warren Elinor Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Barbara Burwinkel Frederik Marme Andreas Schneeweiss Chistof Sohn Pascal Guénel Thérèse Truong Emilie Cordina-Duverger Marie Sanchez Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Javier Benitez Maria Pilar Zamora Jose Ignacio Arias Perez Primitiva Menéndez Hoda Anton-Culver Susan L Neuhausen Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Ute Hamann Hiltrud Brauch Christina Justenhoven Thomas Brüning Yon-Dschun Ko Heli Nevanlinna Kristiina Aittomäki Carl Blomqvist Sofia Khan Natalia Bogdanova Thilo Dörk Annika Lindblom Sara Margolin Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Georgia Chenevix-Trench Jonathan Beesley Diether Lambrechts Matthieu Moisse Guiseppe Floris Benoit Beuselinck Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Paolo Radice Paolo Peterlongo Bernard Peissel Valeria Pensotti Fergus J Couch Janet E Olson Seth Slettedahl Celine Vachon Graham G Giles Roger L Milne Catriona McLean Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Jacques Simard Mark S Goldberg France Labrèche Martine Dumont Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne-Lise Borresen-Dale Wei Zheng Sandra Deming-Halverson Martha Shrubsole Jirong Long Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Irene L Andrulis Julia A Knight Gord Glendon Sandrine Tchatchou Peter Devilee Robertus A E M Tollenaar Caroline M Seynaeve Christi J Van Asperen Montserrat Garcia-Closas Jonine Figueroa Stephen J Chanock Jolanta Lissowska Kamila Czene Hatef Darabi Mikael Eriksson Daniel Klevebring Maartje J Hooning Antoinette Hollestelle Carolien H M van Deurzen Mieke Kriege Per Hall Jingmei Li Jianjun Liu Keith Humphreys Angela Cox Simon S Cross Malcolm W R Reed Paul D P Pharoah Alison M Dunning Mitul Shah Barbara J Perkins Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Alan Ashworth Anthony Swerdlow Michael Jones Minouk J Schoemaker Alfons Meindl Rita K Schmutzler Curtis Olswold Susan Slager Amanda E Toland Drakoulis Yannoukakos Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Keitaro Matsuo Hidema Ito Hiroji Iwata Junko Ishiguro Anna H Wu Chiu-Chen Tseng David Van Den Berg Daniel O Stram Soo Hwang Teo Cheng Har Yip Peter Kang Mohammad Kamran Ikram Xiao-Ou Shu Wei Lu Yu-Tang Gao Hui Cai Daehee Kang Ji-Yeob Choi Sue K Park Dong-Young Noh Mikael Hartman Hui Miao Wei Yen Lim Soo Chin Lee Suleeporn Sangrajrang Valerie Gaborieau Paul Brennan James Mckay Pei-Ei Wu Ming-Feng Hou Jyh-Cherng Yu Chen-Yang Shen William Blot Qiuyin Cai Lisa B Signorello Craig Luccarini Caroline Bayes Shahana Ahmed Mel Maranian Catherine S Healey Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot David J Hunter Sara Lindstrom Joe Dennis Kyriaki Michailidou Manjeet K Bolla Douglas F Easton Isabel dos Santos Silva Olivia Fletcher Julian Peto

Hum Mol Genet 2015 May 4;24(10):2966-84. Epub 2015 Feb 4.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

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May 2015