Alan Aderem

Alan Aderem

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Alan Aderem

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Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response in vivo.

Sci Immunol 2019 Jul;4(37)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/sciimmunol.aaw6693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910245PMC
July 2019

Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.

Cell Host Microbe 2018 03;23(3):366-381.e9

Center for Infectious Disease Research, Seattle, WA 98109, USA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.chom.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176724PMC
March 2018

Systems integration of innate and adaptive immunity.

Vaccine 2015 Sep 21;33(40):5241-8. Epub 2015 Jun 21.

The Center for Infectious Disease Research, formerly Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.05.098DOI Listing
September 2015

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

Cell Host Microbe 2015 Sep 27;18(3):320-32. Epub 2015 Aug 27.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128150030
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http://dx.doi.org/10.1016/j.chom.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567510PMC
September 2015

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.

Immunity 2015 Apr;42(4):679-91

Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(15)00127-2.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500127
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http://dx.doi.org/10.1016/j.immuni.2015.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407145PMC
April 2015

Systems-level analysis of innate immunity.

Annu Rev Immunol 2014 ;32:547-77

Seattle BioMed, Seattle, Washington 98109; email:

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http://dx.doi.org/10.1146/annurev-immunol-032713-120254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084718PMC
November 2014

Macrophage activation as an effector mechanism for cell-mediated immunity.

J Immunol 2014 Oct;193(7):3183-4

Seattle Biomedical Research Institute, Seattle, WA 98109

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http://dx.doi.org/10.4049/jimmunol.1402046DOI Listing
October 2014

A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis.

Cell Host Microbe 2014 Feb;15(2):153-63

Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974621PMC
February 2014

Editorial overview. System immunology.

Authors:
Alan Aderem

Semin Immunol 2013 Oct;25(3):191-2

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http://dx.doi.org/10.1016/j.smim.2013.10.020DOI Listing
October 2013

Systems approaches to dissecting immunity.

Curr Top Microbiol Immunol 2013 ;363:1-19

Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, 98109, Seattle, WA, USA.

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http://dx.doi.org/10.1007/82_2012_246DOI Listing
April 2013

Caspase-11 protects against bacteria that escape the vacuole.

Science 2013 Feb 24;339(6122):975-8. Epub 2013 Jan 24.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/science.1230751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697099PMC
February 2013

Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.

J Immunol 2012 Dec 14;189(12):5903-11. Epub 2012 Nov 14.

Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.

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http://dx.doi.org/10.4049/jimmunol.1201940DOI Listing
December 2012

miR-451 regulates dendritic cell cytokine responses to influenza infection.

J Immunol 2012 Dec 19;189(12):5965-75. Epub 2012 Nov 19.

Seattle Biomedical Research Institute, Seattle, WA 98109, USA.

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http://dx.doi.org/10.4049/jimmunol.1201437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528339PMC
December 2012

Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells.

J Immunol 2012 Jul 1;189(1):23-7. Epub 2012 Jun 1.

Seattle Biomedical Research Institute, Seattle, WA 98109, USA.

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http://dx.doi.org/10.4049/jimmunol.1102477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381877PMC
July 2012

Vaccines. Editorial overview.

Curr Opin Immunol 2012 Jun 12;24(3):308-9. Epub 2012 Jun 12.

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http://dx.doi.org/10.1016/j.coi.2012.05.008DOI Listing
June 2012

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.

Nat Immunol 2012 May 20;13(7):659-66. Epub 2012 May 20.

Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/ni.2307DOI Listing
May 2012

Overcoming limitations in the systems vaccinology approach: a pathway for accelerated HIV vaccine development.

Curr Opin HIV AIDS 2012 Jan;7(1):58-63

Seattle Biomedical Research Institute, Seattle, Washington, USA.

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http://dx.doi.org/10.1097/COH.0b013e32834ddd31DOI Listing
January 2012

Caspase-1-induced pyroptotic cell death.

Immunol Rev 2011 Sep;243(1):206-14

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01044.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609431PMC
September 2011

Generation of a Listeria vaccine strain by enhanced caspase-1 activation.

Eur J Immunol 2011 Jul 8;41(7):1934-40. Epub 2011 Jun 8.

Institute for Systems Biology, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1002/eji.201041214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375905PMC
July 2011

Alan Aderem. Interview with Asher Mullard.

Authors:
Alan Aderem

Nat Rev Drug Discov 2011 Jul 1;10(7):486. Epub 2011 Jul 1.

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http://dx.doi.org/10.1038/nrd3491DOI Listing
July 2011

Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200.

Cell Host Microbe 2011 Jun;9(6):463-71

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1016/j.chom.2011.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118640PMC
June 2011

The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.

J Virol 2011 May 2;85(9):4167-72. Epub 2011 Feb 2.

Institute for Systems Biology, 1441 34th Avenue N., Seattle, WA 98104, USA.

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http://dx.doi.org/10.1128/JVI.01687-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126243PMC
May 2011

Fast track to vaccines.

Authors:
Alan Aderem

Sci Am 2011 May;304(5):66-71

Seattle BioMed, USA.

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http://dx.doi.org/10.1038/scientificamerican0511-66DOI Listing
May 2011

A 2020 vision for vaccines against HIV, tuberculosis and malaria.

Nature 2011 May;473(7348):463-9

Novartis Vaccines and Diagnostics, 53100 Siena, Italy.

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http://dx.doi.org/10.1038/nature10124DOI Listing
May 2011

Activation of the NLRP3 inflammasome by intracellular poly I:C.

FEBS Lett 2010 Nov 23;584(22):4627-32. Epub 2010 Oct 23.

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://doi.wiley.com/10.1016/j.febslet.2010.10.036
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http://dx.doi.org/10.1016/j.febslet.2010.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005299PMC
November 2010

A systems biology approach to understanding atherosclerosis.

EMBO Mol Med 2010 Mar;2(3):79-89

Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.1002/emmm.201000063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992755PMC
March 2010

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.

Proc Natl Acad Sci U S A 2009 Dec 3;106(51):21978-83. Epub 2009 Dec 3.

Department of Pharmacology, University of Washington Medical School, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.0911684106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799834PMC
December 2009

A systems view of host defense.

Nat Biotechnol 2009 Nov;27(11):999-1001

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http://dx.doi.org/10.1038/nbt1109-999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076594PMC
November 2009

A microfluidic device for multiplexed protein detection in nano-liter volumes.

Anal Biochem 2009 Mar 24;386(1):30-5. Epub 2008 Dec 24.

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1016/j.ab.2008.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678059PMC
March 2009

Systems biology of innate immunity.

Immunol Rev 2009 Jan;227(1):264-82

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00721.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697920PMC
January 2009

Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling.

Rejuvenation Res 2008 Dec;11(6):1001-11

Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1089/rej.2008.0747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848531PMC
December 2008

Taming data.

Cell Host Microbe 2008 Oct;4(4):312-3

Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1016/j.chom.2008.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074406PMC
October 2008

Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis.

PLoS Pathog 2008 Oct 17;4(10):e1000179. Epub 2008 Oct 17.

Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562527PMC
October 2008

The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.

Infect Immun 2008 Jun 7;76(6):2439-47. Epub 2008 Apr 7.

Department of Medicine, University of California-San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1128/IAI.00115-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423085PMC
June 2008

Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.

J Immunol 2008 Jun;180(11):7558-64

Department of Immunology, University of Washington, Seattle WA 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991040PMC
http://dx.doi.org/10.4049/jimmunol.180.11.7558DOI Listing
June 2008

Pseudomonas aeruginosa activates caspase 1 through Ipaf.

Proc Natl Acad Sci U S A 2008 Feb 6;105(7):2562-7. Epub 2008 Feb 6.

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1073/pnas.0712183105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268176PMC
February 2008

ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2544-9. Epub 2008 Feb 11.

Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1073/pnas.0712182105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268173PMC
February 2008

Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.

J Immunol 2007 Nov;179(10):6981-7

Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

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http://dx.doi.org/10.4049/jimmunol.179.10.6981DOI Listing
November 2007