Publications Authored by Alain Sarasin

Psychological correlates of adherence to photoprotection in a rare disease: International survey of people with Xeroderma Pigmentosum.

Authors:

Jessica Walburn Martha Canfield Sam Norton Kirby Sainsbury Vera Araújo-Soares Lesley Foster Mark Berneburg Alain Sarasin Natalie Morrison-Bowen Falko F Sniehotta Robert Sarkany John Weinman

Br J Health Psychol 2019 09 10;24(3):668-686. Epub 2019 Jun 10.

School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, UK.

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http://dx.doi.org/10.1111/bjhp.12375	DOI Listing

September 2019

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype.

Am J Hum Genet 2019 Aug;105(2):434-440

Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.06.017	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698936	PMC

August 2019

XPD/ERCC2 mutations interfere in cellular responses to oxidative stress.

Authors:

Leticia K Lerner Natália C Moreno Clarissa R R Rocha Veridiana Munford Valquíria Santos Daniela T Soltys Camila C M Garcia Alain Sarasin Carlos F M Menck

Mutagenesis 2019 Jul 26. Epub 2019 Jul 26.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1093/mutage/gez020	DOI Listing

July 2019

Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum.

Blood 2019 Jun 26;133(25):2718-2724. Epub 2019 Mar 26.

Institut National de la Santé et de la Recherche Médicale/CNRS U944/7212 and University Paris Diderot, University of Paris, France.

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http://dx.doi.org/10.1182/blood-2019-01-895698	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610036	PMC

June 2019

The key role of UVA-light induced oxidative stress in human Xeroderma Pigmentosum Variant cells.

Authors:

Natália Cestari Moreno Camila Carrião Machado Garcia Veridiana Munford Clarissa Ribeiro Reily Rocha Alessandra Luiza Pelegrini Camila Corradi Alain Sarasin Carlos Frederico Martins Menck

Free Radic Biol Med 2019 02 13;131:432-442. Epub 2018 Dec 13.

Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.012	DOI Listing

February 2019

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.

J Clin Invest 2018 04 19;128(4):1671-1687. Epub 2018 Mar 19.

Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1172/JCI90277	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873862	PMC

April 2018

Diagnosis of Xeroderma pigmentosum variant in a young patient with two novel mutations in the POLH gene.

Authors:

Armando De Palma Marie-Anne Morren Cécile Ged Caroline Pouvelle Alain Taïeb Said Aoufouchi Alain Sarasin

Am J Med Genet A 2017 Sep 8;173(9):2511-2516. Epub 2017 Jul 8.

Laboratory of Genetic Instability and Oncogenesis, UMR8200 CNRS, Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1002/ajmg.a.38340	DOI Listing

September 2017

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells.

Authors:

Leticia K Lerner Guilherme Francisco Daniela T Soltys Clarissa R R Rocha Annabel Quinet Alexandre T Vessoni Ligia P Castro Taynah I P David Silvina O Bustos Bryan E Strauss Vanesa Gottifredi Anne Stary Alain Sarasin Roger Chammas Carlos F M Menck

Nucleic Acids Res 2017 02;45(3):1270-1280

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1093/nar/gkw1196	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388406	PMC

February 2017

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.

Authors:

Annabel Quinet Davi Jardim Martins Alexandre Teixeira Vessoni Denis Biard Alain Sarasin Anne Stary Carlos Frederico Martins Menck

Nucleic Acids Res 2016 07 19;44(12):5717-31. Epub 2016 Apr 19.

Institute of Biomedical Sciences, University of São Paulo, SP, 05508-000, Brazil

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http://dx.doi.org/10.1093/nar/gkw280	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937316	PMC

July 2016

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis.

Authors:

Florian Rambow Bastien Job Valérie Petit Franck Gesbert Véronique Delmas Hannah Seberg Guillaume Meurice Eric Van Otterloo Philippe Dessen Caroline Robert Daniel Gautheret Robert A Cornell Alain Sarasin Lionel Larue

Cell Rep 2015 Oct 17;13(4):840-853. Epub 2015 Oct 17.

Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France; Centre National de la Recherche Scientifique (CNRS) UMR3347, 91405 Orsay, France; INSERM U1021, 91405 Orsay, France; Equipe Labellisée - Ligue Nationale contre le Cancer, 91405 Orsay, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.037	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970542	PMC

October 2015

Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma.

Eur J Hum Genet 2015 Jul 15;23(7):957-62. Epub 2014 Oct 15.

1] Equipe d'Accueil 4271, Génétique des Anomalies du Développement, Université de Bourgogne, Dijon, France [2] Centre de Génétique et Centre de Référence Anomalies du Développement et Syndromes Malformatifs de l'Interrégion Est, Centre Hospitalier Universitaire Dijon, Dijon, France.

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http://dx.doi.org/10.1038/ejhg.2014.213	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463501	PMC

July 2015

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

Authors:

Laurent Chatre Denis S F Biard Alain Sarasin Miria Ricchetti

Proc Natl Acad Sci U S A 2015 Jun 18;112(22):E2910-9. Epub 2015 May 18.

Institut Pasteur, Department of Genomes and Genetics, Unité de Génétique Moléculaire des Levures, 75724 Paris, France; CNRS UMR 3525, Team Stability of Nuclear and Mitochondrial DNA,

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http://dx.doi.org/10.1073/pnas.1422264112	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460464	PMC

June 2015

DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease.

Authors:

Aurélie Dupuy Alain Sarasin

Mutat Res 2015 Jun 6;776:2-8. Epub 2014 Sep 6.

Laboratory of Genetic Instability and Oncogenesis UMR8200CNRS, Institut Gustave Roussy and University Paris-Sud, Villejuif, France; Service de Génétique, Institut Gustave Roussy, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00275107140014	Publisher Site
http://dx.doi.org/10.1016/j.mrfmmm.2014.08.007	DOI Listing

June 2015

Aberrant C-terminal domain of polymerase η targets the functional enzyme to the proteosomal degradation pathway.

Authors:

Sana Ahmed-Seghir Caroline Pouvelle Emmanuelle Despras Agnès Cordonnier Alain Sarasin Patricia L Kannouche

DNA Repair (Amst) 2015 May 26;29:154-65. Epub 2015 Feb 26.

Université Paris-Sud, CNRS-UMR8200, Equipe labellisée Ligue Contre le Cancer, Gustave Roussy, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.02.017	DOI Listing

May 2015

Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN™.

Authors:

Aurélie Dupuy Julien Valton Sophie Leduc Jacques Armier Roman Galetto Agnès Gouble Céline Lebuhotel Anne Stary Frédéric Pâques Philippe Duchateau Alain Sarasin Fayza Daboussi

PLoS One 2013 13;8(11):e78678. Epub 2013 Nov 13.

Cellectis S.A., Paris, France ; Unité mixte de recherche 8200, Institut Gustave Roussy, Villejuif, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078678	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827243	PMC

September 2014

Genetic variants in DNA repair pathways and risk of upper aerodigestive tract cancers: combined analysis of data from two genome-wide association studies in European populations.

Authors:

Marie-Claude Babron Rémi Kazma Valérie Gaborieau James McKay Paul Brennan Alain Sarasin Simone Benhamou

Carcinogenesis 2014 Jul 21;35(7):1523-7. Epub 2014 Mar 21.

Inserm, U946, Genetic Variation and Human, Diseases and Université Paris-Diderot, Sorbonne Paris-Cité, UMRS-946, Paris, F-75010, France, Gustave Roussy, Villejuif, F-94805, France

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c	Publisher Site
http://dx.doi.org/10.1093/carcin/bgu075	DOI Listing

July 2014

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

Authors:

Annabel Quinet Alexandre T Vessoni Clarissa R R Rocha Vanesa Gottifredi Denis Biard Alain Sarasin Carlos F M Menck Anne Stary

DNA Repair (Amst) 2014 Feb 28;14:27-38. Epub 2013 Dec 28.

CNRS-UMR8200, Université Paris Sud, Institut de Cancérologie Gustave Roussy, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2013.12.005	DOI Listing

February 2014

Correlation of phenotype/genotype in a cohort of 23 xeroderma pigmentosum-variant patients reveals 12 new disease-causing POLH mutations.

Authors:

Kristina Opletalova Agnès Bourillon Wei Yang Caroline Pouvelle Jacques Armier Emmanuelle Despras Martin Ludovic Christine Mateus Caroline Robert Patricia Kannouche Nadem Soufir Alain Sarasin

Hum Mutat 2014 Jan;35(1):117-28

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http://dx.doi.org/10.1002/humu.22462	DOI Listing

January 2014

Novel XPG (ERCC5) mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress.

Authors:

Daniela T Soltys Clarissa R R Rocha Letícia K Lerner Tiago A de Souza Veridiana Munford Fernanda Cabral Tiziana Nardo Miria Stefanini Alain Sarasin Januário B Cabral-Neto Carlos F M Menck

Hum Mutat 2013 Mar 17;34(3):481-9. Epub 2013 Jan 17.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1002/humu.22259	DOI Listing

March 2013

A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.

Authors:

Craig Carson Bernard Omolo Haitao Chu Yingchun Zhou Maria J Sambade Eldon C Peters Patrick Tompkins Dennis A Simpson Nancy E Thomas Cheng Fan Alain Sarasin Philippe Dessen Janiel M Shields Joseph G Ibrahim William K Kaufmann

Pigment Cell Melanoma Res 2012 Jul 1;25(4):514-26. Epub 2012 Jun 1.

Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/j.1755-148X.2012.01010.x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397470	PMC

July 2012

Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.

Authors:

Rémi Kazma Marie-Claude Babron Valérie Gaborieau Emmanuelle Génin Paul Brennan Rayjean J Hung John R McLaughlin Hans E Krokan Maiken B Elvestad Frank Skorpen Endre Anderssen Tõnu Vooder Kristjan Välk Andres Metspalu John K Field Mark Lathrop Alain Sarasin Simone Benhamou

Carcinogenesis 2012 May 1;33(5):1059-64. Epub 2012 Mar 1.

Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1093/carcin/bgs116	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334518	PMC

May 2012

UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells.

Authors:

Alain Sarasin

Genome Med 2012 May 23;4(5):44. Epub 2012 May 23.

Laboratory of Genetic Stability and Oncogenesis, UMR8200 CNRS, Institut Gustave Roussy and University Paris-Sud, 114, rue Edouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.1186/gm343	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506910	PMC

May 2012

Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.

Authors:

Emilie Warrick Marta Garcia Corinne Chagnoleau Odile Chevallier Valérie Bergoglio Daniela Sartori Fulvio Mavilio Jaime F Angulo Marie-Françoise Avril Alain Sarasin Fernando Larcher Marcela Del Rio Françoise Bernerd Thierry Magnaldo

Mol Ther 2012 Apr 8;20(4):798-807. Epub 2011 Nov 8.

Laboratory of genomes biology and pathologies, CNRS UMR/INSERM, Nice, France.

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http://dx.doi.org/10.1038/mt.2011.233	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321585	PMC

April 2012

Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions.

Authors:

Maria Carolina S Moraes Annabel Quinet de Andrade Helotonio Carvalho Temenouga Guecheva Mateus H Agnoletto João A P Henriques Alain Sarasin Anne Stary Jenifer Saffi Carlos F M Menck

Cancer Lett 2012 Jan 24;314(1):108-18. Epub 2011 Sep 24.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.canlet.2011.09.019	DOI Listing

January 2012

Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1.

Clin Cancer Res 2012 Jan 17;18(1):263-72. Epub 2011 Nov 17.

Department of Medical Oncology and Pathology, Institute Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1344	DOI Listing

January 2012

Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells.

Authors:

Daniele G Soares Miriana S Machado Céline J Rocca Virginie Poindessous Djamila Ouaret Alain Sarasin Carlos M Galmarini João A P Henriques Alexandre E Escargueil Annette K Larsen

Mol Cancer Ther 2011 Aug 27;10(8):1481-9. Epub 2011 May 27.

Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine, Institut National de la Santé et de la Recherche Médicale U938, Paris, France.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0252	DOI Listing

August 2011

A new XPC gene splicing mutation has lead to the highest worldwide prevalence of xeroderma pigmentosum in black Mahori patients.

Authors:

François Cartault Caroline Nava Anne-Claire Malbrunot Patrick Munier Jean-Christophe Hebert Patrick N'guyen Nadia Djeridi Philippe Pariaud Joelle Pariaud Aurélie Dupuy Frédéric Austerlitz Alain Sarasin

DNA Repair (Amst) 2011 Jun 8;10(6):577-85. Epub 2011 Apr 8.

Department of Medical Genetics, INSERM U781 CHR Félix Guyon, La Réunion, and CHU Necker, Paris, France.

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http://dx.doi.org/10.1016/j.dnarep.2011.03.005	DOI Listing

June 2011

The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.

Authors:

Céline J Rocca Virginie Poindessous Daniele G Soares Karima El Ouadrani Alain Sarasin Eric Guérin Aimery de Gramont João A P Henriques Alexandre E Escargueil Annette K Larsen

Biochem Pharmacol 2010 Aug 22;80(3):335-43. Epub 2010 Apr 22.

Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine, Paris 75571, France.

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http://dx.doi.org/10.1016/j.bcp.2010.04.012	DOI Listing

August 2010

A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa.

Authors:

Nadem Soufir Cecile Ged Agnes Bourillon Frederic Austerlitz Cécile Chemin Anne Stary Jacques Armier Daniele Pham Khadija Khadir Joelle Roume Smail Hadj-Rabia Bakar Bouadjar Alain Taieb Hubert de Verneuil Hakima Benchiki Bernard Grandchamp Alain Sarasin

J Invest Dermatol 2010 Jun 7;130(6):1537-42. Epub 2010 Jan 7.

Laboratoire de Biochimie hormonale et génétique, Hôpital Bichat, APHP, Université Paris VII, 46 Rue Henri Huchard, Paris, France.

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http://dx.doi.org/10.1038/jid.2009.409	DOI Listing

June 2010

2nd German-French DNA repair meeting - DNA damage and repair in ageing and degenerative diseases, Konstanz, Germany, September 20-23, 2009.

Authors:

Alexander Bürkle Alain Sarasin Lisa Wiesmüller

Mech Ageing Dev 2010 May 17;131(5):370-6. Epub 2010 Mar 17.

Department of Biology, Box X911, University of Konstanz, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.mad.2010.03.003	DOI Listing

May 2010

Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells.

Authors:

Jenifer Saffi Mateus H Agnoletto Temenouga N Guecheva Luís F Z Batista Helotonio Carvalho João A P Henriques Anne Stary Carlos F M Menck Alain Sarasin

DNA Repair (Amst) 2010 Jan 17;9(1):40-7. Epub 2009 Nov 17.

Biophysics Department, UFRGS, Porto Alegre, Brazil.

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http://dx.doi.org/10.1016/j.dnarep.2009.10.003	DOI Listing

January 2010

New clinico-genetic classification of trichothiodystrophy.

Authors:

Fanny Morice-Picard Muriel Cario-André Hamid Rezvani Didier Lacombe Alain Sarasin Alain Taïeb

Am J Med Genet A 2009 Sep;149A(9):2020-30

Department of Pediatric Dermatology, National Reference Center for Rare Skin Disorders, Pellegrin University Hospitals, Bordeaux, France.

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http://dx.doi.org/10.1002/ajmg.a.32902	DOI Listing

September 2009

Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cells.

Authors:

Damien Brégeon Paul-Antoine Peignon Alain Sarasin

PLoS Genet 2009 Jul 24;5(7):e1000577. Epub 2009 Jul 24.

Laboratoire Génomes et Cancer, CNRS FRE-2939, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1371/journal.pgen.1000577	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708909	PMC

July 2009

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

Authors:

Stefan Michiels Agnès Laplanche Thomas Boulet Philippe Dessen Bertrand Guillonneau Arnaud Méjean François Desgrandchamps Mark Lathrop Alain Sarasin Simone Benhamou

Carcinogenesis 2009 May 23;30(5):763-8. Epub 2009 Feb 23.

Department of Biostatistics and Epidemiology, Institut Gustave Roussy, Villejuif 94805, France.

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http://dx.doi.org/10.1093/carcin/bgp046	DOI Listing

May 2009

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.

Authors:

Ahmad Faili Anne Stary Frédéric Delbos Sandra Weller Said Aoufouchi Alain Sarasin Jean-Claude Weill Claude-Agnès Reynaud

J Immunol 2009 May;182(10):6353-9

Faculté de Médecine, Institut National de la Santé et de la Recherche Médicale Unite 783 Développement du Système immunitaire, Université Paris Descartes, Site Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.0900177	DOI Listing

May 2009

Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.

Authors:

Caroline Kannengiesser Sharon Brookes Anna Gutierrez del Arroyo Danielle Pham Johny Bombled Michel Barrois Olivier Mauffret Marie-Françoise M Avril Agnès Chompret Gilbert M Lenoir Alain Sarasin Gordon Peters Brigitte Bressac-de Paillerets

Hum Mutat 2009 Apr;30(4):564-74

Service de Génétique, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/humu.20845	DOI Listing

April 2009

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.

Authors:

Tiziana Nardo Roberta Oneda Graciela Spivak Bruno Vaz Laurent Mortier Pierre Thomas Donata Orioli Vincent Laugel Anne Stary Philip C Hanawalt Alain Sarasin Miria Stefanini

Proc Natl Acad Sci U S A 2009 Apr 27;106(15):6209-14. Epub 2009 Mar 27.

Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, 27100 Pavia, Italy.

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http://dx.doi.org/10.1073/pnas.0902113106	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667150	PMC

April 2009

Progress and prospects of xeroderma pigmentosum therapy.

Authors:

Alain Sarasin

Adv Exp Med Biol 2008 ;637:144-51

Laboratory of Genomes and Cancers, Institute Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1007/978-0-387-09599-8_16	DOI Listing

February 2009

Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.

Authors:

Tomohisa Nishiwaki Nobuhiko Kobayashi Takaaki Iwamoto Aya Yamamoto Shigeki Sugiura Yin-Chang Liu Alain Sarasin Yumiko Okahashi Makito Hirano Satoshi Ueno Toshio Mori

DNA Repair (Amst) 2008 Dec 10;7(12):1990-8. Epub 2008 Oct 10.

Radioisotope Research Center, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan.

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http://dx.doi.org/10.1016/j.dnarep.2008.08.009	DOI Listing

December 2008

Human DNA polymerase iota protects cells against oxidative stress.

Authors:

Tirzah Braz Petta Satoshi Nakajima Anastasia Zlatanou Emmanuelle Despras Sophie Couve-Privat Alexander Ishchenko Alain Sarasin Akira Yasui Patricia Kannouche

EMBO J 2008 Nov 16;27(21):2883-95. Epub 2008 Oct 16.

Centre National de la Recherche Scientifique FRE2939, Unit of genetic stability and oncogenesis, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1038/emboj.2008.210	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580789	PMC

November 2008

Overexpression of DNA repair genes is associated with metastasis: a new hypothesis.

Authors:

Alain Sarasin Audrey Kauffmann

Mutat Res 2008 Jul-Aug;659(1-2):49-55. Epub 2008 Jan 16.

Genomes and Cancers, FRE2939-CNRS, Institute Gustave Roussy, PR2, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://linkinghub.elsevier.com/retrieve/pii/S138357420800003	Publisher Site
http://dx.doi.org/10.1016/j.mrrev.2007.12.002	DOI Listing

September 2008

Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.

Authors:

Quentin Gueranger Anne Stary Saïd Aoufouchi Ahmad Faili Alain Sarasin Claude-Agnès Reynaud Jean-Claude Weill

DNA Repair (Amst) 2008 Sep 21;7(9):1551-62. Epub 2008 Jul 21.

Institut National de la Santé et de la Recherche Médicale U783 (Développement du Système Immunitaire), Université Paris Descartes, Faculté de Médecine René Descartes, Site Necker-Enfants Malades, Paris Cedex 15, France.

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https://hal-descartes.archives-ouvertes.fr/docs/00/32/06/55/	Web Search
http://linkinghub.elsevier.com/retrieve/pii/S156878640800215	Publisher Site
http://dx.doi.org/10.1016/j.dnarep.2008.05.012	DOI Listing

September 2008

Identification of new RECQL4 mutations in Caucasian Rothmund-Thomson patients and analysis of sensitivity to a wide range of genotoxic agents.

Authors:

Rosa Estela Caseira Cabral Sophie Queille Christine Bodemer Yves de Prost Januario Bispo Cabral Neto Alain Sarasin Leela Daya-Grosjean

Mutat Res 2008 Aug 21;643(1-2):41-7. Epub 2008 Jun 21.

Laboratoire Génomes et Cancers, FRE2939 CNRS, Institut Gustave-Roussy, Université Paris-Sud, PRII, 39 Rue Camille Desmoulins, 94805 Villejuif, France.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070800120	Publisher Site
http://dx.doi.org/10.1016/j.mrfmmm.2008.06.002	DOI Listing

August 2008

Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome.

Authors:

Vanessa Chiganças Keronninn M Lima-Bessa Anne Stary Carlos F M Menck Alain Sarasin

Cancer Res 2008 Aug;68(15):6074-83

Laboratory of Genetic Stability and Oncogenesis, Centre National de la Recherche Scientifique, Formation de Recherche en Evolution 2939, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6695	DOI Listing

August 2008

Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.

Authors:

Patrick Danoy Stefan Michiels Philippe Dessen Cécile Pignat Thomas Boulet Marion Monet Christine Bouchardy Mark Lathrop Alain Sarasin Simone Benhamou

Int J Cancer 2008 Jul;123(2):457-463

INSERM, U794, Centre d'Etude du Polymorphisme Humain, Paris, France.

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http://dx.doi.org/10.1002/ijc.23524	DOI Listing

July 2008

Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.

Authors:

Wim J Kleijer Vincent Laugel Mark Berneburg Tiziana Nardo Heather Fawcett Alexei Gratchev Nicolaas G J Jaspers Alain Sarasin Miria Stefanini Alan R Lehmann

DNA Repair (Amst) 2008 May 10;7(5):744-50. Epub 2008 Mar 10.

Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2008.01.014	DOI Listing

May 2008

Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage.

Authors:

Renata M A da Costa Carolina Quayle Jaqueline de Fátima Jacysyn Gustavo P Amarante-Mendes Alain Sarasin Carlos F M Menck

Mutat Res 2008 Apr 17;640(1-2):1-7. Epub 2007 Dec 17.

Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, Av. Prof. Lineu Prestes 1374, 05508-900 São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.11.010	DOI Listing

April 2008

Influence of irofulven, a transcription-coupled repair-specific antitumor agent, on RNA polymerase activity, stability and dynamics in living mammalian cells.

Authors:

Alexandre E Escargueil Virginie Poindessous Daniele Grazziotin Soares Alain Sarasin Peter R Cook Annette K Larsen

J Cell Sci 2008 Apr;121(Pt 8):1275-83

Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine, Paris, France.

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http://dx.doi.org/10.1242/jcs.023259	DOI Listing

April 2008

Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas.

Authors:

Caroline Kannengiesser Alain Spatz Stefan Michiels Alain Eychène Philippe Dessen Vladimir Lazar Véronique Winnepenninckx Fabienne Lesueur Sabine Druillennec Caroline Robert Joost J van den Oord Alain Sarasin Brigitte Bressac-de Paillerets

Mol Oncol 2008 Apr 12;1(4):425-30. Epub 2008 Jan 12.

Service de Génétique & CNRS FRE 2939, Institut Gustave Roussy, Villejuif, France.

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http://doi.wiley.com/10.1016/j.molonc.2008.01.002	Publisher Site
http://dx.doi.org/10.1016/j.molonc.2008.01.002	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543835	PMC

April 2008

Deletion of 5' sequences of the CSB gene provides insight into the pathophysiology of Cockayne syndrome.

Authors:

Vincent Laugel Cecile Dalloz Anne Stary Valerie Cormier-Daire Isabelle Desguerre Michel Renouil Alain Fourmaintraux Renier Velez-Cruz Jean-Marc Egly Alain Sarasin Helene Dollfus

Eur J Hum Genet 2008 Mar 9;16(3):320-7. Epub 2008 Jan 9.

Laboratory of Medical Genetics, Faculte de Medecine, Strasbourg, France.

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http://dx.doi.org/10.1038/sj.ejhg.5201991	DOI Listing

March 2008

CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells.

Authors:

Keronninn Moreno de Lima-Bessa Melissa Gava Armelini Vanessa Chiganças Jacqueline F Jacysyn Gustavo P Amarante-Mendes Alain Sarasin Carlos Frederico Martins Menck

DNA Repair (Amst) 2008 Feb 21;7(2):303-12. Epub 2007 Dec 21.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Avenue Prof Lineu Prestes, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.dnarep.2007.11.003	DOI Listing

February 2008

Safe selection of genetically manipulated human primary keratinocytes with very high growth potential using CD24.

Authors:

Valérie Bergoglio Fernando Larcher Odile Chevallier-Lagente Alain Bernheim Olivier Danos Alain Sarasin Marcela Del Rio Thierry Magnaldo

Mol Ther 2007 Dec 21;15(12):2186-93. Epub 2007 Aug 21.

Centre National de la Recherche Scientifique, Genomes and Cancers Unit, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1038/sj.mt.6300292	DOI Listing

December 2007

Expression profiling of melanoma cell lines: in search of a progression-related molecular signature.

Authors:

Joost J Van den Oord Alain Sarasin Vèronique Winnepenninckx Alain Spatz

Future Oncol 2007 Dec;3(6):609-11

Katholieke Universiteit Leuven, Department of Pathology, Morphology & Molecular Pathology Laboratory, University Hospitals Minderbroedersstraat 12, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.2217/14796694.3.6.609	DOI Listing

December 2007

Transcription through 8-oxoguanine in DNA repair-proficient and Csb(-)/Ogg1(-) DNA repair-deficient mouse embryonic fibroblasts is dependent upon promoter strength and sequence context.

Authors:

Manuela Pastoriza-Gallego Jacques Armier Alain Sarasin

Mutagenesis 2007 Sep 14;22(5):343-51. Epub 2007 Jul 14.

Laboratory of Genetic Instability and Cancer, FRE 2939 CNRS, Institut Gustave Roussy, 94805 Villejuif, France.

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http://dx.doi.org/10.1093/mutage/gem024	DOI Listing

September 2007

New founder germline mutations of CDKN2A in melanoma-prone families and multiple primary melanoma development in a patient receiving levodopa treatment.

Authors:

Caroline Kannengiesser Stéphane Dalle Marie-Thérèse Leccia Marie Françoise Avril Valerie Bonadona Agnès Chompret Christine Lasset Dominique Leroux Luc Thomas Fabienne Lesueur Gilbert Lenoir Alain Sarasin Brigitte Bressac-de Paillerets

Genes Chromosomes Cancer 2007 Aug;46(8):751-60

Service de Génétique, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/gcc.20461	DOI Listing

August 2007

Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.

Authors:

Stefan Michiels Patrick Danoy Philippe Dessen Alex Bera Thomas Boulet Christine Bouchardy Mark Lathrop Alain Sarasin Simone Benhamou

Carcinogenesis 2007 Aug 10;28(8):1731-9. Epub 2007 May 10.

Department of Biostatistics and Epidemiology, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif cedex, France.

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http://dx.doi.org/10.1093/carcin/bgm111	DOI Listing

August 2007

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

Authors:

Daniele Grazziotin Soares Alexandre E Escargueil Virginie Poindessous Alain Sarasin Aimery de Gramont Diego Bonatto João Antonio Pêgas Henriques Annette K Larsen

Proc Natl Acad Sci U S A 2007 Aug 26;104(32):13062-7. Epub 2007 Jul 26.

Group of Cancer Biology and Therapeutics, Institut National de la Santé et de la Recherche Médicale, Unité 673, and Université Pierre et Marie Curie, Hôpital Saint-Antoine, 75571 Paris Cedex 12, France.

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http://dx.doi.org/10.1073/pnas.0609877104	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941813	PMC

August 2007

Prevalence of human papillomavirus in skin tumors from repair deficient xeroderma pigmentosum patients.

Authors:

Lionel Luron Marie-Françoise Avril Alain Sarasin Leela Daya-Grosjean

Cancer Lett 2007 Jun 28;250(2):213-9. Epub 2006 Nov 28.

Laboratoire Génomes et Cancers, FRE 2939 CNRS Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.canlet.2006.10.008	DOI Listing

June 2007

Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling.

Authors:

Anne-Celine Le Fevre Eric Boitier Jean-Pierre Marchandeau Alain Sarasin Veronique Thybaud

Mutat Res 2007 Jun 8;619(1-2):16-29. Epub 2007 Feb 8.

sanofi aventis R&D, Drug Safety Evaluation, 13 quai Jules Guesde, 94403 Vitry-Sur-Seine Cedex, France.

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http://dx.doi.org/10.1016/j.mrfmmm.2006.12.007	DOI Listing

June 2007

BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.

Authors:

Fabien P Gosselet Thierry Magnaldo Raphaël M Culerrier Alain Sarasin Jean-Claude Ehrhart

Cell Signal 2007 Apr 4;19(4):731-9. Epub 2006 Oct 4.

Laboratory of Genomes and Cancers, FRE 2939 CNRS, Institut Gustave Roussy-PR2, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.cellsig.2006.09.006	DOI Listing

April 2007

Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene.

Authors:

Sophie Queille Lionel Luron Alain Spatz Marie Françoise Avril Vincent Ribrag Pierre Duvillard Christian Hiesse Alain Sarasin Jean Pierre Armand Leela Daya-Grosjean

Carcinogenesis 2007 Mar 25;28(3):724-31. Epub 2006 Oct 25.

Laboratoire Génomes et Cancers, FRE2939 CNRS, Institut Gustave-Roussy, PRII, 39 Rue Camille Desmoulins 94805 Villejuif, France.

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http://dx.doi.org/10.1093/carcin/bgl191	DOI Listing

March 2007

New insights for understanding the transcription-coupled repair pathway.

Authors:

Alain Sarasin Anne Stary

DNA Repair (Amst) 2007 Feb 27;6(2):265-9. Epub 2006 Dec 27.

Genomes and Cancers, Institut Gustave Roussy, CNRS FRE 2939, 39, rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.dnarep.2006.12.001	DOI Listing

February 2007

Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships.

Authors:

Elena Botta Judith Offman Tiziana Nardo Roberta Ricotti Giovanna Zambruno Daniela Sansone Paolo Balestri Anja Raams Wim J Kleijer Nicolaas G J Jaspers Alain Sarasin Alan R Lehmann Miria Stefanini

Hum Mutat 2007 Jan;28(1):92-6

Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (CNR), Pavia, Italy.

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http://dx.doi.org/10.1002/humu.20419	DOI Listing

January 2007

Adenovirus mediated transduction of the human DNA polymerase eta cDNA.

Authors:

Keronninn Moreno Lima-Bessa Vanessa Chiganças Anne Stary Patricia Kannouche Alain Sarasin Melissa Gava Armelini Jacqueline de Fátima Jacysyn Gustavo P Amarante-Mendes Marila Cordeiro-Stone James E Cleaver Carlos Frederico Martins Menck

DNA Repair (Amst) 2006 Aug 23;5(8):925-34. Epub 2006 Jun 23.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1374 São Paulo, SP 05508-900, Brazil.

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http://dx.doi.org/10.1016/j.dnarep.2006.05.037	DOI Listing

August 2006

DNA repair: from molecular mechanism to human disease.

Authors:

Errol C Friedberg Andres Aguilera Martin Gellert Philip C Hanawalt John B Hays Alan R Lehmann Tomas Lindahl Noel Lowndes Alain Sarasin Richard D Wood

DNA Repair (Amst) 2006 Aug;5(8):986-96

Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA.

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August 2006

Complementation assays adapted for DNA repair-deficient keratinocytes.

Authors:

Mathilde Fréchet Valérie Bergoglio Odile Chevallier-Lagente Alain Sarasin Thierry Magnaldo

Methods Mol Biol 2006 ;314:9-23

Laboratory of Genetic Instability and Cancer, Institute Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1385/1-59259-973-7:009	DOI Listing

June 2006

Gene expression profiling of primary cutaneous melanoma and clinical outcome.

Authors:

Véronique Winnepenninckx Vladimir Lazar Stefan Michiels Philippe Dessen Marguerite Stas Soledad R Alonso Marie-Françoise Avril Pablo L Ortiz Romero Thomas Robert Ovidiu Balacescu Alexander M M Eggermont Gilbert Lenoir Alain Sarasin Thomas Tursz Joost J van den Oord Alain Spatz

J Natl Cancer Inst 2006 Apr;98(7):472-82

Department of Pathology, Gustave-Roussy Institute, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1093/jnci/djj103	DOI Listing

April 2006

The DNA repair genes XPB and XPD defend cells from retroviral infection.

Authors:

Kristine Yoder Alain Sarasin Kenneth Kraemer Michael McIlhatton Frederic Bushman Richard Fishel

Proc Natl Acad Sci U S A 2006 Mar 13;103(12):4622-7. Epub 2006 Mar 13.

Department of Molecular Virology, and Ohio State University Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0509828103	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450221	PMC

March 2006

Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients.

Authors:

Sikandar G Khan Kyu-Seon Oh Tala Shahlavi Takahiro Ueda David B Busch Hiroki Inui Steffen Emmert Kyoko Imoto Vanessa Muniz-Medina Carl C Baker John J DiGiovanna Deborah Schmidt Arash Khadavi Ahmet Metin Engin Gozukara Hanoch Slor Alain Sarasin Kenneth H Kraemer

Carcinogenesis 2006 Jan 4;27(1):84-94. Epub 2005 Aug 4.

Basic Research Laboratory and Laboratory of Cellular Oncology, CCR, NCI, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/carcin/bgi204	DOI Listing

January 2006

Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.

Authors:

Florence Le Page Ely E Kwoh Anna Avrutskaya Alain Gentil Steven A Leadon Alain Sarasin Priscilla K Cooper

Cell 2005 Nov;123(4):711

Laboratory of Molecular Genetics, UPR42 Centre National de la Recherche Scientifique, 94801 Villejuif, France.

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http://dx.doi.org/10.1016/j.cell.2005.11.005	DOI Listing

November 2005

Hypothetical role of RNA damage avoidance in preventing human disease.

Authors:

Damien Brégeon Alain Sarasin

Mutat Res 2005 Sep;577(1-2):293-302

Institut Gustave Roussy PR2, CNRS UPR-2169, 39 rue Camille Desmoulins 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.04.002	DOI Listing

September 2005

ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer.

Authors:

Jérôme Viguier Valérie Boige Catherine Miquel Marc Pocard Bruno Giraudeau Jean-Christophe Sabourin Michel Ducreux Alain Sarasin Françoise Praz

Clin Cancer Res 2005 Sep;11(17):6212-7

Centre National de la Recherche Scientifique UPR 2169, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2216	DOI Listing

September 2005

Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing.

Authors:

Denis S F Biard Emmanuelle Despras Alain Sarasin Jaime F Angulo

Mol Cancer Res 2005 Sep;3(9):519-29

Laboratoire de Génétique de la Radiosensibilité, Commissariat à l'Energie Atomique, Département de Radiobiologie et de Radiopathologie, Direction des Sciences du Vivant, BP 6, 92265 Fontenay aux Roses, France.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0044	DOI Listing

September 2005

Reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro: a model to study hypersensitivity to UV light.

Authors:

Françoise Bernerd Daniel Asselineau Mathilde Frechet Alain Sarasin Thierry Magnaldo

Photochem Photobiol 2005 Jan-Feb;81(1):19-24

L'Oréal, Life Sciences Research, Centre C. Zviak, 90 Rue du général Roguet, 92583 Clichy cedex, France.

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http://dx.doi.org/10.1562/2004-07-29-IR-250	DOI Listing

June 2005

Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus.

Authors:

Melissa Gava Armelini Alysson Renato Muotri Maria Carolina Nasser Marchetto Keronninn Moreno de Lima-Bessa Alain Sarasin Carlos Frederico Martins Menck

Cancer Gene Ther 2005 Apr;12(4):389-96

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900 SP, Brazil.

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http://dx.doi.org/10.1038/sj.cgt.7700797	DOI Listing

April 2005

The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors.

Authors:

Leela Daya-Grosjean Alain Sarasin

Mutat Res 2005 Apr 25;571(1-2):43-56. Epub 2005 Jan 25.

Laboratory of Genetic Instability and Cancer, UPR2169 CNRS, IFR 54, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.mrfmmm.2004.11.013	DOI Listing

April 2005

Xeroderma pigmentosum: from symptoms and genetics to gene-based skin therapy.

Authors:

Thierry Magnaldo Alain Sarasin

Cells Tissues Organs 2004 ;177(3):189-98

Laboratory of Genetic Instability and Cancer, CNRS UPR2169, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1159/000079993	DOI Listing

March 2005

Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele.

Authors:

Renata Maria Augusto da Costa Lydia Riou Apuã Paquola Carlos Frederico Martins Menck Alain Sarasin

Oncogene 2005 Feb;24(8):1359-74

Laboratory of Genetic Instability and Cancer UPR2169 CNRS, Gustave Roussy Institute, 94805, Villejuif Cedex, France.

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http://dx.doi.org/10.1038/sj.onc.1208288	DOI Listing

February 2005

Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines.

Authors:

Sandrine Jacob Catherine Miquel Alain Sarasin Françoise Praz

Nucleic Acids Res 2005 7;33(1):106-13. Epub 2005 Jan 7.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 2169, Genetic Instability and Cancer, Institut Gustave Roussy 39 rue Camille Desmoulins, 94 800 Villejuif, France.

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http://dx.doi.org/10.1093/nar/gki154	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546142	PMC

February 2005

ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.

Authors:

Simone Benhamou Alain Sarasin

Am J Epidemiol 2005 Jan;161(1):1-14

Institut National de la Santé et de la Recherche Médicale-Evry University, 91034 Evry, France.

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http://dx.doi.org/10.1093/aje/kwi018	DOI Listing

January 2005

DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract.

Authors:

Simone Benhamou Jarno Tuimala Christine Bouchardy Pierre Dayer Alain Sarasin Ari Hirvonen

Int J Cancer 2004 Dec;112(5):901-4

INSERM and Evry University, EMI 00-06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France.

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http://dx.doi.org/10.1002/ijc.20474	DOI Listing

December 2004

Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells.

Authors:

Florence Koeppel Virginie Poindessous Vladimir Lazar Eric Raymond Alain Sarasin Annette K Larsen

Clin Cancer Res 2004 Aug;10(16):5604-13

Group of Biology and Pharmacogenetics of Human Tumors, Centre National de la Recherche Scientifique, UMR 8113, Institut Gustave-Roussy, Villejuif, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0442	DOI Listing

August 2004

CPD-photolyase adenovirus-mediated gene transfer in normal and DNA-repair-deficient human cells.

Authors:

Vanessa Chiganças Alain Sarasin Carlos Frederico Martins Menck

J Cell Sci 2004 Jul;117(Pt 16):3579-92

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1374. Ed. Biomédicas 2, São Paulo 05508-900, Brazil.

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http://dx.doi.org/10.1242/jcs.01241	DOI Listing

July 2004

Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.

Authors:

Romina Zanier Delphine Briot Jean-Antoine Dugas du Villard Alain Sarasin Filippo Rosselli

Oncogene 2004 Jun;23(29):5004-13

UPR2169 CNRS, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif cedex, France.

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http://dx.doi.org/10.1038/sj.onc.1207677	DOI Listing

June 2004

Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients.

Authors:

Sophie Couvé-Privat Marc Le Bret Elisabeth Traiffort Sophie Queille Josée Coulombe Bakar Bouadjar Marie Françoise Avril Martial Ruat Alain Sarasin Leela Daya-Grosjean

Cancer Res 2004 May;64(10):3559-65

Laboratoire Instabilité Génétique et Cancer, UPR2169 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif Cedex, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-4040	DOI Listing

May 2004

Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes.

Authors:

Stéphane Arbault Neso Sojic Delphine Bruce Christian Amatore Alain Sarasin Monique Vuillaume

Carcinogenesis 2004 Apr 19;25(4):509-15. Epub 2003 Dec 19.

Département de Chimie, UMR CNRS 8640 'PASTEUR', Ecole Normale Supérieure, 24 rue Lhomond, F-75231 Paris Cedex 05, France.

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http://dx.doi.org/10.1093/carcin/bgh046	DOI Listing

April 2004

Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process.

Authors:

Florence Brellier Claire Marionnet Odile Chevallier-Lagente Rune Toftgard Alain Mauviel Alain Sarasin Thierry Magnaldo

Cancer Res 2004 Apr;64(8):2699-704

Laboratory of Genetic Instability and Cancer, Centre National de la Recherche Scientifique UPR2169, Institut Gustave Roussy, Villejuif Cedex, France.

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http://cancerres.aacrjournals.org/content/64/8/2699.full.pdf	Web Search

April 2004

Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts.

Authors:

Lydia Riou Eric Eveno Anneke van Hoffen Albert A van Zeeland Alain Sarasin Leon H F Mullenders

Cancer Res 2004 Feb;64(3):889-94

Laboratory of Instability Genetic and Cancer, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France.

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February 2004

Trichothiodystrophy fibroblasts are deficient in the repair of ultraviolet-induced cyclobutane pyrimidine dimers and (6-4)photoproducts.

Authors:

Yoko Nishiwaki Nobuhiko Kobayashi Kyoko Imoto Taka-aki Iwamoto Aya Yamamoto Sachiko Katsumi Toshihiko Shirai Shigeki Sugiura Yu Nakamura Alain Sarasin Sachiko Miyagawa Toshio Mori

J Invest Dermatol 2004 Feb;122(2):526-32

Radioisotope Research Center and Department of Dermatology, Nara Medical University, Kashihara, Nara, Japan.

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http://dx.doi.org/10.1046/j.0022-202X.2004.22226.x	DOI Listing

February 2004

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

Authors:

Ahmad Faili Said Aoufouchi Sandra Weller Françoise Vuillier Anne Stary Alain Sarasin Claude-Agnès Reynaud Jean-Claude Weill

J Exp Med 2004 Jan;199(2):265-70

INSERM U373, Faculté de Médecine Necker-Enfants Malades, Université Paris V, France.

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http://www.jem.org/lookup/doi/10.1084/jem.20031831	Publisher Site
http://dx.doi.org/10.1084/jem.20031831	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211761	PMC

January 2004

DNA damage and mutations induced by arachidonic acid peroxidation.

Authors:

Punnajit Lim Kianoush Sadre-Bazzaz Jesse Shurter Alain Sarasin John Termini

Biochemistry 2003 Dec;42(51):15036-44

Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA.

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http://dx.doi.org/10.1021/bi035555w	DOI Listing

December 2003

An overview of the mechanisms of mutagenesis and carcinogenesis.

Authors:

Alain Sarasin

Mutat Res 2003 Nov;544(2-3):99-106

Laboratory of Genetic Instability and Cancer, Gustave Roussy Institute, UPR2169-CNRS, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.mrrev.2003.06.024	DOI Listing

November 2003

Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells.

Authors:

Helotonio Carvalho Renata Maria Augusto da Costa Vanessa Chiganças Ricardo Weinlich Gabriela Brumatti Gustavo P Amarante-Mendes Alain Sarasin Carlos Frederico Martins Menck

Mutat Res 2003 Nov;544(2-3):159-66

Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1374, Ed. Biomédicas, 2, 05508-900 Sao Paulo, SP, Brazil.

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