Alain Sarasin

Alain Sarasin

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Alain Sarasin

Publications by authors named "Alain Sarasin"

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Psychological correlates of adherence to photoprotection in a rare disease: International survey of people with Xeroderma Pigmentosum.

Br J Health Psychol 2019 09 10;24(3):668-686. Epub 2019 Jun 10.

School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, UK.

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http://dx.doi.org/10.1111/bjhp.12375DOI Listing
September 2019

XPD/ERCC2 mutations interfere in cellular responses to oxidative stress.

Mutagenesis 2019 Jul 26. Epub 2019 Jul 26.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1093/mutage/gez020DOI Listing
July 2019

The key role of UVA-light induced oxidative stress in human Xeroderma Pigmentosum Variant cells.

Free Radic Biol Med 2019 02 13;131:432-442. Epub 2018 Dec 13.

Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.012DOI Listing
February 2019

Diagnosis of Xeroderma pigmentosum variant in a young patient with two novel mutations in the POLH gene.

Am J Med Genet A 2017 Sep 8;173(9):2511-2516. Epub 2017 Jul 8.

Laboratory of Genetic Instability and Oncogenesis, UMR8200 CNRS, Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1002/ajmg.a.38340DOI Listing
September 2017

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.

Nucleic Acids Res 2016 07 19;44(12):5717-31. Epub 2016 Apr 19.

Institute of Biomedical Sciences, University of São Paulo, SP, 05508-000, Brazil

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http://dx.doi.org/10.1093/nar/gkw280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937316PMC
July 2016

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis.

Cell Rep 2015 Oct 17;13(4):840-853. Epub 2015 Oct 17.

Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France; Centre National de la Recherche Scientifique (CNRS) UMR3347, 91405 Orsay, France; INSERM U1021, 91405 Orsay, France; Equipe Labellisée - Ligue Nationale contre le Cancer, 91405 Orsay, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970542PMC
October 2015

Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma.

Eur J Hum Genet 2015 Jul 15;23(7):957-62. Epub 2014 Oct 15.

1] Equipe d'Accueil 4271, Génétique des Anomalies du Développement, Université de Bourgogne, Dijon, France [2] Centre de Génétique et Centre de Référence Anomalies du Développement et Syndromes Malformatifs de l'Interrégion Est, Centre Hospitalier Universitaire Dijon, Dijon, France.

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http://dx.doi.org/10.1038/ejhg.2014.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463501PMC
July 2015

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

Proc Natl Acad Sci U S A 2015 Jun 18;112(22):E2910-9. Epub 2015 May 18.

Institut Pasteur, Department of Genomes and Genetics, Unité de Génétique Moléculaire des Levures, 75724 Paris, France; CNRS UMR 3525, Team Stability of Nuclear and Mitochondrial DNA,

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http://dx.doi.org/10.1073/pnas.1422264112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460464PMC
June 2015

DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease.

Mutat Res 2015 Jun 6;776:2-8. Epub 2014 Sep 6.

Laboratory of Genetic Instability and Oncogenesis UMR8200CNRS, Institut Gustave Roussy and University Paris-Sud, Villejuif, France; Service de Génétique, Institut Gustave Roussy, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00275107140014
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http://dx.doi.org/10.1016/j.mrfmmm.2014.08.007DOI Listing
June 2015

Aberrant C-terminal domain of polymerase η targets the functional enzyme to the proteosomal degradation pathway.

DNA Repair (Amst) 2015 May 26;29:154-65. Epub 2015 Feb 26.

Université Paris-Sud, CNRS-UMR8200, Equipe labellisée Ligue Contre le Cancer, Gustave Roussy, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.02.017DOI Listing
May 2015

Genetic variants in DNA repair pathways and risk of upper aerodigestive tract cancers: combined analysis of data from two genome-wide association studies in European populations.

Carcinogenesis 2014 Jul 21;35(7):1523-7. Epub 2014 Mar 21.

Inserm, U946, Genetic Variation and Human, Diseases and Université Paris-Diderot, Sorbonne Paris-Cité, UMRS-946, Paris, F-75010, France, Gustave Roussy, Villejuif, F-94805, France

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgu075DOI Listing
July 2014

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

DNA Repair (Amst) 2014 Feb 28;14:27-38. Epub 2013 Dec 28.

CNRS-UMR8200, Université Paris Sud, Institut de Cancérologie Gustave Roussy, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2013.12.005DOI Listing
February 2014

Novel XPG (ERCC5) mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress.

Hum Mutat 2013 Mar 17;34(3):481-9. Epub 2013 Jan 17.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1002/humu.22259DOI Listing
March 2013

UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells.

Authors:
Alain Sarasin

Genome Med 2012 May 23;4(5):44. Epub 2012 May 23.

Laboratory of Genetic Stability and Oncogenesis, UMR8200 CNRS, Institut Gustave Roussy and University Paris-Sud, 114, rue Edouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.1186/gm343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506910PMC
May 2012

Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions.

Cancer Lett 2012 Jan 24;314(1):108-18. Epub 2011 Sep 24.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.canlet.2011.09.019DOI Listing
January 2012

Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells.

Mol Cancer Ther 2011 Aug 27;10(8):1481-9. Epub 2011 May 27.

Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine, Institut National de la Santé et de la Recherche Médicale U938, Paris, France.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0252DOI Listing
August 2011

A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa.

J Invest Dermatol 2010 Jun 7;130(6):1537-42. Epub 2010 Jan 7.

Laboratoire de Biochimie hormonale et génétique, Hôpital Bichat, APHP, Université Paris VII, 46 Rue Henri Huchard, Paris, France.

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http://dx.doi.org/10.1038/jid.2009.409DOI Listing
June 2010

2nd German-French DNA repair meeting - DNA damage and repair in ageing and degenerative diseases, Konstanz, Germany, September 20-23, 2009.

Mech Ageing Dev 2010 May 17;131(5):370-6. Epub 2010 Mar 17.

Department of Biology, Box X911, University of Konstanz, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.mad.2010.03.003DOI Listing
May 2010

New clinico-genetic classification of trichothiodystrophy.

Am J Med Genet A 2009 Sep;149A(9):2020-30

Department of Pediatric Dermatology, National Reference Center for Rare Skin Disorders, Pellegrin University Hospitals, Bordeaux, France.

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http://dx.doi.org/10.1002/ajmg.a.32902DOI Listing
September 2009

Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cells.

PLoS Genet 2009 Jul 24;5(7):e1000577. Epub 2009 Jul 24.

Laboratoire Génomes et Cancer, CNRS FRE-2939, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1371/journal.pgen.1000577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708909PMC
July 2009

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

Carcinogenesis 2009 May 23;30(5):763-8. Epub 2009 Feb 23.

Department of Biostatistics and Epidemiology, Institut Gustave Roussy, Villejuif 94805, France.

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http://dx.doi.org/10.1093/carcin/bgp046DOI Listing
May 2009

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.

J Immunol 2009 May;182(10):6353-9

Faculté de Médecine, Institut National de la Santé et de la Recherche Médicale Unite 783 Développement du Système immunitaire, Université Paris Descartes, Site Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.0900177DOI Listing
May 2009

Progress and prospects of xeroderma pigmentosum therapy.

Authors:
Alain Sarasin

Adv Exp Med Biol 2008 ;637:144-51

Laboratory of Genomes and Cancers, Institute Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1007/978-0-387-09599-8_16DOI Listing
February 2009

Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.

DNA Repair (Amst) 2008 Dec 10;7(12):1990-8. Epub 2008 Oct 10.

Radioisotope Research Center, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan.

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http://dx.doi.org/10.1016/j.dnarep.2008.08.009DOI Listing
December 2008

Human DNA polymerase iota protects cells against oxidative stress.

EMBO J 2008 Nov 16;27(21):2883-95. Epub 2008 Oct 16.

Centre National de la Recherche Scientifique FRE2939, Unit of genetic stability and oncogenesis, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1038/emboj.2008.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580789PMC
November 2008

Overexpression of DNA repair genes is associated with metastasis: a new hypothesis.

Mutat Res 2008 Jul-Aug;659(1-2):49-55. Epub 2008 Jan 16.

Genomes and Cancers, FRE2939-CNRS, Institute Gustave Roussy, PR2, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://linkinghub.elsevier.com/retrieve/pii/S138357420800003
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http://dx.doi.org/10.1016/j.mrrev.2007.12.002DOI Listing
September 2008

Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.

DNA Repair (Amst) 2008 Sep 21;7(9):1551-62. Epub 2008 Jul 21.

Institut National de la Santé et de la Recherche Médicale U783 (Développement du Système Immunitaire), Université Paris Descartes, Faculté de Médecine René Descartes, Site Necker-Enfants Malades, Paris Cedex 15, France.

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https://hal-descartes.archives-ouvertes.fr/docs/00/32/06/55/
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http://linkinghub.elsevier.com/retrieve/pii/S156878640800215
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http://dx.doi.org/10.1016/j.dnarep.2008.05.012DOI Listing
September 2008

Identification of new RECQL4 mutations in Caucasian Rothmund-Thomson patients and analysis of sensitivity to a wide range of genotoxic agents.

Mutat Res 2008 Aug 21;643(1-2):41-7. Epub 2008 Jun 21.

Laboratoire Génomes et Cancers, FRE2939 CNRS, Institut Gustave-Roussy, Université Paris-Sud, PRII, 39 Rue Camille Desmoulins, 94805 Villejuif, France.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070800120
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http://dx.doi.org/10.1016/j.mrfmmm.2008.06.002DOI Listing
August 2008

Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome.

Cancer Res 2008 Aug;68(15):6074-83

Laboratory of Genetic Stability and Oncogenesis, Centre National de la Recherche Scientifique, Formation de Recherche en Evolution 2939, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6695DOI Listing
August 2008

Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage.

Mutat Res 2008 Apr 17;640(1-2):1-7. Epub 2007 Dec 17.

Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, Av. Prof. Lineu Prestes 1374, 05508-900 São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.11.010DOI Listing
April 2008

CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells.

DNA Repair (Amst) 2008 Feb 21;7(2):303-12. Epub 2007 Dec 21.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Avenue Prof Lineu Prestes, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.dnarep.2007.11.003DOI Listing
February 2008

Safe selection of genetically manipulated human primary keratinocytes with very high growth potential using CD24.

Mol Ther 2007 Dec 21;15(12):2186-93. Epub 2007 Aug 21.

Centre National de la Recherche Scientifique, Genomes and Cancers Unit, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1038/sj.mt.6300292DOI Listing
December 2007

Expression profiling of melanoma cell lines: in search of a progression-related molecular signature.

Future Oncol 2007 Dec;3(6):609-11

Katholieke Universiteit Leuven, Department of Pathology, Morphology & Molecular Pathology Laboratory, University Hospitals Minderbroedersstraat 12, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.2217/14796694.3.6.609DOI Listing
December 2007

Transcription through 8-oxoguanine in DNA repair-proficient and Csb(-)/Ogg1(-) DNA repair-deficient mouse embryonic fibroblasts is dependent upon promoter strength and sequence context.

Mutagenesis 2007 Sep 14;22(5):343-51. Epub 2007 Jul 14.

Laboratory of Genetic Instability and Cancer, FRE 2939 CNRS, Institut Gustave Roussy, 94805 Villejuif, France.

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http://dx.doi.org/10.1093/mutage/gem024DOI Listing
September 2007

Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.

Carcinogenesis 2007 Aug 10;28(8):1731-9. Epub 2007 May 10.

Department of Biostatistics and Epidemiology, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif cedex, France.

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http://dx.doi.org/10.1093/carcin/bgm111DOI Listing
August 2007

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

Proc Natl Acad Sci U S A 2007 Aug 26;104(32):13062-7. Epub 2007 Jul 26.

Group of Cancer Biology and Therapeutics, Institut National de la Santé et de la Recherche Médicale, Unité 673, and Université Pierre et Marie Curie, Hôpital Saint-Antoine, 75571 Paris Cedex 12, France.

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http://dx.doi.org/10.1073/pnas.0609877104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941813PMC
August 2007

Prevalence of human papillomavirus in skin tumors from repair deficient xeroderma pigmentosum patients.

Cancer Lett 2007 Jun 28;250(2):213-9. Epub 2006 Nov 28.

Laboratoire Génomes et Cancers, FRE 2939 CNRS Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.canlet.2006.10.008DOI Listing
June 2007

Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling.

Mutat Res 2007 Jun 8;619(1-2):16-29. Epub 2007 Feb 8.

sanofi aventis R&D, Drug Safety Evaluation, 13 quai Jules Guesde, 94403 Vitry-Sur-Seine Cedex, France.

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http://dx.doi.org/10.1016/j.mrfmmm.2006.12.007DOI Listing
June 2007

BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.

Cell Signal 2007 Apr 4;19(4):731-9. Epub 2006 Oct 4.

Laboratory of Genomes and Cancers, FRE 2939 CNRS, Institut Gustave Roussy-PR2, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.cellsig.2006.09.006DOI Listing
April 2007

Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene.

Carcinogenesis 2007 Mar 25;28(3):724-31. Epub 2006 Oct 25.

Laboratoire Génomes et Cancers, FRE2939 CNRS, Institut Gustave-Roussy, PRII, 39 Rue Camille Desmoulins 94805 Villejuif, France.

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http://dx.doi.org/10.1093/carcin/bgl191DOI Listing
March 2007

New insights for understanding the transcription-coupled repair pathway.

DNA Repair (Amst) 2007 Feb 27;6(2):265-9. Epub 2006 Dec 27.

Genomes and Cancers, Institut Gustave Roussy, CNRS FRE 2939, 39, rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.dnarep.2006.12.001DOI Listing
February 2007

Adenovirus mediated transduction of the human DNA polymerase eta cDNA.

DNA Repair (Amst) 2006 Aug 23;5(8):925-34. Epub 2006 Jun 23.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1374 São Paulo, SP 05508-900, Brazil.

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http://dx.doi.org/10.1016/j.dnarep.2006.05.037DOI Listing
August 2006

DNA repair: from molecular mechanism to human disease.

DNA Repair (Amst) 2006 Aug;5(8):986-96

Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA.

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August 2006

Complementation assays adapted for DNA repair-deficient keratinocytes.

Methods Mol Biol 2006 ;314:9-23

Laboratory of Genetic Instability and Cancer, Institute Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1385/1-59259-973-7:009DOI Listing
June 2006

The DNA repair genes XPB and XPD defend cells from retroviral infection.

Proc Natl Acad Sci U S A 2006 Mar 13;103(12):4622-7. Epub 2006 Mar 13.

Department of Molecular Virology, and Ohio State University Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0509828103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450221PMC
March 2006

Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.

Cell 2005 Nov;123(4):711

Laboratory of Molecular Genetics, UPR42 Centre National de la Recherche Scientifique, 94801 Villejuif, France.

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http://dx.doi.org/10.1016/j.cell.2005.11.005DOI Listing
November 2005

Hypothetical role of RNA damage avoidance in preventing human disease.

Mutat Res 2005 Sep;577(1-2):293-302

Institut Gustave Roussy PR2, CNRS UPR-2169, 39 rue Camille Desmoulins 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.04.002DOI Listing
September 2005

Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing.

Mol Cancer Res 2005 Sep;3(9):519-29

Laboratoire de Génétique de la Radiosensibilité, Commissariat à l'Energie Atomique, Département de Radiobiologie et de Radiopathologie, Direction des Sciences du Vivant, BP 6, 92265 Fontenay aux Roses, France.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0044DOI Listing
September 2005

Reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro: a model to study hypersensitivity to UV light.

Photochem Photobiol 2005 Jan-Feb;81(1):19-24

L'Oréal, Life Sciences Research, Centre C. Zviak, 90 Rue du général Roguet, 92583 Clichy cedex, France.

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http://dx.doi.org/10.1562/2004-07-29-IR-250DOI Listing
June 2005

Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus.

Cancer Gene Ther 2005 Apr;12(4):389-96

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900 SP, Brazil.

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http://dx.doi.org/10.1038/sj.cgt.7700797DOI Listing
April 2005

The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors.

Mutat Res 2005 Apr 25;571(1-2):43-56. Epub 2005 Jan 25.

Laboratory of Genetic Instability and Cancer, UPR2169 CNRS, IFR 54, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.mrfmmm.2004.11.013DOI Listing
April 2005

Xeroderma pigmentosum: from symptoms and genetics to gene-based skin therapy.

Cells Tissues Organs 2004 ;177(3):189-98

Laboratory of Genetic Instability and Cancer, CNRS UPR2169, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1159/000079993DOI Listing
March 2005

Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele.

Oncogene 2005 Feb;24(8):1359-74

Laboratory of Genetic Instability and Cancer UPR2169 CNRS, Gustave Roussy Institute, 94805, Villejuif Cedex, France.

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http://dx.doi.org/10.1038/sj.onc.1208288DOI Listing
February 2005

Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines.

Nucleic Acids Res 2005 7;33(1):106-13. Epub 2005 Jan 7.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 2169, Genetic Instability and Cancer, Institut Gustave Roussy 39 rue Camille Desmoulins, 94 800 Villejuif, France.

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http://dx.doi.org/10.1093/nar/gki154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546142PMC
February 2005

ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.

Am J Epidemiol 2005 Jan;161(1):1-14

Institut National de la Santé et de la Recherche Médicale-Evry University, 91034 Evry, France.

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http://dx.doi.org/10.1093/aje/kwi018DOI Listing
January 2005

DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract.

Int J Cancer 2004 Dec;112(5):901-4

INSERM and Evry University, EMI 00-06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France.

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http://dx.doi.org/10.1002/ijc.20474DOI Listing
December 2004

Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells.

Clin Cancer Res 2004 Aug;10(16):5604-13

Group of Biology and Pharmacogenetics of Human Tumors, Centre National de la Recherche Scientifique, UMR 8113, Institut Gustave-Roussy, Villejuif, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0442DOI Listing
August 2004

CPD-photolyase adenovirus-mediated gene transfer in normal and DNA-repair-deficient human cells.

J Cell Sci 2004 Jul;117(Pt 16):3579-92

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1374. Ed. Biomédicas 2, São Paulo 05508-900, Brazil.

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http://dx.doi.org/10.1242/jcs.01241DOI Listing
July 2004

Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.

Oncogene 2004 Jun;23(29):5004-13

UPR2169 CNRS, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif cedex, France.

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http://dx.doi.org/10.1038/sj.onc.1207677DOI Listing
June 2004

Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients.

Cancer Res 2004 May;64(10):3559-65

Laboratoire Instabilité Génétique et Cancer, UPR2169 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif Cedex, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-4040DOI Listing
May 2004

Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes.

Carcinogenesis 2004 Apr 19;25(4):509-15. Epub 2003 Dec 19.

Département de Chimie, UMR CNRS 8640 'PASTEUR', Ecole Normale Supérieure, 24 rue Lhomond, F-75231 Paris Cedex 05, France.

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http://dx.doi.org/10.1093/carcin/bgh046DOI Listing
April 2004

Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process.

Cancer Res 2004 Apr;64(8):2699-704

Laboratory of Genetic Instability and Cancer, Centre National de la Recherche Scientifique UPR2169, Institut Gustave Roussy, Villejuif Cedex, France.

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April 2004

Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts.

Cancer Res 2004 Feb;64(3):889-94

Laboratory of Instability Genetic and Cancer, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France.

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February 2004

DNA damage and mutations induced by arachidonic acid peroxidation.

Biochemistry 2003 Dec;42(51):15036-44

Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA.

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http://dx.doi.org/10.1021/bi035555wDOI Listing
December 2003

An overview of the mechanisms of mutagenesis and carcinogenesis.

Authors:
Alain Sarasin

Mutat Res 2003 Nov;544(2-3):99-106

Laboratory of Genetic Instability and Cancer, Gustave Roussy Institute, UPR2169-CNRS, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.mrrev.2003.06.024DOI Listing
November 2003

Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells.

Mutat Res 2003 Nov;544(2-3):159-66

Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1374, Ed. Biomédicas, 2, 05508-900 Sao Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.mrrev.2003.06.004DOI Listing
November 2003

DNA repair pathways and associated human diseases.

Biochimie 2003 Nov;85(11):1041

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http://dx.doi.org/10.1016/j.biochi.2003.11.006DOI Listing
November 2003

Transcription-coupled repair of 8-oxoguanine in human cells and its deficiency in some DNA repair diseases.

Biochimie 2003 Nov;85(11):1073-82

Laboratory of Genetic Instability and Cancer, UPR 2169 CNRS, Institut Gustave Roussy, PR2, 39, rue Camille-Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.biochi.2003.11.005DOI Listing
November 2003

Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis.

J Invest Dermatol 2003 Sep;121(3):596-606

Genotoxicity Group, L'Oreal Research, 1 avenue Eugene Schueller, 93600 Aulnay-sous-bois, France.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12422.xDOI Listing
September 2003

Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells.

J Mol Biol 2003 Sep;332(2):337-51

Department of Biology, Beckman Research Institute, City of Hope National Medical Center, 1450 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/s0022-2836(03)00793-9DOI Listing
September 2003

UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair.

Cell 2003 Sep;114(5):599-610

Institut de Biologie Structurale J.-P. Ebel, 41 rue Jules Horowitz, F38027 Grenoble, France.

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http://dx.doi.org/10.1016/j.cell.2003.08.001DOI Listing
September 2003

UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis.

Photochem Photobiol Sci 2003 Aug;2(8):825-34

Laboratory of Genetic Instability and Cancer, UPR2169, CNRS, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif, France.

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August 2003

Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes.

Hum Gene Ther 2003 Jul;14(10):983-96

Laboratory of Genetic Instability and Cancer, CNRS UPR2169, Institut Gustave Roussy, 94805 Villejuif Cedex 05, France.

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http://dx.doi.org/10.1089/104303403766682241DOI Listing
July 2003