Publications by authors named "Alain Hovnanian"

99Publications

Glucosylated cholesterol in skin: Synthetic role of extracellular glucocerebrosidase.

Clin Chim Acta 2020 Nov 16;510:707-710. Epub 2020 Sep 16.

Medical Biochemistry Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2020.09.017DOI Listing
November 2020

Duality of Netherton syndrome manifestations and response to ixekizumab.

J Am Acad Dermatol 2020 Jul 18. Epub 2020 Jul 18.

INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, 75015 Paris, France; University of Paris, 75006 Paris, France; Department of Genetics, Necker Hospital for sick children (AP-HP), 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.07.054DOI Listing
July 2020

The Surface Microbiome of Clinically Unaffected Skinfolds in Hidradenitis Suppurativa: A Cross-Sectional Culture-Based and 16S rRNA Gene Amplicon Sequencing Study in 60 Patients.

J Invest Dermatol 2020 Sep 25;140(9):1847-1855.e6. Epub 2020 Apr 25.

Normandie Univ, UNICAEN, UNIROUEN, CHU de Caen Normandie, Department of Microbiology, Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0, EA 2656), Caen, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.02.046DOI Listing
September 2020

SPCA1 governs the stability of TMEM165 in Hailey-Hailey disease.

Biochimie 2020 Jul 23;174:159-170. Epub 2020 Apr 23.

Univ. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2020.04.017DOI Listing
July 2020

Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature.

J Invest Dermatol 2020 Jun 10;140(6):1184-1194. Epub 2020 Mar 10.

INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France; University of Paris, Paris, France; Department of Genetics, Necker Hospital for Sick Children (AP-HP), Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.10.026DOI Listing
June 2020

Low Prevalence of GSC Gene Mutations in a Large Cohort of Predominantly Caucasian Patients with Hidradenitis Suppurativa.

J Invest Dermatol 2020 Oct 3;140(10):2085-2088.e14. Epub 2020 Mar 3.

Laboratory of Genetic Skin Diseases, INSERM UMR1163 Imagine Institute, Paris, France; Paris University, Paris, France; European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany; Department of Genetics, Necker-Enfants Malades Hospital, AP-HP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.10.025DOI Listing
October 2020

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome.

Cell Rep 2020 03;30(9):2923-2933.e7

Department of Dermatology, University of California, San Diego, San Diego, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183042PMC
March 2020

Efficacy of Dupilumab for Controlling Severe Atopic Dermatitis in a Patient with Hyper-IgE Syndrome.

J Clin Immunol 2020 02 28;40(2):418-420. Epub 2020 Jan 28.

Université de Paris, Imagine Institute, 75015, Paris, France.

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http://dx.doi.org/10.1007/s10875-020-00751-4DOI Listing
February 2020

A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia.

J Invest Dermatol 2020 May 1;140(5):1103-1106.e4. Epub 2019 Nov 1.

Laboratory of Genetic Skin Diseases, INSERM Imagine Institute, Paris, France; Paris Descartes University, Paris, France; Department of Genetics, Necker-Enfants Malades Hospital, Assistance Publique des Hôpitaux de Paris, (AP-HP), Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.06.154DOI Listing
May 2020

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.

Bioorg Med Chem Lett 2019 10 7;29(20):126675. Epub 2019 Sep 7.

INSERM UMR1163 Laboratory of Genetic Skin Diseases, Imagine Institute and Université Paris Descarte-Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.bmcl.2019.126675DOI Listing
October 2019

Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.

Acta Crystallogr F Struct Biol Commun 2019 May 26;75(Pt 5):385-391. Epub 2019 Apr 26.

INSERM UMR1163 Laboratory of Genetic Skin Diseases, Imagine Institute and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1107/S2053230X19003169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497096PMC
May 2019

Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.

Bioorg Med Chem Lett 2019 06 12;29(12):1454-1458. Epub 2019 Apr 12.

INSERM UMR1163 Laboratory of Genetic Skin Diseases, Imagine Institute and Université Paris Descarte - Sorbonne Paris Cité, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193024
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http://dx.doi.org/10.1016/j.bmcl.2019.04.022DOI Listing
June 2019

Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.

Bioorg Med Chem Lett 2019 03 22;29(6):821-825. Epub 2019 Jan 22.

INSERM UMR1163 Laboratory of Genetic Skin Diseases, Imagine Institute and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193003
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http://dx.doi.org/10.1016/j.bmcl.2019.01.020DOI Listing
March 2019

Mutations in PERP Cause Dominant and Recessive Keratoderma.

J Invest Dermatol 2019 02 12;139(2):380-390. Epub 2018 Oct 12.

Laboratory of Genetic Skin Diseases, INSERM Imagine Institute, Paris, France; University Paris Descartes, Paris, France; Department of Genetics, Necker-Enfants Malades Hospital, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183266
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http://dx.doi.org/10.1016/j.jid.2018.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586468PMC
February 2019

Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair.

Mol Ther Nucleic Acids 2018 Sep 26;12:554-567. Epub 2018 Jun 26.

Laboratory of Genetic Skin Diseases, INSERM UMR 1163, Imagine Institute, 24 bd du Montparnasse, Paris, France; University Paris Descartes-Sorbonne Cité, Paris, France; Department of Genetics, Necker Hospital for Sick Children, APHP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2018.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077132PMC
September 2018

Antisense-Mediated Splice Modulation to Reframe Transcripts.

Methods Mol Biol 2018 ;1828:531-552

INSERM UMR 1163, Paris, France.

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http://dx.doi.org/10.1007/978-1-4939-8651-4_35DOI Listing
April 2019

Intradermal Injection of Bone Marrow Mesenchymal Stromal Cells Corrects Recessive Dystrophic Epidermolysis Bullosa in a Xenograft Model.

J Invest Dermatol 2018 11 12;138(11):2483-2486. Epub 2018 Jul 12.

Laboratory of Genetic Skin Diseases, INSERM UMR 1163 and Imagine Institute of Genetic Diseases, Paris, France; Paris Descartes University-Sorbonne Paris Cite, Paris, France; Department of Genetics, Necker Hospital for Sick Children, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183196
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http://dx.doi.org/10.1016/j.jid.2018.04.028DOI Listing
November 2018

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

Cell Host Microbe 2017 Oct;22(4):460-470.e5

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952603PMC
October 2017

The Molecular Revolution in Cutaneous Biology: Emerging Landscape in Genomic Dermatology: New Mechanistic Ideas, Gene Editing, and Therapeutic Breakthroughs.

J Invest Dermatol 2017 05;137(5):e123-e129

INSERM UMR 1163, Paris, France; Imagine Institute, Paris, France; University Paris Descartes Sorbonne Cité, Paris, France; Department of Genetics, Necker Hospital for Sick Children, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.08.038DOI Listing
May 2017

Epidermolytic Ichthyosis Sine Epidermolysis.

Am J Dermatopathol 2017 Jun;39(6):440-444

*Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; †Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; ‡Department of Dermatology, Kirov State Medical Academy, Kirov, Russia; §Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; ¶Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; ‖INSERM UMR 1163, Imagine Institute, University Paris Descartes Sorbonne Cité, Paris, France; **Department of Genetics, Necker hospital for sick children, APHP, Paris, France; ††Department of Dermatology and Allergology, Ludwig-Maximilian-University, Munich, Germany; and Departments of ‡‡Pathology, §§Dermatology, and ¶¶Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1097/DAD.0000000000000674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489912PMC
June 2017

Mechanistic insight from murine models of Netherton syndrome.

Biol Chem 2016 12;397(12):1223-1228

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http://dx.doi.org/10.1515/hsz-2016-0203DOI Listing
December 2016

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.

J Invest Dermatol 2017 02 30;137(2):430-439. Epub 2016 Sep 30.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.09.017DOI Listing
February 2017

Targeted Exon Skipping Restores Type VII Collagen Expression and Anchoring Fibril Formation in an In Vivo RDEB Model.

J Invest Dermatol 2016 12 3;136(12):2387-2395. Epub 2016 Aug 3.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1163, Paris, France; Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Cité, Paris, France; Department of Genetics, Necker Hospital for Sick Children, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.07.029DOI Listing
December 2016

Gene-Corrected Fibroblast Therapy for Recessive Dystrophic Epidermolysis Bullosa using a Self-Inactivating COL7A1 Retroviral Vector.

J Invest Dermatol 2016 07 16;136(7):1346-1354. Epub 2016 Mar 16.

Laboratory of Genetic Skin Diseases, Inserm UMR1163 and Imagine Institute of Genetic Diseases, Paris, France; University Paris Descartes-Sorbonne Paris Cite, Paris, France; Department of Genetics, Necker Hospital, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.02.811DOI Listing
July 2016

Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epidermolysis bullosa acquisita (EBA).

J Am Acad Dermatol 2016 Jun 3;74(6):1166-72. Epub 2016 Mar 3.

Department of Dermatology, APHP, Avicenne Hospital, Bobigny, France; Department of Histology, Unité de Formation et de Recherche (UFR) Léonard de Vinci, University Paris 13, Bobigny, France; Department of Pathology, APHP, Avicenne Hospital, Bobigny, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2016.01.005DOI Listing
June 2016

Meganuclease-Mediated COL7A1 Gene Correction for Recessive Dystrophic Epidermolysis Bullosa.

J Invest Dermatol 2016 Apr 17;136(4):872-875. Epub 2016 Feb 17.

INSERM UMR, Imagine Institute, Paris, France; University Paris Descartes Sorbonne Cité, Paris, France; Department of Genetics, Necker Hospital for Sick Children, APHP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2015.11.028DOI Listing
April 2016

Skin Biopsy in Netherton Syndrome: A Histological Review of a Large Series and New Findings.

Am J Dermatopathol 2016 Feb;38(2):83-91

*Dermatopathologist and Dermatologist, Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris, France; Reference Center for Rare Cutaneous Diseases MAGEC, Hôpital Necker-Enfants Malades, APHP, Paris, France; Department of Dermatology, Hôpital Necker-Enfants Malades, APHP, Paris, France; †Head of the Department of Dermatology, Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris, France; Reference Center for Rare Cutaneous Diseases MAGEC, Hôpital Necker-Enfants Malades, APHP, Paris, France; University Paris Descartes-Sorbonne Paris Cité, Paris, France; ‡Researcher, University Paris Descartes-Sorbonne Paris Cité, Paris, France; INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France; §Senior Consultant in Dermatology, Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris, France; Reference Center for Rare Cutaneous Diseases MAGEC, Hôpital Necker-Enfants Malades, APHP, Paris, France; University Paris Descartes-Sorbonne Paris Cité, Paris, France; ¶Dermatologist, Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris, France; Reference Center for Rare Cutaneous Diseases MAGEC, Hôpital Necker-Enfants Malades, APHP, Paris, France; ‖Head of the Department of Pediatric Dermatology, University Children's Hospital Zürich and University Hospital Zürich, Zürich, Switzerland; **Senior Dermatologist, Department of Dermatology, Hôpital Fournier, Nancy, France; ††Medical Doctor, Department of Dermatology, MAGEC, Hôpital Saint Louis, APHP, Paris, France; ‡‡Assistant Professor, Department of Pathology, Hôpital Henri Mondor, APHP, Paris, France; §§Head of the Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris, France; University Paris Descartes-Sorbonne Paris Cité, Paris, France; ¶¶Professor of Genetics, University Paris Descartes-Sorbonne Paris Cité, Paris, France; Director of Genetic Skin Disease Laboratory, INSERM UMR 1163, Laboratory o

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http://dx.doi.org/10.1097/DAD.0000000000000425DOI Listing
February 2016

Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patients.

J Antimicrob Chemother 2016 Feb 12;71(2):513-20. Epub 2015 Nov 12.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France Centre d'Infectiologie Necker-Pasteur, Paris, France Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France Institut Pasteur, Centre Médical, Paris, France.

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http://jac.oxfordjournals.org/content/early/2015/11/12/jac.d
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http://www.jac.oxfordjournals.org/lookup/doi/10.1093/jac/dkv
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http://dx.doi.org/10.1093/jac/dkv361DOI Listing
February 2016

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.

PLoS Genet 2015 Sep 21;11(9):e1005389. Epub 2015 Sep 21.

INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France; University Paris Descartes - Sorbonne Paris Cité, Paris, France; Department of Genetics, Necker Hospital, Paris, France.

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http://dx.doi.org/10.1371/journal.pgen.1005389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577096PMC
September 2015

Erythrokeratodermia variabilis et progressiva allelic to oculo-dento-digital dysplasia.

J Invest Dermatol 2015 Jun;135(6):1475-1478

INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute for Genetic Diseases, Paris, France; University Paris Descartes, Sorbonne Paris Cité, Paris, France; Department of Genetics, Necker Enfants Malades Hospital, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153726
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http://dx.doi.org/10.1038/jid.2014.535DOI Listing
June 2015

Olmsted syndrome: clinical, molecular and therapeutic aspects.

Orphanet J Rare Dis 2015 Mar 17;10:33. Epub 2015 Mar 17.

INSERM UMR 1163, Laboratory of Genetic skin diseases, Imagine Institute, 2nd floor, 24 bld du Montparnasse, 75015, Paris, France.

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http://dx.doi.org/10.1186/s13023-015-0246-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373112PMC
March 2015

Olmsted syndrome: clinical, molecular and therapeutic aspects.

Orphanet J Rare Dis 2015 Mar 17;10:33. Epub 2015 Mar 17.

INSERM UMR 1163, Laboratory of Genetic skin diseases, Imagine Institute, 2nd floor, 24 bld du Montparnasse, 75015, Paris, France.

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http://dx.doi.org/10.1186/s13023-015-0246-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373112PMC
March 2015

Bathing suit ichthyosis caused by a TGM1 mutation in a Tunisian child.

Int J Dermatol 2014 Dec 10;53(12):1478-80. Epub 2014 Sep 10.

Department of Dermatology, Habib Thameur Teaching Hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

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http://dx.doi.org/10.1111/ijd.12569DOI Listing
December 2014

IgE allergen component-based profiling and atopic manifestations in patients with Netherton syndrome.

J Allergy Clin Immunol 2014 Oct 23;134(4):985-8. Epub 2014 Aug 23.

Department of Dermatology and Allergology, University of Helsinki and Skin and Allergy Hospital, Helsinki University Central Hospital (HUCH), Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jaci.2014.07.008DOI Listing
October 2014

Proteases and proteomics: cutting to the core of human skin pathologies.

Proteomics Clin Appl 2014 Jun 13;8(5-6):389-402. Epub 2014 Apr 13.

Université Paris Descartes - Sorbonne Paris Cité, Paris, France; INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

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http://dx.doi.org/10.1002/prca.201300081DOI Listing
June 2014

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.

J Exp Med 2014 Mar 17;211(3):499-513. Epub 2014 Feb 17.

Université Paris Descartes-Sorbonne Paris Cité, 75006 Paris, France.

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http://dx.doi.org/10.1084/jem.20131797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949577PMC
March 2014

A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia.

JAMA Dermatol 2014 Mar;150(3):303-6

Institut National de la Santé et de la Recherche Médicale, U781, Paris, France2Université Paris Descartes-Sorbonne Paris Cité, Paris, France3Institut Imagine, Paris, France9Department of Genetics, Necker-Enfants Malades Hospital, Assistance Publique-Hôpit.

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http://dx.doi.org/10.1001/jamadermatol.2013.8709DOI Listing
March 2014

Genetics of atopic dermatitis: beyond filaggrin-the role of thymic stromal lymphopoietin in disease persistence.

JAMA Dermatol 2014 Mar;150(3):248-50

The Institut National de la Santé et de la Recherche Médicale (INSERM), U781, Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France2Department of Genetics, Necker-Enfants Malades Hospital, Paris, France.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2013.7994DOI Listing
March 2014

SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat.

J Invest Dermatol 2014 Jul 3;134(7):1961-1970. Epub 2014 Jan 3.

INSERM UMR 1163, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Paris, France; Institut Imagine, Paris, France; Department of Genetics, Necker Hospital, F-75015, France. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.8DOI Listing
July 2014

Proteases: common culprits in human skin disorders.

Trends Mol Med 2014 Mar 28;20(3):166-78. Epub 2013 Dec 28.

INSERM, U781, 75743 Cedex 15, Paris, France; Université Paris Descartes and Institute Imagine, 75743 Cedex 15, Paris, France; Department of Genetics, CHU Necker-Enfants Malades, 75743 Cedex 15, Paris, France. Electronic address:

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http://www.cell.com/trends/molecular-medicine/pdf/S1471-4914
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http://linkinghub.elsevier.com/retrieve/pii/S147149141300208
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http://dx.doi.org/10.1016/j.molmed.2013.11.005DOI Listing
March 2014

Intercellular skin barrier lipid composition and organization in Netherton syndrome patients.

J Invest Dermatol 2014 May 29;134(5):1238-1245. Epub 2013 Nov 29.

Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.517DOI Listing
May 2014

Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins.

Eur J Med Chem 2013 22;70:661-8. Epub 2013 Oct 22.

Enzymologie Moléculaire et Fonctionnelle, UR4, Université Pierre et Marie Curie - Sorbonne Universités (UPMC), case courrier 256, 7, quai St Bernard, 75252 Paris Cedex 05, France.

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http://dx.doi.org/10.1016/j.ejmech.2013.10.040DOI Listing
September 2014

1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases.

Bioorg Med Chem Lett 2013 Aug 24;23(16):4547-51. Epub 2013 Jun 24.

Enzymologie Moléculaire et Fonctionnelle, UR4, Université Pierre et Marie Curie-Sorbonne Universités (UPMC), Case Courrier 256, 7, Quai St Bernard, 75252 Paris Cedex 05, France.

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http://dx.doi.org/10.1016/j.bmcl.2013.06.039DOI Listing
August 2013

Systemic protein therapy for recessive dystrophic epidermolysis bullosa: how far are we from clinical translation?

Authors:
Alain Hovnanian

J Invest Dermatol 2013 Jul;133(7):1719-21

University Paris Descartes Sorbonne Paris Cité, Imagine Institute, Paris, France.

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http://dx.doi.org/10.1038/jid.2013.137DOI Listing
July 2013

Netherton syndrome: skin inflammation and allergy by loss of protease inhibition.

Authors:
Alain Hovnanian

Cell Tissue Res 2013 Feb 24;351(2):289-300. Epub 2013 Jan 24.

Laboratory of Genetic Skin Diseases, INSERM U781, Paris, France.

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http://dx.doi.org/10.1007/s00441-013-1558-1DOI Listing
February 2013

Antisense-mediated exon skipping to reframe transcripts.

Methods Mol Biol 2012 ;867:221-38

INSERM, U781, Paris, France.

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http://dx.doi.org/10.1007/978-1-61779-767-5_15DOI Listing
July 2012

Darier disease : a disease model of impaired calcium homeostasis in the skin.

Biochim Biophys Acta 2011 May 15;1813(5):1111-7. Epub 2010 Dec 15.

INSERM, U563, Toulouse, F-31300, France.

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http://dx.doi.org/10.1016/j.bbamcr.2010.12.006DOI Listing
May 2011

Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa.

J Invest Dermatol 2011 Apr 2;131(4):848-56. Epub 2010 Dec 2.

Division of Hematology-Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1038/jid.2010.346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151825PMC
April 2011

Gene therapy for recessive dystrophic epidermolysis bullosa.

Dermatol Clin 2010 Apr;28(2):361-6, xii

Institut National de la santé et de la recherche médicale, U563, Toulouse France.

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http://dx.doi.org/10.1016/j.det.2010.02.003DOI Listing
April 2010

Modifier genes in pseudoxanthoma elasticum: novel insights from the Ggcx mouse model.

Authors:
Alain Hovnanian

J Mol Med (Berl) 2010 Feb 11;88(2):149-53. Epub 2010 Feb 11.

Department of Genetics, University Paris V René Descartes, Necker Hospital for Sick Children and Inserm U563, 149 Rue de Sèvres, 75743, Paris Cedex 15, France.

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http://dx.doi.org/10.1007/s00109-009-0576-7DOI Listing
February 2010

HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz.

AIDS 2008 Feb;22(4):540-1

INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.

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http://dx.doi.org/10.1097/QAD.0b013e3282f37812DOI Listing
February 2008