Publications by authors named "Alain Doucet"

67Publications

Patient Safety Culture Bundle for CEOs and Senior Leaders.

Healthc Q 2020 Feb;22(SP):82-95

Healthcare risk management, of the Health Insurance Reciprocal of Canada and adjunct faculty at the University of Toronto. She has over 30 years of healthcare experience, including leadership roles in clinical program delivery, quality improvement, patient safety and risk management.

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http://dx.doi.org/10.12927/hcq.2020.26044DOI Listing
February 2020

ANP-stimulated Na secretion in the collecting duct prevents Na retention in the renal adaptation to acid load.

Am J Physiol Renal Physiol 2019 08 12;317(2):F435-F443. Epub 2019 Jun 12.

Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Université Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Paris, France.

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http://dx.doi.org/10.1152/ajprenal.00059.2019DOI Listing
August 2019

A Renal Olfactory Receptor Aids in Kidney Glucose Handling.

Sci Rep 2016 10 14;6:35215. Epub 2016 Oct 14.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/srep35215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064317PMC
October 2016

Oxidative Stress and Nuclear Factor κB (NF-κB) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome.

J Biol Chem 2016 May 31;291(21):11105-13. Epub 2016 Mar 31.

From the Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL8228, Centre de Recherche des Cordeliers, F-75006, Paris, France,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.724690
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http://dx.doi.org/10.1074/jbc.M116.724690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900260PMC
May 2016

Albuminuria induces a proinflammatory and profibrotic response in cortical collecting ducts via the 24p3 receptor.

Am J Physiol Renal Physiol 2013 Oct 24;305(7):F1053-63. Epub 2013 Jul 24.

Univ. of Geneva, Univ. Medical Center, Service of Nephrology, Dept. of Physiology and Metabolism, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00006.2013DOI Listing
October 2013

A link between fertility and K+ homeostasis: role of the renal H,K-ATPase type 2.

Pflugers Arch 2013 Aug 26;465(8):1149-58. Epub 2013 Feb 26.

UPMC Univ Paris 6/INSERM/CNRS UMRS 872 Equipe 3 Laboratoire de Génomique, Physiologie et Physiopathologie Rénales ERL 7226, 75006, Paris, France.

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http://dx.doi.org/10.1007/s00424-013-1252-xDOI Listing
August 2013

Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level.

J Biol Chem 2013 Apr 19;288(14):10124-31. Epub 2013 Feb 19.

Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Université Paris-Descartes, INSERM, UMRS872 and Centre National de la Recherche Scientifique, ERL7226, 75270 Paris cedex 06, France.

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http://dx.doi.org/10.1074/jbc.M112.446393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617255PMC
April 2013

Of mice and men: divergence of gene expression patterns in kidney.

PLoS One 2012 3;7(10):e46876. Epub 2012 Oct 3.

Unité Mixte de Recherche 872, Université Paris 6 and Institut National de la Santé et de la Recherche Médicale, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046876PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463552PMC
May 2013

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

Proc Natl Acad Sci U S A 2012 May 1;109(20):7929-34. Epub 2012 May 1.

Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Tlalpan 14000 Mexico City, Mexico.

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http://dx.doi.org/10.1073/pnas.1200947109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356635PMC
May 2012

Regulation of pendrin by cAMP: possible involvement in β-adrenergic-dependent NaCl retention.

Am J Physiol Renal Physiol 2012 May 18;302(9):F1180-7. Epub 2012 Jan 18.

UPMC Université Paris 06, Université Paris 05, INSERM, UMRS872, and CNRS ERL7226, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Centre de Recherche des Cordeliers, Paris, France.

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http://dx.doi.org/10.1152/ajprenal.00403.2011DOI Listing
May 2012

Amino-Terminal Oriented Mass Spectrometry of Substrates (ATOMS) N-terminal sequencing of proteins and proteolytic cleavage sites by quantitative mass spectrometry.

Methods Enzymol 2011 ;501:275-93

Centre for Blood Research, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/B978-0-12-385950-1.00013-4DOI Listing
March 2012

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates.

Nat Protoc 2011 Sep 22;6(10):1578-611. Epub 2011 Sep 22.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nprot.2011.382DOI Listing
September 2011

Development of soluble ester-linked aldehyde polymers for proteomics.

Anal Chem 2011 Sep 11;83(17):6500-10. Epub 2011 Aug 11.

Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1021/ac200419pDOI Listing
September 2011

Inhibition of K+ secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria.

J Physiol 2011 Jul 23;589(Pt 14):3611-21. Epub 2011 May 23.

UPMC University of Paris 06, and INSERM UMRS 872 team 3, and CNRS ERL 7226, Centre de recherche des Cordeliers, Paris, France.

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http://dx.doi.org/10.1113/jphysiol.2011.209692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167121PMC
July 2011

Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS).

Methods Mol Biol 2011 ;753:273-87

Department of Pathology and Laboratory Medecine, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.

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http://link.springer.com/content/pdf/10.1007/978-1-61779-148
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http://link.springer.com/10.1007/978-1-61779-148-2_18
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http://dx.doi.org/10.1007/978-1-61779-148-2_18DOI Listing
September 2011

Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium.

Kidney Int 2011 Aug 16;80(3):256-62. Epub 2011 Feb 16.

UPMC Univ Paris 6/INSERM/CNRS, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Centre de Recherche des Cordeliers, Paris, France.

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http://linkinghub.elsevier.com/retrieve/pii/S008525381555038
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http://dx.doi.org/10.1038/ki.2011.15DOI Listing
August 2011

[Pendrin: its role in kidney function and hypertension].

Med Sci (Paris) 2010 Dec;26(12):1074-8

Universités Paris 5 et Paris 6, Inserm (UMRS 872) et CNRS (ERL 7226), Laboratoire de génomique, physiologie et physiopathologie rénales, Centre de recherche des Cordeliers, 15, rue de l'École de Médecine, 75006 Paris, France.

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http://dx.doi.org/10.1051/medsci/201026121074DOI Listing
December 2010

Atlas of gene expression in the mouse kidney: new features of glomerular parietal cells.

Physiol Genomics 2011 Feb 16;43(3):161-73. Epub 2010 Nov 16.

UPMC Univ Paris 06, Univ Paris Descartes and INSERM, UMRS 872, Centre de recherche des Cordeliers, Paris, France.

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http://dx.doi.org/10.1152/physiolgenomics.00093.2010DOI Listing
February 2011

Regulation of pendrin by pH: dependence on glycosylation.

Biochem J 2011 Feb;434(1):61-72

Université Pierre et Marie Curie, Université Paris Descartes, INSERM/UMRS 812, Centre National de la Recherche Scientifique ERL 7226, Laboratoire de génomique, physiologie et physiopathologie ŕenales, Center de Recherche des Cordeliers, 15 rue de I'Ecole de Medecine, Paris, France.

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http://dx.doi.org/10.1042/BJ20101411DOI Listing
February 2011

Broad coverage identification of multiple proteolytic cleavage site sequences in complex high molecular weight proteins using quantitative proteomics as a complement to edman sequencing.

Mol Cell Proteomics 2011 May 28;10(5):M110.003533. Epub 2010 Sep 28.

Department of Biochemistry and Oral Biological and Medical Sciences, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M110.003533
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http://dx.doi.org/10.1074/mcp.M110.003533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098582PMC
May 2011

Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance.

BMC Nephrol 2010 Jul 22;11:15. Epub 2010 Jul 22.

Université Pierre et Marie Curie, Institut National de la Santé et de la Recherche Médicale, Centre National de Recherche Scientifique, Paris, France.

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http://dx.doi.org/10.1186/1471-2369-11-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915970PMC
July 2010

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products.

Nat Biotechnol 2010 Mar 7;28(3):281-8. Epub 2010 Mar 7.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nbt.1611DOI Listing
March 2010

François Morel: four decades of interdisciplinary search for the logic of life.

Kidney Int 2008 Sep;74(5):545-6

Laboratoire de Physiologie et Génomique Rénales, Paris, France.

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http://dx.doi.org/10.1038/ki.2008.384DOI Listing
September 2008

Proteinase-activated receptor 2 stimulates Na,K-ATPase and sodium reabsorption in native kidney epithelium.

J Biol Chem 2008 Oct 4;283(42):28020-8. Epub 2008 Aug 4.

Université Pierre et Marie Curie, Univ Paris 06, UMR 7134, 75005 Paris.

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http://dx.doi.org/10.1074/jbc.M804399200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661380PMC
October 2008

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.

Blood 2008 Oct 25;112(8):3455-64. Epub 2008 Jul 25.

Departments ofOral Biological & Medical Sciences, Centre for Blood Research, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1182/blood-2007-12-129080DOI Listing
October 2008

GDF15 triggers homeostatic proliferation of acid-secreting collecting duct cells.

J Am Soc Nephrol 2008 Oct 23;19(10):1965-74. Epub 2008 Jul 23.

UPMC University of Paris 06, Unité Mixte de Recherche Scientifique UMRS 872, and INSERM, UMRS 872, Paris France.

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http://www.jasn.org/lookup/doi/10.1681/ASN.2007070781
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http://dx.doi.org/10.1681/ASN.2007070781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551573PMC
October 2008

Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

Mol Cell Proteomics 2008 Oct 2;7(10):1925-51. Epub 2008 Jul 2.

Centre for Blood Research, 4.401 Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1074/mcp.R800012-MCP200DOI Listing
October 2008

Protease proteomics: revealing protease in vivo functions using systems biology approaches.

Mol Aspects Med 2008 Oct 1;29(5):339-58. Epub 2008 May 1.

University of British Columbia, Centre for Blood Research, 4.401 Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3.

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http://linkinghub.elsevier.com/retrieve/pii/S009829970800016
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http://dx.doi.org/10.1016/j.mam.2008.04.003DOI Listing
October 2008

Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.

Endocrinology 2008 Jul 3;149(7):3294-305. Epub 2008 Apr 3.

Institut National de la Santé et de la Recherche Médicale Unité 693, Faculté de Médecine Paris-Sud, 63 rue Gabriel Péri, Le Kremlin Bicêtre Cedex, France.

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http://dx.doi.org/10.1210/en.2008-0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527214PMC
July 2008

Protease research in the era of systems biology.

Biol Chem 2007 Nov;388(11):1159-62

The UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1515/BC.2007.146DOI Listing
November 2007

Sodium retention and ascites formation in a cholestatic mice model: role of aldosterone and mineralocorticoid receptor?

Hepatology 2007 Jul;46(1):173-9

Laboratoire de Physiologie et Génomique Rénales, CNRS/UPMC UMR 7134, IFR 58, Institut des Cordeliers, Paris cedex, France.

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http://dx.doi.org/10.1002/hep.21699DOI Listing
July 2007

Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications.

Pediatr Nephrol 2007 Dec 7;22(12):1983-90. Epub 2007 Jun 7.

Laboratoire de Physiologie et Génomique Rénales, CNRS/UPMC UMR 7134, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75270, Paris, France.

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http://dx.doi.org/10.1007/s00467-007-0521-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064946PMC
December 2007

Increased local levels of granulocyte colony-stimulating factor are associated with the beneficial effect of pre-elafin (SKALP/trappin-2/WAP3) in experimental emphysema.

Biol Chem 2006 Jul;387(7):903-9

Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, Sainte-Foy G1V 4G5, Canada.

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https://www.degruyter.com/view/j/bchm.2006.387.issue-7/bc.20
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http://dx.doi.org/10.1515/BC.2006.114DOI Listing
July 2006

Kidney collecting duct acid-base "regulon".

Physiol Genomics 2006 Nov 25;27(3):271-81. Epub 2006 Jul 25.

Laboratoire de Physiologie et Génomique Rénales, Unité mixte de recherche 7134, Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, Institut Fédératif de Recherche 58, Paris cedex 6, France.

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http://dx.doi.org/10.1152/physiolgenomics.00069.2006DOI Listing
November 2006

Molecular identification of Sch28080-sensitive K-ATPase activities in the mouse kidney.

Pflugers Arch 2006 Mar 6;451(6):769-75. Epub 2005 Oct 6.

Laboratoire de Physiologie et Génomique Rénales, Unité Mixte de Recherche CNRS/UPMC 7134, IFR 58, Institut des Cordeliers, 15 Rue de l'Ecole de Médecine, 75270 Paris Cedex 6, France.

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http://dx.doi.org/10.1007/s00424-005-1508-1DOI Listing
March 2006

Global analysis of gene expression in mammalian kidney.

Pflugers Arch 2005 Apr 21;450(1):13-25. Epub 2004 Dec 21.

Laboratoire de Physiologie et Génomique Rénales, CNRS-UPMC, UMR 7134, Institut des Cordeliers, IFR 58, 15 rue de l'Ecole de Médecine, 75270 Paris cedex 6, France.

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http://dx.doi.org/10.1007/s00424-004-1368-0DOI Listing
April 2005

ERK1/2 controls Na,K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney.

J Biol Chem 2004 Dec 28;279(49):51002-12. Epub 2004 Sep 28.

Département de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1074/jbc.M405674200DOI Listing
December 2004

Plasticity of mouse renal collecting duct in response to potassium depletion.

Physiol Genomics 2004 Sep 6;19(1):61-73. Epub 2004 Jul 6.

Laboratoire de Physiologie et Génomique Rénales, Unité Mixte de Recherche Centre National de la Recherche Scientifique/UPMC 7134, Paris, France.

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http://dx.doi.org/10.1152/physiolgenomics.00055.2004DOI Listing
September 2004

Differential regulation of collecting duct Na+, K+-ATPase and K+ excretion by furosemide and piretanide: role of bradykinin.

J Am Soc Nephrol 2004 Apr;15(4):876-84

Laboratoire de Physiologie et Génomique des Cellules Rénales (UMR 7134 CNRS/Université Paris 6), Institut des Cordeliers, Paris, France.

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http://dx.doi.org/10.1097/01.asn.0000117773.22969.b3DOI Listing
April 2004

A panoramic view of gene expression in the human kidney.

Proc Natl Acad Sci U S A 2003 Nov 31;100(23):13710-5. Epub 2003 Oct 31.

Département de Biologie Joliot-Curie, Service de Biochimie et de Génétique Moléculaire, Commissariat à l'Energie Atomique Saclay, 91191 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1073/pnas.2234604100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263878PMC
November 2003

Mechanism of control of Na,K-ATPase in principal cells of the mammalian collecting duct.

Ann N Y Acad Sci 2003 Apr;986:570-8

Division de Néphrologie, Fondation pour Recherches Médicales, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb07255.xDOI Listing
April 2003

Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney.

Am J Physiol Renal Physiol 2003 Sep 6;285(3):F507-14. Epub 2003 May 6.

Institut National de la Santé et de la Recherche Médicale Unité 367, Physiologie et Pathologie Expérimentale Vasculaires, Université Paris VI, Paris, France.

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http://dx.doi.org/10.1152/ajprenal.00430.2002DOI Listing
September 2003

Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct.

Am J Physiol Renal Physiol 2003 May;284(5):F948-54

Laboratoire de Biologie Intégrée des Cellules Rénales, Service de Biologie Cellulaire, Commissariat a l'Energie Atomique, Saclay, France.

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http://ajprenal.physiology.org/content/ajprenal/284/5/F948.f
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http://ajprenal.physiology.org/lookup/doi/10.1152/ajprenal.0
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http://dx.doi.org/10.1152/ajprenal.00394.2002DOI Listing
May 2003

Mechanisms of oedema in nephrotic syndrome: old theories and new ideas.

Nephrol Dial Transplant 2003 Mar;18(3):454-6

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http://dx.doi.org/10.1093/ndt/18.3.454DOI Listing
March 2003

Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter, along the rat nephron.

J Am Soc Nephrol 2002 Aug;13(8):1999-2008

Institut National de la Santé et de la Recherche Médicale Unité 356, Institut Fédératif de Recherche 58, Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1097/01.asn.0000025280.02386.9dDOI Listing
August 2002

Large-scale analysis of gene expression: methods and application to the kidney.

J Nephrol 2002 Mar-Apr;15 Suppl 5:S170-83

CEA Saclay, Laboratoire de Biologie Intégrée des Cellules Rénales, Gif sur Yvette, France.

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November 2002

Renal transcriptomes: segmental analysis of differential expression.

Exp Nephrol 2002 ;10(2):75-81

Département de Biologie Cellulaire et Moléculaire, Service de Biologie Cellulaire, CNRS URA 1859, CEA SACLAY, F-91191 Gif-sur-Yvette, France.

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http://dx.doi.org/10.1159/000049902DOI Listing
September 2002

Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I.

J Biol Chem 2002 May 15;277(21):18598-604. Epub 2002 Mar 15.

Laboratoire de Biologie Intégrée des Cellules Rénales, Service de Biologie Cellulaire, Commissariat á l'Energie Atomique, Saclay, Unité de Recherche Associée 1859, CNRS, 91191 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1074/jbc.M201868200DOI Listing
May 2002

Engineering nutritious proteins: improvement of stability in the designer protein MB-1 via introduction of disulfide bridges.

J Agric Food Chem 2002 Jan;50(1):92-8

Groupe de Recherche en Energie et Information Biomoléculaire, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, C.P. 500, Trois-Rivières, Québec G9A 5H7, Canada.

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http://dx.doi.org/10.1021/jf010839dDOI Listing
January 2002