Publications by authors named "Alain Deroussent"

25Publications

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

J Med Chem 2019 02 21;62(4):1902-1916. Epub 2018 Dec 21.

BioCIS, Université Paris-Sud, CNRS, Équipe Labellisée Ligue Contre le Cancer , Université Paris-Saclay , F-92290 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01386DOI Listing
February 2019

Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies.

Int J Pharm 2017 Nov 22;532(2):748-756. Epub 2017 May 22.

Vectorologie des anticancéreux et des acides nucléiques, UMR 8203, CNRS, Université Paris-Sud, Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France; Service de Pharmacologie, Département de Biologie et Pathologie médicales, Gustave Roussy, 94805 Villejuif, France; Département de Pharmacocinétique & Pharmacie Clinique, Université Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, 92296 Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.05.044DOI Listing
November 2017

Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 Jun 20;992:30-5. Epub 2015 Apr 20.

CNRS UMR 8203, Laboratory of Vectorology and Anticancer Therapeutics, Paris-Sud University, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France; Pharmacology and Drug Analysis Department, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.

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http://dx.doi.org/10.1016/j.jchromb.2015.04.025DOI Listing
June 2015

Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.

J Med Chem 2015 Jan 23;58(2):705-17. Epub 2014 Dec 23.

Université Paris-Sud, Centre National de la Recherche Scientifique (CNRS), and Gustave Roussy Cancer Campus Grand Paris, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203 , Villejuif, France -94805.

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http://dx.doi.org/10.1021/jm501224xDOI Listing
January 2015

Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model.

Am J Obstet Gynecol 2012 Dec 8;207(6):514.e1-7. Epub 2012 Oct 8.

Department of Clinical Pharmacology and Clinical Research Unit, INSERM Cliniques P 0901, Cochin Teaching Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.ajog.2012.10.007DOI Listing
December 2012

Quantification of dimethyl-ifosfamide and its N-deschloropropylated metabolites in mouse plasma by liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Apr 13;879(11-12):743-50. Epub 2011 Feb 13.

CNRS UMR 8203, Vectorologie et Thérapeutiques Anticancéreuses, Université Paris XI, Institut de Cancérologie Gustave Roussy, IRCIV, Villejuif, France.

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http://dx.doi.org/10.1016/j.jchromb.2011.02.012DOI Listing
April 2011

Oxazaphosphorines: new therapeutic strategies for an old class of drugs.

Expert Opin Drug Metab Toxicol 2010 Aug;6(8):919-38

Paris XI University and Integrated Research Cancer Institute Villejuif , France.

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http://dx.doi.org/10.1517/17425255.2010.487861DOI Listing
August 2010

Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2010 Jul 16;52(3):391-7. Epub 2009 Sep 16.

Institut de cancérologie Gustave Roussy, Research Department IFR54, Mass Spectrometry Facility, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1016/j.jpba.2009.09.014DOI Listing
July 2010

Metabolism evaluation of biomimetic prodrugs by in vitro models and mass spectrometry.

Int J Pharm 2009 Sep 23;379(2):235-43. Epub 2009 May 23.

Université Paris-Sud, CNRS, UMR 8612, IFR 141, 5, rue J.B. Clément, F-92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1016/j.ijpharm.2009.05.030DOI Listing
September 2009

New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity.

J Pharmacol Exp Ther 2009 Feb 18;328(2):598-609. Epub 2008 Nov 18.

Unité Mixte de Recherche 8638 Centre National de Recherche Scientifique Medicinal Chemistry Laboratory-Faculty of Pharmacy, University Paris Descartes, Paris, France.

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http://dx.doi.org/10.1124/jpet.108.144170DOI Listing
February 2009

Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.

Drug Metab Dispos 2008 Aug 12;36(8):1570-7. Epub 2008 May 12.

Faculté de Pharmacie, Unité Mixte de Recherche Centre National de la Recherche Scientifique 8612, Institut Fédératif de Recherche 141, Université Paris XI, Châtenay-Malabry cedex, France.

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http://dx.doi.org/10.1124/dmd.108.020735DOI Listing
August 2008

Busulphan-loaded long-circulating nanospheres, a very attractive challenge for both galenists and pharmacologists.

J Microencapsul 2007 Dec;24(8):715-30

CNRS & Université Paris XI, Pharmacotechnie, BiopharmacieChatenay Malabry, France.

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http://dx.doi.org/10.1080/02652040701500905DOI Listing
December 2007

Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Oct 22;858(1-2):71-8. Epub 2007 Aug 22.

UPRES EA3535 Pharmacology and New Cancer Treatments, Institute Gustave Roussy - IFR54 and Paris XI University, 94800 Villejuif, France.

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http://dx.doi.org/10.1016/j.jchromb.2007.08.018DOI Listing
October 2007

Induction of glutathione synthesis explains pharmacodynamics of high-dose busulfan in mice and highlights putative mechanisms of drug interaction.

Drug Metab Dispos 2007 Feb 28;35(2):306-14. Epub 2006 Nov 28.

Unité Propre de Recherche et de l'Enseignement Supérieur, Equipe d'Accueil 3535, Pharmacology and New Treatments of Cancers, IFR54, University Paris XI and Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1124/dmd.106.012880DOI Listing
February 2007

Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors.

Drug Metab Dispos 2006 Nov 8;34(11):1918-26. Epub 2006 Aug 8.

Unité Propre de Recherche et de l'Enseignement Supérieur, Equipe d'Accueil, Pharmacology and New Treatments of Cancer, l'Institut Fédératif de Recherches, Institute Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1124/dmd.106.010512DOI Listing
November 2006

Liquid chromatography-tandem mass spectrometry assay of reduced and oxidized glutathione and main precursors in mice liver.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Feb 24;832(1):67-74. Epub 2006 Jan 24.

UPRES EA3535 Pharmacology and New Cancer Treatments, Institute Gustave Roussy and Paris XI University, Villejuif, France.

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http://dx.doi.org/10.1016/j.jchromb.2005.12.037DOI Listing
February 2006

The solution synthesis of antisense oligonucleotide-peptide conjugates directly linked via phosphoramide bond by using a fragment coupling approach.

Nucleosides Nucleotides Nucleic Acids 2004 ;23(12):1911-27

A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russian Federation.

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http://dx.doi.org/10.1081/NCN-200040672DOI Listing
May 2005

Quantitative liquid chromatographic determination of sanguinarine in cell culture medium and in rat urine and plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Jan;799(2):195-200

CNRS UPR 2301, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Cedex, Gif sur Yvette, France.

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http://dx.doi.org/10.1016/j.jchromb.2003.10.023DOI Listing
January 2004