Dr Alaa El-Din Sayed, PhD - Zoology department, faculty of Science, Assiut university - Dr

Dr Alaa El-Din Sayed

PhD

Zoology department, faculty of Science, Assiut university

Dr

Assiut, Assiut | Egypt

Main Specialties: Biology, Cytopathology, Hematology, Molecular Genetic Pathology

Additional Specialties: Fish Biology and Toxicology

ORCID logohttps://orcid.org/0000-0001-7487-4729


Top Author

Dr Alaa El-Din Sayed, PhD - Zoology department, faculty of Science, Assiut university - Dr

Dr Alaa El-Din Sayed

PhD

Introduction

Dr Alaa Sayed is currently working as Associate professor at Zoology Department, Faculty of Science, Assiut University, Egypt. Dr Sayed is received master’s level training in Stockholm University, Sweden. He obtained his master degree (2008) and doctoral degree (2011) from Assiut University. His postdoc was at Tokyo University (JSPS). He works as member at molecular biology unit, Assiut University for protein electrophoresis. Dr Sayed teaches theoretical courses as fish biology, aquaculture, and vertebrate taxonomy to undergraduate students and postgraduate students. He is the supervisors 12 master and 4 Ph.D. students. He also provides consultation to faculty and fellows within the Assiut University and for community sector in his field on research design and data analysis. He published about 75 international papers and two books. His interesting in research related to Fish Toxicology, Environmental Pollution, Aquaculture and Aquatic Toxicology

Primary Affiliation: Zoology department, faculty of Science, Assiut university - Assiut, Assiut , Egypt

Specialties:

Additional Specialties:


View Dr Alaa El-Din Sayed’s Resume / CV

Education

Dec 2008 - May 2011
Assiut University Faculty of Science
Ph.D.
Zoology
Nov 2004 - Oct 2008
Assiut University Faculty of Science
M.sc.
Zoology
Sep 2000 - Jun 2004
Assiut University Faculty of Science
B.sc.
Zoology

Experience

Jul 2018 - Oct 2018
University of Tokyo
Visiting associate professor
Integrated Bioscienes
Nov 2015 - Nov 2017
University of Tokyo
JSPS postdoctoral fellow
Integrated Bioscienes
May 2011 - Jun 2016
Assiut University Faculty of Science
Lecturer
Zoology
Sep 2011 - Feb 2012
University of Tokyo
Visiting researcher
Integrated Bioscienes
Oct 2008 - May 2011
Assiut University Faculty of Science
Assistant lecturer
Zoology
Nov 2004 - Oct 2008
Assiut University Faculty of Science
Demonstrator
Zoology
Jun 2016
Assiut University Faculty of Science
Associate professor
Zoology

Publications

41Publications

404Reads

167Profile Views

22PubMed Central Citations

γ-H2AX foci as indication for the DNA damage in erythrocytes of medaka (Oryzias latipes) intoxicated with 4-nonylphenol.

Environ Sci Pollut Res Int 2020 Jun 24;27(16):18966-18971. Epub 2018 Aug 24.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8562, Japan.

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http://dx.doi.org/10.1007/s11356-018-2985-zDOI Listing
June 2020
12 Reads
2.830 Impact Factor

Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics.

Environ Sci Pollut Res Int 2020 May 11;27(13):14581-14588. Epub 2020 Feb 11.

Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

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http://dx.doi.org/10.1007/s11356-020-07898-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190598PMC
May 2020
2.828 Impact Factor

Comparative study of two carnivorous fish (Parupeneus forsskali and Thalassoma klunzingeri) from the Red Sea: Hemato-biochemical parameters and cellular characterization.

Tissue Cell 2020 Apr 11;63:101316. Epub 2019 Nov 11.

Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

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http://dx.doi.org/10.1016/j.tice.2019.101316DOI Listing
April 2020
1.049 Impact Factor

Comparative histology of wild-type and p53-deficient medaka (Oryzias latipes): nephrotoxic effect of ultraviolet A radiation.

Photochem Photobiol Sci 2020 Feb;19(2):261-273

Zoology department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

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http://dx.doi.org/10.1039/c9pp00236gDOI Listing
February 2020
2.267 Impact Factor

Correction to: Hemotoxic effects of some herbicides on juvenile of Nile tilapia Oreochromis niloticus.

Environ Sci Pollut Res Int 2020 Jan;27(3):3541

Zoology Department, Faculty of Sciences, Assiut University, Assiut, 71516, Egypt.

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http://dx.doi.org/10.1007/s11356-019-07375-1DOI Listing
January 2020
2.828 Impact Factor

Hepatotoxic effects of silver nanoparticles on ; Biochemical, histopathological, and histochemical studies.

Toxicol Rep 2020 7;7:133-141. Epub 2020 Jan 7.

Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

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http://dx.doi.org/10.1016/j.toxrep.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962648PMC
January 2020

Silver nanoparticle-induced nephrotoxicity in Clarias gariepinus: physio-histological biomarkers.

Fish Physiol Biochem 2019 Dec 10;45(6):1895-1905. Epub 2019 Aug 10.

Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

The present study investigates the nephrotoxic effects of two acute doses of silver nanoparticles (AgNPs) and silver nitrate (AgNO) on the African catfish, Clarias gariepinus, using biochemical, histochemical, and histopathological changes as biomarkers. AgNP-induced impacts were recorded in some of these characteristics on the bases of their size (20 and 40 nm) and concentration (10 and 100 ?g/L) but no significant interaction between size and concentration. AgNO had low significant adverse effects on some parameters in comparison with those impacts of AgNPs. The concentrations of creatinine and uric acid exhibited different significant variations under stress in all exposed groups compared with those in the control group. On the tissue and cell levels, histopathological changes were observed. These changes include hypertrophies of glomeruli, proliferation in the haemopoietic tissue, dissociation in renal tubules, shrinkage of glomerulus, hydropic degeneration, dilatation of renal tubules, aggregation of melanomacrophages, rupture of Bowman's capsule, and the glomerular tuft and dilatation of Bowman's space. In more severe cases, the degenerative process leads to tissue necrosis in the kidney of AgNP-exposed fish as well as carbohydrate depletion; a faint coloration was also observed in the brush borders and basement membrane with a large amount of connective tissue fibers around the blood vessels and the renal tubules. Recovery period for 15 days led to improvement of most of the alterations in biochemical, histopathological, and histochemical parameters induced by AgNPs and AgNO. In conclusion, one can postulate on the sensitivity of the kidney of C. gariepinus to AgNPs and recovery strategy is a must.

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http://dx.doi.org/10.1007/s10695-019-00686-7DOI Listing
December 2019
3 Reads
1.622 Impact Factor

Protective effect of p53 knockout on 4-nonylphenol-induced nephrotoxicity in medaka (Oryzias latipes).

Chemosphere 2019 Dec 8;236:124314. Epub 2019 Jul 8.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.

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http://dx.doi.org/10.1016/j.chemosphere.2019.07.045DOI Listing
December 2019
1 Read
3.340 Impact Factor

Hemotoxic effects of some herbicides on juvenile of Nile tilapia Oreochromis niloticus.

Environ Sci Pollut Res Int 2019 Oct 24;26(30):30857-30865. Epub 2019 Aug 24.

Zoology Department, Faculty of Sciences, Assiut University, Assiut, 71516, Egypt.

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http://dx.doi.org/10.1007/s11356-019-06280-xDOI Listing
October 2019
3 Reads
2.828 Impact Factor

Assessment the effect of exposure to microplastics in Nile Tilapia (Oreochromis niloticus) early juvenile: I. blood biomarkers.

Chemosphere 2019 Aug 22;228:345-350. Epub 2019 Apr 22.

Department of Zoology, Faculty of Science, Assiut University, 71516, Assiut, Egypt.

There is a scarcity of knowledge about the impacts of microplastics (MPs) on the early juvenile stage of freshwater fish. The current study aims to inspect the exposure and post-exposure recovery of microplastics (MPs) on accumulation and blood biomarkers of Nile Tilapia (Oreochromis niloticus) early juvenile. Four groups of fishes were used; the first group was the control group, the second group was exposed to (1?mg/L of MPs), the third group was exposed to (10?mg/L of MPs), and the fourth group was exposed to (100?mg/L of MPs) for 15 days and 15 days of recovery. The results showed that significantly higher numbers of microplastics were observed in microplastics-exposed groups compared to control group. Biochemical parameters (creatinine, uric acid, AST, ALT, ALP, glucose, cholesterol, total protein, albumin, globulin, and A/G ratio) showed significant increment after exposure to microplastics for 15 days compared to control group in dose dependent manner. The hematological indices (RBC's count, Hb, Ht, MCHC, Platelets, WBC's count, and monocytes) showed a significant decline after exposure to microplastics for 15 days compared to control group, while MCV and MCH showed a significant increase after exposure to microplastics for 15 days. After the recovery period, microplastics accumulations, hemato-biochemical alterations were still detected in microplastics exposed groups compared to the control group except for WBC's count and MCV which return to normal levels. MPs caused anemia and perturbations in hemato-biochemical parameters which may cause mortality of tilapia early juvenile and should be considered in a program for monitoring hazard materials in the ecosystem.

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.153DOI Listing
August 2019
9 Reads
3.340 Impact Factor

Ameliorative effect of Spirulina platensis against lead nitrate-induced cytotoxicity and genotoxicity in catfish Clarias gariepinus.

Environ Sci Pollut Res Int 2019 Jul 18;26(20):20610-20618. Epub 2019 May 18.

Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

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http://link.springer.com/10.1007/s11356-019-05319-3
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http://dx.doi.org/10.1007/s11356-019-05319-3DOI Listing
July 2019
14 Reads
2.828 Impact Factor

Adverse effects, expression of defense-related genes, and oxidative stress-induced MAPK pathway in the benzo[α]pyrene-exposed rotifer Brachionus rotundiformis.

Aquat Toxicol 2019 May 6;210:188-195. Epub 2019 Mar 6.

Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.aquatox.2019.03.004DOI Listing
May 2019
12 Reads
3.451 Impact Factor

Cytotoxic and hemotoxic effects of silver nanoparticles on the African Catfish, Clarias gariepinus (Burchell, 1822).

Ecotoxicol Environ Saf 2019 Apr 15;171:638-646. Epub 2019 Jan 15.

Department of Zoology, Faculty of Science, Assiut University, Assiut 71516, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.011DOI Listing
April 2019
6 Reads
2.762 Impact Factor

Protective effects of a novel pyrazolecarboxamide derivative against lead nitrate induced oxidative stress and DNA damage in Clarias gariepinus.

Environ Pollut 2019 Apr 25;247:678-684. Epub 2019 Jan 25.

Department of Zoology, Faculty of Science, Assiut University, 71516, Assiut, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.envpol.2019.01.074DOI Listing
April 2019
8 Reads
4.143 Impact Factor

The microstructure of buccal cavity and alimentary canal of Siganus rivulatus: Scanning electron microscope study.

Microsc Res Tech 2019 Apr 16;82(4):443-451. Epub 2019 Jan 16.

Department of Zoology, Faculty of Science, Fish Biology and Pollution Lab, Assiut University, Assiut, Egypt.

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http://dx.doi.org/10.1002/jemt.23185DOI Listing
April 2019
7 Reads
1.170 Impact Factor

Immunotoxic effects of 4-nonylphenol on Clarias gariepinus: Cytopathological changes in hepatic melanomacrophages.

Aquat Toxicol 2019 Feb 3;207:83-90. Epub 2018 Dec 3.

Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

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http://dx.doi.org/10.1016/j.aquatox.2018.12.002DOI Listing
February 2019
8 Reads
3.451 Impact Factor

UVA-induced neurotoxicity in Japanese medaka (Oryzias latipes).

Photochem Photobiol Sci 2019 Jan 11;18(1):71-79. Epub 2018 Oct 11.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.

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http://xlink.rsc.org/?DOI=C8PP00169C
Publisher Site
http://dx.doi.org/10.1039/c8pp00169cDOI Listing
January 2019
6 Reads
2.270 Impact Factor

The protective role of Spirulina platensis to alleviate the Sodium dodecyl sulfate toxic effects in the catfish Clarias gariepinus (Burchell, 1822).

Ecotoxicol Environ Saf 2018 Nov 24;163:136-144. Epub 2018 Jul 24.

Hydrobiology Department, National Research Centre, Dokki 12622, Giza, Egypt.

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http://dx.doi.org/10.1016/j.ecoenv.2018.07.060DOI Listing
November 2018
5 Reads
2.762 Impact Factor

SDS-PAGE technique as biomarker for fish toxicological studies.

Toxicol Rep 2018 31;5:905-909. Epub 2018 Aug 31.

Laboratory of Fish Biology and Pollution, Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

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https://linkinghub.elsevier.com/retrieve/pii/S22147500183017
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http://dx.doi.org/10.1016/j.toxrep.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129688PMC
August 2018
27 Reads

Oocyte atresia in WT (HdrR) and P53 (-/-) medaka (Oryzias latipes) exposed to UVA.

J Photochem Photobiol B 2018 Jun 12;183:57-63. Epub 2018 Apr 12.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.

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http://dx.doi.org/10.1016/j.jphotobiol.2018.04.016DOI Listing
June 2018
9 Reads
2.960 Impact Factor

Protective effect of Nigella sativa on 4-nonylphenol-induced nephrotoxicity in Clarias gariepinus (Burchell, 1822).

Sci Total Environ 2018 Apr 29;619-620:692-699. Epub 2017 Nov 29.

Zoology department, Faculty of Science, Assiut University, 71516 Assiut, Egypt; Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2017.11.131DOI Listing
April 2018
8 Reads
1 Citation
4.100 Impact Factor

Modulatory effects of green tea extract against the hepatotoxic effects of 4-nonylphenol in catfish (Clarias gariepinus).

Ecotoxicol Environ Saf 2018 Mar 19;149:159-165. Epub 2017 Dec 19.

Zoology Department, Faculty of Science, Sohag University, 8562 Sohag, Egypt.

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http://dx.doi.org/10.1016/j.ecoenv.2017.11.007DOI Listing
March 2018
9 Reads
2.762 Impact Factor

Sensitivity of medaka (Oryzias latipes) to 4-nonylphenol subacute exposure; erythrocyte alterations and apoptosis.

Environ Toxicol Pharmacol 2018 Mar 26;58:98-104. Epub 2017 Dec 26.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.

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http://dx.doi.org/10.1016/j.etap.2017.12.023DOI Listing
March 2018
20 Reads
1.862 Impact Factor

Surface architecture of the oropharyngeal cavity and the digestive tract of Mulloidichthys flavolineatus from the red sea, Egypt: A scanning electron microscope study.

Tissue Cell 2016 Dec 5;48(6):624-633. Epub 2016 Sep 5.

Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.tice.2016.09.001DOI Listing
December 2016
7 Reads
1.050 Impact Factor

The notochord curvature in medaka (Oryzias latipes) embryos as a response to ultraviolet A irradiation.

J Photochem Photobiol B 2016 Nov 19;164:132-140. Epub 2016 Sep 19.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.09.023DOI Listing
November 2016
14 Reads
1 Citation
2.960 Impact Factor

Apoptotic cell death in erythrocytes of p53-deficient medaka (Oryzias latipes) after γ-irradiation.

Int J Radiat Biol 2016 10 1;92(10):572-6. Epub 2016 Sep 1.

b Department of Integrated Biosciences, Graduate School of Frontier Sciences , The University of Tokyo , Kashiwa , Chiba , Japan.

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http://dx.doi.org/10.1080/09553002.2016.1222091DOI Listing
October 2016
35 Reads
1 Citation
1.840 Impact Factor

Antioxidant and antiapoptotic activities of Calotropis procera latex on Catfish (Clarias gariepinus) exposed to toxic 4-nonylphenol.

Ecotoxicol Environ Saf 2016 Jun 3;128:189-94. Epub 2016 Mar 3.

Department of Botany and Microbiology, Faculty of Science, Assiut University, Assiut, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.ecoenv.2016.02.023DOI Listing
June 2016
17 Reads
1 Citation
2.762 Impact Factor

Hematotoxic and biochemical effects of UVA on the Egyptian toad (Bufo regularis).

Int J Radiat Biol 2016 20;92(1):35-41. Epub 2015 Nov 20.

a Zoology Department , Faculty of Science, Assiut University , Assiut , Egypt.

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http://dx.doi.org/10.3109/09553002.2015.1106023DOI Listing
May 2016
5 Reads
1.840 Impact Factor

Arsenic-induced genotoxicity in Nile tilapia (Orechromis niloticus); the role of Spirulina platensis extract.

Environ Monit Assess 2015 Dec 14;187(12):751. Epub 2015 Nov 14.

Department of Internal Medicine, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.

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http://link.springer.com/content/pdf/10.1007/s10661-015-4983
Web Search
http://link.springer.com/10.1007/s10661-015-4983-7
Publisher Site
http://dx.doi.org/10.1007/s10661-015-4983-7DOI Listing
December 2015
33 Reads
1.680 Impact Factor

Nuclear and cytoplasmic changes in erythrocytes of p53-deficient medaka fish (Oryzias latipes) after exposure to gamma-radiation.

Mutat Res Genet Toxicol Environ Mutagen 2014 Sep 26;771:64-70. Epub 2014 Apr 26.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.

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http://dx.doi.org/10.1016/j.mrgentox.2014.01.013DOI Listing
September 2014
11 Reads
1 Citation
2.420 Impact Factor

Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol.

Ecotoxicol Environ Saf 2012 Apr 16;78:310-9. Epub 2011 Dec 16.

Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

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http://dx.doi.org/10.1016/j.ecoenv.2011.11.041DOI Listing
April 2012
7 Reads
4 Citations
2.762 Impact Factor

Effects of 4-nonylphenol on blood cells of the African catfish Clarias gariepinus (Burchell, 1822).

Tissue Cell 2011 Aug 17;43(4):223-9. Epub 2011 Apr 17.

Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

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http://dx.doi.org/10.1016/j.tice.2011.03.006DOI Listing
August 2011
7 Reads
5 Citations
1.050 Impact Factor

Effects of short time UV-A exposures on compound eyes and haematological parameters in Procambarus clarkii (Girad, 1852).

Ecotoxicol Environ Saf 2011 May 11;74(4):960-6. Epub 2011 Feb 11.

Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

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http://dx.doi.org/10.1016/j.ecoenv.2011.01.010DOI Listing
May 2011
6 Reads
1 Citation
2.762 Impact Factor

Effects of ultraviolet A on the activity of two metabolic enzymes, DNA damage and lipid peroxidation during early developmental stages of the African catfish, Clarias gariepinus (Burchell, 1822).

Fish Physiol Biochem 2010 Sep 17;36(3):605-626. Epub 2009 Jul 17.

Zoology Department, Faculty of Science, Assiut University, 71516, Assiut, Egypt.

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http://dx.doi.org/10.1007/s10695-009-9334-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923706PMC
September 2010
10 Reads
3 Citations
1.622 Impact Factor

Use of hematological parameters to assess the efficiency of quince (Cydonia oblonga Miller) leaf extract in alleviation of the effect of ultraviolet--A radiation on African catfish Clarias gariepinus (Burchell, 1822).

J Photochem Photobiol B 2010 Apr 25;99(1):1-8. Epub 2010 Jan 25.

Zoology Department, Faculty of Science, Al-Azhar University, 71524 Assiut, Egypt.

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http://dx.doi.org/10.1016/j.jphotobiol.2010.01.002DOI Listing
April 2010
10 Reads
2 Citations
2.960 Impact Factor

Ultraviolet radiation-A (366 nm) induced morphological and histological malformations during embryogenesis of Clarias gariepinus (Burchell, 1822).

J Photochem Photobiol B 2009 May 20;95(2):117-28. Epub 2009 Feb 20.

Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

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http://dx.doi.org/10.1016/j.jphotobiol.2009.02.003DOI Listing
May 2009
6 Reads
2.960 Impact Factor

Acute effects of ultraviolet-A radiation on African catfish Clarias gariepinus (Burchell, 1822).

J Photochem Photobiol B 2007 Dec 5;89(2-3):170-4. Epub 2007 Nov 5.

Zoology Department, Faculty of Science, Assiut University, Egypt.

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http://dx.doi.org/10.1016/j.jphotobiol.2007.09.010DOI Listing
December 2007
69 Reads
2 Citations
2.960 Impact Factor

Top co-authors

Usama M Mahmoud
Usama M Mahmoud

Assiut University

12
Hiroshi Mitani
Hiroshi Mitani

The University of Tokyo

9
Shoji Oda
Shoji Oda

Graduate School of Frontier Sciences

5
Imam A Mekkawy
Imam A Mekkawy

Assiut University

4
Mohamed Hamed
Mohamed Hamed

School of Life Sciences

4
Shosaku Kashiwada
Shosaku Kashiwada

Duke University

3
Fatma Essa
Fatma Essa

Assiut University

2
Tomomi Watanabe-Asaka
Tomomi Watanabe-Asaka

MRC National Institute for Medical Research

2