Akseli Hemminki

Akseli Hemminki

UNVERIFIED PROFILE

Are you Akseli Hemminki?   Register this Author

Register author
Akseli Hemminki

Akseli Hemminki

Publications by authors named "Akseli Hemminki"

Are you Akseli Hemminki?   Register this Author

100Publications

861Reads

Second primary cancers in non-Hodgkin lymphoma: Bidirectional analyses suggesting role for immune dysfunction.

Int J Cancer 2018 Nov 21;143(10):2449-2457. Epub 2018 Sep 21.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article
November 2018

Second primary cancer after female breast cancer: Familial risks and cause of death.

Cancer Med 2018 Nov 26. Epub 2018 Nov 26.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article
November 2018

Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy.

Mol Ther 2018 Sep 13;26(9):2243-2254. Epub 2018 Jul 13.

TILT Biotherapeutics Ltd., 00290 Helsinki, Finland; Cancer Gene Therapy Group, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland; Helsinki University Hospital Comprehensive Cancer Center, 00290 Helsinki, Finland. Electronic address:

View Article
September 2018

Risk of second primary cancer following myeloid neoplasia and risk of myeloid neoplasia as second primary cancer: a nationwide, observational follow up study in Sweden.

Lancet Haematol 2018 Aug;5(8):e368-e377

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Center for Primary Health Care Research, Lund University, Malmö, Sweden.

View Article
August 2018

Multiple myeloma: family history and mortality in second primary cancers.

Blood Cancer J 2018 Aug 7;8(8):75. Epub 2018 Aug 7.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.

View Article
August 2018

Oncograms Visualize Factors Influencing Long-Term Survival of Cancer Patients Treated with Adenoviral Oncolytic Immunotherapy.

Mol Ther Oncolytics 2018 Jun 22;9:41-50. Epub 2018 Apr 22.

Cancer Gene Therapy Group, Department of Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

View Article
June 2018

Cancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System.

Curr Cancer Drug Targets 2018 ;18(2):124-138

Cancer Gene Therapy Group, Transplantation Laboratory and Haartman Institute, University of Helsinki, Finland.

View Article
January 2018

T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma.

J Immunother 2016 Nov/Dec;39(9):343-354

*Cancer Gene Therapy Group, Department of Pathology, Faculty of Medicine, University of Helsinki §TILT Biotherapeutics Ltd ∥Department of Obstetrics and Gynecology ¶Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland †Skin Cancer Unit, German Cancer Research Center (DKFZ) ‡Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

View Article
December 2017

Familial associations of female breast cancer with other cancers.

Int J Cancer 2017 12 26;141(11):2253-2259. Epub 2017 Aug 26.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.

View Article
December 2017

Familial associations of male breast cancer with other cancers.

Breast Cancer Res Treat 2017 Dec 23;166(3):897-902. Epub 2017 Aug 23.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.

View Article
December 2017

Familial Associations of Colorectal Cancer with Other Cancers.

Sci Rep 2017 Jul 12;7(1):5243. Epub 2017 Jul 12.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.

View Article
July 2017

Genetics of gallbladder cancer.

Lancet Oncol 2017 06;18(6):e296

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

View Article
June 2017

TILT Biotherapeutics.

Authors:
Akseli Hemminki

Hum Vaccin Immunother 2017 05 1;13(5):970-971. Epub 2017 Mar 1.

a TILT Biotherapeutics Ltd , Helsinki , Finland ; Cancer Gene Therapy Group, Department of Oncology , University of Helsinki , Helsinki , Finland ; Helsinki University Comprehensive Cancer Center , Helsinki , Finland.

View Article
May 2017

Common cancers share familial susceptibility: implications for cancer genetics and counselling.

J Med Genet 2017 04 20;54(4):248-253. Epub 2016 Sep 20.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

View Article
April 2017

Concordant and discordant familial cancer: Familial risks, proportions and population impact.

Int J Cancer 2017 04 20;140(7):1510-1516. Epub 2017 Jan 20.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, Heidelberg, D-69120, Germany.

View Article
April 2017

Other cancers in lung cancer families are overwhelmingly smoking-related cancers.

ERJ Open Res 2017 Apr 27;3(2). Epub 2017 Jun 27.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article
April 2017

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy.

Mol Ther Oncolytics 2017 Mar 31;4:77-86. Epub 2016 Dec 31.

Cancer Gene Therapy Group, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland; TILT Biotherapeutics, Ltd., 00290 Helsinki, Finland; Comprehensive Cancer Center, Helsinki University Hospital, 00290 Helsinki, Finland.

View Article
March 2017

Familial Associations Between Prostate Cancer and Other Cancers.

Eur Urol 2017 02 4;71(2):162-165. Epub 2016 Aug 4.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Center for Primary Health Care Research, Lund University, Malmö, Sweden. Electronic address:

View Article
February 2017

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models.

Cancer Immunol Res 2017 02 10;5(2):157-169. Epub 2017 Jan 10.

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

View Article
February 2017

Risk of other Cancers in Families with Melanoma: Novel Familial Links.

Sci Rep 2017 02 15;7:42601. Epub 2017 Feb 15.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.

View Article
February 2017

The epidemiology of metastases in neuroendocrine tumors.

Int J Cancer 2016 Dec 9;139(12):2679-2686. Epub 2016 Sep 9.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

View Article
December 2016

Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy.

Oncoimmunology 2017 7;6(2):e1265717. Epub 2016 Dec 7.

Cancer Gene Therapy Group, Department of Oncology, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd, Helsinki, Finland; Helsinki University Comprehensive Cancer Center, Helsinki, Finland.

View Article
December 2016

Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer.

Mol Cancer Ther 2016 09 25;15(9):2259-69. Epub 2016 Jul 25.

Cancer Gene Therapy Group, Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. TILT Biotherapeutics, Ltd., Helsinki, Finland.

View Article
September 2016

Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity.

Mol Ther Oncolytics 2016 23;3:16002. Epub 2016 Mar 23.

Laboratory of ImmunoViroTherapy, Centre for Drug Research (CDR), Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki , Helsinki, Finland.

View Article
September 2016

Metastatic spread in patients with gastric cancer.

Oncotarget 2016 Aug;7(32):52307-52316

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

View Article
August 2016

Patterns of metastasis in colon and rectal cancer.

Sci Rep 2016 07 15;6:29765. Epub 2016 Jul 15.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

View Article
July 2016

Syngeneic syrian hamster tumors feature tumor-infiltrating lymphocytes allowing adoptive cell therapy enhanced by oncolytic adenovirus in a replication permissive setting.

Oncoimmunology 2016 May 18;5(5):e1136046. Epub 2016 Feb 18.

Cancer Gene Therapy Group, Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd, Helsinki, Finland; Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

View Article
May 2016

Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles.

Mol Ther Oncolytics 2014 10;1:14002. Epub 2014 Dec 10.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki , Helsinki, Finland.

View Article
April 2016

Combinatorial treatment with oncolytic adenovirus and helper-dependent adenovirus augments adenoviral cancer gene therapy.

Mol Ther Oncolytics 2014 17;1:14008. Epub 2014 Dec 17.

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.

View Article
April 2016

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy.

Mol Ther Oncolytics 2015 7;1:14006. Epub 2015 Jan 7.

Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd, Helsinki, Finland.

View Article
April 2016

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.

PLoS One 2015 24;10(6):e0131242. Epub 2015 Jun 24.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd, Helsinki, Finland; Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

View Article
April 2016

Location of metastases in cancer of unknown primary are not random and signal familial clustering.

Sci Rep 2016 Mar 9;6:22891. Epub 2016 Mar 9.

Center for Primary Health Care Research, Lund University, Sweden.

View Article
March 2016

Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.

PLoS One 2015 23;10(3):e0120496. Epub 2015 Mar 23.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
February 2016

Oncolytic virotherapy for treatment of breast cancer, including triple-negative breast cancer.

Oncoimmunology 2016 Feb 27;5(2):e1078057. Epub 2015 Aug 27.

University of Helsinki, Faculty of Medicine, Department of Pathology, Cancer Gene Therapy Group, Helsinki, Finland; TILT Biotherapeutics Ltd., Helsinki, Finland; Helsinki University Central Hospital, Department of Oncology, Helsinki, Finland.

View Article
February 2016

Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues.

Mol Ther 2015 Oct 9;23(10):1641-52. Epub 2015 Jul 9.

Cancer Gene Therapy Group, Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

View Article
October 2015

Adenovirus Improves the Efficacy of Adoptive T-cell Therapy by Recruiting Immune Cells to and Promoting Their Activity at the Tumor.

Cancer Immunol Res 2015 Aug 14;3(8):915-25. Epub 2015 May 14.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland. TILT Biotherapeutics Ltd, Helsinki, Finland. Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

View Article
August 2015

Attenuated Semliki Forest virus for cancer treatment in dogs: safety assessment in two laboratory Beagles.

BMC Vet Res 2015 Jul 28;11:170. Epub 2015 Jul 28.

A. I. Virtanen Institute for Molecular Sciences, Biotechnology and Molecular Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

View Article
July 2015

T-cell subsets in peripheral blood and tumors of patients treated with oncolytic adenoviruses.

Mol Ther 2015 05 6;23(5):964-973. Epub 2015 Feb 6.

Cancer Gene Therapy Group, Department of Pathology and Transplantation laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd., Helsinki, Finland. Electronic address:

View Article
May 2015

GMCSF-armed vaccinia virus induces an antitumor immune response.

Int J Cancer 2015 Mar 10;136(5):1065-72. Epub 2014 Jul 10.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
March 2015

Immunological effects of a tumor necrosis factor alpha-armed oncolytic adenovirus.

Hum Gene Ther 2015 Mar 10;26(3):134-44. Epub 2015 Feb 10.

1 Laboratory of Immunovirotherapy, Division of Pharmaceutical Biosciences and Centre for Drug Research, Faculty of Pharmacy, University of Helsinki , 00790 Helsinki, Finland .

View Article
March 2015

Serum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy.

Oncoimmunology 2015 Mar 2;4(3):e989771. Epub 2015 Apr 2.

Transplantation laboratory; Cancer Gene Therapy Group (CGTG); Haartman Institute; University of Helsinki ; Helsinki, Finland ; TILT Biotherapeutics Ltd. ; Helsinki, Finland.

View Article
March 2015

Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma.

Int J Cancer 2015 Feb 3;136(4):945-54. Epub 2014 Jul 3.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
February 2015

Case-control estimation of the impact of oncolytic adenovirus on the survival of patients with refractory solid tumors.

Mol Ther 2015 Feb 10;23(2):321-9. Epub 2014 Nov 10.

1] Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, Helsinki, Finland [2] Docrates Hospital, Helsinki, Finland [3] TILT Biotherapeutics Ltd, Helsinki, Finland.

View Article
February 2015

Smoking and body mass index as risk factors for subtypes of cancer of unknown primary.

Int J Cancer 2015 Jan 20;136(1):246-7. Epub 2014 May 20.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany; Center for Primary Health Care Research, Lund University, Malmö, Sweden.

View Article
January 2015

Collection and use of family history in oncology clinics.

J Clin Oncol 2014 Oct 2;32(29):3344-5. Epub 2014 Sep 2.

Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
October 2014

Consensus guidelines for the detection of immunogenic cell death.

Oncoimmunology 2014 Oct 13;3(9):e955691. Epub 2014 Dec 13.

Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers ; Paris, France ; INSERM; U1138 ; Paris, France ; Gustave Roussy Cancer Campus ; Villejuif, France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris, France.

View Article
October 2014

Oncolytic immunotherapy: where are we clinically?

Authors:
Akseli Hemminki

Scientifica (Cairo) 2014 16;2014:862925. Epub 2014 Jan 16.

Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland ; TILT Biotherapeutics Ltd., P. Hesperiankatu 37A22, 00260 Helsinki, Finland.

View Article
June 2014

Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site.

BMC Cancer 2014 Jun 14;14:439. Epub 2014 Jun 14.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany.

View Article
June 2014

[(18)F]-fluorodeoxyglucose positron emission tomography and computed tomography in response evaluation of oncolytic adenovirus treatments of patients with advanced cancer.

Hum Gene Ther 2013 Dec 7;24(12):1029-41. Epub 2013 Nov 7.

1 Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki , 00290 Helsinki, Finland .

View Article
December 2013

Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism.

PLoS One 2013 9;8(4):e60032. Epub 2013 Apr 9.

Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
October 2013

Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment.

J Transl Med 2013 Aug 21;11:193. Epub 2013 Aug 21.

Cancer Gene Therapy Group, Department of Pathology and Transplantation laboratory, Haartman Institute, University of Helsinki, Haartmaninkatu 3, Helsinki 00290, Finland.

View Article
August 2013

Site-specific survival rates for cancer of unknown primary according to location of metastases.

Int J Cancer 2013 Jul 15;133(1):182-9. Epub 2013 Jan 15.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

View Article
July 2013

MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver.

PLoS One 2013 22;8(1):e54506. Epub 2013 Jan 22.

Department of Virology, Haartman Institute, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.

View Article
July 2013

Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus.

Clin Cancer Res 2013 May 14;19(10):2734-44. Epub 2013 Mar 14.

Cancer Gene Therapy Group, Department of Pathology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
May 2013

Chapter eight--Oncolytic adenoviruses for cancer immunotherapy: data from mice, hamsters, and humans.

Adv Cancer Res 2012 ;115:265-318

Laboratory of Immunovirotherapy, Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

View Article
February 2013

Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer.

BMC Cancer 2013 Jan 28;13:36. Epub 2013 Jan 28.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre, DKFZ, 69120 Heidelberg, Germany.

View Article
January 2013

Deficiency of the complex I of the mitochondrial respiratory chain but improved adenylate control over succinate-dependent respiration are human gastric cancer-specific phenomena.

Mol Cell Biochem 2012 Nov 21;370(1-2):69-78. Epub 2012 Jul 21.

Department of Pathophysiology, Institute of General and Molecular Pathology, Faculty of Medicine, University of Tartu, Tartu, Estonia.

View Article
November 2012

An oncolytic adenovirus enhanced for toll-like receptor 9 stimulation increases antitumor immune responses and tumor clearance.

Mol Ther 2012 Nov 24;20(11):2076-86. Epub 2012 Jul 24.

Cancer Gene Therapy Group, Molecular Cancer Biology Research Program, Transplantation Laboratory, Haartman Institute and Finnish Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article
November 2012

Capsid-modified adenoviral vectors for improved muscle-directed gene therapy.

Hum Gene Ther 2012 Oct 13;23(10):1065-70. Epub 2012 Aug 13.

Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

View Article
October 2012

Ad3-hTERT-E1A, a fully serotype 3 oncolytic adenovirus, in patients with chemotherapy refractory cancer.

Mol Ther 2012 Sep 7;20(9):1821-30. Epub 2012 Aug 7.

Cancer Gene Therapy Group, Haartman Institute and Transplantation Laboratory, University of Helsinki, Helsinki, Finland.

View Article
September 2012

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.

Chem Commun (Camb) 2012 Sep 9;48(74):9310-2. Epub 2012 Aug 9.

Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy.

View Article
September 2012

Oncolytic adenoviruses: A potent form of tumor immunovirotherapy.

Oncoimmunology 2012 Sep;1(6):979-981

Laboratory of Immunovirotherapy; University of Helsinki; Helsinki, Finland ; Cancer Gene Therapy Group, Molecular Cancer Biology Program & Transplantation Laboratory & Haartman Institute; University of Helsinki; Helsinki, Finland.

View Article
September 2012

SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I.

PLoS One 2012 7;7(3):e32871. Epub 2012 Mar 7.

Cancer Gene Therapy Group, Molecular Cancer Biology Program, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
August 2012

Portrait of a leader in immunotherapeutics: oncolytic viruses for treatment of cancer.

Authors:
Akseli Hemminki

Hum Vaccin Immunother 2012 Aug 1;8(8):1018-21. Epub 2012 Aug 1.

K. Albin Johansson Research Professor, Finnish Cancer Institute, Group leader, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
August 2012

Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer.

Int J Cancer 2012 Jul 14;131(1):253-63. Epub 2011 Sep 14.

Cancer Gene Therapy Group, Molecular Cancer Biology Program, Transplantation Laboratory, Haartman Institute and Finnish Institute of Molecular Medicine, University of Helsinki, Finland.

View Article
July 2012

Radiation-induced upregulation of gene expression from adenoviral vectors mediated by DNA damage repair and regulation.

Int J Radiat Oncol Biol Phys 2012 May 20;83(1):376-84. Epub 2011 Oct 20.

Cancer Gene Therapy Group, Molecular Cancer Biology Program, Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.

View Article
May 2012

Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.

Cancer Res 2012 May 6;72(9):2327-38. Epub 2012 Mar 6.

Cancer Gene Therapy Group, Molecular Cancer Biology Program & Transplantation Laboratory & Haartman Institute & Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article
May 2012

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy.

PLoS One 2011 3;6(11):e26810. Epub 2011 Nov 3.

Cancer Gene Therapy Group, Molecular Cancer Biology Program, Transplantation Laboratory, Haartman Institute and Finnish Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article
March 2012

Verapamil results in increased blood levels of oncolytic adenovirus in treatment of patients with advanced cancer.

Mol Ther 2012 Jan 1;20(1):221-9. Epub 2011 Nov 1.

Cancer Gene Therapy Group, Transplantation Laboratory, Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article
January 2012

Induction of interferon pathways mediates in vivo resistance to oncolytic adenovirus.

Mol Ther 2011 Oct 26;19(10):1858-66. Epub 2011 Jul 26.

Cancer Gene Therapy Group, Molecular Cancer Biology Program, Transplantation Laboratory, Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article
October 2011

Serotype chimeric human adenoviruses for cancer gene therapy.

Viruses 2010 Oct 30;2(10):2196-212. Epub 2010 Sep 30.

Cancer Gene Therapy Group, Molecular Cancer Biology Program, University of Helsinki, P.O. Box 63, 00014 University of Helsinki, Finland; E-Mail:

View Article
October 2010