Akram Ghantous

Akram Ghantous

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Akram Ghantous

Akram Ghantous

Publications by authors named "Akram Ghantous"

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38Publications

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Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system.

Nucleic Acids Res 2019 Aug 14. Epub 2019 Aug 14.

Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.

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http://dx.doi.org/10.1093/nar/gkz709DOI Listing
August 2019

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 04 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478731PMC
April 2019

The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C).

Int J Cancer 2019 01 26;144(1):26-33. Epub 2018 Oct 26.

The George Institute for Global Health, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1002/ijc.31635DOI Listing
January 2019

The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review).

Curr Environ Health Rep 2018 12;5(4):544-578

Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

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http://link.springer.com/10.1007/s40572-018-0218-8
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http://dx.doi.org/10.1007/s40572-018-0218-8DOI Listing
December 2018

Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon.

J Assist Reprod Genet 2018 Sep 21;35(9):1691-1701. Epub 2018 Jun 21.

Environment Core Laboratory, Department of Pathology and Laboratory Medicine, Faculty of Medicine, American University of Beirut Medical Center, American University of Beirut, PO Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon.

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http://link.springer.com/10.1007/s10815-018-1236-z
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http://dx.doi.org/10.1007/s10815-018-1236-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133818PMC
September 2018

Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes.

Int J Cancer 2018 08 6;143(3):597-609. Epub 2018 Apr 6.

Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, Lyon, 69372, France.

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http://dx.doi.org/10.1002/ijc.31381DOI Listing
August 2018

DNA Methylation Analysis from Blood Spots: Increasing Yield and Quality for Genome-Wide and Locus-Specific Methylation Analysis.

Methods Mol Biol 2018 ;1708:605-619

Epigenetics Group, International Agency for Research on Cancer (IARC), 150 rue Albert-Thomas, 69008, Lyon, France.

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http://link.springer.com/10.1007/978-1-4939-7481-8_31
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http://dx.doi.org/10.1007/978-1-4939-7481-8_31DOI Listing
July 2018

Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of .

Clin Epigenetics 2017 8;9:62. Epub 2017 Jun 8.

Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008 Lyon, France.

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http://dx.doi.org/10.1186/s13148-017-0359-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465463PMC
April 2018

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.

Authors:
Janine F Felix Bonnie R Joubert Andrea A Baccarelli Gemma C Sharp Catarina Almqvist Isabella Annesi-Maesano Hasan Arshad Nour Baïz Marian J Bakermans-Kranenburg Kelly M Bakulski Elisabeth B Binder Luigi Bouchard Carrie V Breton Bert Brunekreef Kelly J Brunst Esteban G Burchard Mariona Bustamante Leda Chatzi Monica Cheng Munthe-Kaas Eva Corpeleijn Darina Czamara Dana Dabelea George Davey Smith Patrick De Boever Liesbeth Duijts Terence Dwyer Celeste Eng Brenda Eskenazi Todd M Everson Fahimeh Falahi M Daniele Fallin Sara Farchi Mariana F Fernandez Lu Gao Tom R Gaunt Akram Ghantous Matthew W Gillman Semira Gonseth Veit Grote Olena Gruzieva Siri E Håberg Zdenko Herceg Marie-France Hivert Nina Holland John W Holloway Cathrine Hoyo Donglei Hu Rae-Chi Huang Karen Huen Marjo-Riitta Järvelin Dereje D Jima Allan C Just Margaret R Karagas Robert Karlsson Wilfried Karmaus Katerina J Kechris Juha Kere Manolis Kogevinas Berthold Koletzko Gerard H Koppelman Leanne K Küpers Christine Ladd-Acosta Jari Lahti Nathalie Lambrechts Sabine A S Langie Rolv T Lie Andrew H Liu Maria C Magnus Per Magnus Rachel L Maguire Carmen J Marsit Wendy McArdle Erik Melén Phillip Melton Susan K Murphy Tim S Nawrot Lorenza Nisticò Ellen A Nohr Björn Nordlund Wenche Nystad Sam S Oh Emily Oken Christian M Page Patrice Perron Göran Pershagen Costanza Pizzi Michelle Plusquin Katri Raikkonen Sarah E Reese Eva Reischl Lorenzo Richiardi Susan Ring Ritu P Roy Peter Rzehak Greet Schoeters David A Schwartz Sylvain Sebert Harold Snieder Thorkild I A Sørensen Anne P Starling Jordi Sunyer Jack A Taylor Henning Tiemeier Vilhelmina Ullemar Marina Vafeiadi Marinus H Van Ijzendoorn Judith M Vonk Annette Vriens Martine Vrijheid Pei Wang Joseph L Wiemels Allen J Wilcox Rosalind J Wright Cheng-Jian Xu Zongli Xu Ivana V Yang Paul Yousefi Hongmei Zhang Weiming Zhang Shanshan Zhao Golareh Agha Caroline L Relton Vincent W V Jaddoe Stephanie J London

Int J Epidemiol 2018 02;47(1):22-23u

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, USA.

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http://dx.doi.org/10.1093/ije/dyx190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837319PMC
February 2018

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.

Hum Mol Genet 2017 10;26(20):4067-4085

MRC Integrative Epidemiology Unit.

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http://dx.doi.org/10.1093/hmg/ddx290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656174PMC
October 2017

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference.

EMBO Mol Med 2016 08 1;8(8):863-77. Epub 2016 Aug 1.

Dependence Receptors, Cancer and Development Laboratory - Equipe labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon (CRCL), INSERM U1052-CNRS UMR5286 Université de Lyon Centre Léon Bérard, Lyon, France

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http://dx.doi.org/10.15252/emmm.201505945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967941PMC
August 2016

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.

Authors:
Bonnie R Joubert Janine F Felix Paul Yousefi Kelly M Bakulski Allan C Just Carrie Breton Sarah E Reese Christina A Markunas Rebecca C Richmond Cheng-Jian Xu Leanne K Küpers Sam S Oh Cathrine Hoyo Olena Gruzieva Cilla Söderhäll Lucas A Salas Nour Baïz Hongmei Zhang Johanna Lepeule Carlos Ruiz Symen Ligthart Tianyuan Wang Jack A Taylor Liesbeth Duijts Gemma C Sharp Soesma A Jankipersadsing Roy M Nilsen Ahmad Vaez M Daniele Fallin Donglei Hu Augusto A Litonjua Bernard F Fuemmeler Karen Huen Juha Kere Inger Kull Monica Cheng Munthe-Kaas Ulrike Gehring Mariona Bustamante Marie José Saurel-Coubizolles Bilal M Quraishi Jie Ren Jörg Tost Juan R Gonzalez Marjolein J Peters Siri E Håberg Zongli Xu Joyce B van Meurs Tom R Gaunt Marjan Kerkhof Eva Corpeleijn Andrew P Feinberg Celeste Eng Andrea A Baccarelli Sara E Benjamin Neelon Asa Bradman Simon Kebede Merid Anna Bergström Zdenko Herceg Hector Hernandez-Vargas Bert Brunekreef Mariona Pinart Barbara Heude Susan Ewart Jin Yao Nathanaël Lemonnier Oscar H Franco Michael C Wu Albert Hofman Wendy McArdle Pieter Van der Vlies Fahimeh Falahi Matthew W Gillman Lisa F Barcellos Ashish Kumar Magnus Wickman Stefano Guerra Marie-Aline Charles John Holloway Charles Auffray Henning W Tiemeier George Davey Smith Dirkje Postma Marie-France Hivert Brenda Eskenazi Martine Vrijheid Hasan Arshad Josep M Antó Abbas Dehghan Wilfried Karmaus Isabella Annesi-Maesano Jordi Sunyer Akram Ghantous Göran Pershagen Nina Holland Susan K Murphy Dawn L DeMeo Esteban G Burchard Christine Ladd-Acosta Harold Snieder Wenche Nystad Gerard H Koppelman Caroline L Relton Vincent W V Jaddoe Allen Wilcox Erik Melén Stephanie J London

Am J Hum Genet 2016 Apr 31;98(4):680-96. Epub 2016 Mar 31.

National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833289PMC
April 2016

Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk.

Mutagenesis 2015 Nov 26;30(6):733-42. Epub 2015 Feb 26.

The George Institute for Global Health and Nuffield Department of Population Health, Oxford Martin School | University of Oxford, 34 Broad Street Oxford OX1 3BD, UK.

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http://dx.doi.org/10.1093/mutage/gev010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757935PMC
November 2015

Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling.

BMC Biotechnol 2014 Jul 1;14:60. Epub 2014 Jul 1.

Epigenetics Group, International Agency for Research on Cancer (IARC), 150 rue Albert-Thomas, 69008 Lyon, France.

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http://dx.doi.org/10.1186/1472-6750-14-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086704PMC
July 2014

Parthenolide: from plant shoots to cancer roots.

Drug Discov Today 2013 Sep 17;18(17-18):894-905. Epub 2013 May 17.

International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1016/j.drudis.2013.05.005DOI Listing
September 2013

Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21.

Cancer Prev Res (Phila) 2012 Nov 4;5(11):1298-309. Epub 2012 Oct 4.

Department of Biology, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0230DOI Listing
November 2012

Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells.

BMC Complement Altern Med 2012 Jul 9;12:89. Epub 2012 Jul 9.

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1186/1472-6882-12-89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439278PMC
July 2012

Epigenetic mechanisms of plant-derived anticancer drugs.

Front Biosci (Landmark Ed) 2012 Jan 1;17:129-73. Epub 2012 Jan 1.

Division Experimental Tumorpathology, Institute for Pathology, University Erlangen-Nuremberg, Erlangen, Germany.

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January 2012

What made sesquiterpene lactones reach cancer clinical trials?

Drug Discov Today 2010 Aug 9;15(15-16):668-78. Epub 2010 Jun 9.

Biology Department, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.drudis.2010.06.002DOI Listing
August 2010

Structure-activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth.

Eur J Med Chem 2009 Sep 4;44(9):3794-7. Epub 2009 May 4.

American University of Beirut, Department of Biology, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.ejmech.2009.04.029DOI Listing
September 2009