Akos Nemecz

Akos Nemecz

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Akos Nemecz

Akos Nemecz

Publications by authors named "Akos Nemecz"

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Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.

Proc Natl Acad Sci U S A 2018 04 9;115(17):E3959-E3968. Epub 2018 Apr 9.

Unité Dynamique Structurale des Macromolécules, Institut Pasteur, UMR 3528, CNRS, 75015 Paris, France;

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http://dx.doi.org/10.1073/pnas.1717700115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924894PMC
April 2018

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.

PLoS Biol 2017 12 27;15(12):e2004470. Epub 2017 Dec 27.

Unité Récepteurs-Canaux, Unité Mixte de Recherche 3571 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1371/journal.pbio.2004470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760087PMC
December 2017

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels.

Neuron 2016 05;90(3):452-70

Channel-Receptors Unit, Institut Pasteur, 75015 Paris, France; CNRS UMR 3571, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.03.032DOI Listing
May 2016

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Proc Natl Acad Sci U S A 2014 Jan 23;111(3):966-71. Epub 2013 Dec 23.

Unité de Dynamique Structurale des Macromolécules, Unité Mixte de Recherche (UMR) 3528 du Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, 75015 Paris, France.

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http://dx.doi.org/10.1073/pnas.1314997111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903189PMC
January 2014

Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.

Mol Pharmacol 2012 Oct 11;82(4):687-99. Epub 2012 Jul 11.

Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1124/mol.112.080291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463225PMC
October 2012

The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor.

Life Sci 2012 Aug 28;91(3-4):107-14. Epub 2012 Jun 28.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1016/j.lfs.2012.06.017DOI Listing
August 2012

Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses.

J Biol Chem 2011 Dec 18;286(49):42555-65. Epub 2011 Oct 18.

Departments of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0650, USA.

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http://dx.doi.org/10.1074/jbc.M111.286583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234955PMC
December 2011

Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.

PLoS One 2011 Jan 28;6(1):e16519. Epub 2011 Jan 28.

Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016519PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030600PMC
January 2011