Publications by authors named "Akira Nakagawara"

100Publications

De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers.

Jpn J Clin Oncol 2020 Aug;50(8):839-846

Saga HIMAT Foundation, Tosu, Saga, Japan.

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http://dx.doi.org/10.1093/jjco/hyaa097DOI Listing
August 2020

TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma.

Biochem Biophys Res Commun 2019 10 17;518(2):311-318. Epub 2019 Aug 17.

Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Nitona 666-2, Chuo-ku, Chiba, 260-8717, Japan; Saga HIMAT Foundation, 3049 Harakoga-machi, Tosu, Saga, 841-0071, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.08.052DOI Listing
October 2019

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells.

Int J Mol Sci 2019 Jul 29;20(15). Epub 2019 Jul 29.

Department of Biomedical Sciences, Division of Biochemistry, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.

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http://dx.doi.org/10.3390/ijms20153700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696225PMC
July 2019

Pediatric patients with cancer predisposition in Japan: Results of a questionnaire survey.

Pediatr Blood Cancer 2019 10 19;66(10):e27937. Epub 2019 Jul 19.

Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1002/pbc.27937DOI Listing
October 2019

Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.

BMC Cancer 2019 Jun 6;19(1):542. Epub 2019 Jun 6.

Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1186/s12885-019-5772-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555734PMC
June 2019

Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1.

Mol Carcinog 2019 07 11;58(7):1134-1144. Epub 2019 Mar 11.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://doi.wiley.com/10.1002/mc.22997
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http://dx.doi.org/10.1002/mc.22997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593999PMC
July 2019

Neuroblastoma.

Jpn J Clin Oncol 2018 Mar;48(3):214-241

Department of Pediatrics, Saga University, Saga 849-8501, Japan.

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https://academic.oup.com/jjco/article/48/3/214/4825045
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http://dx.doi.org/10.1093/jjco/hyx176DOI Listing
March 2018

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.

J Natl Cancer Inst 2017 11;109(11)

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan; Department of Pediatrics, Graduate School of Medicine, Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Pediatrics and Adolescent Medicine, School of Medicine, Juntendo University, Tokyo, Japan; Department of Pediatric Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan, Department of Pediatrics, Nagara Medical Center, Gifu, Japan; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan; Division of Cancer Genomics, Saitama Cancer Center Research Institute, Saitama, Japan; Division of Cancer Genomics, Chiba Cancer Center, Chiba, Japan; Gunma Children's Medical Center, Gunma, Japan; Saga Medical Center, Saga, Japan.

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http://dx.doi.org/10.1093/jnci/djx062DOI Listing
November 2017

Neuroblastoma.

Nat Rev Dis Primers 2016 11 10;2:16078. Epub 2016 Nov 10.

Department of Pediatrics and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nrdp.2016.78DOI Listing
November 2016

Transcriptional regulation of BMCC1 mediated by E2F1 in neuroblastoma cells.

Biochem Biophys Res Commun 2016 09 22;478(1):81-86. Epub 2016 Jul 22.

Saga Medical Center KOSEIKAN, Saga, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2016.07.089DOI Listing
September 2016

Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior.

Neurochem Int 2016 07 7;97:42-8. Epub 2016 May 7.

Saga-ken Medical Center Koseikan, Saga 840-8571, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2016.04.017DOI Listing
July 2016

Clinical Experience of SAGA HIMAT.

Int J Part Ther 2016 9;2(3):464-467. Epub 2016 Feb 9.

Ion Beam Therapy Center, SAGA HIMAT Foundation, 3049 Harakoga-machi, Tosu, Saga 841-0071 Japan.

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http://dx.doi.org/10.14338/IJPT-15-00017.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874195PMC
February 2016

Advances in Risk Classification and Treatment Strategies for Neuroblastoma.

J Clin Oncol 2015 Sep 24;33(27):3008-17. Epub 2015 Aug 24.

Navin R. Pinto, Mark A. Applebaum, Samuel L. Volchenboum, and Susan L. Cohn, Comer Children's Hospital, University of Chicago, Chicago, IL; Katherine K. Matthay, University of California San Francisco (UCSF) Benioff Children's Hospital, UCSF School of Medicine, San Francisco, CA; Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Peter F. Ambros, Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria; Akira Nakagawara, Saga Medical Center Koseikan, Saga, Japan; Frank Berthold, Children's Hospital, University of Cologne, Koln, Germany; Gudrun Schleiermacher, Institut Curie, Paris; Dominique Valteau-Couanet, Gustave Roussy, Villejuif, France; Julie R. Park, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA; and Andrew D.J. Pearson, Institute of Cancer Research and Royal Marsden Hospital, Surrey, United Kingdom.

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http://jco.ascopubs.org/content/33/27/3008.full.pdf
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http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-07.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.4648
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http://dx.doi.org/10.1200/JCO.2014.59.4648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567703PMC
September 2015

Sendai virus-mediated expression of reprogramming factors promotes plasticity of human neuroblastoma cells.

Cancer Sci 2015 Oct 18;106(10):1351-61. Epub 2015 Aug 18.

Division of Biochemistry and Innovative Cancer Therapeutics and Children's Cancer Research Center, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1111/cas.12746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638011PMC
October 2015

Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.

Exp Anim 2015 6;64(4):407-14. Epub 2015 Jul 6.

Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho, Chuouku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1538/expanim.15-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637378PMC
June 2016

NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells.

Biochem Biophys Res Commun 2015 Jun 17;461(3):501-6. Epub 2015 Apr 17.

Division of Biochemistry and Innovative Cancer Therapeutics and Children's Cancer Research Center, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.04.050DOI Listing
June 2015

Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas.

Cancer Sci 2015 Jul 19;106(7):840-7. Epub 2015 May 19.

Division of Biochemistry and Innovative Cancer Therapeutics and Children's Cancer Research Center, Chiba, Japan.

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http://dx.doi.org/10.1111/cas.12677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520635PMC
July 2015

Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiation.

Biochem Biophys Res Commun 2014 Oct 23;453(1):86-93. Epub 2014 Sep 23.

Saga Medical Centre, 840-8571, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2014.09.065DOI Listing
October 2014

Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project.

J Clin Oncol 2014 Oct 25;32(28):3169-76. Epub 2014 Aug 25.

Kieuhoa T. Vo, Katherine K. Matthay, John Neuhaus, and Steven G. DuBois, Benioff Children's Hospital and University of California, San Francisco, San Francisco; Doug Miniati, Kaiser Permanente Medical Center, Roseville, CA; Wendy B. London, Children's Oncology Group Statistics and Data Center and Dana-Farber Children's Hospital Cancer Center, Boston, MA; Barbara Hero, Children's Hospital, University of Cologne, Köln, Germany; Peter F. Ambros, Children's Cancer Research Institute, St Anne Kinderkrebsforschung, Vienna, Austria; Akira Nakagawara, Chiba Cancer Center Research Institute and Chiba University, Chiba, Japan; Kate Wheeler, Oxford Children's Hospital, Oxford; Andrew D.J. Pearson, Institute of Cancer Research and Royal Marsden Hospital, Surrey, United Kingdom; Susan L. Cohn, The University of Chicago, Chicago, IL.

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http://jco.ascopubs.org/content/early/2014/08/25/JCO.2014.56
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.56.1621
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http://dx.doi.org/10.1200/JCO.2014.56.1621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171360PMC
October 2014

Significance of clinical and biologic features in Stage 3 neuroblastoma: a report from the International Neuroblastoma Risk Group project.

Pediatr Blood Cancer 2014 Nov 7;61(11):1932-9. Epub 2014 Jul 7.

Department of Hematology/Oncology, Children's National Medical Center, Washington, District of Columbia.

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http://dx.doi.org/10.1002/pbc.25134DOI Listing
November 2014

Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.

Cancer Res 2014 Jul 15;74(14):3790-801. Epub 2014 May 15.

Authors' Affiliations: Division of Metastasis and Invasion Signaling, National Cancer Center Research Institute;

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0241DOI Listing
July 2014

RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients.

Cancer Lett 2014 Jun 26;348(1-2):167-76. Epub 2014 Mar 26.

Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835140017
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http://dx.doi.org/10.1016/j.canlet.2014.03.022DOI Listing
June 2014

Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: A study from the International Neuroblastoma Risk Group Database.

J Clin Oncol 2014 Apr 24;32(12):1228-35. Epub 2014 Mar 24.

Daniel A. Morgenstern and Meredith S. Irwin, Hospital for Sick Children and University of Toronto; Derek Stephens, Hospital for Sick Children, Toronto, ON, Canada; Daniel A. Morgenstern, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London; Andrew D.J. Pearson, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Samuel L. Volchenboum and Susan L. Cohn, University of Chicago, Chicago, IL; Barbara Hero, University Children's Hospital, Köln, Germany; Andrea Di Cataldo, University of Catania, Catania, Italy; Akira Nakagawara, Chiba University School of Medicine, Chiba, Japan; Hiroyuki Shimada, University of Southern California at Los Angeles, Los Angeles; Katherine K. Matthay, University of California at San Francisco, San Francisco, CA; and Peter F. Ambros, St. Anna Kinderkrebsforschung, Vienna, Austria.

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http://dx.doi.org/10.1200/JCO.2013.53.6342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876342PMC
April 2014

Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway.

Eur J Cancer 2014 May 19;50(8):1555-65. Epub 2014 Feb 19.

Division of Biochemistry and Molecular Carcinogenesis, Chiba Cancer Center Research Institute, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.01.023DOI Listing
May 2014

Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma.

Cancer Med 2014 Feb 1;3(1):25-35. Epub 2014 Jan 1.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, 260-8717, Japan.

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http://dx.doi.org/10.1002/cam4.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930387PMC
February 2014

[A novel role of RUNX2 in the regulation of p53-dependent DNA damage response].

Seikagaku 2013 Nov;85(11):1002-7

Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.

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November 2013

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma.

Sci Rep 2013 Dec 20;3:3450. Epub 2013 Dec 20.

1] Division of Biochemistry & Innovative Cancer Therapeutics, and Children's Cancer Research Center, Chiba Cancer Center, Chiba, Japan [2] Department of Molecular Biology and Oncology, Chiba University Graduate School of Medicine, Chiba, Japan.

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http://dx.doi.org/10.1038/srep03450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868972PMC
December 2013

NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.

PLoS One 2013 11;8(12):e82744. Epub 2013 Dec 11.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082744PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859618PMC
October 2014

Two cases of neuroblastoma comprising two distinct clones.

Pediatr Blood Cancer 2014 Apr 20;61(4):760-2. Epub 2013 Sep 20.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/pbc.24779DOI Listing
April 2014

RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response.

Int J Genomics 2013 3;2013:271347. Epub 2013 Sep 3.

Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuohku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1155/2013/271347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775453PMC
June 2014

Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.

J Clin Invest 2013 Jul 17;123(7):2935-47. Epub 2013 Jun 17.

Division of Biochemistry and Innovative Cancer Therapeutics and Children's Cancer Research Center, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1172/JCI65988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696554PMC
July 2013

Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas.

Jpn J Clin Oncol 2013 Jun 25;43(6):641-5. Epub 2013 Apr 25.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyt058DOI Listing
June 2013

Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.

Sci Rep 2013 29;3:1160. Epub 2013 Jan 29.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1038/srep01160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557454PMC
July 2013

Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma.

Cancer Sci 2013 May 13;104(5):563-72. Epub 2013 Mar 13.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1111/cas.12115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657181PMC
May 2013

Apoptotic cell death in neuroblastoma.

Cells 2013 Jun 20;2(2):432-59. Epub 2013 Jun 20.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.3390/cells2020432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972687PMC
June 2013

A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.

Cancer Lett 2013 Apr 23;331(1):115-21. Epub 2012 Dec 23.

Saiseikai Shiga Hospital, Saiseikai Imperial Gift Foundation Inc., Ritto, Shiga, Japan.

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http://dx.doi.org/10.1016/j.canlet.2012.12.011DOI Listing
April 2013

Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2.

Biochem Biophys Res Commun 2013 Jan 21;430(3):1034-9. Epub 2012 Dec 21.

Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.11.121DOI Listing
January 2013

Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation.

J Biol Chem 2013 Jan 12;288(2):1353-64. Epub 2012 Nov 12.

Laboratory of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1074/jbc.M112.402594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543018PMC
January 2013

Epithelial-mesenchymal transition-related gene expression as a new prognostic marker for neuroblastoma.

Int J Oncol 2013 Jan 6;42(1):134-40. Epub 2012 Nov 6.

Department of Pediatric Surgery, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.3892/ijo.2012.1684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583632PMC
January 2013

Towards a turning point of neuroblastoma therapy.

Cancer Lett 2012 Dec 23;326(2):128-34. Epub 2012 Aug 23.

Italian Neuroblastoma Foundation, IRCCS A.O.U. San Martino-IST, National Cancer Research Institute, Genoa, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835120050
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http://dx.doi.org/10.1016/j.canlet.2012.08.017DOI Listing
December 2012

NLRR1 enhances EGF-mediated MYCN induction in neuroblastoma and accelerates tumor growth in vivo.

Cancer Res 2012 Sep 19;72(17):4587-96. Epub 2012 Jul 19.

Divisions of Biochemistry & Innovative Cancer Therapeutics and Biochemistry and Molecular Carcinogenesis, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0943DOI Listing
September 2012

Molecular and genetic bases of neuroblastoma.

Int J Clin Oncol 2012 Jun 16;17(3):190-5. Epub 2012 May 16.

Division of Biochemistry and Molecular Carcinogenesis, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, Chiba, 260-8717, Japan.

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http://dx.doi.org/10.1007/s10147-012-0415-7DOI Listing
June 2012

Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response.

Biochem Biophys Res Commun 2012 Apr 29;421(1):57-63. Epub 2012 Mar 29.

Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.03.108DOI Listing
April 2012

A novel potent tumour promoter aberrantly overexpressed in most human cancers.

Sci Rep 2011 14;1:15. Epub 2011 Jun 14.

Division of Molecular and Clinical Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1038/srep00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216503PMC
August 2013

Calreticulin mediates nerve growth factor-induced neuronal differentiation.

J Mol Neurosci 2012 Jul 7;47(3):571-81. Epub 2011 Dec 7.

Laboratory of Molecular Neurobiology, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.

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http://dx.doi.org/10.1007/s12031-011-9683-3DOI Listing
July 2012

[Novel role of RUNX3 in the regulation of p53-mediated apoptosis in response to DNA damage].

Seikagaku 2011 Aug;83(8):751-4

Chiba Cancer Center Research Institute, Chiba, Japan.

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August 2011

Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma.

Clin Cancer Res 2011 Nov 9;17(21):6681-92. Epub 2011 Sep 9.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center, Chiba, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0313DOI Listing
November 2011

Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.

PLoS One 2011 May 5;6(5):e19297. Epub 2011 May 5.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chuoh-ku, Chiba, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019297PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088666PMC
May 2011

The 7th Asia Cancer Forum: from the perspective of human security, how can we collaborate as Asians in order to place cancer on the global health agenda? How can we fill in the gaps that exist among us?

Jpn J Clin Oncol 2011 Jun 28;41(6):825-31. Epub 2011 Apr 28.

Department of Strategic Investigation on Comprehensive Cancer Network, Research, Center for Advanced Science and Technology (RCAST), 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904 Japan.

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http://dx.doi.org/10.1093/jjco/hyr052DOI Listing
June 2011

Multigene mutation analysis of metastatic lymph nodes in non-small cell lung cancer diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration.

Chest 2011 Nov 28;140(5):1319-1324. Epub 2011 Apr 28.

Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S001236921160601
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http://dx.doi.org/10.1378/chest.10-3186DOI Listing
November 2011

The 6th Asia cancer forum: what should we do to place cancer on the global health agenda? Sharing information leads to human security.

Jpn J Clin Oncol 2011 May 29;41(5):723-9. Epub 2011 Mar 29.

Department of Strategic Investigation on Comprehensive Cancer Network, Research, Center for Advanced Science and Technology (RCAST), 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1093/jjco/hyr036DOI Listing
May 2011

[Novel molecular mechanism behind p53-dependent apoptosis in response to energetic stress].

Seikagaku 2010 Dec;82(12):1117-20

Chiba Cancer Center Research Institute, 666-2 Nitona, Chuou-ku, Chiba 260-8717, Japan.

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December 2010

CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation.

Biochem Biophys Res Commun 2011 Mar 3;406(1):79-84. Epub 2011 Feb 3.

Laboratory of Anti-tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1100166
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http://dx.doi.org/10.1016/j.bbrc.2011.01.114DOI Listing
March 2011

Bmi1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells.

Cancer Sci 2011 May 15;102(5):983-90. Epub 2011 Mar 15.

Division of Biochemistry and Molecular Carcinogenesis, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2011.01891.xDOI Listing
May 2011

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues.

J Mol Neurosci 2011 Jun 14;44(2):103-14. Epub 2011 Jan 14.

Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

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http://dx.doi.org/10.1007/s12031-010-9490-2DOI Listing
June 2011

Role of p53 in Cell Death and Human Cancers.

Cancers (Basel) 2011 Mar 3;3(1):994-1013. Epub 2011 Mar 3.

Laboratory of Anti-tumor Research, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.

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http://www.mdpi.com/2072-6694/3/1/994
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http://dx.doi.org/10.3390/cancers3010994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756401PMC
March 2011

p53: the attractive tumor suppressor in the cancer research field.

J Biomed Biotechnol 2011 6;2011:603925. Epub 2010 Dec 6.

Laboratory of Anti-Tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1155/2011/603925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004423PMC
May 2011

Concordance for neuroblastoma in monozygotic twins: case report and review of the literature.

J Pediatr Surg 2010 Dec;45(12):2312-6

Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.jpedsurg.2010.08.025DOI Listing
December 2010

MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells.

Biochem Biophys Res Commun 2010 Dec 17;403(3-4):405-11. Epub 2010 Nov 17.

Laboratory of Anti-tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.11.043DOI Listing
December 2010

Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice.

J Biomed Biotechnol 2011 3;2011:831092. Epub 2010 Oct 3.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-Ku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1155/2011/831092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952905PMC
February 2011

Global genomic and RNA profiles for novel risk stratification of neuroblastoma.

Cancer Sci 2010 Nov;101(11):2295-301

Division of Biochemistry and Innovative Cancer Therapeutics Laboratory of Cancer Genomics, Chiba Cancer Center Research Institute, Chuoh-ku, Chiba, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01681.xDOI Listing
November 2010

HDM2 impairs Noxa transcription and affects apoptotic cell death in a p53/p73-dependent manner in neuroblastoma.

Eur J Cancer 2010 Aug 28;46(12):2324-34. Epub 2010 Jun 28.

Division of Biochemistry and Molecular Carcinogenesis, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1016/j.ejca.2010.05.026DOI Listing
August 2010

NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells.

Biochem Biophys Res Commun 2010 Jun 1;397(2):157-62. Epub 2010 Jun 1.

Division of Biochemistry and Anti-tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.05.063DOI Listing
June 2010

Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma.

Cancer Sci 2010 Jul 7;101(7):1646-52. Epub 2010 Apr 7.

Division of Biochemistry and Molecular Carcinogenesis, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01586.xDOI Listing
July 2010

RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.

J Biol Chem 2010 May 30;285(22):16693-703. Epub 2010 Mar 30.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1074/jbc.M109.055525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878082PMC
May 2010

p73-Binding Partners and Their Functional Significance.

Int J Proteomics 2010 13;2010:283863. Epub 2011 Jan 13.

Laboratory of Anti-tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1155/2010/283863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195385PMC
November 2011

LMO3 interacts with p53 and inhibits its transcriptional activity.

Biochem Biophys Res Commun 2010 Feb 6;392(3):252-7. Epub 2009 Dec 6.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.010DOI Listing
February 2010

Dysregulation of platelet-derived growth factor beta-receptor expression by DeltaNp73 in neuroblastoma.

Mol Cancer Res 2009 Dec 1;7(12):2031-9. Epub 2009 Dec 1.

Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0501DOI Listing
December 2009