Publications


A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium.
Cell Death Differ 2017 Aug 19;24(8):1443-1458. Epub 2017 May 19.
Department de Ciències Mèdiques Bàsiques, Oncologic Pathology Group, Universitat de Lleida, Hospital Universitari Arnau de Vilanova, Institut de Recerca Biomèdica de Lleida, Lleida, Spain.


Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy.
Nat Commun 2017 May 22;8:15338. Epub 2017 May 22.
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

The efficacy of surgical treatment of recurrent or persistent cervical cancer that develops in a previously irradiated field: a monoinstitutional experience.
Int J Clin Oncol 2017 May 27. Epub 2017 May 27.
Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation.
Sci Rep 2017 Apr 10;7:46174. Epub 2017 Apr 10.
Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan.

E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation.
Int Immunol 2017 Mar;29(3):133-143
Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0045, Japan.

Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
Mol Cancer Res 2017 Jan 6;15(1):78-92. Epub 2016 Oct 6.
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation.
Biochem Biophys Res Commun 2016 Nov 1;480(1):114-119. Epub 2016 Oct 1.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:

IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema.
Am J Respir Cell Mol Biol 2016 Nov;55(5):697-707
1 Department of Hematology, Oncology, Allergy and Respiratory Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and.





The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice.
Int J Gynecol Cancer 2016 May;26(4):610-8
*Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka; and †Institute of Medicinal Molecular Design, Inc, Bunkyo-ku, Tokyo, Japan.

Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome.
Arthritis Res Ther 2016 May 14;18(1):106. Epub 2016 May 14.
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.



Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
Cytokine 2016 Feb 14;78:87-93. Epub 2015 Dec 14.
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8552, Japan. Electronic address:

A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl(2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and collagen-induced arthritis in vivo.
Biochem Biophys Res Commun 2015 Dec 10;468(4):766-73. Epub 2015 Nov 10.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection.
J Virol 2015 Oct 5;89(20):10399-406. Epub 2015 Aug 5.
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA Washington National Primate Research Center, Seattle, Washington, USA

Control of IFN-γ production and regulatory function by the inducible nuclear protein IκB-ζ in T cells.
J Leukoc Biol 2015 Sep 27;98(3):385-93. Epub 2015 May 27.
*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications.
Eur J Immunol 2015 Sep 26;45(9):2683-93. Epub 2015 Jun 26.
Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, P. R. China.

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
J Exp Med 2015 Sep 24;212(10):1623-40. Epub 2015 Aug 24.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology, Chiyoda-ku, Tokyo 102-0075, Japan

Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens.
Allergol Int 2015 Sep 16;64 Suppl:S24-9. Epub 2015 May 16.
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan.

STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
J Biol Chem 2015 Jul 28;290(28):17462-73. Epub 2015 May 28.
From the Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, 060-0812, Japan,

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells.
Immunity 2015 Jul 30;43(1):65-79. Epub 2015 Jun 30.
Department of Microbiology and Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan, and Japan Science and Technology Agency, CREST, Tokyo 102-0076, Japan. Electronic address:

Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Nat Commun 2015 Jun 10;6:7360. Epub 2015 Jun 10.
1] Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan [2] Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan.

A gp130-Src-YAP module links inflammation to epithelial regeneration.
Nature 2015 Mar 25;519(7541):57-62. Epub 2015 Feb 25.
1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [3] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

Anti-IL-12/23 p40 antibody attenuates experimental chronic graft-versus-host disease via suppression of IFN-γ/IL-17-producing cells.
J Immunol 2015 Feb 19;194(3):1357-63. Epub 2014 Dec 19.
Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan;

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.
Proc Natl Acad Sci U S A 2015 Jan 24;112(1):160-5. Epub 2014 Dec 24.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan; Core Research for Evolutional Science and Technology Program, Japan Science and Technology Agency, Tokyo 102-0076, Japan;


Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression.
Biochem Biophys Res Commun 2014 May 13;447(3):471-8. Epub 2014 Apr 13.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan; Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan. Electronic address:


A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis.
J Hepatol 2014 Jan 20;60(1):175-82. Epub 2013 Aug 20.
Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:



Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
J Immunol 2013 Sep 2;191(5):2360-71. Epub 2013 Aug 2.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.

Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging.
J Cell Biol 2013 Sep;202(6):967-83
Institute for Integrated Cell-Material Sciences, 2 Institute for Frontier Medical Sciences, and 3 Department of Materials Science and Engineering, Kyoto University, Kyoto 606-8501, Japan.

CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice.
Biochem Biophys Res Commun 2013 Jun 9;435(3):378-84. Epub 2013 May 9.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.
Cell Host Microbe 2013 Jun;13(6):711-22
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

Overexpression of SOCS3 in T lymphocytes leads to impaired interleukin-17 production and severe aortic aneurysm formation in mice--brief report.
Arterioscler Thromb Vasc Biol 2013 Mar 17;33(3):581-4. Epub 2013 Jan 17.
Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Research Center, and Université Paris-Descartes, Paris, France.





Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice.
Clin Immunol 2012 Sep 14;144(3):272-82. Epub 2012 Jul 14.
Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.
Diabetes 2012 Aug 14;61(8):1935-48. Epub 2012 May 14.
Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines.
PLoS One 2012 5;7(7):e40343. Epub 2012 Jul 5.
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan.


Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo.
Biochem Biophys Res Commun 2012 Jun 24;423(2):247-52. Epub 2012 May 24.
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.

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