Publications by authors named "Akeem Lasisi"

26 Publications

  • Page 1 of 1

Design and methods of the prevalence and pharmacogenomics of tenofovir nephrotoxicity in HIV-positive adults in south-western Nigeria study.

BMC Nephrol 2020 10 16;21(1):436. Epub 2020 Oct 16.

Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Individuals of African descent are at higher risk of developing kidney disease than their European counterparts, and HIV infection is associated with increased risk of nephropathy. Despite a safe renal profile in the clinical trials, long-term use of tenofovir disoproxil fumarate (TDF) has been associated with proximal renal tubulopathy although the underlying mechanisms remain undetermined. We aim to establish the prevalence of and risk factors for TDF-induced kidney tubular dysfunction (KTD) among HIV-I and II individuals treated with TDF in south-west Nigeria. Association between TDF-induced KTD and genetic polymorphisms in renal drug transporter genes and the APOL1 (Apolipoprotein L1) gene will be examined.

Methods: This study has two phases. An initial cross-sectional study will screen 3000 individuals attending the HIV clinics in south-west Nigeria for KTD to determine the prevalence and risk factors. This will be followed by a case-control study of 400 KTD cases and 400 matched controls to evaluate single nucleotide polymorphism (SNP) associations. Data on socio-demographics, risk factors for kidney dysfunction and HIV history will be collected by questionnaire. Blood and urine samples for measurements of severity of HIV disease (CD4 count, viral load) and renal function (creatinine, eGFR, phosphate, uric acid, glucose) will also be collected. Utility of urinary retinol binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG) levels as surrogate markers of KTD will be evaluated. Genomic DNA will be extracted from whole blood and SNP analyses performed using the rhAMP SNP genotyping assays. Statistical analysis including univariate and multivariate logistic regression analyses will be performed to identify factors associated with KTD.

Discussion: In spite of TDF being the most commonly used antiretroviral agent and a key component of many HIV treatment regimens, it has potential detrimental effects on the kidneys. This study will establish the burden and risk factors for TDF-induced KTD in Nigerians, and explore associations between KTD and polymorphisms in renal transporter genes as well as APOL1 risk variants. This study may potentially engender an approach for prevention as well as stemming the burden of CKD in sub-Saharan Africa where GDP per capita is low and budgetary allocation for health is inadequate.
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http://dx.doi.org/10.1186/s12882-020-02082-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565751PMC
October 2020

Childhood hearing loss; a need for primary health care.

Int J Pediatr Otorhinolaryngol 2017 Mar 11;94:117-120. Epub 2017 Jan 11.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan and University College Hospital, Ibadan, Nigeria.

Introduction: Essential health care for children is the care of the ear.

Methods: A cross-sectional descriptive study of 155 children with hearing loss.

Results: A total of 155 pupils with hearing impairment and their parents were interviewed; 77(49.7%) males and 78(50.3%) females, age ranged from 6 to 15years (mean 9.11 ± 2.5 years). None of the participants had neonatal hearing screening. Parents detected the hearing loss at a mean age of 2.3 ± 1.1years. Initial care was given by community health workers and general medical practitioners, only 21 participants had otolaryngological consultation and none had audiological rehabilitation. Barriers to accessing services were financial constraints, poor awareness and non-availability of otolaryngological service for the hearing impaired in the communities.

Conclusion: Hearing impaired children in Nigeria have poor access to ear care. There is a need to create awareness of otological services and incorporate ear-care into the primary health care.
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http://dx.doi.org/10.1016/j.ijporl.2017.01.013DOI Listing
March 2017

Spectrum of DNA variants for non-syndromic deafness in a large cohort from multiple continents.

Hum Genet 2016 08 25;135(8):953-61. Epub 2016 Jun 25.

Department of Otolaryngology (D-48), University of Miami Miller School of Medicine, 1666 NW 12th Avenue, Miami, FL, 33136, USA.

Hearing loss is the most common sensory deficit in humans with causative variants in over 140 genes. With few exceptions, however, the population-specific distribution for many of the identified variants/genes is unclear. Until recently, the extensive genetic and clinical heterogeneity of deafness precluded comprehensive genetic analysis. Here, using a custom capture panel (MiamiOtoGenes), we undertook a targeted sequencing of 180 genes in a multi-ethnic cohort of 342 GJB2 mutation-negative deaf probands from South Africa, Nigeria, Tunisia, Turkey, Iran, India, Guatemala, and the United States (South Florida). We detected causative DNA variants in 25 % of multiplex and 7 % of simplex families. The detection rate varied between 0 and 57 % based on ethnicity, with Guatemala and Iran at the lower and higher end of the spectrum, respectively. We detected causative variants within 27 genes without predominant recurring pathogenic variants. The most commonly implicated genes include MYO15A, SLC26A4, USH2A, MYO7A, MYO6, and TRIOBP. Overall, our study highlights the importance of family history and generation of databases for multiple ethnically discrete populations to improve our ability to detect and accurately interpret genetic variants for pathogenicity.
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http://dx.doi.org/10.1007/s00439-016-1697-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497215PMC
August 2016

Perception of Genetic Testing for Deafness and Factors Associated with Interest in Genetic Testing Among Deaf People in a Selected Population in Sub-Saharan Africa.

J Genet Couns 2015 Dec 19;24(6):1037-43. Epub 2015 May 19.

Department of Otorhinolaryngology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, PO Box 22040, Ibadan, Nigeria.

Understanding the perceptions of genetic testing by members of the deaf community may help in planning deafness genetics research, especially so in the context of strong adherence to cultural values as found among native Africans. Among Yorubas in Nigeria, deafness is perceived to be caused by some offensive actions of the mother during pregnancy, spiritual attack, and childhood infections. We studied attitudes towards, and acceptance of genetic testing by the deaf community in Nigeria. Structured questionnaires were administered to individuals sampled from the Vocational Training Centre for the Deaf, the religious Community, and government schools, among others. The main survey items elicited information about the community in which the deaf people participate, their awareness of genetic testing, whether or not they view genetic testing as acceptable, and their understanding of the purpose of genetic testing. There were 150 deaf participants (61.3 % males, 38.7 % females) with mean age of 26.7 years ±9.8. A majority of survey respondents indicated they relate only with other members of the deaf community (78 %) and reported believing genetic testing does more good than harm (79.3 %); 57 % expressed interest in genetic testing. Interest in genetic testing for deafness or in genetic testing in pregnancy was not related to whether respondents relate primarily to the deaf or to the hearing community. However, a significantly higher number of male respondents and respondents with low education reported interest in genetic testing.
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http://dx.doi.org/10.1007/s10897-015-9843-7DOI Listing
December 2015

Novel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations.

BMC Med Genet 2015 Feb 25;16. Epub 2015 Feb 25.

John P. Hussmann Institute for Human Genomics and John T. Macdonald Foundation, Department of Human Genetics, Miller school of Medicine, University of Miami, 1501 NW 10th Avenue, BRB-610 (M-860), Miami, FL, 33136, USA.

Background: Mutations in the POU3F4 gene cause X-linked deafness type 3 (DFN3), which is characterized by inner ear anomalies.

Methods: Three Turkish, one Ecuadorian, and one Nigerian families were included based on either inner ear anomalies detected in probands or X-linked family histories. Exome sequencing and/or Sanger sequencing were performed in order to identify the causative DNA variants in these families.

Results: Four novel, c.707A>C (p.(Glu236Ala)), c.772delG (p.(Glu258ArgfsX30)), c.902C>T (p.(Pro301Leu)), c.987T>C (p.(Ile308Thr)), and one previously reported mutation c.346delG (p.(Ala116ProfsX26)) in POU3F4, were identified. All mutations identified are predicted to affect the POU-specific or POU homeo domains of the protein and co-segregated with deafness in all families.

Conclusions: Expanding the spectrum of POU3F4 mutations in different populations along with their associated phenotypes provides better understanding of their clinical importance and will be helpful in clinical evaluation and counseling of the affected individuals.
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http://dx.doi.org/10.1186/s12881-015-0149-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422282PMC
February 2015

Evaluation of serum antioxidants in age-related hearing loss.

Aging Clin Exp Res 2015 Jun 2;27(3):265-9. Epub 2014 Nov 2.

Departments of Physiology and Oral Pathology, College of Medicine, University of Ibadan, P. O. Box 22040, Ibadan, Nigeria,

Background: Age-related hearing loss (ARHL) has been linked to the shift in the pro-oxidant/antioxidant ratio. Our objectives were to assess serum levels of retinol and zinc among the elderly individuals and to correlate the levels with hearing threshold.

Methods: Prospective study of apparently healthy individuals aged ≥60 years of age. Participants had complete clinical history, physical examination and pure tone average conducted. Blood samples were collected for determination of serum levels of retinol and zinc. Mann-Whitney U test was used to compare retinol and zinc values. Pearson's correlation test was used to determine the relationship between hearing threshold and serum levels of retinol and zinc.

Results: Among 126 elderly participants with mean age 67 ± 2.7 years; the mean pure tone average for air conduction was 29.3 ± 1.6 dBHL while the mean bone conduction was 36.5 ± 1.8 dBHL. The median values of serum retinol and zinc levels in the elderly participants who had hearing loss in the speech frequencies were 52 and 83.3 μg/L, respectively, while among participants with normal hearing threshold, values were 50 and 89.9 μg/L, respectively (p = 0.59 and 0.99, respectively). For the high frequencies, the median value of serum retinol and zinc levels among the elderly participants with normal hearing threshold was 70.3 and 99.9 μg/L, while among those with hearing loss, it was 46.9 and 83.2 μg/L, respectively (p = 0.000 and 0.005, respectively).

Conclusion: Serum retinol and zinc levels were significantly lower among elderly with hearing loss involving the high frequencies. This is added evidence to extant literature on the possible role of antioxidants in the development of ARHL and suggests further study on the effect of antioxidants supplementation in the control of ARHL which is presently controversial and inconclusive.
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http://dx.doi.org/10.1007/s40520-014-0282-3DOI Listing
June 2015

Common genes for non-syndromic deafness are uncommon in sub-Saharan Africa: a report from Nigeria.

Int J Pediatr Otorhinolaryngol 2014 Nov 23;78(11):1870-3. Epub 2014 Aug 23.

Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

Introduction: Little is known about the molecular epidemiology of deafness in sub-Saharan Africa (SSA). Even in Nigeria, the most populous African nation, no genetic studies of deafness have been conducted. This pioneering work aims at investigating the frequencies of gene mutations relatively common in other parts of the world (i.e. those in GJB2, GJB6, and mitochondrial DNA) among subjects from Nigeria with hearing loss (HL) with no evidence of acquired pathology or syndromic findings. In addition, we review the literature on the genetics of deafness in SSA.

Method: We evaluated 81 unrelated deaf probands from the Yoruba tribe residing in Ibadan, a suburban city in Nigeria, for the aetiology of their deafness. Subjects underwent genetic testing if their history was negative for an environmental cause and physical examination did not find evidence of a syndrome. Both exons of GJB2 and mitochondrial DNA flanking the 1555A>G mutations were PCR-amplified followed by Sanger sequencing. GJB6 deletions were screened via quantitative PCR.

Result: We identified 44 probands who had nonsyndromic deafness with no environmental cause. The age at study time ranged between 8 months and 45 years (mean=24 years) and age at onset was congenital or prelingual (
Conclusion: GJB2, GJB6 and mitochondrial DNA 1555A>G mutations were not found among this initial cohort of the deaf in Nigeria. This makes imperative the search for other genes in the aetiology of HL in this population.
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http://dx.doi.org/10.1016/j.ijporl.2014.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208623PMC
November 2014

Neonatal hearing screening in a rural/sub-urban community in Nigeria, sub-Saharan Africa-a preliminary report.

Int J Pediatr Otorhinolaryngol 2014 Sep 16;78(9):1452-5. Epub 2014 Jun 16.

Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: The implementation of Neonatal Hearing Screening (NHS) program is still at the preliminary stage particularly in developing countries despite the burden of permanent congenital and early-onset hearing impairment. There has been an earlier report of NHS in a city in Nigeria, however, this is a report of a preliminary NHS carried in a rural/sub-urban area in Nigeria.

Method: This prospective study, which took place between October 2009 and April 2010, involved all newborns delivered at the University College Hospital, Ibadan and the Bilal Missionary Maternity, Agodi, Ibadan, a small maternity service located in Agodi community serving predominantly low socioeconomic class people. All the neonates delivered during the study period were included in the screening. The screening was performed within 72 h of delivery using automated auditory brainstem response (AABR) and repeated after 6 weeks among those with referral result. Subsequently the neonates were referred to diagnostic audiology.

Result: Among the 453 newborns (231 males and 222 female), AABR screening showed referral, in 43.7% of neonates. At first screening, 224 (49.4%) were referred while 229 (50.6%) passed, however, during the post-natal period 40/229 (17.5%) reported for second screening, out of these 26 showed pass to the screening. This gave a total pass of 255/453 (56.3%). The presence of maternal pre-ecclampsia (P = 0.05) was found to be a significant morbidity factor associated with referral in the screening, while parental socioepidemiological variables; and the neonates' birthweight, gestational age and APGAR score were not.

Conclusion: The proportion of referral on hearing screening encountered was far higher than previously reported, however, continuation of infant screening in future should be comprehensive with viral and genetic analysis in order to address the issue of aetiologic diagnosis; in addition, the implementation should factor the high drop out from the first stage screening in order to substantiate the findings in our region.
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http://dx.doi.org/10.1016/j.ijporl.2014.06.003DOI Listing
September 2014

Prevalence and correlates of dizziness in the Ibadan Study of Ageing.

Ear Nose Throat J 2014 Apr-May;93(4-5):E37-44

Department of Otorhinolaryngology, University of Ibadan College of Medicine, PO Box 22040, Ibadan, Nigeria. From the Department of Otorhinolaryngology (Prof. Lasisi) and the.

Dizziness is common among older people, but little is known about its prevalence and risk factors in the sub-Saharan population. We conducted a cross-sectional study to determine the prevalence of dizziness and its sociodemographic, lifestyle, and clinical correlates in 1,299 subjects--551 men (42.4%) and 748 women (57.6%), aged 65 years and older (mean: 77.3 ± 6.3)--who lived in the Yoruba-speaking areas of Nigeria. Among this group, 318 persons reported dizziness, which represents a prevalence of 24.5%. Univariate analysis of sociodemographic and lifestyle variables revealed that low economic status (p = 0.05) and smoking (p = 0.01) were significantly correlated with dizziness; however, on logistic regression analysis, only smoking (p = 0.01) was found to be significant. Neither sex (p = 0.07), age (p = 0.71), area of residence (p = 0.34), education level (p = 0.74), nor alcohol consumption (p = 0.44) had a significant correlation with dizziness. On multivariate modeling, significant clinical correlates in patients with dizziness included self-reports of a history of suppurative otitis media (p = 0.01), head injury (p = 0.03), and recurrent rhinosinusitis (p = 0.01); no significant correlation was seen between dizziness and hypertension, transient ischemic attack, and diabetes. Finally, balance testing conducted in a subset of 1,006 subjects revealed poor balance in 93 of 250 persons with dizziness (37.2%) and in 189 of 756 subjects without dizziness (25.0%) (p = 0.01). Logistic regression analysis of sex and age revealed that the probability of poor balance was 1.5 times greater among those persons with dizziness. We conclude that the high incidence of dizziness among community-dwelling elderly and its significant correlations with remediable medical conditions suggest the need for policy formulation for the care of the elderly in Nigeria.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568290PMC
April 2015

Correlation between plasma levels of radical scavengers and hearing threshold among elderly subjects with age-related hearing loss.

Acta Otolaryngol 2011 Nov;131(11):1160-4

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Conclusion: Low plasma melatonin is significant in the development of high frequency hearing loss (HL) among the elderly.

Objective: To determine the correlation between hearing threshold and the plasma melatonin and ascorbic acid (vitamin C).

Methods: This was a cross-sectional study involving 126 apparently healthy elderly subjects, 59 males and 67 females, aged >60 years. Subjects underwent pure tone audiometry and plasma melatonin and vitamin C were assayed using high-performance liquid chromatography.

Results: The mean ± SD of plasma melatonin among the subjects with normal hearing (NH) (0-30 dB) and those with HL in the speech frequencies was 18.3 ± 3.6 μg/L and 16.4 ± 4.7 μg/L, respectively. In the high frequencies the values were 17.7 ± 6.2 μg/L and 13.1 ± 6.4 μg/L for NH and HL, respectively. For vitamin C, the mean ± SD among subjects with NH and those with HL in the speech frequencies were 1.2 ± 0.2 μg/L and 1.0 ± 0.1 μg/L, respectively. In the high frequencies, the values were 1.0 ± 0.2 μg/L and 0.9 ± 0.3 μg/L for NH and HL, respectively. Among subjects with high frequency HL, Spearman's correlation revealed significant correlation between increasing hearing threshold and melatonin (correlation coefficient = -0.30, p = 0.01), but not for vitamin C (correlation coefficient = -0.12, p = 0.22). Linear regression, adjusting for age, still revealed significant correlation between the melatonin (correlation coefficient = -0.03, p = 0.00) and hearing threshold in the high frequencies.
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http://dx.doi.org/10.3109/00016489.2010.549840DOI Listing
November 2011

Prevalence of insomnia and impact on quality of life among community elderly subjects with tinnitus.

Ann Otol Rhinol Laryngol 2011 Apr;120(4):226-30

Department of Otorhinolaryngology, University of Ibadan, Ibadan, Nigeria.

Objectives: We sought to determine the prevalence of insomnia and its impact on the quality of life (QoL) among community elderly subjects (at least 65 years of age) with subjective tinnitus.

Methods: After household selection with multistage stratified area probability sampling, face-to-face interviews were used to obtain self-reports of subjective tinnitus and insomnia, and QoL was assessed with the WHOQoL-Bref instrument.

Results: Among 1302 elderly subjects, there were 183 subjects (109 female and 74 male) with tinnitus. Among those with tinnitus, insomnia was encountered in 95 (51.9%) and was found to be significantly more common among those with tinnitus than among those without (378 of 1119, or 33.8%; p = 0.002). The insomnia symptoms included difficulty in maintaining sleep in 73.4% of subjects, difficulty in falling asleep in 70.0%, early morning wakefulness in 64.3%, nonrestorative sleep in 35.1%, and daytime sleepiness in 34.7%. Univariate analysis revealed difficulty with falling asleep (p = 0.01) and early morning wakefulness (p = 0.05) to be significantly associated with tinnitus among the symptoms. Student's t-test and logistic regression analysis revealed significant deterioration in the total QoL and in the physical, psychological, social, and environmental QoL domains among elderly subjects who had tinnitus with insomnia as compared with those without insomnia.

Conclusions: We believe that insomnia is significantly more common among elderly subjects with tinnitus than among those without, and that its presence further depreciates the QoL in these elderly individuals.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097393PMC
http://dx.doi.org/10.1177/000348941112000402DOI Listing
April 2011

Correlation between serum immunoglobulin G and hearing threshold among elderly subjects with age-related hearing loss.

ORL J Otorhinolaryngol Relat Spec 2011 8;73(2):88-92. Epub 2011 Feb 8.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background And Purpose: This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation.

Method: This prospective study involved 126 participants ≥ 60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500-2,000 Hz) and high frequencies (3,000-8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed.

Results: There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01).

Conclusion: Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.
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http://dx.doi.org/10.1159/000323830DOI Listing
July 2011

Age-related hearing loss, vitamin B12, and folate in the elderly.

Otolaryngol Head Neck Surg 2010 Dec 25;143(6):826-30. Epub 2010 Oct 25.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Objective: Determine the correlation between the hearing threshold and the serum levels of vitamin B12 (cobalamin) and folic acid among elderly subjects (> 60 years) with age-related hearing loss (ARHL).

Study Design: Cross-sectional.

Setting: Community.

Subjects And Methods: Subjects included elderly who were found apparently healthy following repeated examination by physicians. The pure tone average (PTA) for the speech and high frequencies, and the serum folate and cobalamin were determined and the correlation found.

Results: The mean ± SD values of serum folate among the subjects with normal PTA in the speech frequencies (0-30 dB) was 412.3 nmol/L ± 17.6 nmol/L, while among those with hearing loss (HL), it was 279.1 nmol/L ± 17.2 nmol/L (P = 0.01). In the high frequencies, the mean ± SD values among the subjects with normal PTA was 426.3 nmol/L ± 17.6 nmol/L, while among those with HL, it was 279.14 nmol/L ± 171.2 nmol/L. The serum cobalamin among the subjects with normal PTA within the speech frequencies was 49.7 pmol/L ± 9.4 pmol/L, while among those with speech-frequency HL, it was 42.6 pmol/L ± 10.2 pmol/L. However, for high frequencies, the mean ± SD values among the subjects with normal PTA was 47.4 pmol/L ± 7.3 pmol/L, while among those with HL, it was 41.3 pmol/L ± 9.2 pmol/L. Spearman's correlation revealed that low folate (correlation coefficient = -0.27, P = 0.01) and cyanocobalamin (correlation coefficient = -0.35, P = 0.02) were significantly associated with increasing hearing threshold in the high frequencies. After adjusting for age, serum folate (correlation coefficient = -0.01, P = 0.01) was significant, while vitamin B12 (correlation coefficient = -0.01, P = 0.74) was not.

Conclusion: Serum folate was significantly lower among elderly with ARHL. Trials on nutritional supplementation may substantiate the role of serum folate in ARHL.
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http://dx.doi.org/10.1016/j.otohns.2010.08.031DOI Listing
December 2010

Tinnitus in the elderly: Profile, correlates, and impact in the Nigerian Study of Ageing.

Otolaryngol Head Neck Surg 2010 Oct;143(4):510-5

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Objective: To determine the prevalence and correlates of tinnitus among community elderly and its impact on their quality of life.

Study Design: Longitudinal cohort.

Setting: Yoruba-speaking communities in Nigeria.

Subjects And Methods: Face-to-face interviews of 1302 subjects 65 years or older selected by the use of a multistage stratified sampling of households. Subjects were assessed for subjective tinnitus, chronic health conditions, functional impairment, and quality of life by use of the brief version of the World Health Organization quality of life instrument.

Results: Tinnitus was reported in 184 (110 female and 74 male subjects), giving a prevalence of 14.1 percent (SE = 0.49). Gender, age, economic status, educational level, residence, smoking, and alcohol consumption were not significantly associated with tinnitus. Univariate analysis revealed a history of recurrent otitis media (odds ratio [OR] = 4.5, 95% confidence interval [95% CI] 3.1-6.6, P = 0.01), head injury (OR 3.4, 95% CI 2.1-5.6, P = 0.01), rhinosinusitis (OR 2.4, 95% CI 1.5-4.0, P = 0.01), dizziness (OR 2.1, 95% CI 1.4-3.1, P = 0.01), and hypertension (OR 1.7, 95% CI 1.0-2.7, P = 0.05) as significant correlates. However, in multivariate analysis, only a history of otitis media and of head injury remained significant. Compared with those without, persons with tinnitus had a more negative perception of their overall health and a poorer quality of life as well as twofold likelihood to experience impairment in both activities of daily living and instrumental activities of daily living.

Conclusion: Tinnitus is common among elderly Nigerians and is associated with treatable health conditions, such as otitis media, rhinosinusitis, head injury, and hypertension. Its association with functional impairment and reduced quality of life highlights the need for inclusion in any comprehensive health care for the elderly.
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http://dx.doi.org/10.1016/j.otohns.2010.06.817DOI Listing
October 2010

The prevalence and correlates of self-reported hearing impairment in the Ibadan study of ageing.

Trans R Soc Trop Med Hyg 2010 Aug 11;104(8):518-23. Epub 2010 May 11.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

This cohort study of 1302 persons aged >or=65 years, conducted in the Yoruba-speaking regions of Nigeria, determines the prevalence and correlates of hearing impairment (HI) in the elderly population. Self-reports of HI and its putative risk factors among several indices were obtained using face-to-face interviews, and confirmed by observer's evaluation. Hearing impairment was found in 79 respondents, giving a prevalence of 6.1%. Gender difference was not significant but increasing age was associated with higher prevalence. Logistic regression analysis, adjusted for age and sex, revealed that history of recurrent suppurative otitis media [odds ratio (OR)=4.6, 95% CI 2.34-8.99, P=0.01], head injury (OR=2.2, 95% CI 1.14-4.26, P=0.02) and current hypertension (OR=2.1, 95% CI 1.18-3.57, P=0.01) were significantly associated with HI. No identifiable risk factors were found in 32 (40.5%) of the 79 respondents with HI. We conclude that the prevalence of HI among the elderly in Nigeria is comparable to reports from other countries. Identified risk factors were preventable or controllable. The large proportion of elderly with no identifiable risk factors, presumably presbyacusis, suggests a need for further study. The strategies for control of these risk factors and hearing aid support should be integrated into health care policy initiatives for elderly persons in sub-Saharan Africa.
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http://dx.doi.org/10.1016/j.trstmh.2010.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904808PMC
August 2010

Comparative analysis of middle ear immune response and micronutrient level between mucoid and purulent otitis media.

Authors:
Akeem O Lasisi

J Otolaryngol Head Neck Surg 2009 Aug;38(4):477-82

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Objective: To determine the differences in the outcome of treatment, the middle ear immune response, and micronutrient status between patients with purulent (POM) and mucoid (MOM) otitis media.

Design: Children with acute otitis media were recruited, treated, and followed up for between 6 and 10 months. The sera and middle ear secretion (MES) were analyzed for immunoglobulins and zinc using enzyme-linked immunoassay and flame atomic absorption spectrophotometry, respectively. The parameters were compared with selected healthy controls.

Subjects: There were 399 participants: 228 children with acute otitis media selected using the American Academy of Otolaryngology-Head and Neck Surgery criteria and 171 healthy controls, with ages ranging between 6 months and 9 years (mean 7 years; SD 2.32 years).

Result: POM accounted for 126 of 228 patients, and MOM accounted for 102. The chronicity of otitis media (using the 3-month duration cutoff) was seen in 87 subjects (46%): 31 of 126 POM subjects and 56 of 102 MOM subjects (p = .002). The serum IgA to IgG ratios were 0.03 and 0.07 among POM and MOM, respectively; however, the MES IgA to IgG ratios were higher, 0.3 and 0.2, for POM and MOM, respectively. This gives a MES to serum ratio of IgA to IgG value of 0.3 to 0.03 (10) for POM and 0.2 to 0.07 (2.67) for MOM, which showed a significant statistical difference (p = .001). The MES to serum ratios of IgE were 0.89 and 1.3 among POM and MOM, respectively (p = .03). There was a significant difference in the serum IgG (p = .019), serum zinc (p = .009), and MES IgA (p = .028) and IgG (p = .01).

Conclusion: Chronicity was greater in MOM than in POM; POM had a higher middle ear immune response (measured by the MES to serum ratio of IgA to IgG) and serum zinc than MOM but a lower MES IgE.
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August 2009

The role of maternal social factors and antenatal events in determination of the serum retinol in normal full term infant.

Nig Q J Hosp Med 2009 Apr-Jun;19(2):83-7

Department of Otorhinolaryngology, Faculty of Clinical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: The nutritional status of mothers affects their babies. However, the factors responsible for the control of fetal retinol levels are unknown. This study evaluates the role of maternal social factors in the determination of fetal serum retinol.

Method: Consecutive mothers with normal pregnancy as judged by obstetrician (excluding those with sepsis and medical illnesses) were recruited. The maternal social factors and antenatal history were determined using questionnaires and the retinol level of the cord blood of the neonates were estimated using the high performance liquid chromatography.

Results: There were 106 mothers (ages between 21 and 39 years, mean of 26 years) and neonates, made up of 57 females and 49 males with gestational age 30-45 weeks, mean of 373 weeks). The range of the neonatal serum retinol level was 0.12 ig/L--1.57 ig/L, with a mean of 0.94 ig/L (SD = 0.17) and median value of 0.98 ig/L. The mean serum retinol in the females was 0.94 ig/L while males were 1.13 ig/L. Ihe mean serum retinol according to the socioeconomic classes were high (I and II) 1.2 ig/L, middle (III) 1.1 ig/L and low (IV and V) 0.9 ig/L. The mean fetal serum retinol among the mothers with fever in pregnancy (31/106), incomplete vaccination in pregnancy (17/106) and neonates with low birthweight (<2.5 Kg) was 0.9 ig/L. Bivariate analysis revealed significant correlation between the mean serum retinol and the socioeconomic class (P = 0.038), but there was no correlation with maternal age (P = 0.7), sex (P = 0.07), gestational age (P = 0.39), birth weight (P = 0.7), maternal tetanus vaccination (P = 0.28), fever (P = 0.64) and antenatal care (P = 0.97).

Conclusion: Socioeconomic status of the mothers was a significant factor in the determination of neonatal serum retinol level, suggesting that maternal retinol supplementation may help in control of neonatal hyporetinolaemia.
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September 2010

Serum and middle ear immunoglobulins in suppurative otitis media.

ORL J Otorhinolaryngol Relat Spec 2008 4;70(6):389-92. Epub 2008 Nov 4.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background And Purpose: Despite the increasing occurrence of suppurative otitis media (SOM), the content of immunoglobulin fractions in the middle ear secretion (MES) has still not been determined.

Method: The serum and MESwere analyzed for IgG and M using enzyme-linked immunoassay.

Result: The subjects and controls were 30 males and 22 females, between 6 months and 9 years old, with a mean age of 6 years (SD = 3.26). The patient group included 20 chronic SOM (CSOM) and 17 acute SOM (ASOM) cases, and sera of 15 subjects made the control group. The mean serum IgG levels were for controls 1,051 mg/dl, ASOM 666.1 mg/dl and CSOM 1,321.1 mg/dl; the MES levels were for ASOM 203.4 mg/dl and CSOM 511.5 mg/dl. The mean serum IgM levels were for controls 35 mg/dl, ASOM 64.1 mg/dl and CSOM 40 mg/dl; the MES levels were for ASOM 22.59 mg/dl and CSOM 3.44 mg/dl. The mean MES:serum ratios for IgG and IgM were between 0.1 and 0.4 in ASOM and CSOM. The ratio of serum IgG levels of controls to ASOM cases was 0.66 while that of controls to CSOM was 1.3. The corresponding ratios of IgM were 1.6 and 0.88. Multivariate analysis revealed a significant correlation between serum IgG levels of ASOM and CSOM (p = 0.043) and MES IgG (p = 0.02) in ASOM and CSOM but no correlation between serum IgG levels in controls and ASOM (p = 0.25), serum IgM levels in controls and CSOM (p = 0.62) and serum IgM levels in controls and ASOM (p = 0.73), ASOM and CSOM (p = 0.064) and MES IgM levels of ASOM and CSOM (p = 0.06).

Conclusions: Monitoring of the serum and MES IgG in ASOM may provide a useful index to assess the possibility of progression to chronicity. This forms a database for the immunological status of SOM patients.
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http://dx.doi.org/10.1159/000163035DOI Listing
February 2009

The inner ear in patients with nasal allergy.

J Natl Med Assoc 2008 Aug;100(8):903-5

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: The endolymphatic sac has been proposed as a target organ responsible for inner-ear symptom in allergic subjects. This is a report of inner-ear symptoms in patients with nasal allergy.

Method: Retrospective review of record charts of patients with known nasal allergy presenting to the otorhinolaryngology out-patient department of the University College Hospital, Ibadan in 5 years.

Result: Ear symptoms were found in 95/144 (66%) subjects with nasal allergy. This comprises of 41 males and 44 females (M: F = 1:1). Of these, itching of the external ear canal, hearing loss and tinnitus accounted for 63 (66%), 55 (58%) and 39 (41%), respectively, while vertigo was found in 12 (13%). Peripheral vestibular signs of imbalance were seen in 11/95. The audiological assessment of 73 subjects revealed normal pure-tone average in 43 (59%), and sensorineural hearing loss (SHL) in 17 (23.3%). The severity of SHL was mild in 6/17, moderate in 7 and moderate-to-severe in 4. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were elevated in 10/15 (67%) and 6/15 (40%), while the skin sensitivity test showed reactions to dust in 32, cold in 25, cockroach in 7, perfume in 11, vegetable oil in 1 and insecticide in 2. The clinical diagnoses were idiopathic tinnitus in 25 (26.3%), Idiopathic SHL in 17 (18%), cochlear hydrop in 6 (6%) and autoimmune inner-ear disease in 6 (6%).

Conclusion: This report suggests some peculiar predisposition to inner-ear pathology in patients with nasal allergy. However a longitudinal assessment of cochleovestibular features of nasal allergy subjects will help in its validation.
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http://dx.doi.org/10.1016/s0027-9684(15)31403-6DOI Listing
August 2008

The role of retinol in the etiology and outcome of suppurative otitis media.

Authors:
Akeem O Lasisi

Eur Arch Otorhinolaryngol 2009 May 14;266(5):647-52. Epub 2008 Aug 14.

Department of Otorhinolaryngology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Vitamin A deficiency is still a serious public health problem affecting an estimated 127 million preschool children. The resulting immunological dysfunctions lead to increased risks of respiratory tract infections, diarrhoeal diseases and blindness, among others. The aim of this study is to determine the significance of the role of serum retinol in the etiology of acute suppurative otitis media (ASOM) and its chronicity (CSOM). In a prospective follow-up of patients with ASOM for 6-9 months, serum retinol determination was done using the high performance liquid chromatography. Participants comprised 358 ASOM and 52 control subjects. Six-month follow-up was achieved in 264 subjects (74%); of these, there was persistence of otorrhoea (CSOM) in 116, while 148 had resolved ASOM. Of the 264 subjects, 146 were males and 118 were females, between the ages of 6 months and 9 years and a mean of 7 years (SD = 2.32), whereas the control subjects comprised 29 males and 22 females, between the ages of 6 months and 11 years and a mean of 7.8 years (SD = 3.6). The range of serum retinol in the ASOM subjects was 1.63-2.64 microg/L, mean of 1.53 microg/L, median value of 2.61 microg/L and (SD = 0.16). Among control subjects, the range was 2.5-2.8 microg/L, mean of 2.58 microg/L and median value of 2.61 microg/L (SD = 0.14) (Table 1). The range of serum retinol in the resolved ASOM subjects was 1.61-2.63 microg/L, mean of 2.07 microg/L and median value of 2.09 microg/L (SD = 0.16) while the CSOM subjects ranged between 0.8-2.86 microg/L, mean of 1.58 microg/L and median value of 1.28 microg/L, (SD = 0.48) (Table 2). Univariate analysis using unpaired t test to compare the mean serum retinol revealed significant difference between ASOM and control (P = 0.0000) and between resolved ASOM and CSOM (P = 0.0000). In conclusion, hyporetinolaemia was a significant etiological factor in the etiology ASOM and CSOM, suggesting retinol supplementation as one strategy in control of SOM.
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http://dx.doi.org/10.1007/s00405-008-0794-6DOI Listing
May 2009

Role of elevated immunoglobulin E levels in suppurative otitis media.

Ann Trop Paediatr 2008 Jun;28(2):123-7

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Nigeria.

Background And Objectives: An association between suppurative otitis media (SOM) and allergy has been reported in about 80% of patients with allergy. However, there is controversy regarding their relationship and the concept of middle-ear allergic response. We test the hypothesis that increased secretion of IgE in the middle ear is higher in chronic than in acute SOM.

Methods: Allergy skin testing and enzyme-linked immunoassay of specimens of middle-ear secretions and sera were analysed.

Results: Paired sera and middle-ear secretions (MES) from 37 subjects with SOM, 20 chronic (CSOM) and 17 acute (ASOM), and sera of 15 controls selected from children without otitis media were analysed. There were 30 males and 27 females aged between 6 months and 9 years, mean (SD) 6 years (3.26). A history of allergy and skin test positive to one or more of dust, house dust mite, mould, cockroach and poultry feathers were found in 80% of CSOM, 47% ASOM and 33% controls. The mean IgE levels in sera were: controls 52.1 mg/dL, ASOM 63.9 mg/dL and CSOM 79.2 mg/dL; the MES levels were: AOM 60.4 mg/dL and CSOM 102.0 mg/dL. The MES to serum IgE ratios were 0.75 for ASOM and 1.4 for CSOM. The serum IgE ratio of controls to ASOM was 1.22 and to CSOM was 1.5. Multivariate analysis of the mean showed significant correlation between IgE level of MES in ASOM and CSOM (p=0.04) but no correlation between IgE levels in control and ASOM sera (p=0.10), control and CSOM sera (p=0.7) or AOM and CSOM sera (p=0.3).

Conclusion: Allergy appears to play a contributory role in CSOM and elevated IgE in the MES suggests a likely mucosal response.
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http://dx.doi.org/10.1179/146532808X302143DOI Listing
June 2008

Sinonasal malignancies: a 10-year review in a tertiary health institution.

J Natl Med Assoc 2007 Dec;99(12):1407-10

Department of Otorhinolaryngology, College of Medicine of University of Ibadan, University College Hospital, Ibadan, Nigeria.

Sinonasal malignancy is a cause of otorhinolaryngologic morbidity and mortality in West Africa. However, there is a dearth of information in the literature on its clinicopathologic presentation in West Africa. It is our aim to determine the prevalence of sinonasal malignancy and highlight the clinicopathologic features in our environment. A 10-year retrospective review of cases with histologically diagnosed malignant sinonasal tumors in University College Hospital, Ibadan, Oyo State, Nigeria was carried out. There were 82 cases-56 (68.29%) males and 26 (31.71%) females-whose ages ranged from 4-69 years. Epistaxis, rhinorrhea and nasal blockage were seen in all patients; other symptoms were facial [76 (93%)], oral cavity [48 (59%)], ophthalmic [33 (40%)] and [otologic 21 (25%)]. Squamous cell carcinoma accounted for 69/75 (92%) of epithelial tumors, and malignant lymphoma accounted for 4/7 (57%) of nonepithelial tumors. Advanced disease was the predominant presentation in our series, stage 3 in 59 (79%) and stage 4 in 12 (16%) cases. Therefore, health education on early presentation to hospitals and efforts at early detection of the disease are needed in order to achieve cure. Industrial workers should always wear face masks to protect their nasal cavity.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575924PMC
December 2007

Socio-economic status and hearing loss in chronic suppurative otitis media in Nigeria.

Ann Trop Paediatr 2007 Dec;27(4):291-6

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Hearing loss is reported in about 50% of cases of chronic suppurative otitis media (CSOM).

Aim: To report the prevalence, type and severity of hearing loss in CSOM and identify risk factors.

Methods: A prospective study of hearing loss in CSOM was undertaken in University College Hospital, Ibadan, two general hospitals and two primary health care centres, all in densely populated, semi-urban areas in south-west Nigeria. Controls were selected from school children, hospital workers' children and children whose parents were visiting the hospitals, all of whom claimed that there had been no episode of otitis media in the past. An oral questionnaire was administered to all, followed by audiometry and examination of the ear, nose and throat in study children.

Results: There were 189 CSOM subjects and 100 controls aged between 4 and 150 months [mean (SD) 59.25 (44.55), 173 girls and 116 boys, M:F 1.5:1]. The prevalence of hearing loss in CSOM was 89/189 (47%) and was conductive in 73/89 (82%) and sensorineural (SHL) in 16/89 (18%). Of the subjects with hearing loss, 72% had had otitis media during the 1st year of life. Of the 89, 61 (69%) were of low social class, 13/37 (35%) were middle class and 15/63 (24%) upper class. The duration of CSOM ranged from 4 weeks to 12 years [mean (SD) 4 yrs (2.04)] and from 5 to 12 years in those with SHL [mean (SD) 9 yrs (6.21)]. There was significant correlation between socio-economic status and hearing loss (r=0.138, p=0.02) while no correlation was found with upper respiratory infection (r=0.054, p=0.36), age of onset (r=0.037, p=0.62) or frequency of attacks (r=-0.068, p=0.35).

Conclusion: About one fifth of patients with CSOM have SHL. Early diagnosis and management of CSOM is imperative to improve outcome. CSOM is strongly associated with low socio-economic status.
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http://dx.doi.org/10.1179/146532807X245689DOI Listing
December 2007

Early onset otitis media: risk factors and effects on the outcome of chronic suppurative otitis media.

Eur Arch Otorhinolaryngol 2008 Jul 29;265(7):765-8. Epub 2007 Nov 29.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

The onset of early otitis media (EOM), in the first few months of life has been reported to predict later chronic otitis media (CSOM), although the prevalence rates are increasing little is known about specific risk factors. In this survey we examined the hypothesis that higher risk factors is associated with the development of OM within 1 year compared to later onset and early onset otitis media (OM) has potential for negative outcome of CSOM. This is a survey of the age at onset of otorrhoea and associated risk factors in children with CSOM, in five sites spread in two sub-urban cities in two states in Nigeria. Questionnaires were administered on the informants followed by examination of the children. EOM was seen in 136/189 (70%) with CSOM, the age range was 1-150 months, mean of 59.25 (SD = 44.55). Of the 85 CSOM subjects with hearing loss, EOM accounted for 49 (57.7%) while 36 (42.4%) was later onset, On multivariate analysis (OR = 0.276, CI = 0.133-0.572, P = 0.001) revealing EOM was significant in the development of hearing loss however there was no correlation with the frequency of attack of otorrhoea (OR = 1.025, CI = 0.88-1.19, P = 0.75). Low socioeconomic status seen in 110/136 EOM (P = 0.000), allergy (P = 0.030) and number of people >10 in household (OR = 4.13, CI = 1.81-9.39, P = 0.001) constituted the significant risk for EOM compared to later onset. Bottlefeeding, adenoiditis/adenoid hypertrophy, indoor cooking and upper respiratory infection were not found to have statistical significance in early onset OM compared to later onset OM. This study found correlation between EOM and hearing loss and identified allergy, low social status and chronic exposure to overcrowding through increased number of children in the household significant risk factors for future research focus. This may help in controlling the prevalence of hearing loss accompanying CSOM.
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http://dx.doi.org/10.1007/s00405-007-0544-1DOI Listing
July 2008

Clinical and demographic risk factors associated with chronic suppurative otitis media.

Int J Pediatr Otorhinolaryngol 2007 Oct 23;71(10):1549-54. Epub 2007 Jul 23.

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: The incidence of chronic suppurative otitis media (CSOM) is high worldwide but increasing occurrence of complications appear peculiar to West Africa. However, knowledge of associated risk factors is sparse, we report the sociodemographic risk factors of CSOM with the aim of control of the disease and complications; and possible preventive strategies.

Method: This is a survey of children with CSOM in five sites spread in two suburban cities in two states in Nigeria. Questionnaire was administered on the informants followed by examination of the children.

Result: Of the 189 children, 114 (60%) had developed ear suppuration before 6 months of age, the number of attacks within the previous 18 months ranged between 2-12 with average of 7. Sociodemographic risk factors included low socioeconomic class in 153 (81%), 136 (72%) live in congested houses with more than 10 people and 79 (42%) belonged to families with more than 5 children. Indoor-cooking and infant daycare attendance were 117 (62%) while supine bottlefeeding was 115 (61%) and 34 (18%) of subjects had smoking father. The clinical risk factors were upper respiratory tract infection (URI) 85 (45%), allergy 53 (28%), adenoid 54 (28%) and malnutrition 65 (34%). The univariate analysis revealed that low social class (OR=7.33, CI=4.18-12.83, P=0.0001), malnutrition (OR=3.57, CI=1.88-6.76, P=0.00001), bottlefeeding (OR=2.93, CI=1.63-5.28, P=0.0001), indoor-cooking (OR=1.35, CI=0.88-2.10, P=0.161) and high number of people in a household (OR=0.59, CI=0.34-0.98, P=0.04) are significant in development of OM; while multivariate logistic regression analysis showed malnutrition (OR=3.48, CI=1.633-7.425, P=0.001), low social status (OR=7.74, CI=4.15-14.43, P=0.0001) and indoor-cooking (OR=2.34, CI=1.18-4.66, P=0.014), second table. Parental smoking, daycare attendance, allergy, adenoiditis/adenoidal hypertrophy and upper respiratory tract infection were not found significant.

Conclusion: Low socioeconomic class, malnutrition, congestion from high number of children in the household and bottlefeeding constitute significant risk factor. The early onset of disease (<6 months) may suggest a prenatal predisposition. We need further research for the understanding of the biologic effect of these factors while this remains a database for prevention and control of disease.
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http://dx.doi.org/10.1016/j.ijporl.2007.06.005DOI Listing
October 2007

Hearing threshold in patients with chronic renal failure.

Saudi Med J 2007 May;28(5):744-6

Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, PO Box 22040,

Objective: To determine the pattern of hearing loss among patients with chronic renal failure (CRF).

Methods: This is a case control study carried out jointly by the Otorhinolaryngology and Nephrology Departments of the University College Hospital Ibadan, Nigeria between December 2004 and March 2006. Consecutive CRF patients who satisfied the inclusion criteria were recruited, the patients had not had hemodialysis prior to inception of the study. Parameters like age, gender, duration of illness and blood pressure were recorded and pure tone audiometry was carried out. The data was analyzed using the Statistical Package for Social Sciences.

Results: Thirty-three CRF patients and 28 healthy controls (34 males and 27 females) were used. The age range was 16-72 years, mean of 45.30 (SD 16.20). Sensorineural hearing loss was found in 67% of CRF and 32% of controls. The mean hearing threshold of CRF was 47.42 (SD 18.55) while the controls was 35 db, unpaired t-test (value -5.155) and Pearson correlation p=0.0008, r=0.614 showed the difference was significant. There was a correlation between duration of renal disease and hearing threshold p=0.00387 (r=0.73). There was no correlation between the hearing threshold and the diastolic blood pressure p=0.056 dosage of diuretics p=-0.155 (r=0.12) and creatinine level of the patients p=0.35 (r=0.31).

Conclusion: Sensorineural hearing loss is common among patients with CRF and related to the duration of renal disease, we recommend periodic audiological assessment incorporated in the care of these patients.
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May 2007