Ake Lernmark

Ake Lernmark

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Ake Lernmark

Publications by authors named "Ake Lernmark"

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Genetic Variation Within the Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes.

Diabetes 2019 Jul 8;68(7):1523-1527. Epub 2019 Apr 8.

Division of Endocrinology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA

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http://dx.doi.org/10.2337/db18-1128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609989PMC
July 2019

Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report.

Diabetes Care 2019 Jun 9;42(6):1051-1060. Epub 2019 Apr 9.

Department of Clinical Sciences, Clinical Research Centre, Lund University, Skane University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.2337/dc18-2282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609953PMC
June 2019

Autoantibodies in Pandemrix-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test.

Autoimmunity 2019 Jun 22;52(4):185-191. Epub 2019 Jul 22.

Department of Clinical Sciences Malmö, Lund University/CRC, Skåne University Hospital SUS , Malmö , Sweden.

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http://dx.doi.org/10.1080/08916934.2019.1643843DOI Listing
June 2019

Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes.

Diabetes 2018 11 13;67(11):2329-2336. Epub 2018 Aug 13.

Department of Clinical Sciences, Lund University/Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.2337/db18-0355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198343PMC
November 2018

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Curr Diab Rep 2018 10 23;18(12):136. Epub 2018 Oct 23.

Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/s11892-018-1113-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415767PMC
October 2018

First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age.

J Reprod Immunol 2018 06 2;127:1-6. Epub 2018 Mar 2.

Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, 205 02 Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jri.2018.02.004DOI Listing
June 2018

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

Lancet Diabetes Endocrinol 2018 05 5;6(5):361-369. Epub 2018 Mar 5.

Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(18)30051-2DOI Listing
May 2018

Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study.

J Pediatr Gastroenterol Nutr 2018 03;66(3):417-424

*Dr. v. Hauner Children's Hospital, University Munich Medical Center, Munich, Germany †Health Informatics Institute, Department of Paediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, USA ‡Institute of Diabetes Research, Helmholtz Zentrum München, Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany §Department of Clinical Sciences, Lund University, Skane University Hosptial, Malmo, Sweden ||Digestive Health Institute, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA ¶Medicity Laboratory, University of Turku, Turku, Finland #Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland **Pacific Northwest Diabetes Research Institute, Seattle WA, USA ††Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora CO, USA ‡‡Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta GA, USA §§Department of Paediatrics, Turku University Hospital, Turku, Finland ||||Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland ¶¶Departments of Physiology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1097/MPG.0000000000001682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787038PMC
March 2018

Genetic risk scores in adult-onset type 1 diabetes.

Lancet Diabetes Endocrinol 2018 03;6(3):168-169

Diabetes and Celiac Unit, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/S2213-8587(18)30039-1DOI Listing
March 2018

HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes.

Acta Diabetol 2018 Jan 24;55(1):41-47. Epub 2017 Oct 24.

Department of Paediatric Cardiology, Paediatric Heart Center, Lund University and Skåne University Hospital, 22185, Lund, Sweden.

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http://dx.doi.org/10.1007/s00592-017-1063-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794827PMC
January 2018

Are Perinatal Events Risk Factors for Childhood Thyroid Autoimmunity?

Eur Thyroid J 2017 Nov 19;6(6):298-306. Epub 2017 Sep 19.

Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1159/000479964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704722PMC
November 2017

Early prediction of autoimmune (type 1) diabetes.

Diabetologia 2017 08 26;60(8):1370-1381. Epub 2017 May 26.

Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Jan Waldenströms gata 35, SE-20502, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-017-4308-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491594PMC
August 2017

Type 1 diabetes mellitus.

Nat Rev Dis Primers 2017 Mar 30;3:17016. Epub 2017 Mar 30.

Department of Clinical Sciences, Lund University, Skåne University Hospital, Jan Waldenströms gata 35, 20502 Malmö, Sweden.

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http://dx.doi.org/10.1038/nrdp.2017.16DOI Listing
March 2017

Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden.

J Med Virol 2017 01 21;89(1):24-31. Epub 2016 Jun 21.

Department of Clinical Sciences, Skåne University Hospital SUS, Lund University/CRC, Malmö, Sweden.

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http://dx.doi.org/10.1002/jmv.24597DOI Listing
January 2017

Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.

Diabetes Care 2016 Sep 16;39(9):1535-42. Epub 2016 Jun 16.

Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL.

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http://dx.doi.org/10.2337/dc16-0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001144PMC
September 2016

Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy.

Authors:
Åke Lernmark

Pediatr Diabetes 2016 07;17 Suppl 22:65-72

Department of Clinical Sciences, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1111/pedi.12390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473290PMC
July 2016

Genetic risk factors for type 1 diabetes.

Lancet 2016 Jun;387(10035):2331-2339

Department of Clinical Sciences, Lund University, Skåne University Hospital, SE-20502 Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)30582-7DOI Listing
June 2016

An Object-Oriented Regression for Building Disease Predictive Models with Multiallelic HLA Genes.

Genet Epidemiol 2016 May;40(4):315-32

Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1002/gepi.21968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834870PMC
May 2016

Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort.

Clin Gastroenterol Hepatol 2016 Mar 25;14(3):403-409.e3. Epub 2015 Nov 25.

Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565150133
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http://dx.doi.org/10.1016/j.cgh.2015.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897964PMC
March 2016

Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment.

Diabetologia 2016 Jan;59(1):13-20

Department of Clinical Sciences, Lund University/CRC, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-015-3789-zDOI Listing
January 2016

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.

JAMA Pediatr 2016 Jan;170(1):20-8

National Institute for Health and Welfare, Nutrition Unit, Helsinki, Finland12School of Health Sciences and Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland 13The Science Center of Pirkanmaa Hospita.

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http://www.melk.no/sitefiles/6/EarlyExposureofProbioticsandI
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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamapediatrics.2015.2757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803028PMC
January 2016

Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Pediatr Diabetes 2015 Dec 25;16(8):621-8. Epub 2014 Sep 25.

Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, SE-20502, Malmö, Sweden.

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http://dx.doi.org/10.1111/pedi.12222DOI Listing
December 2015

Prevalence of celiac disease autoimmunity in children with type 1 diabetes: regional variations across the Øresund strait between Denmark and southernmost Sweden.

Pediatr Diabetes 2015 Nov 18;16(7):504-9. Epub 2014 Aug 18.

Department of Clinical Sciences, Skåne University Hospital SUS, Lund University/CRC, Malmö, Sweden.

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http://dx.doi.org/10.1111/pedi.12200DOI Listing
November 2015

Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls.

Metabolism 2015 Aug 15;64(8):872-8. Epub 2015 Apr 15.

Paediatric Endocrinology, Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University/Clinical Research Centre and Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1016/j.metabol.2015.04.002DOI Listing
August 2015

Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention.

Acta Diabetol 2015 Jun 8;52(3):473-81. Epub 2014 Nov 8.

Department of Clinical Sciences Malmö/Pediatric Endocrinology, Skåne University Hospital SUS, Lund University, Jan Waldenströms gata 35, CRC 60:11, 20502, Malmö, Sweden,

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http://dx.doi.org/10.1007/s00592-014-0680-1DOI Listing
June 2015

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

J Clin Endocrinol Metab 2015 Jun 27;100(6):2314-21. Epub 2015 Mar 27.

Diabetes Research Center and Universitair Ziekenhuis Brussel (Z.L., P.D.P., D.J.-T.-T., R.M., G.A.M., P.I.V., B.K., F.G., D.P.), Brussels Free University-VUB, B-1090 Brussels, Belgium; Department of Endocrinology (P.G.), Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven-KUL, B-3000 Leuven, Belgium; Department of Medicine (C.S.H.), University of Washington, Seattle, Washington 98109; and Department of Clinical Sciences (Å.L.), Lund University, Skåne University Hospital, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.1210/jc.2015-1216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393519PMC
June 2015

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.

Sci Rep 2015 Jun 16;5:11196. Epub 2015 Jun 16.

Dept. of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1038/srep11196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468815PMC
June 2015

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study.

Diabetologia 2015 May 10;58(5):980-7. Epub 2015 Feb 10.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, 3650 Spectrum Boulevard, Suite 100, Tampa, FL, 33612, USA,

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http://dx.doi.org/10.1007/s00125-015-3514-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393776PMC
May 2015

The streetlight effect--is there light at the end of the tunnel?

Authors:
Åke Lernmark

Diabetes 2015 Apr;64(4):1105-7

Department of Clinical Sciences, Lund University/Clinical Research Centre, Skåne University Hospital, Malmö, Sweden

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http://dx.doi.org/10.2337/db15-0011DOI Listing
April 2015

A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.

J Immunol 2015 Jan 12;194(2):615-29. Epub 2014 Dec 12.

Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada;

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http://dx.doi.org/10.4049/jimmunol.1302689DOI Listing
January 2015

GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial.

Diabetes Care 2014 Jun 5;37(6):1675-80. Epub 2014 Mar 5.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, GermanyForschergruppe Diabetes e.V., Neuherberg, Germany

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http://dx.doi.org/10.2337/dc13-1719DOI Listing
June 2014

Carl-David Agardh, 1946-2013.

Diabetologia 2014 Apr;57(4):651-2

Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Skåne University Hospital SUS, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-014-3182-3DOI Listing
April 2014

Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes.

Diabetes 2013 Nov 8;62(11):3951-6. Epub 2013 Aug 8.

Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.2337/db13-0215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806611PMC
November 2013

Depleting T cells in newly diagnosed autoimmune (type 1) diabetes--are we getting anywhere?

Authors:
Åke Lernmark

Diabetes 2013 Nov;62(11):3669-70

Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmoe, Sweden.

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http://dx.doi.org/10.2337/db13-1207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806610PMC
November 2013

Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets.

J Biol Chem 2013 Oct 9;288(40):29013-23. Epub 2013 Aug 9.

From the Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Skåne University Hospital SUS, SE-205 02 Malmö, Sweden and.

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http://www.jbc.org/content/288/40/29013.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.478222
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.478222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789998PMC
October 2013

Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?

Authors:
Ake Lernmark

Diabetologia 2013 Sep 11. Epub 2013 Sep 11.

Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden,

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http://dx.doi.org/10.1007/s00125-013-3041-7DOI Listing
September 2013