Publications by authors named "Akari Suzuki"

79Publications

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells.

EBioMedicine 2020 Aug 22;58:102913. Epub 2020 Jul 22.

Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo105-8512, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT), Minato-ku, Tokyo108-8639, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387783PMC
August 2020

Chromosomal alterations among age-related haematopoietic clones in Japan.

Nature 2020 08 24;584(7819):130-135. Epub 2020 Jun 24.

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1038/s41586-020-2426-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489641PMC
August 2020

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.

Nat Genet 2020 07 8;52(7):669-679. Epub 2020 Jun 8.

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1038/s41588-020-0640-3DOI Listing
July 2020

Linking of genetic risk variants to disease-specific gene expression via multi-omics studies in rheumatoid arthritis.

Semin Arthritis Rheum 2019 12;49(3S):S49-S53

Laboratory for Autoimmune diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.semarthrit.2019.09.007DOI Listing
December 2019

Effects of short-term immobilization of the upper limb on the somatosensory pathway: a study of short-latency somatosensory evoked potentials.

J Phys Ther Sci 2019 Aug 19;31(8):603-607. Epub 2019 Aug 19.

Department of Physical Therapy, Faculty of Health Sciences at Fukuoka, International University of Health and Welfare: 137-1 Enokizu, Okawa city, Fukuoka 831-8501, Japan.

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http://dx.doi.org/10.1589/jpts.31.603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698469PMC
August 2019

A path analysis of the interdependent relationships between life space assessment scores and relevant factors in an elderly Japanese community.

J Phys Ther Sci 2019 Apr 1;31(4):326-331. Epub 2019 Apr 1.

Department of Physical Therapy, School of Rehabilitation Sciences at Fukuoka, International University of Health and Welfare: 137-1 Enokizu, Okawa-city, Fukuoka 831-8501, Japan.

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http://dx.doi.org/10.1589/jpts.31.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451960PMC
April 2019

Relationship of Cough Strength to Respiratory Function, Physical Performance, and Physical Activity in Older Adults.

Respir Care 2019 Jul 5;64(7):828-834. Epub 2019 Feb 5.

Department of Physical Therapy, School of Health Sciences, Kyoto Tachibana University, Kyoto-shi, Kyoto, Japan.

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http://dx.doi.org/10.4187/respcare.06490DOI Listing
July 2019

Genetics of rheumatoid arthritis: 2018 status.

Ann Rheum Dis 2019 04 8;78(4):446-453. Epub 2018 Dec 8.

Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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http://dx.doi.org/10.1136/annrheumdis-2018-213678DOI Listing
April 2019

Transcriptome analysis of peripheral blood from patients with rheumatoid arthritis: a systematic review.

Inflamm Regen 2018 5;38:21. Epub 2018 Nov 5.

4Center for Integrative Medical Sciences, the Institute of Physical and Chemical Research (RIKEN), 1-7-22 Suehirocho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045 Japan.

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https://inflammregen.biomedcentral.com/articles/10.1186/s412
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http://dx.doi.org/10.1186/s41232-018-0078-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217768PMC
November 2018

HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis.

J Rheumatol 2018 07 15;45(7):905-914. Epub 2018 Apr 15.

From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.

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http://dx.doi.org/10.3899/jrheum.170909DOI Listing
July 2018

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.

Cell Rep 2018 02;22(6):1473-1483

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108-8639, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.031DOI Listing
February 2018

A gene module associated with dysregulated TCR signaling pathways in CD4 T cell subsets in rheumatoid arthritis.

J Autoimmun 2018 05 13;89:21-29. Epub 2017 Nov 13.

Center for Integrative Medical Sciences, The Institute of Physical and Chemical Research (RIKEN), 1-7-22 Suehirocho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan.

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http://dx.doi.org/10.1016/j.jaut.2017.11.001DOI Listing
May 2018

Effect of chest and abdominal wall mobility and respiratory muscle strength on forced vital capacity in older adults.

Respir Physiol Neurobiol 2017 12 8;246:47-52. Epub 2017 Aug 8.

Department of Physical Therapy, School of Health Sciences at Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Okawa-shi, Fukuoka 831-8501, Japan.

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http://dx.doi.org/10.1016/j.resp.2017.08.004DOI Listing
December 2017

Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.

BMC Musculoskelet Disord 2016 05 5;17:205. Epub 2016 May 5.

Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, The Institute of Physical and Chemical Research (RIKEN), 1-7-22 Suehirocho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan.

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http://dx.doi.org/10.1186/s12891-016-1055-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858923PMC
May 2016

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity.

Nat Commun 2016 Mar 3;7:10836. Epub 2016 Mar 3.

Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

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http://dx.doi.org/10.1038/ncomms10836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782062PMC
March 2016

Genetic studies of rheumatoid arthritis.

Proc Jpn Acad Ser B Phys Biol Sci 2015 ;91(8):410-22

Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo.

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http://dx.doi.org/10.2183/pjab.91.410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729856PMC
July 2016

From genetics to functional insights into rheumatoid arthritis.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S40-3. Epub 2015 Oct 12.

Laboratories for Rheumatic Diseases, SNP Research Center, RIKEN, Yokohama, Kanagawa; and Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan.

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December 2015

Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.

Sci Rep 2015 Aug 21;5:13041. Epub 2015 Aug 21.

Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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http://dx.doi.org/10.1038/srep13041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544002PMC
August 2015

Genetics of rheumatoid arthritis in Asia--present and future.

Nat Rev Rheumatol 2015 Jun 10;11(6):375-9. Epub 2015 Feb 10.

Laboratory for Autoimmune Diseases, Center for Integrated Medical Sciences, RIKEN, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1038/nrrheum.2015.7DOI Listing
June 2015

Genetic basis of rheumatoid arthritis: a current review.

Biochem Biophys Res Commun 2014 Sep 29;452(2):254-62. Epub 2014 Jul 29.

Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2014.07.085DOI Listing
September 2014

Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation.

Nucleic Acids Res 2014 Jul 23;42(13):8285-96. Epub 2014 Jun 23.

Laboratory of Cancer Epigenetics, Faculty of Medicine, Université Libre de Bruxelles, 808 route de Lennik, 1070 Brussels, Belgium

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http://dx.doi.org/10.1093/nar/gku522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117755PMC
July 2014

Interaction of di-N-acetylchitobiosyl moranoline with a family GH19 chitinase from moss, Bryum coronatum.

Glycobiology 2014 Oct 6;24(10):945-55. Epub 2014 Jun 6.

Department of Advanced Bioscience, Kinki University, 3327-204, Nakamachi, Nara 631-8505, Japan

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http://dx.doi.org/10.1093/glycob/cwu052DOI Listing
October 2014

Identification of citrullinated cellular fibronectin in synovial fluid from patients with rheumatoid arthritis.

Mod Rheumatol 2014 Sep 5;24(5):766-9. Epub 2014 Feb 5.

Department of Rheumatology, Tokyo Medical University Hospital , Tokyo , Japan.

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http://dx.doi.org/10.3109/14397595.2013.879413DOI Listing
September 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.

Nat Commun 2013 ;4:1836

Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/ncomms2862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674250PMC
December 2013

Facile synthesis of 4-O-β-N-acetylchitooligosyl 2-acetamido-2,3-dideoxydidehydro-gluconolactone based on the transformation of chitooligosaccharide and its suppressive effects against the furylfuramide-induced SOS response.

Biosci Biotechnol Biochem 2012 7;76(7):1362-6. Epub 2012 Jul 7.

Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.

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http://dx.doi.org/10.1271/bbb.120119DOI Listing
November 2012

Regulation of histone modification and chromatin structure by the p53-PADI4 pathway.

Nat Commun 2012 Feb 14;3:676. Epub 2012 Feb 14.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.

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http://dx.doi.org/10.1038/ncomms1676DOI Listing
February 2012

Insight from genome-wide association studies in rheumatoid arthritis and multiple sclerosis.

FEBS Lett 2011 Dec 17;585(23):3627-32. Epub 2011 May 17.

Laboratory for Autoimmune Diseases, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Tsurumi-ku, Yokohama City, Kanagawa, Japan.

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http://dx.doi.org/10.1016/j.febslet.2011.05.025DOI Listing
December 2011

PADI4 polymorphism predisposes male smokers to rheumatoid arthritis.

Ann Rheum Dis 2011 Mar 9;70(3):512-5. Epub 2010 Nov 9.

Correspondence to Dr Yuta Kochi, Laboratory for Autoimmune Diseases, CGM, RIKEN, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1136/ard.2010.130526DOI Listing
March 2011

Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis.

Nat Rev Rheumatol 2010 May 16;6(5):290-5. Epub 2010 Mar 16.

Center for Genomic Medicine, RIKEN, Tokyo, Japan.

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http://dx.doi.org/10.1038/nrrheum.2010.23DOI Listing
May 2010

Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.

Hum Mol Genet 2010 Jun 1;19(11):2313-20. Epub 2010 Mar 1.

Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1093/hmg/ddq092DOI Listing
June 2010

FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.

J Immunol 2009 Nov;183(9):5502-10

Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901982
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http://dx.doi.org/10.4049/jimmunol.0901982DOI Listing
November 2009

Genetics of rheumatoid arthritis: underlying evidence of ethnic differences.

J Autoimmun 2009 May-Jun;32(3-4):158-62. Epub 2009 Mar 26.

University of Tokyo Hospital, Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S08968411090002
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http://dx.doi.org/10.1016/j.jaut.2009.02.020DOI Listing
July 2009

SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis.

J Rheumatol 2008 Sep 15;35(9):1723-8. Epub 2008 Aug 15.

Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.

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September 2008

Citrullinated fibrinogen inhibits thrombin-catalysed fibrin polymerization.

J Biochem 2008 Sep 26;144(3):393-8. Epub 2008 Jun 26.

Daiichi-Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan.

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http://dx.doi.org/10.1093/jb/mvn079DOI Listing
September 2008

Citrullination by peptidylarginine deiminase in rheumatoid arthritis.

Ann N Y Acad Sci 2007 Jun;1108:323-39

Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN), 1-7-22, Suehirocho, Tsurumi-ku, Yokohama City, Kanagawa, Japan.

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http://dx.doi.org/10.1196/annals.1422.034DOI Listing
June 2007

Total syntheses of natural tubelactomicins B, D, and E: establishment of their stereochemistries.

J Org Chem 2007 Aug 11;72(16):6143-8. Epub 2007 Jul 11.

Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

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http://dx.doi.org/10.1021/jo0708442DOI Listing
August 2007

Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.

Biochem Biophys Res Commun 2006 Mar 6;341(1):94-100. Epub 2006 Jan 6.

Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.160DOI Listing
March 2006

Anti-citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis.

Biochem Biophys Res Commun 2005 Jul;333(2):418-26

Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.05.137DOI Listing
July 2005

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis.

Org Lett 2005 May;7(11):2265-7

Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

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http://dx.doi.org/10.1021/ol050763xDOI Listing
May 2005

Comparison of enzymatic properties between hPADI2 and hPADI4.

Biochem Biophys Res Commun 2005 Feb;327(1):192-200

Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2004.11.152DOI Listing
February 2005

Citrullinated proteins in rheumatoid arthritis.

Front Biosci 2005 Jan 1;10:54-64. Epub 2005 Jan 1.

Laboratory for Rheumatic Diseases, SNP Research Center, Riken, Yokohama, Japan.

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http://dx.doi.org/10.2741/1506DOI Listing
January 2005

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.

Nat Genet 2003 Dec 9;35(4):341-8. Epub 2003 Nov 9.

Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN), 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/ng1267DOI Listing
December 2003

Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.

Trends Mol Med 2003 Nov;9(11):503-8

Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

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http://dx.doi.org/10.1016/j.molmed.2003.09.010DOI Listing
November 2003

SNP detection and allele frequency determination by SSCP.

Methods Mol Biol 2003 ;212:37-46

Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan.

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http://dx.doi.org/10.1385/1-59259-327-5:037DOI Listing
May 2003

A single-strand conformation polymorphism method for the large-scale analysis of mutations/polymorphisms using capillary array electrophoresis.

Electrophoresis 2002 Jul;23(14):2259-66

Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/1522-2683(200207)23:14<2259::AID-ELPS2259>3.0.CO;2-8DOI Listing
July 2002