Ajit Thomas

Ajit Thomas

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Ajit Thomas

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A novel and potent brain penetrant inhibitor of extracellular vesicle release.

Br J Pharmacol 2019 Jul 4. Epub 2019 Jul 4.

Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1111/bph.14789DOI Listing
July 2019

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold.

Eur J Med Chem 2019 May 9;170:276-289. Epub 2019 Mar 9.

Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.03.015DOI Listing
May 2019

Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids.

Eur J Med Chem 2018 Nov 18;159:23-34. Epub 2018 Sep 18.

Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183081
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http://dx.doi.org/10.1016/j.ejmech.2018.09.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193832PMC
November 2018

Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.

Nephrol Dial Transplant 2018 08;33(8):1343-1353

Division of Nephrology, New York University Langone Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1093/ndt/gfx349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070111PMC
August 2018

Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.

ACS Chem Neurosci 2018 04 4;9(4):809-816. Epub 2018 Jan 4.

Department of Medicine , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906198PMC
April 2018

Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease.

J Control Release 2017 Oct 31;263:132-138. Epub 2017 Jan 31.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21231, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661937PMC
October 2017

Granulomatosis with polyangiitis presenting as a pituitary lesion.

Br J Hosp Med (Lond) 2017 Apr;78(4):234

Consultant Endocrinologist, Department of Endocrinology and Diabetes, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent ST4 6QG.

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http://dx.doi.org/10.12968/hmed.2017.78.4.234DOI Listing
April 2017

Development of a primary microglia screening assay and its use to characterize inhibition of system x by erastin and its analogs.

Biochem Biophys Rep 2017 Mar 17;9:266-272. Epub 2017 Jan 17.

Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.

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http://dx.doi.org/10.1016/j.bbrep.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614578PMC
March 2017

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain.

Neurobiol Dis 2016 Oct 17;94:116-28. Epub 2016 Jun 17.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, 1800 Orleans St, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394739PMC
October 2016

/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities.

JCI Insight 2016 Aug;1(12)

Department of Neurology, Baltimore, Maryland, USA; Johns Hopkins Drug Discovery, Baltimore, Maryland, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/jci.insight.88634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985244PMC
August 2016

High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.

PLoS One 2015 7;10(8):e0127785. Epub 2015 Aug 7.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127785PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529246PMC
May 2016

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold.

ACS Med Chem Lett 2016 May 13;7(5):520-4. Epub 2016 Mar 13.

Johns Hopkins Drug Discovery Program, Johns Hopkins University, Baltimore, Maryland 21205, United States; Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868099PMC
May 2016

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.

PLoS One 2015 26;10(5):e0124481. Epub 2015 May 26.

Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444023PMC
February 2016

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.

Bioorg Med Chem Lett 2015 Nov 14;25(21):4787-4792. Epub 2015 Jul 14.

Department of Biological Sciences, Columbia University, 550 West 120th Street, 1208 Northwest Corner Building, MC 4846, New York, NY 10027, United States; Department of Chemistry, Columbia University, New York, NY 10027, United States; Howard Hughes Medical Institute, Columbia University, New York, NY 10027, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653046PMC
November 2015

Preventing Allograft Rejection by Targeting Immune Metabolism.

Cell Rep 2015 Oct 17;13(4):760-770. Epub 2015 Oct 17.

Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626381PMC
October 2015

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors.

J Med Chem 2015 Sep 3;58(18):7258-72. Epub 2015 Sep 3.

Brain Science Institute, ‡Department of Neurology, and §Department of Molecular and Comparative Pathobiology, Johns Hopkins University , Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003509PMC
September 2015

Utility of respiratory ward-based NIV in acidotic hypercapnic respiratory failure.

Respirology 2014 Nov 25;19(8):1241-7. Epub 2014 Aug 25.

Academic Department of Sleep & Ventilation, Heart of England NHS Foundation Trust, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/resp.12366DOI Listing
November 2014

Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells.

Exp Brain Res 2014 Aug 27;232(8):2637-44. Epub 2014 Jun 27.

Brain Science Institute, Johns Hopkins University, 855 North Wolfe Street, Baltimore, MD, 21205, USA.

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http://link.springer.com/10.1007/s00221-014-4017-7
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http://dx.doi.org/10.1007/s00221-014-4017-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112047PMC
August 2014

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.

Elife 2014 May 20;3:e02523. Epub 2014 May 20.

Department of Biological Sciences, Columbia University, New York, United States Department of Systems Biology, Columbia University, New York, United States Department of Chemistry, Columbia University, New York, United States Howard Hughes Medical Institute, Columbia University, New York, United States

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http://dx.doi.org/10.7554/eLife.02523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054777PMC
May 2014

Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.

Biochem Biophys Res Commun 2014 Jan 19;443(1):32-6. Epub 2013 Nov 19.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2013.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927782PMC
January 2014

Children must be protected from the tobacco industry's marketing tactics.

Authors:
Nicholas Hopkinson Colin Wallis Bernard Higgins Stephen Gaduzo Rebecca Sherrington Sarah Keilty Myra Stern John Britton Andrew Bush John Moxham Karl Sylvester Valerie Griffiths Tim Sutherland Iain Crossingham Raghu Raju Charlotte Spencer Shahideh Safavi Paul Deegan John Seymour Katherine Hickman John Hughes Jason Wieboldt Fizah Shaheen Clive Peedell Nesta Mackenzie David Nicholl Caroline Jolley Gillian Crooks Gillian Crooks Claire Dow Pete Deveson Oliver Bintcliffe Barry Gray Sanjay Kumar Sarah Haney Marianne Docherty Angela Thomas Felix Chua Akshay Dwarakanath Geoffrey Summers Keith Prowse Stephen Lytton Yee Ean Ong Jennifer Graves Tushar Banerjee Peter English Andrew Leonard Martin Brunet Nauman Chaudhry Robert Ian Ketchell Natalie Cummings Jenny Lebus Charles Sharp Chris Meadows Amelie Harle Tara Stewart Diane Parry Suzanne Templeton-Wright John Moore-Gillon James Stratford- Martin Sarvesh Saini Simon Matusiewicz Simon Merritt Lee Dowson Karnan Satkunam Luke Hodgson Eui-Sik Suh Hannah Durrington Emma Browne Nicola Walters Joerg Steier Simon Barry Mark Griffiths Nicholas Hart Marko Nikolic Matthew Berry Ajit Thomas Joy Miller Diarmuid McNicholl Paul Marsden Geoffrey Warwick Laura Barr David Adeboyeku Mohd Shahrin Mohd Noh Paul Griffiths Lisa Davies Jennifer Quint Rebecca Lyall Jonathan Shribman Andrea Collins Jon Goldman Susannah Bloch Alison Gill William Man Anne Christopher Razouqi Yasso Ashwin Rajhan Dinesh Shrikrishna Caroline Moore Gareth Absalom Richard Booton Robert William Fowler Carolyn Mackinlay Elizabeth Sapey Sara Lock Paul Walker Akhilesh Jha Imran Satia Bethia Bradley Naveed Mustfa Raana Haqqee Matt Thomas Anant Patel Anthony Redington Anilkumar Pillai Niall Keaney Stephen Fowler Lesley Lowe Amanda Brennan Douglas Morrison Clare Murray Jenny Hankinson P Dutta Matthew Maddocks Martino Pengo Katrina Curtis Gerrard Rafferty John Hutchinson Ruth Whitfield Steve Turner Ronan Breen Shams-un-nisa Naveed Chris Goode Georgina Esterbrook Liju Ahmed Woolf Walker David Ford Gary Connett Philip Davidson Will Elston Andrew Stanton David Morgan James Myerson David Maxwell Ann Harrris Sonia Parmar Catherine Houghton Robert Winter Zudin Puthucheary Fiona Thomson Sharon Sturney John Harvey Patricia L Haslam Irem Patel David Jennings Simon Range Brendan Mallia-Milanes Anne Collett Paul Tate Richard Russell Johanna Feary Ronan O'Driscoll James Eaden Jonathan Round Emma Sharkey Mary Montgomery Sophie Vaughan Kate Scheele Anna Lithgow Samuel Partridge Richard Chavasse Louise Restrick Sanjay Agrawal Said Abdallah Amruta Lacy-Colson Nick Adams Sally Mitchell Helmy Haja Mydin Ann Ward Sarah Denniston Mark Steel Dipansu Ghosh Stephen Connellan Lucy Rigge Ruth Williams Alison Grove Sadia Anwar Lee Dobson Harold Hosker David Stableforth Neil Greening Tim Howell Georgina Casswell Sarah Davies Georgia Tunnicliffe Philip Mitchelmore Elpida Phitidis Louise Robinson Keith Prowse Mona Bafadhel Grace Robinson Alison Boland Marc Lipman Stephen Bourke Sundeep Kaul Calvin Cowie Ian Forrest Elizabeth Starren Hannah Burke John Furness Angshu Bhowmik Caroline Everett Douglas Seaton Steve Holmes Simon Doe Samuel Parker Annika Graham Ian Paterson Usman Maqsood Chandra Ohri Peter Iles Samuel Kemp Ahsan Iftikhar Chris Carlin Tim Fletcher Peter Emerson Victoria Beasley Michelle Ramsay Robert Buttery Sarah Mungall Stephen Crooks John Ridyard David Ross Alison Guadagno Emma Holden Ian Coutts Kathy Cullen Sally O'Connor Jack Barker Katherine Sloper John Watson Peter Smith Paul Anderson Louise Brown Cyril Nyman Heather Milburn Amelia Clive Matthew Serlin Charlotte Bolton Jonathan Fuld Helen Powell Mark Dayer Ian Woolhouse Adamantia Georgiadi Helen Leonard James Dodd Ian Campbell Gary Ruiz Andrew Zurek James Y Paton Adam Malin Fraser Wood Gareth Hynes David Connell David Spencer Sarah Brown David Smith David Cooper Cecilia O'Kane Alex Hicks Ben Creagh-Brown James Lordan Annabel Nickol Robert Primhak Louise Fleming Duncan Powrie Joanna Brown Zaid Zoumot Sarah Elkin Joanna Szram Anthony Scaffardi Robert Marshall Ian Macdonald Darren Lightbody Ray Farmer Iain Wheatley Paul Radnan Ian Lane Andrew Booth Sean Tilbrook Toby Capstick Lee Hewitt Martin McHugh Christopher Nelson Patrick Wilson Vijay Padmanaban John White John Davison Una O'Callaghan Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Rosalind Backham Kim Randall Tracey Mathieson Alex Long Marilyn Parkes Sarah Clarke Bev Allen Carol Connelly Georgia Forster Jacky Hoadley Katharine Martin Kate Barnham Katie Khan Maureen Munday Catherine Edwards Doreen O'Hara Sally Turner Sue Pieri-Davies Kate Ford Tracey Daniels Joanne Wright Rebecca Towns Karen Fern Jane Butcher Karen Burgin Barbara Winter Debbie Freeman Sandra Olive Linda Gray Kathy Pye Debbie Roots Nicola Cox Carol-Anne Davies Jacquelyne Wicker Kay Hilton Jananee Lloyd Vicky MacBean Marion Wood Julia Kowal Janis Downs Helen Ryan Fran Guyatt Debby Nicoll Elizabeth Lyons Divya Narasimhan Anne Rodman Sandy Walmsley Alison Newey Maria Buxton Maria Dewar Angela Cooper Jacqui Reilly Julie Lloyd Alison Bennett Macmillan Debbie Roots Amy Olley Nia Voase Sarah Martin Iona McCarvill Anne Christensen Rowan Agate Karen Heslop Amber Timlett Karen Hailes Claire Davey Barbara Pawulska Amber Lane Shona Ioakim Alexandra Hough Jo Treharne Helen Jones Alice Winter-Burke Lauren Miller Bronwen Connolly Lyn Bingham Una Fraser Julia Bott Carol Johnston Alison Graham Denise Curry Helen Sumner Carol Ann Costello Charlotte Bartoszewicz Ros Badman Kathryn Williamson Amy Taylor Helen Purcell Emma Barnett Alanna Molloy Laura Crawfurd Nicola Collins Valerie Monaghan Misbah Mir Victoria Lord Janet Stocks Adrian Edwards Trish Greenhalgh Warren Lenney Martin McKee Danny McAuley Azeem Majeed John Cookson Emma Baker Sam Janes Wisia Wedzicha David Lomas Dean Brian Harrison Tony Davison Peter Calverley Robert Wilson Robert Stockley Jon Ayres John Gibson John Simpson Sherwood Burge John Warner Warren Lenney Neil Thomson Peter Davies Ashley Woodcock Mark Woodhead Stephen Spiro Lawrence Ormerod Graham Bothamley Martyn Partridge Michael Shields Hugh Montgomery Anita Simonds Peter Barnes Stephen Durham Sarah Malone Gilda Arabnia Sharon Olivier Karen Gardiner Sheila Edwards

BMJ 2013 Dec 9;347:f7358. Epub 2013 Dec 9.

British Thoracic Society Chronic Obstructive Pulmonary Disease Specialist Advisory Group, National Heart and Lung Institute, Imperial College, London SW3 6NP, UK.

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http://dx.doi.org/10.1136/bmj.f7358DOI Listing
December 2013

The prevalence and severity of obstructive sleep apnea in severe obesity: the impact of ethnicity.

J Clin Sleep Med 2013 Sep;9(9):853-8

School of Clinical and Experimental Medicine and Birmingham and Black Country NIHR CLAHRC, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.5664/jcsm.2978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746711PMC
September 2013

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.

Biochem Biophys Res Commun 2013 Aug 10;438(2):243-8. Epub 2013 Jul 10.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bbrc.2013.06.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094369PMC
August 2013

Stroke due to Thromboembolism from Congenital Aneurysm of Ventricular Septum.

Acute Med 2008 ;7(1):43-4

Royal Gwent Hospital Cardiff Road Newport NP20 2UB.

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October 2012

Inhibition of xc⁻ transporter-mediated cystine uptake by sulfasalazine analogs.

Bioorg Med Chem Lett 2011 Oct 12;21(20):6184-7. Epub 2011 Aug 12.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.07.081DOI Listing
October 2011

"Cepacia syndrome" associated with Burkholderia cepacia (Genomovar I) infection in an adolescent with cystic fibrosis.

Pediatr Pulmonol 2011 May 30;46(5):512-4. Epub 2010 Dec 30.

West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK.

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http://dx.doi.org/10.1002/ppul.21404DOI Listing
May 2011

The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.

J Pharmacol Exp Ther 2010 Nov 19;335(2):362-8. Epub 2010 Aug 19.

The Brain Science Institute, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Suite 270, Baltimore, MD 21205, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.110.16618
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http://dx.doi.org/10.1124/jpet.110.166181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202469PMC
November 2010

Bioanalysis of N-acetyl-aspartyl-glutamate as a marker of glutamate carboxypeptidase II inhibition.

Anal Biochem 2010 Sep 29;404(1):94-6. Epub 2010 Apr 29.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.ab.2010.04.029DOI Listing
September 2010

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function.

Eur J Pharmacol 2010 Jan 15;626(2-3):193-9. Epub 2009 Oct 15.

Johns Hopkins University School of Medicine, Brain Science Institute Neurotranslational Center, 6611 Tributary Street, Baltimore, MD 21224-6515, USA.

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http://dx.doi.org/10.1016/j.ejphar.2009.10.002DOI Listing
January 2010

Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.

J Neurochem 2010 Jan 6;112(2):564-76. Epub 2009 Nov 6.

Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06478.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809121PMC
January 2010

GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.

J Neurovirol 2009 Sep;15(5-6):449-57

Brain Science Institute, NeuroTranslational Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.3109/13550280903350598DOI Listing
September 2009

Giant cystadenoma of prostate.

Urol J 2009 ;6(1):57-9

Department of Urology, Christian Medical College, Tamil Nadu, India.

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June 2009

Vesicovaginal fistula repair using tunneled gluteal cutaneous fat-pad flap.

Int Urogynecol J Pelvic Floor Dysfunct 2009 Jan 17;20(1):121-2. Epub 2008 Jul 17.

Department of Urology, Christian Medical College and Hospital, Vellore 632004, India.

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http://dx.doi.org/10.1007/s00192-008-0681-0DOI Listing
January 2009

Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.

Adv Exp Med Biol 2006 ;576:327-37; discussion 361-3

Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1007/0-387-30172-0_24DOI Listing
August 2006

Enantiospecificity of glutamate carboxypeptidase II inhibition.

J Med Chem 2005 Apr;48(7):2319-24

Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1021/jm049258gDOI Listing
April 2005

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

Bioorg Med Chem Lett 2003 Jul;13(13):2097-100

Guilford Pharmaceuticals Inc., 6611 Tributary Street, MD 21224, Baltimore, USA.

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http://dx.doi.org/10.1016/s0960-894x(03)00407-4DOI Listing
July 2003

NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Eur J Pharmacol 2003 Jun;471(3):177-84

Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/s0014-2999(03)01832-6DOI Listing
June 2003