Publications by authors named "Ajit Kumar Padhy"

25 Publications

  • Page 1 of 1

Left sinus of Valsalva aneurysm rupturing into superior vena cava.

Asian Cardiovasc Thorac Ann 2019 Oct 18;27(8):677-680. Epub 2019 Sep 18.

Department of Cardiovascular and Thoracic Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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http://dx.doi.org/10.1177/0218492319878019DOI Listing
October 2019

Surgical challenge in situs inversus with dextrocardia and Lutembacher syndrome.

Asian Cardiovasc Thorac Ann 2018 Nov 6;26(9):690-693. Epub 2017 Mar 6.

GB Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Situs inversus with dextrocardia and Lutembacher syndrome is a rare cardiac anomaly. It is associated with other complex cardiac anomalies and anatomical defects. A 30-year-old woman with this condition underwent mitral valve replacement and closure of a secundum atrial septal defect. We describe the surgical approach, position of the surgeon, and bicaval cannulation technique for this anatomical aberration.
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http://dx.doi.org/10.1177/0218492317697449DOI Listing
November 2018

Radioiodine Remnant Ablation: A Critical Review.

World J Nucl Med 2015 Sep-Dec;14(3):144-55

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore 169608, Singapore.

Radioiodine remnant ablation (RRA) is considered a safe and effective method for eliminating residual thyroid tissue, as well as microscopic disease if at all present in thyroid bed following thyroidectomy. The rationale of RRA is that in the absence of thyroid tissue, serum thyroglobulin (Tg) measurement can be used as an excellent tumor marker. Other considerations are like the presence of significant remnant thyroid tissue makes detection and treatment of nodal or distant metastases difficult. Rarely, microscopic disease in the thyroid bed if not ablated, in the future, could be a source of anaplastic transformation. On the other hand, microscopic tumor emboli in distant sites could be the cause of distant metastasis too. The ablation of remnant tissue would in all probability eliminate these theoretical risks. It may be noted that all these are unproven contentious issues except postablation serum Tg estimation that could be a good tumor marker for detecting early biochemical recurrence in long-term follow-up strategy. Radioactive iodine is administered as a form of "adjuvant therapy" for remnant ablation. There have been several reports with regard to the administered dose for remnant ablation. The first report of a prospective randomized clinical trial was published from India by a prospective randomized study conducted at the All India Institute of Medical Sciences, New Delhi in the year 1996. The study reported that increasing the empirical (131)I initial dose to more than 50 mCi results in plateauing of the dose-response curve and thus, conventional high-dose remnant ablation needs critical evaluation. Recently, two important studies were published: One from French group and the other from UK on a similar line. Interestingly, all three studies conducted in three different geographical regions of the world showed exactly similar conclusion. The new era of low-dose remnant ablation has taken a firm scientific footing across the continents.
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http://dx.doi.org/10.4103/1450-1147.163240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564915PMC
September 2015

Spontaneous pneumomediastinum: A complication of swine flu.

Asian Cardiovasc Thorac Ann 2015 Oct 4;23(8):998-1000. Epub 2015 May 4.

Department of Cardiothoracic and Vascular Surgery, Post Graduate Institute of Medical Education and Research and Dr Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India.

The occurrence of spontaneous pneumomediastinum in swine flu, or H1N1 influenza A infection, is a rare phenomenon and only few cases have been reported in children. We describe a case of spontaneous pneumomediastinum in adult infected with swine flu.
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http://dx.doi.org/10.1177/0218492315585907DOI Listing
October 2015

Cor triatriatum sinistrum presenting in adulthood.

Asian Cardiovasc Thorac Ann 2016 Jul 17;24(6):610. Epub 2015 Mar 17.

Department of Cardiothoracic and Vascular Surgery, Post Graduate Institute of Medical Education and Research and Dr Ram Manohar Lohia Hospital, New Delhi, India.

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http://dx.doi.org/10.1177/0218492315577018DOI Listing
July 2016

Extraosseous uptake of technetium-99m methylene diphosphonate by an acute territorial cerebral infarct in a classical biodistribution pattern.

Indian J Nucl Med 2013 Oct;28(4):240-2

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore 768228, Republic of Singapore.

Technetium-99m methylene diphosphonate scintigraphy is usually performed to assess bone lesions, especially skeletal metastases in patients with a history of malignancy. However, it is important to recognize some specific conditions with a unique pattern of tracer uptake, especially in extraosseous locations as they are not related to primary neoplasm or metastases. Diagnosing such unusual presentation is essential as it significantly influences the clinical management. This case report describes an unusual presentation detected in a bone scan of an elderly female patient, who was a treated case of breast cancer and was referred for a bone scan to rule out bone metastases. Incidentally, a large acute territorial cerebral infarct was diagnosed, which was later confirmed by magnetic resonance imaging on diffusion-weighted images. Diagnosis of the typical presentation and timely management saved the patient life.
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http://dx.doi.org/10.4103/0972-3919.121974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866673PMC
October 2013

Controversies about radioactive iodine-131 remnant ablation in low risk thyroid cancers: are we near a consensus?

Asian Pac J Cancer Prev 2013 ;14(11):6209-13

Department of Radiology, The Aga Khan University Hospital, Karachi, Pakistan E-mail :

Well differentiated thyroid cancers (WDTC), including papillary (80%) and follicular (10%) types, are the most common endocrine cancers globally. Over the last few decades most the diagnosed cases have fallen into low risk categories. Radioactive iodine-131 (RAI) has an established role in reducing recurrence and improving the survival in high risk patients. In patients with primary tumor size <1 cm, RAI is not recommended by many thyroid societies. However, low risk WDTC has been an arena of major controversies, most importantly the role and dose of adjuvant RAI for remnant ablation to minimize chances of recurrence and improving survival. This review is an attempt to update readers about the previous and existing practice based on results of non- randomized trials and evolving trends fueled by recently published randomized studies.
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http://dx.doi.org/10.7314/apjcp.2013.14.11.6209DOI Listing
January 2015

Potential requirement of positron emission tomography apparatuses in Asia and latin america including Mexico.

World J Nucl Med 2013 Jan;12(1):33-7

Department of Radiological Sciences, Gunma Prefectural College of Human Health, Maebashi, Japan.

The number of positron emission tomography (PET) machines has been increasing in regions of East-, Southeast-, and South-Asia as well as in Latin America including Mexico. This study was performed to assess the potential requirement of PET machines in 19 countries which already use PET in the aforementioned regions. Data on the number of PET machines and internationally available characteristics of the restrictive countries such as the land area, the total population, the gross national income (GNI), and the average life span of inhabitants were obtained from IAEA, UN, WB, and WHO. Correlation between the number of PET machines and the characteristics of each country was evaluated. The potentially required number of PET machines, which was obtained by adjusting the number of PET machines with statistically significant, correlative characteristics of each country, standardized on the state of Japan, were compared. The number of PET machines could be significantly correlated to the GNI of a country and the average life span of its inhabitants (P < 0.05). Based on Japan, most of the countries in the regions would require considerably more PET machines. With installation of the potentially required number of PET machines in each of the countries, the number of PET machine per 10(6) population would increase by 1.1- to 12-fold, in comparison with the current situation. With regards to the potentially required number of PET machines, most of the countries in these regions may require a considerable increase of PET machines. Nevertheless, some countries in the Asia seem to require outside assistance such as international support in order to introduce PET and enhance the efficacy of their health services.
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http://dx.doi.org/10.4103/1450-1147.113957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745632PMC
January 2013

Good bye general.

Authors:
Ajit Kumar Padhy

World J Nucl Med 2013 Jan;12(1):1-2

Editor in Chief, World Journal of Nuclear Medicine, Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore - 169608 E-mail:

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http://dx.doi.org/10.4103/1450-1147.113929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745626PMC
January 2013

Incidental detection of clinically nondiagnosed inguinal hernia in (131)I whole-body scan.

Clin Nucl Med 2013 Jun;38(6):478-9

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

I whole-body bone scan was performed for an adult male patient after postradioactive iodine ablation of thyroid carcinoma. Besides the small thyroid remnants in the neck region, an incidental detection of left inguinal hernia was made in the scan, which was later confirmed by clinical examination. Despite the large size of the hernia, the patient was unaware of the condition. It can be concluded that, similar to other imaging procedures, incidental detection of unrelated clinical problems is possible in I scan also, and such early diagnosis prevents further complications that the patient may develop in the future.
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http://dx.doi.org/10.1097/RLU.0b013e31828e94efDOI Listing
June 2013

When was the Last Time You did Something for the First Time?

Authors:
Ajit Kumar Padhy

World J Nucl Med 2012 Sep;11(3):99-100

Editor in Chief, World Journal of Nuclear Medicine, Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, 169608 E-mail:

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http://dx.doi.org/10.4103/1450-1147.103404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555359PMC
September 2012

The density factor: the enigma of dense breast.

World J Nucl Med 2012 May;11(2):45-6

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore E-mail:

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http://dx.doi.org/10.4103/1450-1147.103403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555393PMC
May 2012

The Conundrum of PET/MR.

World J Nucl Med 2012 Jan;11(1):1-2

Department of Nuclear Medicine, Singapore General Hospital, 169608, Singapore E-mail:

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http://dx.doi.org/10.4103/1450-1147.98717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425221PMC
January 2012

Unusual presentation of extraosseous metastases on bone scintigraphy.

Clin Nucl Med 2012 Aug;37(8):793-7

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

Osteosarcoma metastases frequently occur in the lungs or the skeleton. Bone scans play an important role in disease staging by identifying other skip areas of skeletal involvement as well as extraosseous metastases. We report a case of aggressive osteosarcoma, with bone metastases and extraosseous areas of involvement in the lungs, distant lymph nodes, and peritoneal and subcutaneous metastasis seen in a preoperative Tc-99m methylene diphosphonate bone scan. These findings were confirmed with histology and correlative cross-sectional imaging.
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http://dx.doi.org/10.1097/RLU.0b013e31824c5ec0DOI Listing
August 2012

Welcome to saigon.

Authors:
Ajit Kumar Padhy

World J Nucl Med 2011 Jul;10(2):111-2

President, WARMTH, and Editor-in-Chief, WJNM E-mail:

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http://dx.doi.org/10.4103/1450-1147.89773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227335PMC
July 2011

"Crossed renal ectopia".

Intern Emerg Med 2012 May 10;7 Suppl 1:S53-4. Epub 2011 Jul 10.

Department of Nuclear Medicine and PET, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.

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http://dx.doi.org/10.1007/s11739-011-0664-xDOI Listing
May 2012

Pancreatic metastasis detected by F-18 FDG PET/CT in a patient with breast cancer.

Clin Nucl Med 2011 Jun;36(6):479-80

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

Pancreatic involvement by metastasis from other primaries is rare and accounts for approximately 2% to 4% of pancreatic tumors. In this article, we describe FDG-avid pancreatic involvement in a patient with diagnosis of breast cancer. We conclude that FDG PET can be a convenient noninvasive method of early detection of recurrence and in monitoring metastatic disease during follow-up in such patients. A positive FDG PET warrants histopathologic correlation for appropriate treatment.
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http://dx.doi.org/10.1097/RLU.0b013e31820adf47DOI Listing
June 2011

Fluorine-18-fluorodeoxyglucose PET/CT for the evaluation of suspected recurrent uterine leiomyosarcomas.

Acta Radiol 2011 May 17;52(4):463-6. Epub 2011 Mar 17.

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

Background: Uterine leiomyosarcomas are rare and aggressive malignancies of the uterine corpus with high recurrence rates and poor prognoses. The current recommendation for detection of recurrent uterine leiomyosarcoma involves periodic physical examination and conventional imaging such as CT or MRI. The role of fluorine-18-fluorodeoxyglucose positron emission tomography with integrated computed tomography (FDG-PET/CT) in the detection of recurrent uterine leiomyosarcomas is not yet established.

Purpose: To evaluate the use of FDG-PET/CT as a single integrated modality for the evaluation of suspected recurrent uterine leiomyosarcomas.

Material And Methods: A retrospective study was performed on patients who underwent FDG-PET/CT scans for suspected recurrent uterine leiomyosarcoma. Only patients with follow-up data were included in the study. FDG-PET/CT was evaluated as a single integrated imaging modality. A positive lesion on FDG-PET/CT was defined as a focal abnormality detected on either the PET or CT components, or both.

Results: Sixteen consecutive patients over 5 years underwent FDG-PET/CT for suspected recurrent uterine leiomyosarcoma. Five patients were excluded due to incomplete follow-up data. The remaining 11 patients were aged 36-58 years (mean age 48). FDG-PET/CT had a sensitivity of 100% (95% CI 63-100) and specificity of 100% (95% CI 20-100) for the detection of recurrent uterine leiomyosarcomas. Sites of metastases include lungs, peritoneum, liver, pancreas and breast, of which lungs and peritoneum were the most common. Two (18%) patients had discordant findings: FDG-PET negative metastatic nodules in the breast and lung detected on the CT component. The maximum standardized uptake value (SUVmax) of metastatic lesions ranged from 2.0 to 16.0 (mean 7.6).

Conclusion: FDG-PET/CT as a single integrated modality may be a useful for the evaluation of suspected recurrent uterine leiomyosarcomas. FDG-PET negative discordant nodules detected on the CT component may represent metastases and should be followed up closely.
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http://dx.doi.org/10.1258/ar.2011.100509DOI Listing
May 2011

Differentiating suspected nasopharyngeal infection from carcinoma using dual-tracer and multiple time-point technetium-99m sestamibi and white blood cell SPECT/CT imaging.

Nucl Med Commun 2011 May;32(5):416-8

Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

The role of molecular and functional imaging lies in its capability to more accurately define and characterize pathologies, with a host of varied radiotracers and techniques being available to the clinician for use. We present a case in which dual-tracer and multiple time-point single photon emission computed tomography/computed tomography imaging using technetium-99m sestamibi and white blood cell radiotracers was used to characterize an indeterminate base of skull lesion.
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http://dx.doi.org/10.1097/MNM.0b013e328344cf6dDOI Listing
May 2011

Intensely hypermetabolic extra-axial brainstem tumor in Erdheim-Chester disease.

Clin Nucl Med 2009 Sep;34(9):604-7

Department of Medical Oncology , National Cancer Centre, Singapore, Singapore.

Erdheim-Chester disease is a rare non-Langerhans cell histiocytosis characterized by progressive histiocytic proliferation with multiorgan involvement, typically of the kidney, skin, brain, and lung, and less frequently, the heart and retro-orbital tissue. Fluorine-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) plays an important role in the management of this disease. It has been reported that FDG PET imaging allows accurate evaluation of the extent of the disease at baseline, as well as assessment of response to any specific therapy. In this case, a 57-year-old Chinese man presented with functional decline and a urinary tract infection. He had a prior history of xanthogranulomas of bilateral canthal masses. On imaging, he was found to have left hydronephrosis, diffuse urothelial thickening, increased density of the perinephric fat, mural thickening of the descending aorta and soft tissue masses along the posterior wall of the right atrium extending into the region of the interatrial septum and involving the right atrioventricular groove. Histopathology revealed retroperitoneal fibrosis. An IV contrast-enhanced FDG PET scan showed increased activity in a previously unidentified brain stem mass and the shafts of bilateral femora. Varying levels of FDG uptake were seen in the other lesions.
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http://dx.doi.org/10.1097/RLU.0b013e3181b06a7eDOI Listing
September 2009

Detection of thyroid metastases from nasopharyngeal carcinoma with F-18 FDG PET/CT.

Clin Nucl Med 2008 Mar;33(3):224-5

Department of Nuclear Medicine and PET, Singapore General Hospital, Outrtam Road, Singapore.

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http://dx.doi.org/10.1097/RLU.0b013e31815976caDOI Listing
March 2008

A report on the implementation aspects of the International Atomic Energy Agency's first doctoral coordinated research project, "Management of liver cancer using radionuclide methods with special emphasis on trans-arterial radio-conjugate therapy and internal dosimetry".

Semin Nucl Med 2008 Mar;38(2):S5-12

Department of Nuclear Medicine & PET, Singapore General Hospital, Singapore.

Liver cancer is one of the most dreaded cancers, and it is highly prevalent in the developing countries, where the resources are extremely scarce to deal with this disease using the current commercially available and expensive therapeutic radiopharmaceuticals. The International Atomic Energy Agency (IAEA), in pursuit of its mandate to promote the application of nuclear technology in the health care in its Member States, has developed and clinically evaluated a new and cost-effective therapeutic radio-conjugate, rhenium-188 ((188)Re)-lipiodol for the treatment of hepatocellular carcinoma through its first Doctoral Coordinated Research Project. The ready availability of no-carrier-added (188)Re from the tungsten-188/(188)Re generator represents a potentially important source of a therapeutic radioisotope for a broad range of therapeutic applications in nuclear medicine. The alumina-based tungsten-188/(188)Re generator system comes with reasonable cost and exhibits attractive therapeutic properties, excellent performance and very long useful shelf-life. Because of the long shelf-life of several months, the use of this generator offers a unique opportunity for the cost-effective and routine availability of a versatile therapeutic radioisotope on an on-demand basis. Further, using its extensive global network and outreach, the IAEA has also transferred the technology of the in-house preparation and use of (188)Re-labeled lipiodol to many institutions around the world, which can now prepare (188)Re-labeled lipiodol in their own radiopharmacy laboratories and treat patients. This effort of the IAEA in trying to address some of the challenges of liver cancer therapy in developing countries has been and truly a global venture with involvement and contributions from several organizations, institutions and numerous individuals. This article discusses some of the implementation aspects of this very important activity of the Agency.
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http://dx.doi.org/10.1053/j.semnuclmed.2007.10.002DOI Listing
March 2008

International Atomic Energy Agency-sponsored multination study of intra-arterial rhenium-188-labeled lipiodol in the treatment of inoperable hepatocellular carcinoma: results with special emphasis on prognostic value of dosimetric study.

Semin Nucl Med 2008 Mar;38(2):S40-5

Fundacion Santa Fe de Bogota, Bogota, Colombia.

A multicenter study was sponsored by the International Atomic Energy Agency (IAEA) to assess the safety and efficacy of transarterial rhenium-188 ((188)Re) HDD lipiodol (radioconjugate to lipiodol using an HDD kit) in the treatment of unresectable hepatocellular carcinoma. During 5 years, 185 patients received at least 1 treatment of radioconjugate, and 51 were retreated. The level of radioconjugate administered was based on radiation-absorbed dose to critical normal organs, calculated after a "scout" dose of radioconjugate. The total injected activity, including the scout dose during the first treatment, ranged from 21 to 364 mCi (mean, 108 mCi/4 GBq). Immediate and late side-effects were minimal. Tumor size could be evaluated in 88 patients. Among these patients, the objective response rate was 25%; stable disease was observed in 53% and tumor progression in 22%. With a median follow-up of 455 days, the estimated 12- and 24-month overall survival was 46% and 23%. This multicenter study shows that (188)Re lipiodol is a safe and cost-effective method to treat primary hepatocellular carcinoma via the transarterial route and requires further evaluation by treatment of greater numbers of patients.
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http://dx.doi.org/10.1053/j.semnuclmed.2007.10.006DOI Listing
March 2008

Thematic planning: the role of the International Atomic Energy Agency in promoting education, medical research, and technology transfer among nuclear medicine communities of developing countries.

Semin Nucl Med 2008 Mar;38(2):S2-4

Department of Nuclear Medicine & PET, Singapore General Hospital, Singapore.

One of the major mechanisms of implementing the International Atomic Energy Agency's (IAEA) programs in nuclear medicine has been through coordinated research projects (CRPs). In recent years, the IAEA has initiated a new type of CRP, called Doctoral CRP, in an attempt to further improve the effectiveness of its programs. The structure of the Doctoral CRP has been built on the structure of the existing CRP concept, but with a broader "thematic" approach. The word "thematic" indicates that these CRPs should both have a fairly broad scope and be designed so that their outcome, in terms of practical applications, might readily fit into the selected nuclear applications that are offered to Member States under the IAEA's mechanism for thematic planning. The Nuclear Medicine Section of IAEA's Division of Human Health initiated the first Doctoral CRP of IAEA in the year 2000, entitled, "Management of Liver Cancer Using Radionuclide Methods with Special Emphasis on Trans-Arterial Radio-conjugate Therapy and Internal Dosimetry." Since then, the CRP has accomplished several milestones, including development of a new therapeutic radiopharmaceutical ((188)Re lipiodol) and successfully carrying out Phase I and Phase II clinical trials on patients using the new therapeutic radiopharmaceutical.
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http://dx.doi.org/10.1053/j.semnuclmed.2007.10.001DOI Listing
March 2008

Preliminary results of transarterial rhenium-188 HDD lipiodol in the treatment of inoperable primary hepatocellular carcinoma.

Eur J Nucl Med Mol Imaging 2004 Feb;31(2):250-7

Nuclear Medicine Department (The PET Centre), Singapore General Hospital, Singapore.

A multicentre study was sponsored by the International Atomic Energy Agency (Vienna) to assess the safety and efficacy of trans-arterial rhenium-188 HDD conjugated lipiodol (radioconjugate) in the treatment of patients with inoperable hepatocellular carcinoma (HCC). The radioconjugate was prepared by using an HDD (4-hexadecyl 1-2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol) kit developed in Korea, and lipiodol. Over a period of 18 months, 70 patients received at least one treatment of radioconjugate. Some patients were re-treated if there was no evidence of disease progression. The level of radioconjugate administered was based on radiation-absorbed dose to critical normal organs, calculated following a "scout" dose of radioconjugate. The organs at greatest risk for radiation toxicity are the normal liver, the lung and the bone marrow. An Excel spreadsheet was used to determine maximum tolerated activity (MTA), defined as the amount of radioactivity calculated to deliver no more than 12 Gy to lungs, or 30 Gy to liver, or 1.5 Gy to bone marrow. These doses have been found to be safe in multiple trials using external beam therapy, but this has not been confirmed for systemically administered radiopharmaceuticals. Patients were followed for at least 12 weeks after therapy, until recovery from all toxicity. The clinical parameters evaluated included toxicity, response as determined by contrast-enhanced computed tomography, palliation of symptoms, overall survival, performance status (Karnofsky) and hepatic function (Child's classification). Liver function tests, serum alpha-fetoprotein (AFP) levels and complete blood counts were done at each follow-up visit. In the majority of patients, the scout dose studies indicated the radiation absorbed dose to normal liver to be the limiting factor to the treatment dose, while in a few patients dose to lung was the limiting factor. Radiation dose to bone marrow was negligible and was thus not a factor for the MTA calculations. Side-effects were minimal and usually presented as loss of appetite, right hypochondrial discomfort and low-grade fever, even at high levels of administered radioactivity. The symptoms resolved with simple supportive therapy within 3 days of onset. Liver function tests at 24 and 72 h showed no significant changes and complete blood counts at 1 week, 4 weeks and 12 weeks showed no changes (no bone marrow suppression). Sixteen patients were treated in the dose escalation phase of the study, when the activities administered started at 1.8 GBq (50 mCi) and rose to 7.7 GBq (206 mCi). In the efficacy phase of the study a further 54 patients were treated. Both groups of patients are included in this paper. The treatment activity of 188Re-lipiodol administered transarterially ranged from 1.8 to 9.8 GBq (50-265 mCi), with a mean activity of 4.6 GBq (124 mCi). Survival at 3 months was 90%, and at 6 months, 60%; 19% survived for 1 year. Mean survival after treatment in the total treated group of 70 patients was 9.5 months, with a range of 1-18 months. The results of this multicentre study show that 188Re-lipiodol is a safe and cost-effective method to treat primary HCC via the transarterial route. In terms of efficacy, it is potentially a new therapeutic approach for further evaluation by treatment of larger numbers of patients.
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http://dx.doi.org/10.1007/s00259-003-1363-2DOI Listing
February 2004
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