Dr Ajay Verma, PGDBT, MSc, PhD - University of Liverpool - Postdoctoral Research Associate

Dr Ajay Verma

PGDBT, MSc, PhD

University of Liverpool

Postdoctoral Research Associate

Liverpool, England | United Kingdom

Main Specialties: Chemistry

Additional Specialties: Organic synthesis, Halogenation, Heterocycles, Organoselenium, Peptide Synthesis

ORCID logohttps://orcid.org/0000-0001-8085-7351


Top Author

Dr Ajay Verma, PGDBT, MSc, PhD - University of Liverpool - Postdoctoral Research Associate

Dr Ajay Verma

PGDBT, MSc, PhD

Introduction

Primary Affiliation: University of Liverpool - Liverpool, England , United Kingdom

Specialties:

Additional Specialties:

Research Interests:


View Dr Ajay Verma’s Resume / CV

Education

Jun 2018
University of Liverpool
Postdoc
Chemisty
Oct 2017
IISER BHOPAL
Research Assistant
Chemisty
Aug 2012 - Jun 2017
Indian Institute of Science Education and Research (IISER) Bhopal
PhD
Chemistry
Jun 2017
IISER BHOPAL
Research Assistant
Chemisty
Jul 2009 - Jun 2011
Chhatrapati Shahu Ji Maharaj University, Kanpur
MSc
Chemistry
Jul 2009
Board of Technical Education, Uttar Pradesh
PGDBT
Biotechnology
Jan 2005 - Jun 2008
Sacred Heart Degree College (CSJMU), Sitapur
BSc
Science (Botany, Chemistry, Zoology)

Experience

Jun 2018 - Jun 2018
University of Liverpool
Postdoctoral Research Associate
Department of Chemistry
Oct 2017 - Mar 2018
Indian Institute of Science Education and Research Bhopal
Research Assistant (RA)
Department of Chemistry
Oct 2015
International conference on Nascent Developments in Chemical Sciences: Opportunities for Academia-Industry Collaboration
Oral Presenter
Best oral presentation award

Publications

18Publications

144Reads

708Profile Views

12PubMed Central Citations

Visible-light-induced oxidant and metal-free dehydrogenative cascade trifluoromethylation and oxidation of 1,6-enynes with water.

Chem Sci 2017 Sep 10;8(9):6633-6644. Epub 2017 Jul 10.

Department of Chemistry , Indian Institute of Science Education and Research (IISER) Bhopal , Bhopal By-pass Road, Bhauri , Bhopal-462066 , India . Email: ; http://home.iiserbhopal.ac.in/∼sangitkumar/.

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http://dx.doi.org/10.1039/c7sc02556dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625288PMC
September 2017
3 Reads
2 Citations
9.211 Impact Factor

Synthesis, structural analysis, antimicrobial evaluation and synergistic studies of imidazo[1,2-a]pyrimidine chalcogenides

RSC Advances

A series of mixed aryl/heteroaryl/alkyl imidazo[1,2-a]pyrimidine chalcogenides have been synthesized by nucleophilic substitution reaction on 2-(chloromethyl)imidazo[1,2-a]pyrimidine (3) with corresponding aryl/heteroaryl selenols and alkyl/aryl thiolates, generated in situ using simple and greener methodologies. Symmetrical chalcogenides were prepared by the reaction of sodium hydrogen chalcogenides with precursor 3 followed by characterization using NMR and mass spectrometry. The X-ray crystal structure was determined for compound 6 and the experimental structural parameters were compared with the theoretical values calculated at the B3LYP 6-31 G(d) level of energy. The newly synthesized compounds were evaluated for their antimicrobial activities against various fungal and bacterial strains. Compounds 6–9 showed mild antifungal activity against N. crassa, while compound 7 was found to be active against C. keyfer (MIC 18.87 μg mL−1). Interestingly, compound 7 showed antibacterial activity against the strain E. coli (MIC 18.87 μg mL−1). Time kill studies showed that the colony forming units of the strains C. keyfer and E. coli reduced rapidly after treatment with compound 7. Cytotoxicity studies were carried out for compounds 6 and 7 against HeLa cells and Hek-293 cells and exhibited less significant cytotoxicity against both the cell lines. Furthermore, as the synthesized compounds did not display potent efficacy against the tested microbial strains, the active compounds 6 and 7 were investigated for synergistic effects against the growth of C. keyfer and E. coli in combination with well known standard antifungal drug amphotericin B (Amp B) and antibacterial drug rifampicin (RIF) displaying an effective synergy with the used antibiotics.

http://dx.doi.org/10.1039/C6RA24020H

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December 2016
2 Reads

Selective Oxidative Decarbonylative Cleavage of Unstrained C(sp(3))-C(sp(2)) Bond: Synthesis of Substituted Benzoxazinones.

Org Lett 2016 09 23;18(17):4388-91. Epub 2016 Aug 23.

Department of Chemistry, IISER Bhopal , Bhopal By-pass Road, Bhauri, Bhopal, Madhya Pradesh, 462066, India.

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http://dx.doi.org/10.1021/acs.orglett.6b02142DOI Listing
September 2016
43 Reads
2 Citations

Organoselenium and DMAP co-catalysis: regioselective synthesis of medium-sized halolactones and bromooxepanes from unactivated alkenes.

Chem Commun (Camb) 2016 Mar;52(22):4179-82

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal By-pass Road, Bhauri, Bhopal, Madhya Pradesh 462066, India.

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http://dx.doi.org/10.1039/c5cc10245fDOI Listing
March 2016
5 Reads
1 Citation
6.834 Impact Factor

Synthesis and structural characterization of monomeric mercury(II) selenolate complexes derived from 2-phenylbenzamide ligands.

Dalton Trans 2016 Mar;45(9):4030-40

Department of Chemistry, Indian Institute of Science Education and Research (IISER), Bhopal, MP, India 462 066.

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http://dx.doi.org/10.1039/c5dt04356eDOI Listing
March 2016
21 Reads
4.200 Impact Factor

Palladium-Catalyzed C-H Functionalization of Ferrocenecarboxylic Acid by using 8-Aminoquinoline as a Removable Directing Group

Adv. Synth. Catal., 358: 240–253

Advanced Synthesis and Catalysis

A mild and efficient palladium-catalyzed synthetic method for the C[BOND]H functionalization of N-(quinolin-8-yl)ferrocenecarboxamide has been developed. Various aryl iodides containing I, NO2, CN, COMe, CO2Et, and NH functionalities and also alkyl iodides underwent the Pd-catalyzed intermolecular carbon-carbon bond forming reaction with ferrocenecarboxamide successfully which led to a diverse array of bis(aryl/alkyl)ferrocenecarboxamides in 34–92% yields. Cross-coupling of the ferrocenyl C[BOND]H bond with aryl iodides can also be achieved utilizing an economical Ni catalyst. Additionally, selective monoalkylation of ferrocenecarboxamide was studied using sodium bicarbonate as base and dibenzylphosphoric acid as additive under Pd-catalyzed reaction conditions. Subsequently, removal of the directing group, 8-aminoquinoline, from bis(aryl)ferrocenecarboxamides led to bis(aryl)ferrocenes bearing versatile methyl ester and carboxaldehyde functional groups.

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January 2016
2 Reads

Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines.

Org Biomol Chem 2015 Aug;13(31):8411-5

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal By-Pass Road, Bhauri, Bhopal, Madhya Pradesh 462066, India.

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http://dx.doi.org/10.1039/c5ob01196eDOI Listing
August 2015
13 Reads
2 Citations
3.562 Impact Factor

KO(t)Bu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones.

Chem Commun (Camb) 2015 Jul 23;51(58):11658-61. Epub 2015 Jun 23.

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh 462 066, India.

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http://dx.doi.org/10.1039/c5cc02964cDOI Listing
July 2015
15 Reads
6.834 Impact Factor

Copper-Catalyzed Trifluoromethylation of Alkenes: Synthesis of Trifluoromethylated Benzoxazines

Organic & Biomolecular Chemistry 2015

Organic & Biomolecular Chemistry

A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto’s reagent. It involves the oxidative difunctionalization of alkenes through tandem C-O and C-CF3 bond formations. Furthermore, synthesized benzoxazines were selectively converted into trifluoromethylated allylic and (E)-vinylic benzamides by the treatment of KOtBu and CH3Li, respectively.

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July 2015
12 Reads

KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Chem. Commun.

The KOtBu-mediated annulation of acetonitrile with aldehyde was observed, in which the cleavage of four C(sp3)–H bonds occurred and a total of eight new bonds were formed during the synthesis of substituted dihydropyridinones in the presence of peroxide. Furthermore, dihydropyridinones have been transformed into pyridinones using KOtBu in DMSO.

http://dx.doi.org/10.1039/C5CC02964C

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June 2015
8 Reads

KOtBu-Mediated Aerobic Transition-Metal-Free Regioselective β-Arylation of Indoles: Synthesis of β-(2-/4-Nitroaryl)-indoles

ChemInform 2015 May

ChemInform

β-Arylation in unprotected indoles can be achieved chemo- and regioselectively by employing KOtBu at room temperature in air without using a transition metal catalyst and aryl halide coupling partner.

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May 2015
13 Reads

KO(t)Bu-mediated aerobic transition-metal-free regioselective β-arylation of indoles: synthesis of β-(2-/4-nitroaryl)-indoles.

Org Lett 2015 Jan 12;17(1):82-5. Epub 2014 Dec 12.

Department of Chemistry, IISER Bhopal , Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh, India -462 066.

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http://dx.doi.org/10.1021/ol503274zDOI Listing
January 2015
16 Reads
2 Citations

Transition metal free intramolecular selective oxidative C(sp3)-N coupling: synthesis of N-aryl-isoindolinones from 2-alkylbenzamides.

Chem Commun (Camb) 2015 Jan;51(7):1371-4

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh, India-462 066.

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http://dx.doi.org/10.1039/c4cc08717hDOI Listing
January 2015
10 Reads
3 Citations
6.834 Impact Factor

Chemoselective arylation of phenols with bromo-nitroarenes: synthesis of nitro-biaryl-ols and their conversion into benzofurans and carbazoles.

Chem Commun (Camb) 2014 Aug;50(67):9481-4

Department of Chemistry, IISER Bhopal, Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh, India-462 066.

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http://dx.doi.org/10.1039/c4cc03090gDOI Listing
August 2014
18 Reads
6.834 Impact Factor

Top co-authors

Sangit Kumar
Sangit Kumar

Uppsala University

9
Sadhan Jana
Sadhan Jana

University of Akron

6
Shailesh Kumar
Shailesh Kumar

CSIR-Institute of Microbial Technology

5
Ch Durga Prasad
Ch Durga Prasad

Indian Institute of Science Education and Research (IISER)

4
Amit Kumar
Amit Kumar

Hohai University

4
Saket Patel
Saket Patel

Indian Institute of Science Education and Research (IISER)

3
Moh Sattar
Moh Sattar

Indian Institute of Science Education and Research Bhopal

2
Vandana Rathore
Vandana Rathore

Indian Institute of Science Education and Research

2