Dr Ajay Sharma, PhD - Career Point University Hamirpur - MMU, Mullana

Dr Ajay Sharma

PhD

Career Point University Hamirpur

MMU, Mullana

Hamirpur, Himachal Pradesh | India

Additional Specialties: Heterocycles, Green Synthesis, Phytochemical, Organic Synthesis, Material Science

ORCID logohttps://orcid.org/0000-0002-1555-1791

Dr Ajay Sharma, PhD - Career Point University Hamirpur - MMU, Mullana

Dr Ajay Sharma

PhD

Introduction

Primary Affiliation: Career Point University Hamirpur - Hamirpur, Himachal Pradesh , India

Additional Specialties:

Research Interests:

Education

Dec 2010 - Aug 2015
Maharishi Markandeshwar University
Ph. D
Chemistry Department
Aug 2015
MMU, Mullana
Ph.D
Jul 2006
JU, Gwalior
M.Sc
Oct 2005
Jammu Uni.
B.Ed

Experience

Oct 2014 - Aug 2015
Maharishi Markandeshwar University
Assistant Professor
Chemistry Department
Aug 2015
CPU, Hamirpur
Assistant Prof.
Oct 2014
MMU, Mullana
Assistant Prof.
Dec 2010
MMU, Mullana
Research Scholar
Dec 2010
MMU, Mullana
Research Scholar
Jan 2008 - Jan 2010
Jiwaji University
Research Scholar And Teaching Associate
SOS Chemicals, Sales and Marketing Management & Industrial Chemistry
Oct 2008
JU, Gwalior
Research Scholar
Teaching Associate
Aug 2015
Career Point University
Assistant Professor
Chemistry Department

Publications

29Publications

307Reads

40Profile Views

86PubMed Central Citations

Probing into Therapeutic Anti-cancer Potential of Apigenin: Recent Trends and Future Directions.

Recent Pat Inflamm Allergy Drug Discov 2019 Aug 16. Epub 2019 Aug 16.

Allergy and Immunology Unit, Advanced Pediatrics Center (APC), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab 160012. India.

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http://dx.doi.org/10.2174/1872213X13666190816160240DOI Listing
August 2019
2 Reads

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges.

Semin Cancer Biol 2019 Aug 14. Epub 2019 Aug 14.

Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.08.014DOI Listing
August 2019
1 Read
9.330 Impact Factor

Double Edge Sword Behavior of Carbendazim: A Potent Fungicide With Anticancer Therapeutic Properties.

Anticancer Agents Med Chem 2018 ;18(1):38-45

Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala (Haryana), India.

Background: A number of benzimidazole derivatives such as benomyl and carbendazim have been known for their potential role as agricultural fungicides. Simultaneously carbendazim has also been found to inhibit proliferation of mammalian tumor cells specifically drug and multidrug resistant cell lines.

Objective: To understand the dual role of Carbendazim as a fungicide and an anticancer agent, the study has been planned referring to the earlier studies in literature.

Results: Studies carried out with fungal and mammalian cells have highlighted the potential role of carbendazim in inhibiting proliferation of cells, thereby exhibiting therapeutic implications against cancer. Because of its promising preclinical antitumor activity, Carbendazim had undergone phase I clinical trials and is under further clinical investigations for the treatment of cancer. A number of theoretical interactions have been pinpointed. There are many anticancer drugs in the market, but their usefulness is limited because of drug resistance in a significant proportion of patients. The hunger for newer drugs drives anticancer drug discovery research on a global platform and requires innovations to ensure a sustainable pipeline of lead compounds.

Conclusion: Current review highlights the dual role of carbendazim as a fungicide and an anticancer agent. Further, the harmful effects of carbendazim and emphasis upon the need for more pharmacokinetic studies and pharmacovigilance data to ascertain its clinical significance, have also been discussed.

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http://dx.doi.org/10.2174/1871520616666161221113623DOI Listing
July 2019
46 Reads
2 Citations
2.469 Impact Factor

Ferulic Acid: A Promising Therapeutic phytochemical and recent patents advances.

Recent patents on inflammation & allergy drug discovery

BACKGROUND:Among the various phenolics metabolites, ferulic acid is considered as the promising mitigating, restorative and antioxidant agent. The ferulic acid is for the mostly found in natural products, vegetables, for example, tomatoes, sweet corn, and rice grain. Phytochemicals are utilized in the treatment of human ailments and these are derived from the dietary compounds. OBJECTIVE:The present review widely argued the calming restorative capability of ferulic acid alongside the scientific evidences and its proposed mechanism for activity. Furthermore, we provided the main practical points for its use of ferulic acid in oxidative damages during various diseases. Additionally, the relevant patents on ferulic acid with various therapeutic potential are also summarized. METHODS:The approach consisted to search several resources, including theses, technical reports, web-based scientific databases such as publications on PubMed, Science-direct, Springer, PROTA, Google Scholar, and other allied databases. Thus, recent patent regarding role of ferulic acid therapeutic potenitial have been discussed. CONCLUSION:Ferulic acids are known to contrarily down-manage an assortment of extracellular and intracellular atomic targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like a malignant growth, diabetes, cardiovascular and neurodegenerative. The current review deals with the antioxidant property of ferulic acid and the recent patent describe the role of ferulic acid against human diseases.

https://doi.org/10.2174/1872213X13666190621125048

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June 2019

Ferulic Acid: A Promising Therapeutic phytochemical and recent patents advances.

Recent Pat Inflamm Allergy Drug Discov 2019 06 21. Epub 2019 Jun 21.

Department of Chemistry, Career Point University, Tikker-Kharwarian, Hamirpur, Himachal Pradesh 176041, India

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http://dx.doi.org/10.2174/1872213X13666190621125048DOI Listing
June 2019
5 Reads

Metal Complexation and Patent Studies of Flavonoid

Current Aspects of Flavonoids: Their Role in Cancer Treatment

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May 2019
1 Read

Chemistry and Synthetic Overview of Flavonoids

Current Aspects of Flavonoids: Their Role in Cancer Treatment

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May 2019

Molecular targets of celastrol in cancer: Recent trends and advancements.

Crit Rev Oncol Hematol 2018 Aug 5;128:70-81. Epub 2018 Jun 5.

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA. Electronic address:

Despite the advancement in the well-equipped and sophisticated laboratories and facilities, cancer remains to be a major cause of death worldwide. Consequently, further investigation of novel strategies need to be evolved. Since the last few decades, the utilization of phytochemicals is emerging against several human cancers, including lung, breast, colon carcinoma, lymphoma, and other hematological malignancies. Terpenoids are a category of therapeutically active phytochemicals that have been utilized against cancer, cardiovascular and neurodegenerative disorders. Particularly, celastrol, a pentacyclic terpenoid, is well-studied for its variety of pharmacological properties. It is well documented that celastrol can modulate a variety of signaling pathways. Celastrol's anti-proliferative role has been found to be associated with its pro-apoptotic (via protein kinase B), anti-angiogenic (via vascular endothelial growth factor and vascular endothelial growth factor receptor), anti-metastatic (via matrix metalloproteinases), and anti-inflammatory (via cytokines and chemokines) activities. This review describes various molecular mechanisms of celastrol for understanding the biology of cancer initiation, progression as well as designing efficacious therapeutic strategies.

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http://dx.doi.org/10.1016/j.critrevonc.2018.05.019DOI Listing
August 2018
66 Reads
1 Citation
4.027 Impact Factor

Celastrol as a pentacyclic triterpenoid with chemopreventive properties.

Pharm Pat Anal 2018 Jul 8;7(4):155-167. Epub 2018 Jun 8.

Walter Bushnell Bioscience Pvt Ltd, New Delhi 110017, India.

Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in significant reduction of cancer growth, survival and metastasis. This review summarizes the varied molecular targets of celastrol along with insight into the various recently published clinical, preclinical and industrial patents (2011-2017).

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http://dx.doi.org/10.4155/ppa-2017-0035DOI Listing
July 2018
66 Reads
1 Citation

Celastrol: Natural pentacyclic triterpene essential to human health

9th Indian Youth Science Congress

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April 2018
74 Reads

Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy.

Life Sci 2018 Feb 7;194:75-87. Epub 2017 Dec 7.

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA.

A wide variety of chronic diseases, such as neurodegenerative and cardiovascular disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are now being treated with cost effective phytomedicines. Since synthetic medicines are very expensive, concerted efforts are being made in developing and poor countries to discover cost effective medicines for the treatment of non-communicable diseases (NCDs). Understanding the underlying mechanisms of bioactive medicines from natural sources would not only open incipient avenues for the scientific community and pharmaceutical industry to discover new drug molecules for the therapy of NCDs, but also help to garner knowledge for alternative therapeutic approaches for the management of chronic diseases. Fisetin is a polyphenolic molecule of flavonoids class, and belongs to the bioactive phytochemicals that have potential to block multiple signaling pathways associated with NCDs such as cell division, angiogenesis, metastasis, oxidative stress, and inflammation. The emerging evidence suggests that fisetin may be useful for the prevention and management of several types of human malignancies. Efforts are being made to enhance the bioavailability of fisetin after oral administration to prevent and/or treat cancer of the liver, breast, ovary and other organs. The intent of this review is to highlight the in vitro and in vivo activities of fisetin and to provide up-to-date information about the molecular interactions of fisetin with its cellular targets involved in cancer initiation, promotion and progression as well as to focus on strategies underway to increase the bioavailability and reduce the risk of deleterious effects, if any, associated with fisetin administration.

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http://dx.doi.org/10.1016/j.lfs.2017.12.005DOI Listing
February 2018
6 Reads
7 Citations
2.702 Impact Factor

Therapeutic charm of quercetin and its derivatives: a review of research and patents.

Pharm Pat Anal 2018 Jan 11;7(1):15-32. Epub 2017 Dec 11.

Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, India.

Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-?B, MAPK, PI3K-AKT and mTOR are found to be regulated by quercetin. In addition, several patents have reported recently on quercetin derivatives describing wide therapeutic applications such as anticancer/antiproliferatory, antioxidative/antiaging, antiviral, anti-inflammatory, cardioprotective. Present review emphasizes the chemistry and sources of quercetin followed by description of its broad-spectrum therapeutic potential along with proposed mechanisms of action. Furthermore, this review also highlights the important modifications in the basic chemical structure of quercetin in terms of published patents. Insolubility of the bioactive compounds restricts their medicinal importance which could be overcome by modifications in the chemical structure of so-called derivatives. Most of the patents deal with the modifications in chemical structure of quercetin mainly at hydroxyl groups and C-6 and C-7 positions.

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http://dx.doi.org/10.4155/ppa-2017-0030DOI Listing
January 2018
9 Reads
12 Citations

Natural moieties as promising anti-cancer drugs

Journal of Biological and Chemical Sciences

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December 2017

2 Citations

2 Reads

Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities.

Recent Pat Inflamm Allergy Drug Discov 2016 ;10(1):21-33

Department of Biotechnology, M. M. University, Mullana-Ambala Haryana-133207, India.

Background: Plant derived products are not only served as dietary components but also used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic agents.

Objectives: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic moieties along with their proposed mechanisms of action. Furthermore, the relevant patents have also been listed to present the health benefits of these promising therapeutic agents to pin down the inflammatory diseases. Expert opinion: Pentacyclic terpenoids are known to negatively down-regulate a variety of extracellular and intracellular molecular targets associated with disease progression. The major anti-inflammatory effects of these molecules have been found to be mediated via inactivation of NFkB, STAT3/6, Akt/mTOR pathways. A number of patents on UA & OA based moieties have been reported between 2010 and 2016. Still there have been only a few compounds which meet the need of sufficient hydro solubility and bioavailability along with higher anti-inflammatory activities. Thus, it is essential to develop novel derivatives of terpenpoids which may not only overcome the solubility issues but also may improve their therapeutic effects. In addition, scientific community may utilize nanotechnology based drug delivery systems so as to increase the bio-availability, selectivity and dosages related problems.

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March 2017
87 Reads
21 Citations

Mechanistic insight into carnosol-mediated pharmacological effects: Recent trends and advancements.

Life Sci 2017 Jan 18;169:27-36. Epub 2016 Nov 18.

Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.

For several decades, bioactive phytochemicals have been appreciated to prevent and cure various lethal diseases. Many studies have proven the ability of dietary phytochemicals to avoid and retard tumor initiation and progression. Among the pharmacologically active moieties, terpenoids are considered one of the most important classes. Carnosol, is also a kind of diterpenoid, which known to possess a range of therapeutic effects such as anti-cancer, anti-inflammatory, and anti-oxidant activities. All these effects are mediated via modulating different signaling cascades, including apoptosis regulating molecules (Bax/Bcl2), prosurvival-proproliferative molecules (Akt/mTOR, MAPK), transcription factors like NF-kappaB, STAT3-6, and steroid receptors, such as androgen and estrogen receptors. The present review highlights the recent trends and advancements have been done in the field of research by using carnosol.

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http://dx.doi.org/10.1016/j.lfs.2016.11.013DOI Listing
January 2017
19 Reads
12 Citations
2.702 Impact Factor

Top co-authors

Dharambir Kashyap
Dharambir Kashyap

Postgraduate Institute of Medical Education and Research (PGIMER)

7
Katrin Sak
Katrin Sak

University of Tartu

6
Hardeep Singh Tuli
Hardeep Singh Tuli

Maharishi Markandeshwar University

6
Hardeep S Tuli
Hardeep S Tuli

Maharishi Markandeshwar University

3
Anupam Bishayee
Anupam Bishayee

College of Pharmacy

3
Vivek K Garg
Vivek K Garg

Weill Cornell Medical College

1
Harpal Singh Buttar
Harpal Singh Buttar

University of Ottawa

1