Ajaikumar B Kunnumakkara

Ajaikumar B Kunnumakkara

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Ajaikumar B Kunnumakkara

Ajaikumar B Kunnumakkara

Publications by authors named "Ajaikumar B Kunnumakkara"

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Microwave-assisted synthesis of cellulose/zinc-sulfate‑calcium-phosphate (ZSCAP) nanocomposites for biomedical applications.

Mater Sci Eng C Mater Biol Appl 2019 Jul 12;100:535-543. Epub 2019 Mar 12.

Advance Energy & Materials Systems Laboratory (AEMSL), Department of Chemical Engineering, Indian Institute of Technology Guwahati, Assam 781039, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173492
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http://dx.doi.org/10.1016/j.msec.2019.02.109DOI Listing
July 2019

In silico Molecular Modelling of Selected Natural Ligands and their Binding Features with Estrogen Receptor Alpha.

Curr Comput Aided Drug Des 2019 ;15(1):89-96

Drug Discovery Lab, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.

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http://dx.doi.org/10.2174/1573409914666181008165356DOI Listing
April 2019

Cancer drug development: The missing links.

Exp Biol Med (Maywood) 2019 Apr 8:1535370219839163. Epub 2019 Apr 8.

4 Inflammation Research Center, San Diego, CA 92109, USA.

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http://dx.doi.org/10.1177/1535370219839163DOI Listing
April 2019

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 17;144:192-209. Epub 2019 Apr 17.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019

Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol.

Nutrients 2019 Mar 26;11(3). Epub 2019 Mar 26.

Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany.

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http://dx.doi.org/10.3390/nu11030704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471988PMC
March 2019

Potential of Zerumbone as an Anti-Cancer Agent.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039, India.

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http://dx.doi.org/10.3390/molecules24040734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413012PMC
February 2019

Sorcin a Potential Molecular Target for Cancer Therapy.

Transl Oncol 2018 Dec 11;11(6):1379-1389. Epub 2018 Sep 11.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134165PMC
December 2018

Nature-inspired development of unnatural meroterpenoids as the non-toxic anti-colon cancer agents.

Eur J Med Chem 2018 Dec 30;160:256-265. Epub 2018 Aug 30.

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.088DOI Listing
December 2018

Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer.

Org Biomol Chem 2018 11;16(45):8769-8782

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India.

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http://xlink.rsc.org/?DOI=C8OB01891J
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http://dx.doi.org/10.1039/c8ob01891jDOI Listing
November 2018

Novel tumor necrosis factor-α induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression.

Cancer Lett 2018 Sep 18;432:260-271. Epub 2018 Jun 18.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.06.017DOI Listing
September 2018

TIPE Family of Proteins and Its Implications in Different Chronic Diseases.

Int J Mol Sci 2018 Sep 29;19(10). Epub 2018 Sep 29.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.

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http://www.mdpi.com/1422-0067/19/10/2974
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http://dx.doi.org/10.3390/ijms19102974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213092PMC
September 2018

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer.

Int J Mol Sci 2018 08 10;19(8). Epub 2018 Aug 10.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.

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http://www.mdpi.com/1422-0067/19/8/2362
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http://dx.doi.org/10.3390/ijms19082362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121321PMC
August 2018

Possible use of Punica granatum (Pomegranate) in cancer therapy.

Pharmacol Res 2018 07 2;133:53-64. Epub 2018 May 2.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.04.021DOI Listing
July 2018

NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance.

Cancers (Basel) 2018 Jul 10;10(7). Epub 2018 Jul 10.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.

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http://dx.doi.org/10.3390/cancers10070228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071146PMC
July 2018

Alarming Burden of Triple-Negative Breast Cancer in India.

Clin Breast Cancer 2018 06 20;18(3):e393-e399. Epub 2017 Jul 20.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2017.07.013DOI Listing
June 2018

Tocotrienols: The promising analogues of vitamin E for cancer therapeutics.

Pharmacol Res 2018 04 27;130:259-272. Epub 2018 Feb 27.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.02.017DOI Listing
April 2018

Therapeutic potential of gambogic acid, a caged xanthone, to target cancer.

Cancer Lett 2018 03 13;416:75-86. Epub 2017 Dec 13.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.12.014DOI Listing
March 2018

Acorus calamus: a bio-reserve of medicinal values.

J Basic Clin Physiol Pharmacol 2018 Mar;29(2):107-122

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India, Phone: +91 361 258 2231 (office), +91 789 600 5326 (mobile), Fax: +91 361 258 2249 (office), E-mail:

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http://www.degruyter.com/view/j/jbcpp.2018.29.issue-2/jbcpp-
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http://dx.doi.org/10.1515/jbcpp-2016-0132DOI Listing
March 2018

Novel AKT1 mutations associated with cell-cycle abnormalities in gastric carcinoma.

Per Med 2018 03 30;15(2):79-86. Epub 2018 Jan 30.

Department of Biotechnology, Mizoram University, Aizawl - 796004, Mizoram, India.

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http://dx.doi.org/10.2217/pme-2017-0053DOI Listing
March 2018

Targeting IκappaB kinases for cancer therapy.

Semin Cancer Biol 2018 Feb 24. Epub 2018 Feb 24.

Laboratory for Translational Cancer Research, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108957PMC
February 2018

NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization.

Curr Pharm Des 2016 ;22(27):4173-200

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, Room # 005, O-Block.

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November 2017

Antiulcer properties of fruits and vegetables: A mechanism based perspective.

Food Chem Toxicol 2017 Oct 12;108(Pt A):104-119. Epub 2017 Jul 12.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2017.07.023DOI Listing
October 2017

Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis.

Phytomedicine 2017 Oct 3;34:14-20. Epub 2017 Jul 3.

Inflammation Research Center, San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2017.07.001DOI Listing
October 2017

Nuclear Factor Kappa B: A Potential Target to Persecute Head and Neck Cancer.

Curr Drug Targets 2017 ;18(2):232-253

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India.

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http://dx.doi.org/10.2174/1389450117666160201112330DOI Listing
September 2017

Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer.

Curr Drug Targets 2017 ;18(4):421-435

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Room # 005, O-Block, Guwahati, Assam-781039, India.

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http://dx.doi.org/10.2174/1389450117666160307145236DOI Listing
September 2017

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

Clin Sci (Lond) 2017 Aug 5;131(15):1781-1799. Epub 2017 Jul 5.

Inflammation Research Center, San Diego, California, U.S.A.

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http://dx.doi.org/10.1042/CS20160935DOI Listing
August 2017

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.

Br J Pharmacol 2017 06 21;174(11):1325-1348. Epub 2016 Oct 21.

Anti-Inflammation Research Institute, San Diego, California, USA.

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http://dx.doi.org/10.1111/bph.13621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429333PMC
June 2017

Butein in health and disease: A comprehensive review.

Phytomedicine 2017 Feb 12;25:118-127. Epub 2016 Dec 12.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781 039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2016.12.002DOI Listing
February 2017

Therapeutic implications of toll-like receptors in peripheral neuropathic pain.

Pharmacol Res 2017 01 25;115:224-232. Epub 2016 Nov 25.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.11.019DOI Listing
January 2017

Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far.

Recent Pat Anticancer Drug Discov 2016 ;11(1):67-97

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India.

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December 2016

The potential role of boswellic acids in cancer prevention and treatment.

Cancer Lett 2016 07 14;377(1):74-86. Epub 2016 Apr 14.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Assam 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.04.017DOI Listing
July 2016

Potential of butein, a tetrahydroxychalcone to obliterate cancer.

Phytomedicine 2015 Dec 13;22(13):1163-71. Epub 2015 Oct 13.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India . Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2015.08.015DOI Listing
December 2015

ATP citrate lyase (ACLY): a promising target for cancer prevention and treatment.

Curr Drug Targets 2015 ;16(2):156-63

Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India.

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October 2015

Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.

Biochem Pharmacol 2011 Dec 8;82(12):1901-9. Epub 2011 Sep 8.

Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.bcp.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216474PMC
December 2011

Targeting TNF for Treatment of Cancer and Autoimmunity.

Adv Exp Med Biol 2009 ;647:37-51

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA.

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http://dx.doi.org/10.1007/978-0-387-89520-8_3DOI Listing
June 2010

Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.

Biochem Pharmacol 2010 Feb 6;79(3):330-8. Epub 2009 Sep 6.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bcp.2009.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181156PMC
February 2010

Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

Ann N Y Acad Sci 2009 Aug;1171:59-76

Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04911.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141289PMC
August 2009

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.

Mol Cancer Ther 2009 Apr;8(4):959-70

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-08
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http://dx.doi.org/10.1158/1535-7163.MCT-08-0905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694943PMC
April 2009

Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Mol Cancer Res 2009 Jan;7(1):118-28

Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-08-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677182PMC
January 2009

SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.

Biochem Pharmacol 2008 Dec 5;76(11):1404-16. Epub 2008 Jul 5.

Cytokine Research Laboratory, Departments of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bcp.2008.05.023DOI Listing
December 2008

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.

Biochem Pharmacol 2008 Dec 19;76(11):1590-611. Epub 2008 Aug 19.

Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520800554
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http://dx.doi.org/10.1016/j.bcp.2008.08.008DOI Listing
December 2008

Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.

Cancer Res 2008 Nov;68(21):8861-70

Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673720PMC
November 2008

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.

Cancer Lett 2008 Oct 13;269(2):199-225. Epub 2008 May 13.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350800193
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http://dx.doi.org/10.1016/j.canlet.2008.03.009DOI Listing
October 2008

Potential of spice-derived phytochemicals for cancer prevention.

Planta Med 2008 Oct 8;74(13):1560-9. Epub 2008 Jul 8.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1055/s-2008-1074578DOI Listing
October 2008

Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.

Mol Cancer Ther 2008 Oct;7(10):3306-17

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0432DOI Listing
October 2008

Cancer is a preventable disease that requires major lifestyle changes.

Pharm Res 2008 Sep 15;25(9):2097-116. Epub 2008 Jul 15.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://link.springer.com/10.1007/s11095-008-9661-9
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http://dx.doi.org/10.1007/s11095-008-9661-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569PMC
September 2008

Curcumin and cancer: an "old-age" disease with an "age-old" solution.

Cancer Lett 2008 Aug 6;267(1):133-64. Epub 2008 May 6.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.canlet.2008.03.025DOI Listing
August 2008

Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.

Cancer Res 2008 Jul;68(13):5370-9

Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0511DOI Listing
July 2008

Phase II trial of curcumin in patients with advanced pancreatic cancer.

Clin Cancer Res 2008 Jul;14(14):4491-9

Department of Investigational Cancer Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0024DOI Listing
July 2008

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.

Clin Cancer Res 2008 Apr;14(7):2128-36

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4722DOI Listing
April 2008

Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.

Clin Cancer Res 2008 Apr;14(8):2476-83

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4529DOI Listing
April 2008

Curcumin as "Curecumin": from kitchen to clinic.

Biochem Pharmacol 2008 Feb 19;75(4):787-809. Epub 2007 Aug 19.

Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, United States.

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http://dx.doi.org/10.1016/j.bcp.2007.08.016DOI Listing
February 2008

Bioavailability of curcumin: problems and promises.

Mol Pharm 2007 Nov-Dec;4(6):807-18. Epub 2007 Nov 14.

Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/mp700113rDOI Listing
February 2008

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.

Blood 2007 11 2;110(10):3517-25. Epub 2007 Aug 2.

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-03-07
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http://dx.doi.org/10.1182/blood-2007-03-079616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077305PMC
November 2007

Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).

Free Radic Biol Med 2007 Aug 16;43(4):568-80. Epub 2007 May 16.

Cytokine Research Laboratory, Department of Experimental Therapeutics, Box 143, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754304PMC
August 2007

Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.

J Biol Chem 2007 Jun 17;282(24):17340-50. Epub 2007 Apr 17.

Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M700890200DOI Listing
June 2007

Natural products as a gold mine for arthritis treatment.

Curr Opin Pharmacol 2007 Jun 1;7(3):344-51. Epub 2007 May 1.

Division of Immunology, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/j.coph.2007.03.002DOI Listing
June 2007

Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.

Clin Cancer Res 2007 May;13(10):3024-32

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-2575DOI Listing
May 2007

Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.

Ann N Y Acad Sci 2006 Dec;1091:151-69

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1196/annals.1378.063DOI Listing
December 2006

Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.

J Immunol 2006 Oct;177(8):5612-22

Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.177.8.5612DOI Listing
October 2006