Publications by authors named "Ainsley A Culbert"

7Publications

FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.

J Biol Chem 2006 Nov 18;281(46):35021-9. Epub 2006 Sep 18.

Discovery Research Biology, Neurology Centre of Excellence in Drug Discovery, Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom.

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November 2006

P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro.

Glia 2006 Aug;54(3):234-42

Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, Essex, United Kingdom.

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August 2006

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.

J Biol Chem 2006 Aug 14;281(33):23658-67. Epub 2006 Jun 14.

Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, Essex, United Kingdom.

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August 2006

Multiple signalling pathways mediate insulin-stimulated gene expression in 3T3-L1 adipocytes.

Biochim Biophys Acta 2002 Oct;1578(1-3):43-50

Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK.

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October 2002

Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 (fos-related antigen-1) transcription and phosphorylation.

Biochem J 2002 Dec;368(Pt 2):573-80

Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, U.K.

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December 2002

Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells.

J Biol Chem 2002 Jun 19;277(26):23330-5. Epub 2002 Apr 19.

Systems Research-Kinase Biology Discovery Research, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, CM19 5AD, United Kingdom.

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June 2002